Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
  • A61K31/60—Salicylic acid; Derivatives thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
  • A61K8/8105—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
  • A61K8/8117—Homopolymers or copolymers of aromatic olefines, e.g. polystyrene; Compositions of derivatives of such polymers
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
  • A61K8/0208—Tissues; Wipes; Patches
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
  • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
  • A61K8/8194—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, at least one having two or more carbon-to-carbon double bonds; Compositions of derivatives of such polymers
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
  • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
  • A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
  • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
  • A61L15/42—Use of materials characterised by their function or physical properties
  • A61L15/44—Medicaments
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
  • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
  • A61L15/42—Use of materials characterised by their function or physical properties
  • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
  • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
  • A61L15/42—Use of materials characterised by their function or physical properties
  • A61L15/48—Surfactants
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
  • A61Q19/10—Washing or bathing preparations

Definitions

• This invention relates to multiple layer laminated medicated cleansing pads which contain a salicylic acid active composition and also to methods for treating acne.
• Acne is a common inflammatory pilobaceous disease charac­terized by comedones, papules, pustules, inflamed nodules, superficial pus-filled cysts, and in extreme cases, sinus formation and deep inflammation, sometimes associated with purulent sacs.
• the pathogenesis of acne is complex. An interaction between hormones, keratinization, sebum and bacteria somehow determines the course and severity of the disease. Acne begins at puberty when the increase of androgens causes an increase in the size and activity of the pilosebaceous glands. The earliest microscopic change is intrafollicular hyperkeratosis, which leads to restriction of the pilosebaceous follicle with consequent form­ation of the comedo composed of sebum, keratin, and micro­organisms, particularly Propionibacterium (Corynebacterium) acnes . Lipases from P.
• FFA free fatty acids
• Acne can be treated by topical application of various lotions, salves and the like or by, for example, localized treatment with, for example, sulphur, resorcinol, salicylic acid, benzoyl peroxide or vitamin A acids.
• Salicylic acid is a well recognized anti-acne active ingredient which causes a reduction in intercellular cohesion of the corneo­cytes (see C. Huber et al, Arch. Derm. Res. 257, 293-297, 1977), thereby dissolving the existing keratin plugs as well as preventing the formation of new ones.
• the ideal anti-acne composition should deliver and retain optimal concentrations of salicylic acid in the stratum corneum with less penetration through the skin and into the general circulation.
• a common method of treating acne is by application of a cleansing pad which contains salicylic acid.
• a cleansing pad which contains salicylic acid.
• such pads have proven not totally satisfactory because they have little loft, lack rigidity and are unsatisfactory carriers of the anti-acne salicylic acid active. Also, such pads have unsatisfactory cosmetics which hinder their effectiveness.
• the present invention relates to medicated cleansing pads comprising:
• This invention also encompasses a method of treating acne in humans and lower animals comprising topically applying to the affected area the medicated pads of the present invention.
• the medicated cleansing pads of the present invention comprise two or more nonwoven materials laminated together to form a multiple layer medicated pad.
• Such pads can have a variety of textural differences such as a smooth nonwoven material laminated to a coarse nonwoven material thereby having varying degrees of textural differences.
• composition and method of the present invention are suitable for the treatment of various dermatological disorders such as psoriasis, idiopathic vitiligo, seborrheic dermatitis and bullous pemphigoid, especially for the treatment of acne.
• various dermatological disorders such as psoriasis, idiopathic vitiligo, seborrheic dermatitis and bullous pemphigoid
• the clinical lesions which typify acne include comedones, papules, pustules, cysts, and scars.
• the present invention contains nonwoven fabrics derived from "oriented" or carded fibrous webs composed of textil-length fibers, the major proportion of which are oriented predominantly in one direction.
• the convention base starting material for the majority of these nonwoven fabrics is usually a fibrous web comprising any of the common textile-length fibers, or mixtures thereof, the fibers varying in average length from approximately 1 ⁇ 2 inch to about 3 inches, preferably 11 ⁇ 2 to 2 inches.
