EP0642830A1 - Dispositif de fermeture pourvu d'un arrangement de zones perforables - Google Patents

Dispositif de fermeture pourvu d'un arrangement de zones perforables Download PDF

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Publication number
EP0642830A1
EP0642830A1 EP94113449A EP94113449A EP0642830A1 EP 0642830 A1 EP0642830 A1 EP 0642830A1 EP 94113449 A EP94113449 A EP 94113449A EP 94113449 A EP94113449 A EP 94113449A EP 0642830 A1 EP0642830 A1 EP 0642830A1
Authority
EP
European Patent Office
Prior art keywords
closure
pipetting
upper wall
closure according
pipetting needle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP94113449A
Other languages
German (de)
English (en)
Inventor
Martin Walter Ellenberger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of EP0642830A1 publication Critical patent/EP0642830A1/fr
Ceased legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5082—Test tubes per se
    • B01L3/50825—Closing or opening means, corks, bungs

Definitions

  • the invention relates to a closure for a reagent container, which can be used in an analytical device in which an automatic pipetting device for transferring small amounts of reagent from the reagent container to the reaction cuvettes is used, the pipetting device having a pipetting needle that is automatically guided by a transport device and has a free open end in lies in a plane which forms an acute angle with the longitudinal axis of the pipetting needle, which closure is a part molded in one piece from a plastic, and has a cylindrical side wall and an annular top wall adjoining the side wall.
  • the invention is therefore based on the object of providing a closure of the type specified at the beginning, with which the disadvantages mentioned above can be eliminated.
  • this object is achieved with a closure, which is characterized in that the central region of the upper wall has an arrangement of depressions of the same size which lie next to one another, adjacent depressions being delimited from one another by a partition wall in each case, which is at their free upper end forms a sharp edge and the bottom of each recess can be pierced with the pipetting needle of the pipetting device.
  • the closure according to the invention makes it possible to automate the treatment of the reagent container in the analysis system, i.e. relieve the laboratory staff of the manual work previously required, and at the same time increase the reliability of this treatment.
  • the closure according to the invention is preferably a screw closure. This ensures a good seal of the reagent container in a simple manner.
  • the outer surface of the partition wall forms a second acute angle with a straight line perpendicular to the floor. It is thereby achieved that the partition wall pushes the tip of the pipetting needle to the center of the depression if the transport device of the pipetting needle does not lead it exactly to the center of a depression.
  • closure cap 1 which can be seen in FIGS. 1 and 3 is, as usual, applied tightly to the neck 2 of a container 3 by means of a threaded connection.
  • the cap 1 consists essentially of a cylindrical wall 4 which on the upper end face by a Basically flat plate 5 is completed. On the outside on the cylindrical wall 4, structures 6 can be seen to increase the grip.
  • a sealing tube 9 which is adapted to the inner diameter of the container neck 2, is formed from the upper cover plate 5 and projects into the container neck 2.
  • recesses 11 which define possible puncture points of a pipetting needle 13 in their base or bottom 12.
  • the cap is preferably molded in one piece from a suitable plastic, e.g. made of polyethylene, e.g. LDPE (low density polyethylene) or HDPE (high density polyethylene).
  • a suitable plastic e.g. made of polyethylene, e.g. LDPE (low density polyethylene) or HDPE (high density polyethylene).
  • the base areas or bottoms 12 of the depressions 11, which have the wall thickness to be penetrated by a pipetting needle 13 and reduced compared to the wall thickness of the cover plate 5, are matched in terms of their surface area to the pipette needle cross section to be used and are advantageously circular.
  • the depressions 11 are advantageously frustoconical, the smaller circular area forming the base area or the base 12 or a puncture point.
  • Recesses 11 are arranged in the central area of the end plate 5 and form a puncture zone 16 in such a way that the highest possible density, i.e. results in the highest possible number of puncture points per unit area, the wall parts 15 remaining between the base areas or floors 12, which stabilize the entire puncture zone 16, being of sufficient quality.
  • the depressions 11 are advantageously arranged in rows offset from one another in such a way that there is essentially a hexagonal outer contour of the puncture zone 16.
  • the depressions 11 are spaced apart from one another in such a way that, due to the intersection of the conical outer surfaces 18 of the depressions 11, sharp cutting edges 17 form, which are viewed from above (FIG. 5) in a hexagonal configuration, a respective one Surrounding floor 12, and seen from the side, manifesting a hyperbolic curve (FIGS. 4 and 6).
  • the resulting roof-shaped boundary walls 15 of the bottom or puncture surfaces 12 provide reliable positive guidance of a pipetting needle 13 positioned relatively roughly above the puncture zone 16 to a corresponding puncture site.
  • the tip angle ⁇ of the pipetting needle 13 is approximately 30 degrees.
  • the tip 14 of the pipetting needle 13 is rounded (FIG. 2).
  • the angle of inclination ⁇ of the conical outer surface 18 (with respect to the longitudinal axis of the pipetting needle) of the depressions 11 is adapted to the tip angle ⁇ of the pipetting needle 13 and is preferably of approximately the same size.
  • the angle of inclination ⁇ is preferably between 20 and 40 degrees.
  • the alignment and centering forces on the pipetting needle 13 and. can act on the closure cap 1 are indicated schematically in Fig. 6 by means of arrows. If, for example, a (Pf1) pipetting needle 13 guided against the puncture zone 16 (indicated by dash-dotted lines in FIG. 5) strikes a boundary wall 15, then on the one hand the pipetting needle 13 can be self-elasticized (Pf2) and on the other hand the closure cap 1 together with the container 3 ( Pf3), due to a movable holder of the container 3 moving in a horizontal plane within certain limits, in such a way that the pipetting needle 13 ultimately reaches the base 12 and pierces it.
  • Pf1 pipetting needle 13 guided against the puncture zone 16 (indicated by dash-dotted lines in FIG. 5) strikes a boundary wall 15, then on the one hand the pipetting needle 13 can be self-elasticized (Pf2) and on the other hand the closure cap 1 together with the container 3 ( Pf3), due to a movable holder

