EP0311029A3 - Verfahren zur Herstellung von 3,3-disubstituierten Indolinen - Google Patents

Verfahren zur Herstellung von 3,3-disubstituierten Indolinen Download PDF

Info

Publication number: EP0311029A3
Authority: EP; European Patent Office
Prior art keywords: preparing; disubstituted indolines; indolines; disubstituted; formula
Prior art date: 1987-10-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP19880116435

Other languages

English (en)

French (fr)

Other versions

EP0311029A2 (de

Inventor

Walter Marvin Bryant, Iii

George Frederick Huhn

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bristol Myers Squibb Pharma Co

Original Assignee

EI Du Pont de Nemours and Co

DuPont Merck Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-07

Filing date

1988-10-05

Publication date

1990-10-17

1988-10-05 Application filed by EI Du Pont de Nemours and Co, DuPont Merck Pharmaceutical Co filed Critical EI Du Pont de Nemours and Co

1989-04-12 Publication of EP0311029A2 publication Critical patent/EP0311029A2/de

1990-10-17 Publication of EP0311029A3 publication Critical patent/EP0311029A3/de

Status Withdrawn legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)

EP19880116435 1987-10-07 1988-10-05 Verfahren zur Herstellung von 3,3-disubstituierten Indolinen Withdrawn EP0311029A3 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US105330		1987-10-07
US07/105,330 US4806651A (en)	1987-10-07	1987-10-07	Process for preparing 3,3-disubstituted indolines

Publications (2)

Publication Number	Publication Date
EP0311029A2 EP0311029A2 (de)	1989-04-12
EP0311029A3 true EP0311029A3 (de)	1990-10-17

Family

ID=22305207

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP19880116435 Withdrawn EP0311029A3 (de)	1987-10-07	1988-10-05	Verfahren zur Herstellung von 3,3-disubstituierten Indolinen

Country Status (16)

Country	Link
US (1)	US4806651A (de)
EP (1)	EP0311029A3 (de)
JP (1)	JPH01128979A (de)
KR (1)	KR890006623A (de)
AU (1)	AU607814B2 (de)
CA (1)	CA1320729C (de)
DK (1)	DK558988A (de)
FI (1)	FI884599A7 (de)
HU (1)	HU199826B (de)
IL (1)	IL87948A0 (de)
MY (1)	MY103414A (de)
NO (1)	NO884442L (de)
NZ (1)	NZ226470A (de)
PT (1)	PT88712B (de)
SU (1)	SU1743355A3 (de)
ZA (1)	ZA887549B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5173489A (en) *	1986-04-10	1992-12-22	The Dupont Merck Pharmaceutical Co.	α,α-disubstituted aromatics and heteroaromatics as cognition enhancers
US5087628A (en) *	1990-01-12	1992-02-11	Du Pont Merck Pharmaceutical Company	4,4'-[9H-fluoren-9-ylidenebis (methylene)]bispyrimidine for treating neurological disorders
US5278045A (en) *	1990-02-28	1994-01-11	Du Pont Merck Pharmaceutical Company	Method and compositions to screen compounds for enhancement of the cholinergic, dopaminergic and serotonergic function

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0241006A2 (de) *	1986-04-10	1987-10-14	E.I. Du Pont De Nemours And Company	3,3-Disubstituierte Indoline

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1154976A (en) *	1967-02-21	1969-06-11	Pfizer Ltd	N-Phenyl Indoline Derivatives
US5173489A (en) *	1986-04-10	1992-12-22	The Dupont Merck Pharmaceutical Co.	α,α-disubstituted aromatics and heteroaromatics as cognition enhancers

1987
- 1987-10-07 US US07/105,330 patent/US4806651A/en not_active Expired - Fee Related
1988
- 1988-10-04 CA CA000579302A patent/CA1320729C/en not_active Expired - Fee Related
- 1988-10-05 MY MYPI88001115A patent/MY103414A/en unknown
- 1988-10-05 NZ NZ226470A patent/NZ226470A/en unknown
- 1988-10-05 EP EP19880116435 patent/EP0311029A3/de not_active Withdrawn
- 1988-10-06 JP JP63251013A patent/JPH01128979A/ja active Pending
- 1988-10-06 IL IL87948A patent/IL87948A0/xx unknown
- 1988-10-06 DK DK558988A patent/DK558988A/da not_active Application Discontinuation
- 1988-10-06 KR KR1019880013026A patent/KR890006623A/ko not_active Withdrawn
- 1988-10-06 SU SU884356635A patent/SU1743355A3/ru active
- 1988-10-06 FI FI884599A patent/FI884599A7/fi not_active Application Discontinuation
- 1988-10-06 NO NO88884442A patent/NO884442L/no unknown
- 1988-10-06 AU AU23506/88A patent/AU607814B2/en not_active Ceased
- 1988-10-06 HU HU885180A patent/HU199826B/hu not_active IP Right Cessation
- 1988-10-07 PT PT88712A patent/PT88712B/pt not_active IP Right Cessation
- 1988-10-07 ZA ZA887549A patent/ZA887549B/xx unknown

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0241006A2 (de) *	1986-04-10	1987-10-14	E.I. Du Pont De Nemours And Company	3,3-Disubstituierte Indoline

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 76, 1972, page 468, abstract no. 113013u, Columbus, Ohio, US; M. MAKOSZA et al.: "Reactions of organic anions. XXXII. Catalytic alkylation of N-substituted oxindole derivatives in aqeous medium", & ROCZ. CHEM. 1971, 45(11), 1861-8 *

