EP0372005A4 - Systemes d'expression destines a la preparation de polypeptides dans des cellules procaryotiques. - Google Patents

Systemes d'expression destines a la preparation de polypeptides dans des cellules procaryotiques.

Info

Publication number: EP0372005A4
Authority: EP; European Patent Office
Prior art keywords: polypeptides; preparation; expression systems; prokaryotic cells; prokaryotic
Prior art date: 1987-10-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP19880910220

Other languages

German (de)

English (en)

Other versions

EP0372005A1 (fr

Inventor

Timothy M Rose

Thomas J Franceschini

A Gregory Bruce

Suo Win Liu

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Oncogen LP

Original Assignee

Oncogen LP

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-30

Filing date

1988-10-28

Publication date

1990-06-26

1988-10-28 Application filed by Oncogen LP filed Critical Oncogen LP

1990-06-13 Publication of EP0372005A1 publication Critical patent/EP0372005A1/fr

1990-06-26 Publication of EP0372005A4 publication Critical patent/EP0372005A4/fr

Status Withdrawn legal-status Critical Current

Links

229920001184 polypeptide Polymers 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
210000001236 prokaryotic cell Anatomy 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
- C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Toxicology (AREA)
Virology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

EP19880910220 1987-10-30 1988-10-28 Systemes d'expression destines a la preparation de polypeptides dans des cellules procaryotiques. Withdrawn EP0372005A4 (fr)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US11513987A	1987-10-30	1987-10-30
US115139		1987-10-30
US24076888A	1988-09-02	1988-09-02
US240768		1988-09-02

Publications (2)

Publication Number	Publication Date
EP0372005A1 EP0372005A1 (fr)	1990-06-13
EP0372005A4 true EP0372005A4 (fr)	1990-06-26

Family

ID=26812881

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP19880910220 Withdrawn EP0372005A4 (fr)	1987-10-30	1988-10-28	Systemes d'expression destines a la preparation de polypeptides dans des cellules procaryotiques.

Country Status (3)

Country	Link
EP (1)	EP0372005A4 (fr)
JP (1)	JP2970811B2 (fr)
WO (1)	WO1989003886A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI891308A7 (fi) *	1988-03-24	1989-09-25	Oncogen	Uudet polypeptidit, joilla on kasvutekijäaktiivisuutta sekä polypeptideitä koodittavat nukleiinihapposekvenssit
US5086164A (en) *	1989-01-10	1992-02-04	Repligen Corporation	Novel methods and compositions for treatment of angiogenic diseases
IE901849A1 (en) *	1989-07-19	1991-06-19	Gruenenthal Gmbh	Plasmids, their preparation and their use in the manufacture¹of a plasminogen activator
EP0423641A3 (en) *	1989-10-18	1992-01-15	Nippon Mining Company Limited	Expression vector, transformed microorganism, fusion protein and method for the production of platelet factor 4 or tgfalpha
JPH05219963A (ja) *	1990-07-18	1993-08-31	Applied Immune Sci Inc	温度誘導分泌発現ベクターおよびその原核細胞での使用
US6083686A (en) *	1990-10-26	2000-07-04	Johnson & Johnson Clinical Diagnostic Systems, Inc.	Increased production of Thermus aquaticus DNA polymerase in E. coli
DE69233336T2 (de) *	1991-02-26	2005-03-31	Astrazeneca Ab	Vektor
JP3762222B2 (ja)	1998-10-07	2006-04-05	ストライカー・コーポレーション	改変型ＴＧＦ−βスーパーファミリータンパク質
DK1368483T3 (da)	2001-03-09	2012-11-05	Genentech Inc	Fremgangsmåde til fremstilling af polypeptider
US7153666B2 (en)	2003-07-17	2006-12-26	General Atomics	Methods and compositions for determination of glycated proteins
US7022494B2 (en)	2003-09-19	2006-04-04	General Atomics	Detection of potassium ions using ion-sensitive enzymes
US8187831B2 (en)	2003-09-19	2012-05-29	General Atomics	Determination of ions using ion-sensitive enzymes
US7943385B2 (en)	2006-07-25	2011-05-17	General Atomics	Methods for assaying percentage of glycated hemoglobin
ES2404059T3 (es)	2006-07-25	2013-05-23	General Atomics	Procedimientos para analizar el porcentaje de hemoglobina glicada
EP2283149A1 (fr)	2008-05-13	2011-02-16	General Atomics	Biodétecteur électrochimique pour une détermination directe du pourcentage d'hémoglobine glyquée

