EP0342155A2 - Appareil de laboratoire pour chauffer ou refroidir à volonté - Google Patents

Appareil de laboratoire pour chauffer ou refroidir à volonté Download PDF

Info

Publication number
EP0342155A2
EP0342155A2 EP89810324A EP89810324A EP0342155A2 EP 0342155 A2 EP0342155 A2 EP 0342155A2 EP 89810324 A EP89810324 A EP 89810324A EP 89810324 A EP89810324 A EP 89810324A EP 0342155 A2 EP0342155 A2 EP 0342155A2
Authority
EP
European Patent Office
Prior art keywords
laboratory device
cooling
heating
peltier elements
laboratory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP89810324A
Other languages
German (de)
English (en)
Other versions
EP0342155A3 (fr
Inventor
Ulrich Christian Dr. Ing. Agr. Knopf
Josef E. Jun. Sieber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AGROGEN-STIFTUNG
Knopf Ulrich C Dr
Original Assignee
AGROGEN-STIFTUNG
Knopf Ulrich C Dr
Seyffer and Co
AGROGEN STIFTUNG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH1918/88A external-priority patent/CH676332A5/de
Priority claimed from CH151989A external-priority patent/CH679282A5/de
Application filed by AGROGEN-STIFTUNG, Knopf Ulrich C Dr, Seyffer and Co, AGROGEN STIFTUNG filed Critical AGROGEN-STIFTUNG
Publication of EP0342155A2 publication Critical patent/EP0342155A2/fr
Publication of EP0342155A3 publication Critical patent/EP0342155A3/fr
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25B—REFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
    • F25B21/00—Machines, plants or systems, using electric or magnetic effects
    • F25B21/02—Machines, plants or systems, using electric or magnetic effects using Peltier effect; using Nernst-Ettinghausen effect
    • F25B21/04—Machines, plants or systems, using electric or magnetic effects using Peltier effect; using Nernst-Ettinghausen effect reversible

