EP0346068A3 - Antagonistes de D-Cys6-vasopressine - Google Patents

Antagonistes de D-Cys6-vasopressine Download PDF

Info

Publication number: EP0346068A3
Authority: EP; European Patent Office
Prior art keywords: alk; tyr; lys; isomer; orn
Prior art date: 1988-06-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP19890305690

Other languages

German (de)

English (en)

Other versions

EP0346068A2 (fr

Inventor

William Francis Huffman

Lewis Boardman Kinter

Michael Lee Moore

Christine Ruth Winslow

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

SmithKline Beecham Corp

Original Assignee

SmithKline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-06-07

Filing date

1989-06-06

Publication date

1991-01-30

1989-06-06 Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp

1989-12-13 Publication of EP0346068A2 publication Critical patent/EP0346068A2/fr

1991-01-30 Publication of EP0346068A3 publication Critical patent/EP0346068A3/fr

Status Withdrawn legal-status Critical Current

Links

229940116211 Vasopressin antagonist Drugs 0.000 title 1
239000003038 vasopressin antagonist Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
ODKSFYDXXFIFQN-UHFFFAOYSA-N Arginine Chemical compound OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 1
ULEBESPCVWBNIF-BYPYZUCNSA-N L-arginine amide Chemical compound NC(=O)[C@@H](N)CCCNC(N)=N ULEBESPCVWBNIF-BYPYZUCNSA-N 0.000 abstract 1
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
125000000174 L-prolyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])[C@@]1([H])C(*)=O 0.000 abstract 1
NTWVQPHTOUKMDI-YFKPBYRVSA-N N-Methyl-arginine Chemical compound CN[C@H](C(O)=O)CCCN=C(N)N NTWVQPHTOUKMDI-YFKPBYRVSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
-1 benzyl ester Chemical class 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/16—Oxytocins; Vasopressins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Diabetes (AREA)
Obesity (AREA)
Biophysics (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Heart & Thoracic Surgery (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

EP19890305690 1988-06-07 1989-06-06 Antagonistes de D-Cys6-vasopressine Withdrawn EP0346068A3 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US20338988A	1988-06-07	1988-06-07
US203389		1988-06-07

Publications (2)

Publication Number	Publication Date
EP0346068A2 EP0346068A2 (fr)	1989-12-13
EP0346068A3 true EP0346068A3 (fr)	1991-01-30

Family

ID=22753787

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP19890305690 Withdrawn EP0346068A3 (fr)	1988-06-07	1989-06-06	Antagonistes de D-Cys6-vasopressine

Country Status (6)

Country	Link
EP (1)	EP0346068A3 (fr)
JP (1)	JPH0232098A (fr)
AU (1)	AU3597289A (fr)
DK (1)	DK268889A (fr)
PT (1)	PT90783A (fr)
ZA (1)	ZA894268B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9125024D0 (en) *	1991-11-25	1992-01-22	Kirby Julian	Rheumatoid arthritus treatment
CA2319649A1 (fr)	1998-01-28	1999-08-05	Mitsunori Waki	Mesures prophylactiques ou remedes contre les troubles de la vision
US7056910B2 (en)	2000-11-28	2006-06-06	Astellas Pharma Inc.	1,4,5.6-tetrahydroimidazo[4,5-d]diazepine derivatives or salts thereof
EP1555029A1 (fr) *	2004-01-19	2005-07-20	Ferring B.V.	Utilisation de substances à activité oxytocique pour la préparation de médicaments destinés au traitement de l'hypertension

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0115379A2 (fr) *	1983-01-05	1984-08-08	Medical College of Ohio	Antagonistes de l'activité antidiurétique d'arginine vasopressine
EP0234935A2 (fr) *	1986-02-25	1987-09-02	Smithkline Beecham Corporation	Composés vasopressine

1989
- 1989-06-01 DK DK268889A patent/DK268889A/da unknown
- 1989-06-05 AU AU35972/89A patent/AU3597289A/en not_active Abandoned
- 1989-06-06 ZA ZA894268A patent/ZA894268B/xx unknown
- 1989-06-06 EP EP19890305690 patent/EP0346068A3/fr not_active Withdrawn
- 1989-06-07 JP JP1146553A patent/JPH0232098A/ja active Pending
- 1989-06-07 PT PT90783A patent/PT90783A/pt not_active Application Discontinuation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0115379A2 (fr) *	1983-01-05	1984-08-08	Medical College of Ohio	Antagonistes de l'activité antidiurétique d'arginine vasopressine
EP0234935A2 (fr) *	1986-02-25	1987-09-02	Smithkline Beecham Corporation	Composés vasopressine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF MEDICAL CHEMISTRY, vol. 30, 1987, pages 2291-2294, Washington, US; F. EL-FEHAIL ALI et al.: "Potent vasopressin antagonists modified at the carboxy-terminal tripeptide tail" *

Also Published As

Publication number	Publication date
JPH0232098A (ja)	1990-02-01
AU3597289A (en)	1989-12-14
DK268889D0 (da)	1989-06-01
DK268889A (da)	1989-12-08
PT90783A (pt)	1989-12-29
EP0346068A2 (fr)	1989-12-13
ZA894268B (en)	1990-06-27

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Legal Events

Date	Code	Title	Description
1989-10-28	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1989-12-13	17P	Request for examination filed	Effective date: 19890622
1989-12-13	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AT BE CH DE ES FR GB GR IT LI LU NL SE
1990-12-14	PUAL	Search report despatched	Free format text: ORIGINAL CODE: 0009013
1991-01-30	AK	Designated contracting states	Kind code of ref document: A3 Designated state(s): AT BE CH DE ES FR GB GR IT LI LU NL SE
1991-03-22	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN
1991-05-08	18W	Application withdrawn	Withdrawal date: 19910311