• Exemplary of such fibers are the natural fibers such as cotton and wool and the synthetic or man-made cellulose fibers, notably rayon or regenerated cellu­lose, such as those supplied by BASF.
• textile-length fibers of a synthetic or man-made origin may be used in various proportions to replace either partially or perhaps even entirely the previously-named fibers.
• Such other fibers include: polyamide fibers such as nylon 6, nylon 66, nylon 610, etc.; polyester fibers such as “Dacron”, “Fortrel” and “Kodel”; acrylic fibers such as “Acrilan”, “Orlon” and “Creslan”; modacrylic fibers derived from polyethylene and polypropylene; cellulose ester fibers such as "Arnel” and “Acele”; polyvinyl alcohol fibers, etc.
• These textile-length fibers may be replaced either partially or entirely by fibers having an average length of less than about one-half inch and down to about one-quarter inch.
• These fibers, or mixtures, thereof are customarily processed through any suitable textile machinery (e.g., a conventional cotton card, a "Rando-Webber” a paper-making machine, or other fibrous web producing apparatus) to form a web or sheet of loosely associated fibers, weighing from about 100 grains to about 2,000 grains per square yard or even higher.
• shorter fibers such as wood pulp fibers or cotton linters
• wood pulp fibers or cotton linters may be used in varying proportions, even up to 100%, where such shorter length fibers can be handled and processed by available apparatus.
• Such shorter fibers have lengths less than 1 ⁇ 4 inch.
• the resulting fibrous web or sheet regardless of its method of production, is then subjected to at least one of several types of bonding operations to anchor the individual fibers together to form a self-sustaining web incorporating the resins described infra .
• One method is to impregnate the fibrous web over its entire surface area with the resins of the present invention. Such over-all impregnation produces a nonwoven fabric of good longitudinal and cross strength, acceptable durability and solvent resistable and satisfactory abrasion resistance.
• nonwoven cloths are not a part of this invention and, being well known in the art, are not described in detail herein.
• such cloths are made by air or water-laying processes in which the fibers or filaments are first cut to desired lengths from long strands, passed into a wateR or air stream, and then deposited onto a screen through which the fiber-laden air or water is passed.
• the deposited fibers or filaments are then adhesively bonded together, using the resins of the present invention, dried, cured, and otherwise treated as desired to form the nonwoven cloth.
• Thermocarded nonwoven cloths are made of polyesters, polyamides, or other thermo­plastic fibers which can be spand bonded, i.e., the fibers are spun out onto a flat surface and bonded (melted) together by heat or chemical reactions, thereby not utilizing a resin.
• Such non-weaving can be bonded together utilizing the resins of the principal invention to form dual-laminated pads.
• the preferred nonwoven cloth substrates used in the invention herein are generally adhesively bonded fibers or fila­mentous products having a web or carded fiber structure (when the fiber strength is suitable to allow carding) or comprising fibrous mats in which the fibers or filaments are distributed haphazardly or in random array (i.e., an array of fibers in a carded web where partial orientation of the fibers is frequently present, as well as a completely haphazard distributional orien­tation), or substantially aligned.
• the fibers or filaments can be natural (e.g., wool, silk, jute, hemp, cotton, linen, sisal, or ramie) or synthetic (e.g., rayon, cellulose ester, polyvinyl derivatives, polyolethins, polyamides, or polyesters) as have been described hereinabove.
• synthetic e.g., rayon, cellulose ester, polyvinyl derivatives, polyolethins, polyamides, or polyesters
• compositions are dual texture laminated nonwovens with coarse (or highly textured) nonwoven laminated to a smoother nonwoven.
• the coarse nonwoven preferably has a denier of above about 5, preferably above about 8 and a loft of above about 60 mills, preferably above about 70 mills and the smooth side has a denier of from about 1 to about 4, preferably from about 1 to about 3, and a loft from about 10 to about 60, preferably from about 10 to about 50.
• air-laid cellulose based nonwovens with a loft of from about 50 to about 150. The loft of these materials can be measured by an Ames 482 guage micrometer using a 2 inch foot and a 5 pound weight.