Definitions

  • thermostated liquid baths especially water baths. They consist of a larger vessel, usually of a few liters, which is equipped with an electric heating device, a stirrer and often also with a circulation pump.
  • the heating device can be controlled by a temperature sensor, so that the temperature of the moved or circulated liquid can be kept at a certain, preset value.
  • a cooling device is also offered for such liquid baths, which makes it possible to keep the liquid temperature below the ambient temperature. This means that the liquid bath can be used as a cryostat in this case.
  • Conventional refrigerators operating on the compression or adsorption principle are used as cooling devices for such cryostats.
  • Such liquid baths which can be kept at a constant temperature by means of heating or cooling, are suitable for many laboratory tasks and are practical to use. They are suitable for the thermostatting of samples in vessels that are placed directly in the liquid bath, as well as for external heating or cooling of samples using liquid circulation.
  • electric heating plates are often also offered, which can also be equipped with a temperature sensor and a thermostat. They are also known in the trade available laboratory hot plates, in which a motor-driven rotating permanent magnet is also installed. This means that a liquid sample on the heating plate can be stirred at the same time by means of a magnetic rod immersed in the liquid.
  • the ice commonly used for cooling in the biological laboratory has many disadvantages: it has to be constantly renewed and requires a large and relatively expensive machine to be available. It is also not easy to keep sterile, and its handling is also impractical in many cases, for example for cooling the flat petri dishes.
  • Another disadvantage of ice as the coolant is due to its constant temperature of 0 o C. Lower temperatures can be reached by adding salt, but programming temperature changes here is also difficult due to the constant temperature of the coolant.
  • the purpose of the present invention is to provide a handy device with which material and liquid samples can be heated and cooled or guided through predetermined temperature cycles in a small space and energy requirement, and which is specifically designed for the needs of biological, biochemical and genetic Laboratory is designed.
  • the device is designed in such a way that temperature cycles, some of which are above and some below room temperature, can also be carried out without any problems.
  • the device also requires very little space and is easy to keep sterile. It can be equipped with the necessary devices for stirring the samples or, due to its low weight and small dimensions, can even be accommodated on a conventional shaker.
  • the separation of the device into a working part on the one hand and a power and control part on the other hand proves to be a special advantage.
  • the working part of the device according to the invention essentially consists of a block (1) made of highly thermally conductive metal, preferably aluminum or stainless steel, which can be electrically heated and cooled with a flat work surface (2), on which either a vessel with the sample is placed, or - in another embodiment - a work module (14), also made of highly heat-conducting metal, with one or preferably several suitable recesses (15) for the sample vessels can.
  • a block (1) made of highly thermally conductive metal, preferably aluminum or stainless steel, which can be electrically heated and cooled with a flat work surface (2), on which either a vessel with the sample is placed, or - in another embodiment - a work module (14), also made of highly heat-conducting metal, with one or preferably several suitable recesses (15) for the sample vessels can.
  • one or more Peltier elements (5) whose thermally active pole faces (6) and (7) are in thermal contact with the metal block (1) and on the other hand stand with a heat exchanger (8).
  • a heat exchanger (8) There is an insulation layer (9) between the metal block (1) and the heat exchanger.
  • the metal block is surrounded by another insulation layer (10) along its edge.
  • the Peltier elements (5) consist of block-shaped blocks in which a large number of semiconductor pairs in a parallel arrangement and electrically connected in series are compactly combined. Such Peltier blocks heat up during the passage of a direct current on one surface and cool down accordingly on the opposite surface. By reversing the direction of the current, the heating and cooling surfaces can be interchanged with one another.
  • the bidding cooling or warming surfaces are referred to below as thermal pole surfaces.
  • the current direction is selected such that the upper thermal pole surfaces (6) of the Peltier elements heat up and the counter surfaces (7) cool down.
  • the heat given off is transferred to the metal block (1), on the surface (2) of which the samples to be heated, respectively.
  • the work modules holding the sample vessels are provided; the cooling of the lower surfaces (7) is transferred to the heat exchanger (8).
  • Peltier elements can be used as required. If these, electrically connected in parallel, are arranged in a single layer, the thermal output multiplies according to the number of elements used; the achievable temperature difference between the pole faces, which is essentially limited by the internal conductivity of the Peltier elements, remains unaffected. However, it is also possible to arrange the Peltier elements in two or more layers lying vertically one above the other, the opposite thermal pole faces of two Peltier elements lying one above the other being in contact with one another. These directly superimposed elements are thus thermally connected in series, and the achievable temperature difference between those with the metal block. The outer pole faces in contact with the heat exchanger can thereby be enlarged. Of course, if a larger number of Peltier elements are used, parallel and series connection can also be used simultaneously.
  • the heat exchanger consists of a metal block which is traversed by a system of channels through which a coolant, e.g. Water is circulated.
  • a coolant e.g. Water
  • the heat exchanger consists of a metal block, the outer surface of which is kept particularly large in the form of ribs. A rapid heat exchange with the surrounding air can be achieved by blowing on by means of an air flow generated by a fan (13). The temperature difference between the warm and the cold surface of the Peltier elements is always kept as small as possible, and the efficiency is optimized.
  • the current direction is reversed so that the upper surface (6) of the Peltier elements cools down and the lower surface (7) heats up.
  • the metal block (1) is thereby cooled; the one at the bottom Area (7) of the the heat emitted by the Peltier elements is transferred to the heat exchanger (8) and is dissipated from there to the environment.
  • the heatable and coolable working part with the metal block (1) is also replaced by additional interchangeable working modules (14, 17) in the form of metal blocks with openings (15) for the insertion of entire series of sample vessels, e.g. Glasses, ampoules, tubes or thin straws, so-called “straws” added.
  • sample vessels e.g. Glasses, ampoules, tubes or thin straws, so-called "straws" added.
  • Such block-shaped modules for different types of vessels are simply placed on the work surface (2) or, if necessary, screwed on, care being taken to ensure good thermal contact by precise surface treatment.
  • the outer surfaces of the modules that are not in contact with the working surface (2) of the metal block (1) are thermally insulated.
  • the interchangeable work module consists of a rectangular open trough (33) with a footplate (34) projecting laterally from it, which is used for heat exchange with the work table (2).
  • Tub and footplate can be made in one piece; the floor surface of the latter must be machined as precisely as possible for good contact with the work table (2).
  • the module can either be simply attached or screwed to the table of the heating and cooling device.
  • the tub of the work module can be filled with a liquid into which the sample vessels are inserted.
  • the pan is either covered with a grid or a lid with matching holes for inserting the vessels.
  • the trough is filled with a solid in particle form (40), for example in powder, granule or spherical form.
  • a solid in particle form 40
  • graphite powder or a filling of balls with a maximum diameter of approx. 5 mm made of metal or glass is suitable.
  • Such a solid filling can hold the sample vessels in any position; there is no need for a special tub cover with holding device.
  • the cavities It is also possible to fill up with a liquid between the solid particles, which can further improve the heat transfer.
  • the open trough serves to hold interchangeable inserts (43, 45) made of metal, which in turn are provided with openings (42, 44) for holding the sample vessels.
  • inserts In order to facilitate heat transfer, the inserts must of course be fitted into the tub with as little tolerance as possible; the same applies to fitting the sample vessels into the openings intended for them.
  • Handle screws (52) which can be screwed into the holes provided in the inserts, are used for easy insertion and removal of the tightly fitting inserts from the tub.
  • a heat-insulating cover (4) is used, which can also be provided with a sealing ring (49) for the purpose of good sealing and can be screwed to the trough.
  • the screws (47) for fastening the cover are expediently designed to be identical and interchangeable with the aforementioned grip screws for the inserts.
  • a module to be placed on the work surface consists of a metal block (17) which is equipped with internal channels (18) through which a liquid is circulated by means of a pump.
  • This liquid is either the sample itself, or e.g. Water or alcohol for use in external heat exchange.
  • a separate supply and control part (32) is provided, which is connected to the implement via the connection socket (27), in which on the one hand a clocked power supply unit (20) for supplying the supply direct current and on the other hand one of one Control electronics (21) influenced by temperature sensors are installed, by means of which a preset temperature is sought.
  • a clocked power supply unit (20) for supplying the supply direct current and on the other hand one of one Control electronics (21) influenced by temperature sensors are installed, by means of which a preset temperature is sought.
  • the clocked power supply used for the DC power supply to the Peltier elements chops the AC power of the network at a high frequency and then transforms it to a low voltage.
  • the low-voltage alternating current is finally rectified and smoothed and is then available as a feed current for the Peltier elements (5).
  • This type of supply allows the construction of a small and light device with optimal efficiency, which only produces a small amount of unwanted waste heat.
  • the control unit also contains a display device (22) on which either the set temperature, or the actual temperature of either the work block or, after switching by means of the switch (33), the sample itself can be read.
  • the signals for this are supplied by appropriate temperature probes: a probe built into the metal block (1) for the temperature of the work surface and an external probe (11) connected to the supply and control unit via the connection socket (27) for measuring the sample temperature.
  • the device is usually powered by the AC network. However, it is also possible to supply the device with a corresponding connection (29) with direct current, for example from a car battery with 12 V voltage. As a result, the device, which is already handy, is also particularly suitable for mobile work, for example in a car, on the train or even in an aircraft or spacecraft.
  • the separation of the working section from the supply and control section offers special advantages wherever the heating and cooling device has to be housed in a confined space or where the heat loss developed at the supply device is undesirable in the vicinity of the sample.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Thermal Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Control Of Temperature (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
EP89810324A 1988-05-13 1989-04-28 Appareil de laboratoire pour chauffer ou refroidir à volonté Withdrawn EP0342155A3 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH1918/88A CH676332A5 (en) 1988-05-13 1988-05-13 Temp. control for laboratory specimens
CH1918/88 1988-05-13
CH1519/89 1989-04-21
CH151989A CH679282A5 (en) 1989-04-21 1989-04-21 Temp. control for laboratory specimens

