EP0365329A3 - Antibiotics active against anaerobic bacteria, their production and use, and strains of enterobacter producing the same - Google Patents

Antibiotics active against anaerobic bacteria, their production and use, and strains of enterobacter producing the same Download PDF

Info

Publication number
EP0365329A3
EP0365329A3 EP89310778A EP89310778A EP0365329A3 EP 0365329 A3 EP0365329 A3 EP 0365329A3 EP 89310778 A EP89310778 A EP 89310778A EP 89310778 A EP89310778 A EP 89310778A EP 0365329 A3 EP0365329 A3 EP 0365329A3
Authority
EP
European Patent Office
Prior art keywords
producing
enterobacter
strains
production
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP89310778A
Other versions
EP0365329B1 (en
EP0365329A2 (en
Inventor
Tadashi Yoshida
Teruo Hattori
Koichi Matsumoto
Yoshihiro Terui
Junichi Shoji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Priority to AT89310778T priority Critical patent/ATE73789T1/en
Publication of EP0365329A2 publication Critical patent/EP0365329A2/en
Publication of EP0365329A3 publication Critical patent/EP0365329A3/en
Application granted granted Critical
Publication of EP0365329B1 publication Critical patent/EP0365329B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Compounds of the formula (I) <CHEM> wherein R is: <CHEM> and salts thereof, have antibiotic activity. The invention includes their use in providing therapeutic formulations, and microorganisms producing them.
EP89310778A 1988-10-20 1989-10-19 Antibiotics active against anaerobic bacteria, their production and use, and strains of enterobacter producing the same Expired - Lifetime EP0365329B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT89310778T ATE73789T1 (en) 1988-10-20 1989-10-19 ANTIBIOTICS EFFECTIVE AGAINST ANAEROBIC BACTERIA, THEIR PRODUCTION AND ENTEROBACTER STRAINS THAT PRODUCE THEM.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP266575/88 1988-10-20
JP26657588 1988-10-20

Publications (3)

Publication Number Publication Date
EP0365329A2 EP0365329A2 (en) 1990-04-25
EP0365329A3 true EP0365329A3 (en) 1990-08-29
EP0365329B1 EP0365329B1 (en) 1992-03-18

Family

ID=17432717

Family Applications (1)

Application Number Title Priority Date Filing Date
EP89310778A Expired - Lifetime EP0365329B1 (en) 1988-10-20 1989-10-19 Antibiotics active against anaerobic bacteria, their production and use, and strains of enterobacter producing the same

Country Status (7)

Country Link
US (1) US5045458A (en)
EP (1) EP0365329B1 (en)
KR (1) KR970005488B1 (en)
AT (1) ATE73789T1 (en)
DE (1) DE68901024D1 (en)
ES (1) ES2052020T3 (en)
GR (1) GR3004095T3 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2052020T3 (en) * 1988-10-20 1994-07-01 Shionogi & Co EFFECTIVE ANTIBIOTICS AGAINST ANAEROBIC BACTERIA, ITS PRODUCTION AND USE, AND ENTEROBACTER STRAINS THAT PRODUCE THEM.
WO1993004055A2 (en) * 1991-08-27 1993-03-04 The Upjohn Company Compounds used for the inhibition of hiv-protease
TW354294B (en) * 1993-09-17 1999-03-11 Upjohn Co Substituted tetronic acids useful for treating HIV and other retroviruses
PT817786E (en) * 1995-03-20 2003-06-30 Upjohn Co SUBSTITUTE UTERIC TETRONIC ACIDS FOR THE TREATMENT OF HIV AND OTHER RETROVIRUS

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60258173A (en) * 1984-06-01 1985-12-20 Kanegafuchi Chem Ind Co Ltd Alpha-(3-tertiary butyl-5-(1,1-dimethyl-2-hydroxyethyl)-4-hydroxybenzylidene)-gamma-butyrolactone, its preparation and anti-inflammatory agent and blood platelet agglutination inhibitor containing same as active ingredient
JPS6471867A (en) * 1987-09-11 1989-03-16 Taisho Pharmaceutical Co Ltd Propionic acid compound
JPH01227355A (en) * 1988-03-11 1989-09-11 Sanyo Electric Co Ltd Nonaqueous electrolyte battery
DE3813806A1 (en) * 1988-04-23 1989-11-02 Basf Ag 11-Hydroxy- gamma -dodecalactone and its preparation
ES2052020T3 (en) * 1988-10-20 1994-07-01 Shionogi & Co EFFECTIVE ANTIBIOTICS AGAINST ANAEROBIC BACTERIA, ITS PRODUCTION AND USE, AND ENTEROBACTER STRAINS THAT PRODUCE THEM.
JPH0396182A (en) * 1989-09-08 1991-04-22 Citizen Watch Co Ltd Display system for liquid crystal television receiver

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF ANTIBIOTICS, vol. 35, no. 2, February 1982, pages 142-150, Toyko, JP; C. KELLER-JUSLEN et al.: "Tetronomycin, a novel polyether of unusual structure" *

Also Published As

Publication number Publication date
ES2052020T3 (en) 1994-07-01
KR900006517A (en) 1990-05-08
DE68901024D1 (en) 1992-04-23
US5045458A (en) 1991-09-03
KR970005488B1 (en) 1997-04-16
EP0365329B1 (en) 1992-03-18
EP0365329A2 (en) 1990-04-25
ATE73789T1 (en) 1992-04-15
GR3004095T3 (en) 1993-03-31

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