Also Published As

Publication number	Publication date
KR890006623A (ko)	1989-06-14
NZ226470A (en)	1990-01-29
IL87948A0 (en)	1989-03-31
US4806651A (en)	1989-02-21
FI884599A7 (fi)	1989-04-08
JPH01128979A (ja)	1989-05-22
HU199826B (en)	1990-03-28
DK558988A (da)	1989-04-08
FI884599A0 (fi)	1988-10-06
DK558988D0 (da)	1988-10-06
CA1320729C (en)	1993-07-27
SU1743355A3 (ru)	1992-06-23
PT88712B (pt)	1992-12-31
AU607814B2 (en)	1991-03-14
EP0311029A2 (de)	1989-04-12
NO884442D0 (no)	1988-10-06
HUT49344A (en)	1989-09-28
MY103414A (en)	1993-06-30
AU2350688A (en)	1989-04-13
ZA887549B (en)	1990-06-27
NO884442L (no)	1989-04-10

Similar Documents

Publication	Publication Date	Title
NO171503C (no)	1993-03-24	Fremgangsmaate for selektiv fremstilling av diorganodialkoxysilaner
IT8321261A0 (it)	1983-05-24	Metodo per la preparazione di 26,26,26,27,27,27-esafluoro-1alfa, 25-diidrossicolesterolo.
JPS52286A (en)	1977-01-05	Method of preparing 1-(3-phenylpropyl)-4-acylpiperazine derivatives
EP0240164A3 (de)	1987-12-09	Herstellung von Azetidinonen
BG43867A3 (en)	1988-08-15	Method for preparing of 6- alpha- methylcorticoids
EP0255717A3 (de)	1990-12-05	Gangliosid-Derivate und Verfahren zur Herstellung davon
IT7924631A0 (it)	1979-07-25	Ammidi dell'acido 1,2,3-triazolcarbossilico, procedimento per preparare questi composti nonche' mezzi biocidi cheli contengono.
PH24207A (en)	1990-04-10	2-acylamino-6-amino-4,5,6,7-tetrahydrobenzothiazoles
EP0298487A3 (de)	1991-02-27	Verfahren zur Herstellung von tertiären Alkyldimethylhalosilanen
DE69021907D1 (de)	1995-10-05	Verfahren zur Herstellung von kristallinem, sinterfähigem Aluminiumnitridpulver.
IT8221939A0 (it)	1982-06-18	Immidazolil-propionitrili, procedimento per la preparazione di questi composti nonche' mezzi biocidi che li contengono.
NL189260C (nl)	1993-02-16	Werkwijze voor de bereiding van (1r,5s) 6,6-dimethyl 4(r) ((s)-cyaan-(3'-fenoxyfenyl)methoxy)-3-oxabicyclo(3,1,0)-hexanon-2.
RU94019424A (ru)	1996-04-20	Способ получения кристаллического моногидрата лоракарбефа из кристаллического дигидрата лоракарбефа
NL7705642A (nl)	1977-11-29	Werkwijze ter bereiding van derivaten van 6'-ami- no-spiro(cycloalkaan-1,2'-penam)-3'-carbonzuur.
AU2350688A (en)	1989-04-13	Process for preparing 3,3-disubstituted indolines
GB2034714B (en)	1983-04-13	Process for preparing cyclo-1,3,2-oxazaphosphoryl derivatives
JPS51139688A (en)	1976-12-02	Process for preparing new alkaloid tm-64 substance by fermentation
JPS5253868A (en)	1977-04-30	Process for preparing aminopropanol derivative
EP0248238A3 (en)	1989-06-14	Process for the preparation by fermentation of l-isoleucine from d,l-alpha-hydroxybutyrate
EP0122419A3 (de)	1985-12-04	Substituierte 3-Mercapto-Pyridazine, ihrer 3-Alkylthio-Derivate, und Verfahren zu ihrer Herstellung
JPS5223086A (en)	1977-02-21	Novel method of preparing 2,3- dioxopiperazine
CA2091569A1 (en)	1992-05-01	Intermediates in the preparation of 4,5-difluoroanthranilic acid
RO82904A2 (ro)	1984-01-14	Procedeu pentru prepararea 2,2-dimetilhidrazidei acidului succinic
IT8223632A0 (it)	1982-10-06	Procedimento per la preparazione di 2,2-dialchilamino-1-nitroeteni.
NO910057D0 (no)	1991-01-07	Fremgangsmaate for fremstilling av 2,6-substituert-3,5-pyridindicarboxylsyrederivater.

Legal Events

Date	Code	Title	Description
1989-02-25	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1989-04-12	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AT BE CH DE ES FR GB GR IT LI LU NL SE
1990-08-29	PUAL	Search report despatched	Free format text: ORIGINAL CODE: 0009013
1990-10-17	AK	Designated contracting states	Kind code of ref document: A3 Designated state(s): AT BE CH DE ES FR GB GR IT LI LU NL SE
1991-01-30	17P	Request for examination filed	Effective date: 19901206
1991-11-13	17Q	First examination report despatched	Effective date: 19910925
1991-12-11	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: THE DU PONT MERCK PHARMACEUTICAL COMPANY
1992-06-12	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN
1992-08-05	18W	Application withdrawn	Withdrawal date: 19920526