Publications (2)

Publication Number Publication Date
EP0342155A2 true EP0342155A2 (fr) 1989-11-15
EP0342155A3 EP0342155A3 (fr) 1990-06-27

Family

ID=25687877

Family Applications (1)

Application Number Title Priority Date Filing Date
EP89810324A Withdrawn EP0342155A3 (fr) 1988-05-13 1989-04-28 Appareil de laboratoire pour chauffer ou refroidir à volonté

Country Status (3)

Country Link
US (1) US5061630A (fr)
EP (1) EP0342155A3 (fr)
CA (1) CA1317646C (fr)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991007504A1 (fr) * 1989-11-21 1991-05-30 Kindconi Pty. Ltd. Dispositif ameliore de polymerisation d'adn
DE4239232A1 (de) * 1992-11-21 1994-05-26 Schubert Werner Vorrichtung und Verfahren für die Wärmedenaturierung frischen Gewebes im histologischen Labor
EP0606961A1 (fr) * 1989-06-12 1994-07-20 Johnson & Johnson Clinical Diagnostics, Inc. Dispositif de régulation de température pour récipient de réaction
WO1998043740A3 (fr) * 1997-03-28 1998-12-17 Perkin Elmer Corp Ameliorations apportees a un cycleur thermique pour pcr
EP1386666A1 (fr) * 1997-03-28 2004-02-04 PE Corporation (NY) Ameliorations apportees à un cycleur thermique pour PCR
EP1452608A1 (fr) * 1990-11-29 2004-09-01 Applera Corporation Réaction de polymérase en chaíne automatisée
US7133726B1 (en) 1997-03-28 2006-11-07 Applera Corporation Thermal cycler for PCR
US7238517B2 (en) 1990-11-29 2007-07-03 Applera Corporation Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
WO2009101211A1 (fr) * 2008-02-15 2009-08-20 Aj Innuscreen Gmbh Appareil mobile pour isolement d'acides nucléiques
DE102008023299A1 (de) * 2008-05-08 2009-11-19 Micropelt Gmbh Aufnahme für eine Probe
CN102047144B (zh) * 2008-03-25 2014-05-07 株式会社岛津制作所 放射线成像装置
CN114234532A (zh) * 2021-12-08 2022-03-25 深圳市瑞沃德生命科技有限公司 一种制冷装置及其冷冻切片机
RU2847136C1 (ru) * 2024-11-08 2025-09-26 Объединенный Институт Ядерных Исследований (Оияи) Устройство для охлаждения биологических образцов