• compositions herein are dual textured pads comprising a high loft carded nonwoven fabric resin-bonded to an air-laid nonwoven.
• pads are made by conventional techniques such as print laying the resin onto one of the substrate materials and nipping or by saturation of the materials and nipping.
• the absorbent properties preferred herein are particularly easy to obtain with nonwoven cloths and are provided merely by building up the thickness of the cloth, i.e., by superimposing a plurality of carded webs or mats to a thickness adequate to obtain the necessary absorbent properties, or by allowing a sufficient thickness of the fibers to deposit on the screen.
• Any denier of the fiber generally up to about 15 denier
• any thickness necessary to obtain the required absorbent capacity can be used.
• the binder-resins used in the manufacture of the nonwoven cloths of the present invention provide substrates possessing a variety of desirable traits. In addition to improved loft and rigidity, there is virtually no degradation of the salicylic acid active composition used in the anti-acne pads of the present invention. Additional benefits provided by these resins include excellent strength in all directions resulting in pads which are not prone to tear or separate in normal use.
• Resins, or polymers as they are often referred to, useful in the present invention are high molecular weight organic compounds and are of a synthetic or man-made origin.
• the resins useful in the present invention are formed from styrene monomers and/or butadiene monomer units and are formed usually either by addition or condensation of one or more monomers.
• the resins have the general formula: (A x ) (B y ) wherein A is one or more monomers selected from styrene or a styrene derivative and B is one or more monomers selected from butadiene or a butadiene derivative, x is the number of different A monomer components present in the copolymer chain, with x being an integer of 1 or more and y is the number of B monomer components present in the copolymer chain, with y being an integer of 0 or more and m:n is the weight ratio of A monomer components to B monomer components, and is generally within the range of from about 10:1 to about 1:5, preferably from about 5:1 to about 1:2.
• Suitable examples of such styrene or butadiene monomer units resins include 1,2 butadiene, 1,4 butadiene, 2-ethyl-1,3 butadiene isoprene, high, medium and carboxylated butadiene-­acrylnitrile, 2 methyl styrene, 3 methyl styrene, 4 methyl styrene, ethyl styrene, butyl styrene, and 2, 3 dimethyl buta­diene.
• resins of the present invention may be used either as homopolymers comprising a single repeating monomer unit, or they may be used as copolymers comprising two, three or more different monomer units which are arranged in random fashion, or in a definite order alternating fashion, within the polymer chain (block copolymers). Also included within the inventive concept are the block polymers comprising relatively long blocks of different monomer units in a polymer chain and graph polymers comprising chains of one monomer attached to the backbone of another polymer chain. These polymers are fully described in Noshay et al.
• the resins of the present invention have a glass transition temperature range of from about -100°C to about 100°C, preferively from about -40°C to about 50°C.
• the resins of the presnt invention have a pH of about 7 or higher, preferably from 7.5 to about 9.
• the resins can be incorporated into one or both of the nonwovens to be laminated together, or can be used to laminate two nonwoven materials which do not contain a resin.
• the depo­sition of the synthetic resin binder particles on the individual fibers may be accomplished in many ways at various points in the manufacture process of the pad, such as by stock chest depo­sition techniques. Such techniques generally include the forma­tion of a substantially uniform, aqueous slurry of the fibers which will make up the fibrous web and inclusion in the aqueous slurry of the synthetic resin particles which are to be deposited on and adhered to the individual fibers. Deposition aids may be used, if necessary, to promote the deposition and adherence of the synthetic resin particles on the particular fibers.
• deposition aids examples include Rohm & Haas deposition aid S-243, polyethylene amine, alum, polymeric amines, polymeric amides, cationic starch, etc.
• Methods of forming such nonwoven textile fabrics are disclosed in, for example, U.S. Patent 3,778,341 to Plummer, et al., assigned to Johnson & Johnson, issued December 11, 1973.
• saturation coating techniques using an engraved roller to lay resin on carded materials, as is well-known in the art.