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Closures For Containers (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
EP94113449A 1993-09-10 1994-08-29 Dispositif de fermeture pourvu d'un arrangement de zones perforables Ceased EP0642830A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH2719/93 1993-09-10
CH271993 1993-09-10

Publications (1)

Publication Number Publication Date
EP0642830A1 true EP0642830A1 (fr) 1995-03-15

Family

ID=4240065

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94113449A Ceased EP0642830A1 (fr) 1993-09-10 1994-08-29 Dispositif de fermeture pourvu d'un arrangement de zones perforables

Country Status (3)

Country Link
EP (1) EP0642830A1 (fr)
JP (1) JPH07191040A (fr)
CA (1) CA2130129A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003065047A1 (fr) * 2002-02-01 2003-08-07 Stago Instruments Dispositif pour l'analyse automatisee d'un echantillon liquide
EP1284160A3 (fr) * 2001-08-17 2004-01-14 Becton, Dickinson and Company Dispositif pour le prélèvement d'échantillons liquides
ITPD20080334A1 (it) * 2008-11-14 2010-05-15 Holos Sro Tappo di chiusura antimanomissione per provette
CN103071556A (zh) * 2012-06-15 2013-05-01 郑州安图绿科生物工程有限公司 用于医疗分析仪的试剂瓶、架
CN112816681A (zh) * 2020-06-19 2021-05-18 上海快灵生物科技有限公司 一种生化试纸管

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1965223A (zh) * 2004-03-02 2007-05-16 丹麦达科有限公司 用于生物学着色仪的试剂传送系统、释放设备和容器
JP2006001600A (ja) * 2004-06-18 2006-01-05 Toppan Printing Co Ltd 不正開封防止機能付きプラスチック口栓キャップ
JP5545233B2 (ja) * 2011-01-31 2014-07-09 コニカミノルタ株式会社 検査システム
JP6513926B2 (ja) * 2014-10-20 2019-05-15 アークレイ株式会社 分析用具、分析装置、それらを含む分析システム、および分析用具の開口を覆うシート状部材の穿孔方法
CN107003330B (zh) * 2014-12-18 2018-08-28 株式会社日立高新技术 采样喷嘴、使用该采样喷嘴的自动分析装置及采样喷嘴的制造方法
BR102017015998A2 (pt) * 2017-07-26 2019-03-26 Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein Película seladora e método de pipetagem utilizando uma película seladora
US12578354B2 (en) 2019-10-28 2026-03-17 Siemens Healthcare Diagnostics Inc. Vibrating pipette tips and methods of preventing pipette tip stiction