Families Citing this family (129)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE35716E (en) * 1988-08-02 1998-01-20 Gene Tec Corporation Temperature control apparatus and method
US5281516A (en) * 1988-08-02 1994-01-25 Gene Tec Corporation Temperature control apparatus and method
US5346672A (en) * 1989-11-17 1994-09-13 Gene Tec Corporation Devices for containing biological specimens for thermal processing
WO1991016675A1 (fr) * 1990-04-06 1991-10-31 Applied Biosystems, Inc. Laboratoire de biologie moleculaire automatise
FI915731A0 (fi) * 1991-12-05 1991-12-05 Derek Henry Potter Foerfarande och anordning foer reglering av temperaturen i ett flertal prov.
US5601141A (en) * 1992-10-13 1997-02-11 Intelligent Automation Systems, Inc. High throughput thermal cycler
US5525300A (en) * 1993-10-20 1996-06-11 Stratagene Thermal cycler including a temperature gradient block
US5483799A (en) * 1994-04-29 1996-01-16 Dalto; Michael Temperature regulated specimen transporter
US5572873A (en) * 1995-03-02 1996-11-12 Emertech Incorporated Carrier method and apparatus for maintaining pharmaceutical integrity
US6063633A (en) * 1996-02-28 2000-05-16 The University Of Houston Catalyst testing process and apparatus
US5995851A (en) * 1996-03-13 1999-11-30 Lim; Jae-Bong Outdoor receiver system of a mobile communication base station
US5746063A (en) * 1996-05-06 1998-05-05 Hall; Renee M. Method and apparatus to cool food contact machines and surface
US5784890A (en) * 1996-06-03 1998-07-28 Polkinghorne; John D. Compact thermoelectric refrigeration drive assembly
US6105659A (en) 1996-09-12 2000-08-22 Jaro Technologies, Inc. Rechargeable thermal battery for latent energy storage and transfer
US5704212A (en) * 1996-09-13 1998-01-06 Itronix Corporation Active cooling system for cradle of portable electronic devices
US5856194A (en) 1996-09-19 1999-01-05 Abbott Laboratories Method for determination of item of interest in a sample
US5795784A (en) 1996-09-19 1998-08-18 Abbott Laboratories Method of performing a process for determining an item of interest in a sample
JP2999425B2 (ja) * 1996-11-06 2000-01-17 明産株式会社 ロータリーカッターのための接圧制御装置
DE19646116A1 (de) * 1996-11-08 1998-05-14 Eppendorf Geraetebau Netheler Temperierblock mit Aufnahmen
DE29623597U1 (de) 1996-11-08 1999-01-07 Eppendorf - Netheler - Hinz Gmbh, 22339 Hamburg Temperierblock mit Temperiereinrichtungen
EP0897518A4 (fr) * 1997-01-06 2005-02-02 Renee M Hall Procede et appareil de refrigeration de machines ou de surfaces au contact d'aliments
CA2283321A1 (fr) 1997-03-03 1998-09-11 O.R. Solutions, Inc. Procede et appareil de perfusion sous pression et de regulation de la temperature de liquides perfuses
US7090658B2 (en) 1997-03-03 2006-08-15 Medical Solutions, Inc. Temperature sensing device for selectively measuring temperature at desired locations along an intravenous fluid line
US6660974B2 (en) 1997-04-07 2003-12-09 Medical Solutions, Inc. Warming system and method for heating various items utilized in surgical procedures
US6467953B1 (en) 1999-03-30 2002-10-22 Medical Solutions, Inc. Method and apparatus for monitoring temperature of intravenously delivered fluids and other medical items
US7276675B2 (en) 1997-04-07 2007-10-02 Patented Medical Solutions, Llc Medical item thermal treatment systems and method of monitoring medical items for compliance with prescribed requirements
US6768085B2 (en) 2001-07-02 2004-07-27 Medical Solutions, Inc. Medical solution warming system and method of heating and maintaining medical solutions at desired temperatures
US7041941B2 (en) 1997-04-07 2006-05-09 Patented Medical Solutions, Llc Medical item thermal treatment systems and method of monitoring medical items for compliance with prescribed requirements
AU7103898A (en) 1997-04-07 1998-10-30 Medical Solutions, Inc. Warming system and method for heating various items utilized in surgical procedures
US5924289A (en) * 1997-07-01 1999-07-20 Medical Products, Inc. Controlled temperature cabinet system and method
DE29714206U1 (de) * 1997-08-08 1997-12-11 Hoechst Marion Roussel Deutschland GmbH, 65929 Frankfurt Pipettierroboter mit verbesserter Temperiervorrichtung
ATE270151T1 (de) * 1997-08-08 2004-07-15 Aventis Pharma Gmbh Pipettierroboter mit temperiervorrichtung
WO1999009137A1 (fr) * 1997-08-20 1999-02-25 Biopore, Inc. Dispositif et systeme de cassette servant a faciliter la cryoconservation
US6106784A (en) * 1997-09-26 2000-08-22 Applied Chemical & Engineering Systems, Inc. Thawing station
US5996353A (en) * 1998-05-21 1999-12-07 Applied Materials, Inc. Semiconductor processing system with a thermoelectric cooling/heating device
US6086831A (en) * 1998-06-10 2000-07-11 Mettler-Toledo Bohdan, Inc. Modular reaction block assembly with thermoelectric cooling and heating
US6787112B1 (en) 1998-08-13 2004-09-07 Symyx Technologies, Inc. Parallel reactor with internal sensing and method of using same
US6455316B1 (en) 1998-08-13 2002-09-24 Symyx Technologies, Inc. Parallel reactor with internal sensing and method of using same
US6548026B1 (en) 1998-08-13 2003-04-15 Symyx Technologies, Inc. Parallel reactor with internal sensing and method of using same
US6528026B2 (en) 1998-08-13 2003-03-04 Symyx Technologies, Inc. Multi-temperature modular reactor and method of using same
US6306658B1 (en) 1998-08-13 2001-10-23 Symyx Technologies Parallel reactor with internal sensing
WO2000024227A1 (fr) 1998-10-16 2000-04-27 Medical Solutions, Inc. Systeme et procede de regulation de temperature pour le chauffage et le maintien d'articles medicaux a des temperatures voulues
US6657169B2 (en) * 1999-07-30 2003-12-02 Stratagene Apparatus for thermally cycling samples of biological material with substantial temperature uniformity
DE29917313U1 (de) * 1999-10-01 2001-02-15 MWG-BIOTECH AG, 85560 Ebersberg Vorrichtung zur Durchführung chemischer oder biologischer Reaktionen
US6358473B1 (en) * 1999-10-05 2002-03-19 Albert Coello Microscope slide heater
WO2001026516A2 (fr) 1999-10-08 2001-04-19 Medical Solutions, Inc. Systeme en caisson thermoregule et procede pour chauffer des articles a des temperatures desirees
US6994827B2 (en) 2000-06-03 2006-02-07 Symyx Technologies, Inc. Parallel semicontinuous or continuous reactors
US6425438B1 (en) 2000-06-13 2002-07-30 Dan-Kar Corporation Method for defrosting a container and a frozen liquid therein
US6640891B1 (en) * 2000-09-05 2003-11-04 Kevin R. Oldenburg Rapid thermal cycling device
US7025120B2 (en) * 2000-09-05 2006-04-11 Oldenburg Kevin R Rapid thermal cycling device
US7727479B2 (en) * 2000-09-29 2010-06-01 Applied Biosystems, Llc Device for the carrying out of chemical or biological reactions
KR100364915B1 (ko) * 2000-10-26 2002-12-16 (주)베스트코리아 미생물 배양기의 온도조절장치
US7431891B2 (en) * 2000-11-29 2008-10-07 Merck Patent Gmbh Device for controlling the temperature of chemical microreactors
US6508062B2 (en) 2001-01-31 2003-01-21 Applied Materials, Inc. Thermal exchanger for a wafer chuck
US7031602B2 (en) 2001-03-12 2006-04-18 Patented Medical Solutions, Llc Method and apparatus for controlling temperature of infused liquids
US7238171B2 (en) 2001-03-12 2007-07-03 Medical Solutions, Inc. Method and apparatus for controlling pressurized infusion and temperature of infused liquids
US6692708B2 (en) * 2001-04-05 2004-02-17 Symyx Technologies, Inc. Parallel reactor for sampling and conducting in situ flow-through reactions and a method of using same
KR100419003B1 (ko) * 2001-05-11 2004-02-14 (주)로봇앤드디자인 디엔에이/프로테인 어레이어의 가습조절 장치
JP2003079254A (ja) * 2001-07-05 2003-03-18 Ccs Inc 植物育成装置およびその制御システム
US8226605B2 (en) 2001-12-17 2012-07-24 Medical Solutions, Inc. Method and apparatus for heating solutions within intravenous lines to desired temperatures during infusion
US7614444B2 (en) 2002-01-08 2009-11-10 Oldenburg Kevin R Rapid thermal cycling device
US7373968B2 (en) * 2002-01-08 2008-05-20 Kevin R. Oldenburg Method and apparatus for manipulating an organic liquid sample