• the salicylic acid active component can be salicylic acid alone, salicylic acid derivatives and salicylic acid in combination with other active ingredients such as benzoyl peroxide, sulfur, resorcinol, derivatives of retinoic acid, chlorhydroxyquinoline, hormonal and antibacterial agents, and the like. Most preferred is salicylic acid in a hydroalcoholic solution.
• Salicylic acid is a well known anti-acne component and is generally described in U.S. Patent 4,514,385, to Damani, et al., assigned to Alcon Laboratories, issued April 30, 1985.
• the preferred anti-acne active comprises a hydroalcoholic solution at pH 2 to 4 of salicylic acid as the active anti-acne ingredient together with a specific anionic surfactant component. More preferably such active is a stable, hydroalcoholic composition having a pH value of from 2 to 4 and containing from about 0.2 to about 5.0 percent by weight of salicylic acid and from about 0.2 to about 5.0 percent by weight of sodium methyl cocoyl taurate and/or sodium methyl oleoyl taurate as the anionic sur­ factant component. Generally, a sufficient amount of a cosme­tically acceptable alkaline component (i.e., alkalizing agent) to provide and maintain the composition with a pH from about 2.0 to about 4 is included.
• a cosme­tically acceptable alkaline component i.e., alkalizing agent
• the alcohol component of the hydroalcoholic solvent from about 10 to about 60 percent by weight of ethyl alcohol, measured as total C2H5OH content, is preferred although a like amount of isopropyl alcohol (C3H7OH) may also be beneficially utilized. From about 30 to about 80 percent by weight of water is also required as the aqueous component of the hydroalcoholic solvent.
• salicylic acid is a well known active anti-acne ingredient.
• a listing of commercially available anti-acne products containing salicylic acid will be found in the Physician's Desk Reference for Nonprescription Drugs, 7th Edition, 1986, page 314.
• the anionic surfactant component of this active composition i.e., the taurate surfactant component
• the taurate surfactant component is specifically directed to sodium methyl cocoyl taurate and sodium methyl oleoyl taurate, both of which are readily available from diverse commercial suppliers, as noted in The Cosmetic, Toiletry and Fragrance Association (CTFA) Cosmetic Ingredient Dictionary, 3rd Edition, 1982, pages 286-287.
• CTFA Cosmetic, Toiletry and Fragrance Association
• taurate surfactant As the sole surfactant in the active compositions, other surfactants may be included, the nonionic type having preference over the anionic type in view of the relative non-irritating characteristic to the skin of the former. Cationic type surfactants, which are most irritating to the skin, are less preferred because of their marked susceptibility to hydrolysis at the low acidic pH of the subject compositions.
• the pH value of the preferred active component may be achieved by use of appropriate cosmeti­cally acceptable primary or dual buffer systems.
• the resultant pH of the hydroalcoholic solution of salicylic acid is slightly below or at the lower end of the indicated range, and all that is required to adjust the pH to a desired higher value within the indicated range is to add an alkaline additive such as is commonly utilized in cosmetic formulations for such purpose.
• an alkaline additive such as is commonly utilized in cosmetic formulations for such purpose.
• sodium carbonate is preferred, other suitable alkalizing agents include potassium carbonate, sodium hydroxide, potassium hydroxide, triethanolamine and the like. If deemed necessary to change or adjust the pH to a lower value, a suitable cosmetically acceptable acidifying agent such as citric acid may be employed.
• the salicylic acid compositions of the present invention may also include optional additives such as, for example, antibacterial agents such as benzyl alcohol or methyl paraben; antioxidants and preservatives such as ethylenediamine tetraacetic acid; astringents such as witch hazel; odorants and sensates such as camphor or menthol; colorants and other cosmetically acceptable adjuvants generally utilized in topical anti-acne compositions.
• antibacterial agents such as benzyl alcohol or methyl paraben
• antioxidants and preservatives such as ethylenediamine tetraacetic acid
• astringents such as witch hazel
• odorants and sensates such as camphor or menthol
• colorants and other cosmetically acceptable adjuvants generally utilized in topical anti-acne compositions.
