EP0593452A4 - Verfahren zur herstellung eines mit metallradionuklid markierten proteins. - Google Patents

Verfahren zur herstellung eines mit metallradionuklid markierten proteins.

Info

Publication number
EP0593452A4
EP0593452A4 EP19910902555 EP91902555A EP0593452A4 EP 0593452 A4 EP0593452 A4 EP 0593452A4 EP 19910902555 EP19910902555 EP 19910902555 EP 91902555 A EP91902555 A EP 91902555A EP 0593452 A4 EP0593452 A4 EP 0593452A4
Authority
EP
European Patent Office
Prior art keywords
radionuclide
preparing
metal
labelled protein
labelled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19910902555
Other languages
English (en)
French (fr)
Other versions
EP0593452A1 (de
Inventor
Wilhelmus Theodorus Goedemans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Medical Inc filed Critical Mallinckrodt Medical Inc
Publication of EP0593452A4 publication Critical patent/EP0593452A4/de
Publication of EP0593452A1 publication Critical patent/EP0593452A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP91902555A 1989-11-30 1990-11-28 Verfahren zur herstellung eines mit metallradionuklid markierten proteins Withdrawn EP0593452A1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NL8902956 1989-11-30
NL8902956 1989-11-30
PCT/US1990/006977 WO1991007991A1 (en) 1989-11-30 1990-11-28 Method for preparing a metal-radionuclide-labelled protein

Publications (2)

Publication Number Publication Date
EP0593452A4 true EP0593452A4 (de) 1992-08-31
EP0593452A1 EP0593452A1 (de) 1994-04-27

Family

ID=19855723

Family Applications (1)

Application Number Title Priority Date Filing Date
EP91902555A Withdrawn EP0593452A1 (de) 1989-11-30 1990-11-28 Verfahren zur herstellung eines mit metallradionuklid markierten proteins

Country Status (5)

Country Link
EP (1) EP0593452A1 (de)
JP (1) JPH05504763A (de)
AU (1) AU654663B2 (de)
CA (1) CA2069868A1 (de)
WO (1) WO1991007991A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
CA2141739A1 (en) * 1993-05-03 1994-11-10 Alfons M. Verbruggen Method for preparing a metal-radionuclide-labelled protein
CA2242750C (en) * 1996-01-11 2007-03-27 Leslie A. Khawli Antibodies with reduced net positive charge
US5990286A (en) * 1996-12-18 1999-11-23 Techniclone, Inc. Antibodies with reduced net positive charge

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0247866A1 (de) * 1986-05-29 1987-12-02 Mallinckrodt, Inc. (a Delaware corporation) Kupplungsmittel zum Radiomarkieren von Proteinen
WO1989007456A1 (en) * 1988-02-09 1989-08-24 Mallinckrodt, Inc. Method of preparing a metal-radionuclide-labelled protein

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59116232A (ja) * 1982-12-24 1984-07-05 Teijin Ltd 細胞毒性複合体及びその製造法
US4707352A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
US4897255A (en) * 1985-01-14 1990-01-30 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US4732974A (en) * 1986-03-05 1988-03-22 Mallinckrodt, Inc. Metal ion labeling of carrier molecules
US4970303A (en) * 1988-02-03 1990-11-13 Xoma Corporation Linking agents and methods
GB8809616D0 (en) * 1988-04-22 1988-05-25 Cancer Res Campaign Tech Further improvements relating to drug delivery systems
AU631802B2 (en) * 1988-06-14 1992-12-10 Cetus Oncology Corporation Coupling agents and sterically hindered disulfide linked conjugates prepared therefrom
US5218128A (en) * 1988-06-15 1993-06-08 Centocor, Inc. Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0247866A1 (de) * 1986-05-29 1987-12-02 Mallinckrodt, Inc. (a Delaware corporation) Kupplungsmittel zum Radiomarkieren von Proteinen
WO1989007456A1 (en) * 1988-02-09 1989-08-24 Mallinckrodt, Inc. Method of preparing a metal-radionuclide-labelled protein

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ANALYTICAL BIOCHEMISTRY vol. 132, no. 1, 1 July 1983, NEW YORK US pages 68 - 73; R J S DUNCAN ET AL.: 'a new reagent which may be used to introduce sulphydryl groups into proteins, and its use in the preparation of conjugates for immunoassay' *
CHEMICAL AND PHARMACEUTICAL BULLETIN. vol. 33, no. 1, 1985, TOKYO JP pages 362 - 367; N FUJII ET AL.: 'studies on peptides. CXXV. 3-(3 -p-methoxybenzylthiopropionyl)thiazolidine-2-thi one and its analogs as reagents for the introduction of the mercapto group into peptides and proteins' *
JOURNAL OF NUCLEAR MEDICINE. vol. 24, no. 5, May 1983, NEW YORK US page 126; E F BYRNE ET AL.: 'technetium-99m bifunctional chelating agents-thiolactone for coupling to biomolecules, N2S2 ligand for chelation to technetium' *
JOURNAL OF NUCLEAR MEDICINE. vol. 25, no. 2, February 1984, NEW YORK US pages 223 - 229; R F SCHNEIDER ET AL.: 'N, N- bis (s-benzoylmercaptoacetamido) ethylenediamine and propylenediamine ligands as renal function imaging agents' *
See also references of WO9107991A1 *

Also Published As

Publication number Publication date
CA2069868A1 (en) 1991-05-31
AU7156691A (en) 1991-06-26
JPH05504763A (ja) 1993-07-22
EP0593452A1 (de) 1994-04-27
WO1991007991A1 (en) 1991-06-13
AU654663B2 (en) 1994-11-17

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Legal Events

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