US6893613B2 (en) * 2002-01-25 2005-05-17 Bristol-Myers Squibb Company Parallel chemistry reactor with interchangeable vessel carrying inserts
US6764818B2 (en) * 2002-02-25 2004-07-20 Diversa Corporation Device for effecting heat transfer with a solution held in a through-hole well of a holding tray
US20030211595A1 (en) * 2002-05-13 2003-11-13 Lee Tzong Hae Rack for handling polymerase chain reaction tubes
JP3651677B2 (ja) * 2002-07-12 2005-05-25 株式会社東芝 発熱素子冷却装置及び電子機器
US6730883B2 (en) * 2002-10-02 2004-05-04 Stratagene Flexible heating cover assembly for thermal cycling of samples of biological material
US20070184548A1 (en) * 2002-12-23 2007-08-09 Lim Hi Tan Device for carrying out chemical or biological reactions
US8676383B2 (en) * 2002-12-23 2014-03-18 Applied Biosystems, Llc Device for carrying out chemical or biological reactions
EP1508791A1 (fr) * 2003-08-22 2005-02-23 Ismatec SA, Laboratoriumstechnik Dispositif de prélèvement automatique d'échantillons d'un bioréacteur
US7611504B1 (en) 2004-03-09 2009-11-03 Patented Medical Solutions Llc Method and apparatus for facilitating injection of medication into an intravenous fluid line while maintaining sterility of infused fluids
US7494823B2 (en) * 2004-04-08 2009-02-24 Sukumar V Raman Mobile intra-operative microscopic diagnosis laboratory
US20060024204A1 (en) * 2004-08-02 2006-02-02 Oldenburg Kevin R Well plate sealing apparatus and method
US7585663B2 (en) * 2004-08-26 2009-09-08 Applied Biosystems, Llc Thermal device, system, and method, for fluid processing device
DE102005044021A1 (de) * 2005-09-14 2007-03-15 Eppendorf Ag Labortemperiereinrichtung mit Oberseite
US7740611B2 (en) 2005-10-27 2010-06-22 Patented Medical Solutions, Llc Method and apparatus to indicate prior use of a medical item
WO2007145657A2 (fr) * 2005-11-01 2007-12-21 Massachusetts Institute Of Technology Dépôt chimique en phase vapeur assisté de polymères vinyliques pour encapsulation de particules
US20090218051A1 (en) * 2006-03-16 2009-09-03 Francisco Cereceda Balic Semiautomatic device, a system and an operation method for solvent evaporation with the help of analytical gas for atmospheric sample concentration, destined to identify and quantify organic chemical compounds with toxic properties.
US8487738B2 (en) 2006-03-20 2013-07-16 Medical Solutions, Inc. Method and apparatus for securely storing medical items within a thermal treatment system
US9675040B2 (en) * 2006-07-13 2017-06-13 California Institute Of Technology Dual spectrum illuminator for containers
US8226293B2 (en) 2007-02-22 2012-07-24 Medical Solutions, Inc. Method and apparatus for measurement and control of temperature for infused liquids
US8549912B2 (en) 2007-12-18 2013-10-08 Teradyne, Inc. Disk drive transport, clamping and testing
US7996174B2 (en) 2007-12-18 2011-08-09 Teradyne, Inc. Disk drive testing
US7848106B2 (en) 2008-04-17 2010-12-07 Teradyne, Inc. Temperature control within disk drive testing systems
US8160739B2 (en) 2008-04-17 2012-04-17 Teradyne, Inc. Transferring storage devices within storage device testing systems
US8102173B2 (en) 2008-04-17 2012-01-24 Teradyne, Inc. Thermal control system for test slot of test rack for disk drive testing system with thermoelectric device and a cooling conduit
US8305751B2 (en) 2008-04-17 2012-11-06 Teradyne, Inc. Vibration isolation within disk drive testing systems
US8041449B2 (en) 2008-04-17 2011-10-18 Teradyne, Inc. Bulk feeding disk drives to disk drive testing systems
US8095234B2 (en) 2008-04-17 2012-01-10 Teradyne, Inc. Transferring disk drives within disk drive testing systems
US20090262455A1 (en) 2008-04-17 2009-10-22 Teradyne, Inc. Temperature Control Within Disk Drive Testing Systems
US8117480B2 (en) 2008-04-17 2012-02-14 Teradyne, Inc. Dependent temperature control within disk drive testing systems
US8238099B2 (en) 2008-04-17 2012-08-07 Teradyne, Inc. Enclosed operating area for disk drive testing systems
US7945424B2 (en) 2008-04-17 2011-05-17 Teradyne, Inc. Disk drive emulator and method of use thereof
MY149779A (en) 2008-06-03 2013-10-14 Teradyne Inc Processing storage devices
US8501115B2 (en) 2008-10-24 2013-08-06 Statspin, Inc. Modular system for performing laboratory protocols and associated methods
US7995349B2 (en) 2009-07-15 2011-08-09 Teradyne, Inc. Storage device temperature sensing
US8547123B2 (en) 2009-07-15 2013-10-01 Teradyne, Inc. Storage device testing system with a conductive heating assembly
US8466699B2 (en) 2009-07-15 2013-06-18 Teradyne, Inc. Heating storage devices in a testing system
US8628239B2 (en) 2009-07-15 2014-01-14 Teradyne, Inc. Storage device temperature sensing
US8116079B2 (en) 2009-07-15 2012-02-14 Teradyne, Inc. Storage device testing system cooling
US7920380B2 (en) 2009-07-15 2011-04-05 Teradyne, Inc. Test slot cooling system for a storage device testing system
US8687356B2 (en) 2010-02-02 2014-04-01 Teradyne, Inc. Storage device testing system cooling
US7975637B1 (en) 2010-02-08 2011-07-12 Brunswick Corporation Temperature control system for a hybrid vehicle
SG184539A1 (en) 2010-04-09 2012-11-29 Life Technologies Corp Improved thermal uniformity for thermal cycler instrumentation using dynamic control
US9779780B2 (en) 2010-06-17 2017-10-03 Teradyne, Inc. Damping vibrations within storage device testing systems
US8687349B2 (en) 2010-07-21 2014-04-01 Teradyne, Inc. Bulk transfer of storage devices using manual loading
US9001456B2 (en) 2010-08-31 2015-04-07 Teradyne, Inc. Engaging test slots
US9211381B2 (en) 2012-01-20 2015-12-15 Medical Solutions, Inc. Method and apparatus for controlling temperature of medical liquids
CN104272082B (zh) 2012-03-09 2017-02-22 徕卡显微系统里士满公司 用于在实验室样品加工系统中控制运动流体中的温度的装置和方法
KR102074024B1 (ko) * 2012-10-31 2020-02-05 플루리스템 리미티드 생물학적 물질을 해동하기 위한 방법 및 장치
US9656029B2 (en) 2013-02-15 2017-05-23 Medical Solutions, Inc. Plural medical item warming system and method for warming a plurality of medical items to desired temperatures
US9459312B2 (en) 2013-04-10 2016-10-04 Teradyne, Inc. Electronic assembly test system
US20160214110A1 (en) 2013-09-16 2016-07-28 Life Technologies Corporation Apparatuses, Systems and Methods for Providing Thermocycler Thermal Uniformity
RU2016134378A (ru) 2014-02-18 2018-03-22 Лайф Текнолоджиз Корпорейшн Устройства, системы и способы для создания термоциклеров в масштабируемом исполнении и изолирования термоэлектрических устройств
KR102627913B1 (ko) 2015-07-23 2024-01-22 세페이드 서멀 제어 기기 및 사용 방법
ES2565560B2 (es) * 2015-07-31 2016-09-05 Universidad De Alicante Termociclador adaptable
WO2018144839A1 (fr) * 2017-02-02 2018-08-09 University Of Wyoming Appareil de modulation de température d'échantillons
US10948534B2 (en) 2017-08-28 2021-03-16 Teradyne, Inc. Automated test system employing robotics
US10725091B2 (en) 2017-08-28 2020-07-28 Teradyne, Inc. Automated test system having multiple stages
US11226390B2 (en) 2017-08-28 2022-01-18 Teradyne, Inc. Calibration process for an automated test system
US10845410B2 (en) 2017-08-28 2020-11-24 Teradyne, Inc. Automated test system having orthogonal robots
US10983145B2 (en) 2018-04-24 2021-04-20 Teradyne, Inc. System for testing devices inside of carriers
US10775408B2 (en) 2018-08-20 2020-09-15 Teradyne, Inc. System for testing devices inside of carriers
US11867749B2 (en) 2020-10-22 2024-01-09 Teradyne, Inc. Vision system for an automated test system
US11953519B2 (en) 2020-10-22 2024-04-09 Teradyne, Inc. Modular automated test system
US11754622B2 (en) 2020-10-22 2023-09-12 Teradyne, Inc. Thermal control system for an automated test system
US11899042B2 (en) 2020-10-22 2024-02-13 Teradyne, Inc. Automated test system
US11754596B2 (en) 2020-10-22 2023-09-12 Teradyne, Inc. Test site configuration in an automated test system
US12007411B2 (en) 2021-06-22 2024-06-11 Teradyne, Inc. Test socket having an automated lid

