EP0652765A4 - Analogues de dynophine des-tyr. - Google Patents

Analogues de dynophine des-tyr.

Info

Publication number: EP0652765A4
Authority: EP; European Patent Office
Prior art keywords: dynorphine; tyr; des; analog; tyr dynorphine
Prior art date: 1992-06-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP93914274A

Other languages

German (de)

English (en)

Other versions

EP0652765A1 (fr

Inventor

Nancy M Lee

Horace H Loh

Akira E Takemori

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Des Tyr Dynorphin Partnership

Original Assignee

Des Tyr Dynorphin Partnership

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-12

Filing date

1993-06-01

Publication date

1997-04-09

1993-06-01 Application filed by Des Tyr Dynorphin Partnership filed Critical Des Tyr Dynorphin Partnership

1995-05-17 Publication of EP0652765A1 publication Critical patent/EP0652765A1/fr

1997-04-09 Publication of EP0652765A4 publication Critical patent/EP0652765A4/fr

Status Withdrawn legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Addiction (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Psychiatry (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

EP93914274A 1992-06-12 1993-06-01 Analogues de dynophine des-tyr. Withdrawn EP0652765A4 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US89792092A	1992-06-12	1992-06-12
US897920		1992-06-12
PCT/US1993/005161 WO1993025217A1 (fr)	1992-06-12	1993-06-01	Analogues de dynophine des-tyr

Publications (2)

Publication Number	Publication Date
EP0652765A1 EP0652765A1 (fr)	1995-05-17
EP0652765A4 true EP0652765A4 (fr)	1997-04-09

Family

ID=25408662

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP93914274A Withdrawn EP0652765A4 (fr)	1992-06-12	1993-06-01	Analogues de dynophine des-tyr.

Country Status (11)

Country	Link
EP (1)	EP0652765A4 (fr)
JP (1)	JPH08501075A (fr)
KR (1)	KR950701818A (fr)
AU (1)	AU4399093A (fr)
CA (1)	CA2137916A1 (fr)
CZ (1)	CZ281630B6 (fr)
FI (1)	FI945811L (fr)
HU (1)	HUT70160A (fr)
NO (1)	NO944778L (fr)
RU (1)	RU95106651A (fr)
WO (1)	WO1993025217A1 (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5482930A (en) *	1993-06-09	1996-01-09	The Regents Of The University Of California	Anti-inflammatory composition and method with des-Tyr dynorphin and analogues
EP1009407B1 (fr)	1997-09-04	2004-04-28	Novoneuron, Inc.	Noribogaine utilisee pour le traitement de la douleur et de la toxicomanie
US7220737B1 (en)	1997-09-04	2007-05-22	Novoneuron, Inc	Noribogaine in the treatment of pain and drug addiction
US6437092B1 (en)	1998-11-06	2002-08-20	Conjuchem, Inc.	Conjugates of opioids and endogenous carriers
US6887470B1 (en)	1999-09-10	2005-05-03	Conjuchem, Inc.	Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
US7601691B2 (en)	1999-05-17	2009-10-13	Conjuchem Biotechnologies Inc.	Anti-obesity agents
PT1105409E (pt)	1999-05-17	2006-07-31	Conjuchem Inc	Proteccao de peptidos terapeuticos endogenos da actividade de peptidases por conjugacao a componentes do sangue
US6849714B1 (en)	1999-05-17	2005-02-01	Conjuchem, Inc.	Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
US6706892B1 (en)	1999-09-07	2004-03-16	Conjuchem, Inc.	Pulmonary delivery for bioconjugation
CN1491233A (zh)	2001-02-02	2004-04-21	康久化学公司	长效生长激素释放因子衍生物
ATE396202T1 (de)	2001-02-16	2008-06-15	Conjuchem Biotechnologies Inc	Lang wirkendes glucagon-ähnliches peptid-2 für die behandlung von gastrointestinalen krankheiten und störungen
US8362007B1 (en)	2010-05-11	2013-01-29	Demerx, Inc.	Substituted noribogaine
US9394294B2 (en)	2010-05-11	2016-07-19	Demerx, Inc.	Methods and compositions for preparing and purifying noribogaine
US8765737B1 (en)	2010-05-11	2014-07-01	Demerx, Inc.	Methods and compositions for preparing and purifying noribogaine
US9586954B2 (en)	2010-06-22	2017-03-07	Demerx, Inc.	N-substituted noribogaine prodrugs
US8741891B1 (en)	2010-06-22	2014-06-03	Demerx, Inc.	N-substituted noribogaine prodrugs
US8637648B1 (en)	2010-06-22	2014-01-28	Demerx, Inc.	Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US8802832B2 (en)	2010-06-22	2014-08-12	Demerx, Inc.	Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
EP2595632A1 (fr)	2010-07-23	2013-05-29	DemeRx, Inc.	Compositions de noribogaïne
EP2481740B1 (fr)	2011-01-26	2015-11-04	DemeRx, Inc.	Procédés et compositions pour préparer de la noribogaïne à partir de voacangine
US9617274B1 (en)	2011-08-26	2017-04-11	Demerx, Inc.	Synthetic noribogaine
CA2855994A1 (fr)	2011-12-09	2013-06-13	Demerx, Inc.	Esters phosphoriques de noribogaine
US9150584B2 (en)	2012-01-25	2015-10-06	Demerx, Inc.	Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
US8877921B2 (en)	2012-01-25	2014-11-04	Demerx, Inc.	Synthetic voacangine
US9783535B2 (en)	2012-12-20	2017-10-10	Demerx, Inc.	Substituted noribogaine
US9045481B2 (en)	2012-12-20	2015-06-02	Demerx, Inc.	Substituted noribogaine
US8940728B2 (en)	2012-12-20	2015-01-27	Demerx, Inc.	Substituted noribogaine
US10428115B2 (en)	2013-05-24	2019-10-01	Arizona Board Of Regents On Behalf Of The University Of Arizona	Dynorphin A analogs with bradykinin receptors specificity for modulation of neuropathic pain
CA2989550C (fr)	2014-06-18	2023-08-08	Demerx, Inc.	Derives d'indole et de benzofurane halogenes d'isoquinuclidene et procedes pour leur preparation.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1996006626A1 (fr) *	1994-08-26	1996-03-07	Lee Nancy M	Procede analgesique utilisant des analogues de dynorphine tronques au niveau de la terminaison n