• the styrene-butadiene resin is laid on the separate fibrous carded webs of substrates A and B utilizing an engraved print roll and are passed through a nip and passed on to a series of dry cans. This results in a nonwoven material, substrate A, weighing about 67 grams per square yard. Substrate B weighs about 36 grams per square yard. The two substrates are bonded together by print laying the lamination resin (styrene-butadiene) onto substrate A and passed through a nip with substrate B. The resulting nonwoven fabric has a total loft of about 81 mills. The resulting material is then cut into a square shape with edges of 5 cm.
• the active components are combined to form a solution and the pad composition is saturated in this solution.
• a fibrous mixture of each of the substrate materials are spun out onto a flat surface bonded (melted) together by a heat reaction as is known to one skilled in the art.
• the two materials (A&B) are then laminated together by print laying the styrene-­butadiene resin containing a ration of styrene to butadiene of 80:20 on either thermal carded substrate A or B.
• the two materials are married and passed through a nip followed by a passing through an oven.
• the material is then cut into a circular shape (diameter of 4.5 cm).
• the active components are combined to form a solution and pad composition is saturated in this solution.
• Substrate A a carded material with a basis weight of about 36 grams pers square yard and a loft of about 11-13 mills
• substrate B a thermal carded material with a basis weight of about 45 gram sper square yard and a loft of 20-25 mills
• the resulting nonwoven fabric has a total loft of about 30 mills.
• the material is then cut into circles with a diameter of 7 cm.
• the active components are combined to form a solution and the pad composition is saturated in this solution.
• Substrate A has a basis weight of about 55 grams per square yard and a loft of about 90-100.
• Substrate B has a basis weight of about 80 grams per square yard and a loft of about 90 to 100 mills.
• the two materials are laminated together as described in Example I.
• the resulting nonwoven fabric has a loft of about 120 mills.
• the resulting material is then cut into an oval shape (5 cm. X 7 cm.).
• Application of the resulting medicated pad twice a day to a person in need of anti-acne treatment increases kera­tinization of the stratum corneum.
• Substrate A with a basis weight of 46 grams per square yard and a loft of 20-25 mills and substrate B with a basis weight of 74 grams per square yard and a loft of 65-70 mills are laminated together as described in Example I.
• the resulting pad with a loft of about 80 mills is cut into circles with a diameter of 6 cm.
• the application and usuage is consistent with that described above.

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• 1988
  • 1988-02-02 US US07/151,339 patent/US4891227A/en not_active Expired - Fee Related
• 1989
  • 1989-01-27 MY MYPI89000104A patent/MY105805A/en unknown
  • 1989-01-30 PH PH38121A patent/PH25967A/en unknown
  • 1989-02-01 DE DE68915558T patent/DE68915558T2/de not_active Expired - Fee Related
  • 1989-02-01 AU AU29517/89A patent/AU613294B2/en not_active Ceased
  • 1989-02-01 NZ NZ227824A patent/NZ227824A/en unknown
  • 1989-02-01 IE IE32289A patent/IE63860B1/en not_active IP Right Cessation
  • 1989-02-01 AT AT89300951T patent/ATE106253T1/de not_active IP Right Cessation
  • 1989-02-01 ES ES89300951T patent/ES2053969T3/es not_active Expired - Lifetime
  • 1989-02-01 KR KR1019890001142A patent/KR0136271B1/ko not_active Expired - Fee Related
  • 1989-02-01 EP EP89300951A patent/EP0327327B1/fr not_active Expired - Lifetime
  • 1989-02-01 CA CA000589783A patent/CA1337797C/fr not_active Expired - Fee Related
  • 1989-02-02 MX MX14755A patent/MX162932B/es unknown
  • 1989-02-02 JP JP1024739A patent/JP2885816B2/ja not_active Expired - Lifetime
  • 1989-02-02 DK DK047889A patent/DK47889A/da not_active Application Discontinuation

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