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1045396A (fr) * 1951-11-23 1953-11-25 Procédé et appareillage pour la détection, avant la mise en cuve, des laits impropres à la fabrication des fromages
US3230723A (en) * 1964-12-18 1966-01-25 Hoy D Mcintire Apparatus for cooling dental cements
FR1531989A (fr) * 1967-06-29 1968-07-05 Tesla Np Platine refroidissante thermo-électrique
US3552133A (en) * 1968-02-20 1971-01-05 Sergei Meerovich Lukomsky Heating and cooling unit
FR2035167A1 (fr) * 1969-03-21 1970-12-18 Siemens Ag
GB1601921A (en) * 1978-03-28 1981-11-04 Corning Ltd Method of and apparatus for heating vessels
US4364234A (en) * 1981-03-25 1982-12-21 Koolatron Industries, Ltd. Control circuitry for thermoelectric environmental chamber
US4384512A (en) * 1981-05-11 1983-05-24 Keith Glenn R Beverage heater and cooler
US4548259A (en) * 1981-10-09 1985-10-22 Olympus Optical Co., Ltd. Liquid containing vessel with temperature control device
DE3149624A1 (de) * 1981-12-15 1983-06-23 Georg 6050 Offenbach May Vorrichtung zur regelung der temperatur von stoffen
US4402185A (en) * 1982-01-07 1983-09-06 Ncr Corporation Thermoelectric (peltier effect) hot/cold socket for packaged I.C. microprobing
DE3525860A1 (de) * 1985-07-19 1987-01-29 Egbert Dr Brandau Thermostat
US4823554A (en) * 1987-04-22 1989-04-25 Leonard Trachtenberg Vehicle thermoelectric cooling and heating food and drink appliance