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1202433A (fr) * 1958-07-16 1960-01-11 Perfectionnements apportés aux moyens de bouchage des récipients notamment de ceux destinés à des produits pharmaceutiques ou produits analogues
US3653528A (en) * 1970-03-03 1972-04-04 West Co Stopper for medicament flasks
EP0019264A2 (fr) * 1979-05-18 1980-11-26 Terumo Corporation Récipient en résine pour un liquide médical
WO1984000530A1 (fr) * 1982-07-21 1984-02-16 Schubert & Co A S Fermeture pour un conteneur tel qu'une bouteille de perfusion
EP0504697A1 (fr) * 1991-03-19 1992-09-23 F. Hoffmann-La Roche Ag Fermeture pour récipients à réactifs

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56137072U (fr) * 1980-03-17 1981-10-17
US4539855A (en) * 1984-05-03 1985-09-10 Eastman Kodak Company Apparatus for transferring liquid out of a capped container, and analyzer utilizing same
EP0221315B1 (fr) * 1985-10-09 1989-06-14 Kontron Instruments Holding N.V. Dispositif pour enlever du liquide
JPS62235570A (ja) * 1986-04-05 1987-10-15 Japan Spectroscopic Co 試料サンプリング装置
JPH0350451Y2 (fr) * 1987-07-16 1991-10-28
CA2046813A1 (fr) * 1990-10-02 1992-04-03 Ueli Stettler Appareil de mise en place d'insert de pipetage dans le dispositif de fermeture d'un porte-echantillon

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1202433A (fr) * 1958-07-16 1960-01-11 Perfectionnements apportés aux moyens de bouchage des récipients notamment de ceux destinés à des produits pharmaceutiques ou produits analogues
US3653528A (en) * 1970-03-03 1972-04-04 West Co Stopper for medicament flasks
EP0019264A2 (fr) * 1979-05-18 1980-11-26 Terumo Corporation Récipient en résine pour un liquide médical
WO1984000530A1 (fr) * 1982-07-21 1984-02-16 Schubert & Co A S Fermeture pour un conteneur tel qu'une bouteille de perfusion
EP0504697A1 (fr) * 1991-03-19 1992-09-23 F. Hoffmann-La Roche Ag Fermeture pour récipients à réactifs

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1284160A3 (fr) * 2001-08-17 2004-01-14 Becton, Dickinson and Company Dispositif pour le prélèvement d'échantillons liquides
US6921395B2 (en) 2001-08-17 2005-07-26 Becton, Dickinson And Company Liquid specimen collection system
WO2003065047A1 (fr) * 2002-02-01 2003-08-07 Stago Instruments Dispositif pour l'analyse automatisee d'un echantillon liquide
FR2835616A1 (fr) * 2002-02-01 2003-08-08 Junior Instruments Dispositif pour l'analyse automatisee d'un echantillon liquide
US7507377B2 (en) 2002-02-01 2009-03-24 Stago Instruments Device for automatic analysis of a liquid sample
ITPD20080334A1 (it) * 2008-11-14 2010-05-15 Holos Sro Tappo di chiusura antimanomissione per provette
CN103071556A (zh) * 2012-06-15 2013-05-01 郑州安图绿科生物工程有限公司 用于医疗分析仪的试剂瓶、架
CN103071556B (zh) * 2012-06-15 2014-11-26 郑州安图生物工程股份有限公司 用于医疗分析仪的试剂瓶架系统
CN112816681A (zh) * 2020-06-19 2021-05-18 上海快灵生物科技有限公司 一种生化试纸管
CN112816681B (zh) * 2020-06-19 2024-05-14 上海快灵生物科技有限公司 一种生化试纸管

Also Published As

Publication number Publication date
JPH07191040A (ja) 1995-07-28
CA2130129A1 (fr) 1995-03-11

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