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0173149A1 (fr) *	1984-08-21	1986-03-05	Hoechst Aktiengesellschaft	Région synthétique de régulation
EP0241446A2 (fr) *	1986-03-27	1987-10-14	Monsanto Company	Production stimulée de protéines par des bactéries, par utilisation d'un nouveau site de fixation de ribosomes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4565785A (en)	1978-06-08	1986-01-21	The President And Fellows Of Harvard College	Recombinant DNA molecule
IL60184A (en) *	1979-05-31	1984-05-31	Schering Ag	Process for the specific cleavage of protein sequences from proteins
US4582800A (en) *	1982-07-12	1986-04-15	Hoffmann-La Roche Inc.	Novel vectors and method for controlling interferon expression
DE3587730T2 (de) *	1984-02-08	1994-05-05	Cetus Oncology Corp	Kontrollsysteme für rekombinant-manipulationen.
US4711845A (en) *	1984-08-31	1987-12-08	Cetus Corporation	Portable temperature-sensitive control cassette
EP0196864A3 (fr) *	1985-03-25	1988-03-23	Cetus Corporation	Scission et sécrétion des protéines recombinantes à l'aide du système de la phosphatase alcaline, séquences de l'ADN à utiliser dans ce système et cellules transformées au moyen de ces séquences

1988
- 1988-10-28 EP EP19880910220 patent/EP0372005A4/fr not_active Withdrawn
- 1988-10-28 WO PCT/US1988/003872 patent/WO1989003886A1/fr not_active Ceased
- 1988-10-28 JP JP63509398A patent/JP2970811B2/ja not_active Expired - Lifetime

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0173149A1 (fr) *	1984-08-21	1986-03-05	Hoechst Aktiengesellschaft	Région synthétique de régulation
EP0241446A2 (fr) *	1986-03-27	1987-10-14	Monsanto Company	Production stimulée de protéines par des bactéries, par utilisation d'un nouveau site de fixation de ribosomes

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHEMCIAL ABSTRACTS *
CHEMICAL ABSTRACTS *
JOURNAL OF BIOTECHNOLOGY *
See also references of WO8903886A1 *

Also Published As

Publication number	Publication date
JPH04502851A (ja)	1992-05-28
EP0372005A1 (fr)	1990-06-13
JP2970811B2 (ja)	1999-11-02
WO1989003886A1 (fr)	1989-05-05

Legal Events

Date	Code	Title	Description
1990-04-28	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1990-06-13	17P	Request for examination filed	Effective date: 19890724
1990-06-13	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE
1990-08-16	A4	Supplementary search report drawn up and despatched	Effective date: 19900626
1996-02-07	17Q	First examination report despatched	Effective date: 19951221
2001-09-28	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2001-11-14	18D	Application deemed to be withdrawn	Effective date: 20010502

Publication	Publication Date	Title
AU585180B2 (en)	1989-06-08	Nor-statine and nor-cyclostatine polypeptides
IL86700A0 (en)	1988-11-30	Polypeptides
AU2232688A (en)	1989-03-23	Water insoluble polypeptides
IL73883A0 (en)	1985-03-31	Cytotoxic protein
EP0315367A3 (en)	1990-11-28	Polypeptides
GB2206352B (en)	1990-10-31	Polypeptides
GB8521137D0 (en)	1985-10-02	-hanp related polypeptides
EP0181578A3 (en)	1988-08-17	Antibiotic polypeptide, process for its preparation and its use
AU2596888A (en)	1989-06-01	Peptide structures, immunogens containing them and their uses in the control of fertility
GB8415186D0 (en)	1984-07-18	Polypeptides
AR242056A1 (es)	1993-02-26	Un gene estructural codificante de un polipeptido hibrido que contiene la secuencia de dna de trp-grf, dicho polipeptido como intermediario para la preparacion de grf44, grf40, grf37 y grf29.
AU1966688A (en)	1988-12-21	Immunosuppressive polypeptides
GR1002113B (en)	1996-02-02	Expression systems for preparation of polypeptides in prokaryotic cells
GB8715737D0 (en)	1987-08-12	Polypeptide
GB8723507D0 (en)	1987-11-11	Polypeptide
GB8626622D0 (en)	1986-12-10	Polypeptides
EP0277021A3 (en)	1988-11-02	Improvements in aircraft
GB2218955B (en)	1992-12-16	Improvements in multiple rudder systems
GB8725598D0 (en)	1987-12-09	Polypeptides
ZA884655B (en)	1990-03-28	Polypeptides
IE880912L (en)	1988-09-27	Pharmaceutical composition comprising altered mammalian¹immune system cells
IE862882L (en)	1987-05-01	Polypeptides
IE860720L (en)	1986-09-20	Polypeptides
IE882178L (en)	1989-01-17	Anti-acne composition
GB8431141D0 (en)	1985-01-16	Soluble protein materials