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0606961A1 (fr) * 1989-06-12 1994-07-20 Johnson & Johnson Clinical Diagnostics, Inc. Dispositif de régulation de température pour récipient de réaction
WO1991007504A1 (fr) * 1989-11-21 1991-05-30 Kindconi Pty. Ltd. Dispositif ameliore de polymerisation d'adn
EP1452608A1 (fr) * 1990-11-29 2004-09-01 Applera Corporation Réaction de polymérase en chaíne automatisée
US7238517B2 (en) 1990-11-29 2007-07-03 Applera Corporation Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control
DE4239232A1 (de) * 1992-11-21 1994-05-26 Schubert Werner Vorrichtung und Verfahren für die Wärmedenaturierung frischen Gewebes im histologischen Labor
US7537377B2 (en) 1997-03-28 2009-05-26 Applied Biosystems, Llc Thermal cycler for PCR
US9044753B2 (en) 1997-03-28 2015-06-02 Applied Biosystems, Llc Thermal cycler for PCR
EP1386666A1 (fr) * 1997-03-28 2004-02-04 PE Corporation (NY) Ameliorations apportees à un cycleur thermique pour PCR
WO1998043740A3 (fr) * 1997-03-28 1998-12-17 Perkin Elmer Corp Ameliorations apportees a un cycleur thermique pour pcr
US9776187B2 (en) 1997-03-28 2017-10-03 Applied Biosystems, Llc Thermal cycler for PCR
US7133726B1 (en) 1997-03-28 2006-11-07 Applera Corporation Thermal cycler for PCR
US7645070B2 (en) 1997-03-28 2010-01-12 Applied Biosystems, Llc Thermal cycler for PCR
US8246243B2 (en) 1997-03-28 2012-08-21 Applied Biosystems, Llc Thermal cycler for PCR
US8685717B2 (en) 1997-03-28 2014-04-01 Applied Biosystems, Llc Thermal cycler for PCR
WO2009101211A1 (fr) * 2008-02-15 2009-08-20 Aj Innuscreen Gmbh Appareil mobile pour isolement d'acides nucléiques
CN102047144B (zh) * 2008-03-25 2014-05-07 株式会社岛津制作所 放射线成像装置
DE102008023299A1 (de) * 2008-05-08 2009-11-19 Micropelt Gmbh Aufnahme für eine Probe
CN114234532A (zh) * 2021-12-08 2022-03-25 深圳市瑞沃德生命科技有限公司 一种制冷装置及其冷冻切片机
RU2847136C1 (ru) * 2024-11-08 2025-09-26 Объединенный Институт Ядерных Исследований (Оияи) Устройство для охлаждения биологических образцов

Also Published As

Publication number Publication date
EP0342155A3 (fr) 1990-06-27
US5061630A (en) 1991-10-29
CA1317646C (fr) 1993-05-11

Similar Documents

Publication Publication Date Title
EP0342155A2 (fr) Appareil de laboratoire pour chauffer ou refroidir à volonté
DE60102361T2 (de) Vorrichtung zum Liefern von Mahlzeiten zu einer passenden Temperatur, insbesondere zur Anwendung in Krankenhäusern
DE102011000353B4 (de) Batterie
EP3369803B1 (fr) Procédé d'humidification d'un incubateur et incubateur
EP1354028A2 (fr) Armoire de stockage climatisee
AT511647A1 (de) Kühl-/heiz-vorrichtung
DE10154663B4 (de) Inkubations- und Lagervorrichtung, insbesondere für Proben aus organischem Material
DE112018007855B4 (de) Thermocycler und diesen enthaltendes echtzeit-pcr-gerät
DE3245414A1 (de) Verfahren und einrichtung zur temperatursteuerung einer vorrichtung
EP1014836A1 (fr) Vitrine frigorifique a circulation d'air
CH676332A5 (en) Temp. control for laboratory specimens
DE102011054365B4 (de) Biotechnologische Vorrichtung, Bioreaktorsystem mit mehreren biotechnologischen Vorrichtungen, Verfahren zum Temperieren eines Kultivierungsraumes in einer biotechnologischen Vorrichtung sowie Verfahren zum Temperieren von Kultivierungsräumen in einem Bioreaktorsystem
DE102020120790B4 (de) Inverses Mikroskop mit Inkubationsraum und Temperatursensor
DE102004037341C5 (de) Vorrichtung zum gekühlten Aufbewahren und Abgeben von Proben für eine integrierte Flüssigkeits-Kühleinheit
EP1732692A1 (fr) Procede et dispositif d'equilibrage de temperature destine au traitement thermique de petites quantites de liquides
GB2250581A (en) Temperature control for sample incubator
DE102008058062A1 (de) Automatisierte Analysevorrichtung mit einem drehbaren Karussell für verschiedene Flüssigkeitsbehälter
EP0202599B1 (fr) Chambre de refroidissement pour le traitement d'objets devant être analysés par microscopie optique ou électronique
DE29716137U1 (de) Tragbares Kühlsystem
EP2566622B1 (fr) Couvercle permettant d'éviter un condensat
DE19950211A1 (de) Ausschankanlage für Getränke
EP4644524A1 (fr) Appareil de laboratoire avec éclairage de chambre d'incubation
CN219024367U (zh) 一种新型低温恒温反应浴槽
WO2025228868A1 (fr) Dispositif de laboratoire présentant un éclairage de chambre d'incubation
RU2847136C1 (ru) Устройство для охлаждения биологических образцов

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE CH DE ES FR GB IT LI NL SE

RIN1 Information on inventor provided before grant (corrected)

Inventor name: SIEBER, JOSEF E., JUN.

Inventor name: KNOPF, ULRICH CHRISTIAN, DR. ING. AGR.

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE CH DE ES FR GB IT LI NL SE

17P Request for examination filed

Effective date: 19901213

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: KNOPF, ULRICH CHRISTIAN

Owner name: SEYFFER & CO.

Owner name: AGROGEN-STIFTUNG

D17Q First examination report despatched (deleted)
RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: KNOPF, ULRICH C., DR.

Owner name: AGROGEN-STIFTUNG

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19940518