1993
- 1993-06-01 WO PCT/US1993/005161 patent/WO1993025217A1/fr not_active Ceased
- 1993-06-01 JP JP6501537A patent/JPH08501075A/ja active Pending
- 1993-06-01 CZ CZ943131A patent/CZ281630B6/cs unknown
- 1993-06-01 CA CA002137916A patent/CA2137916A1/fr not_active Abandoned
- 1993-06-01 HU HU9403563A patent/HUT70160A/hu unknown
- 1993-06-01 EP EP93914274A patent/EP0652765A4/fr not_active Withdrawn
- 1993-06-01 RU RU95106651/14A patent/RU95106651A/ru unknown
- 1993-06-01 FI FI945811A patent/FI945811L/fi not_active Application Discontinuation
- 1993-06-01 AU AU43990/93A patent/AU4399093A/en not_active Abandoned
- 1993-06-01 KR KR1019940704525A patent/KR950701818A/ko not_active Withdrawn
1994
- 1994-12-09 NO NO944778A patent/NO944778L/no unknown

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1996006626A1 (fr) *	1994-08-26	1996-03-07	Lee Nancy M	Procede analgesique utilisant des analogues de dynorphine tronques au niveau de la terminaison n

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BAKSHI R. & FADEN A.I.: "Compeptitive and non-compeptitive NMDA antagonists limit dynorphin A-induced rat hindlimb paralysis", BRAIN RESEARCH, vol. 507, 1990, pages 1 - 5, XP000612654 *
CODD E.E. ET AL.: "A non-opoid pattern characterizes inhibition of growth hormone releasing peptide binding by Dynorphin-related peptides", NEUROPEPTIDES (EDINBOURGH), vol. 15, no. 3, 1990, pages 133 - 137, XP000612963 *
MWYER M.E.: "Intrastrial injections of Dynorphin A fragments potentiate the dorsal immobility response in rats", PHARMACOL.BIOCHEM.BEHAV., vol. 44, no. 2, 1993, pages 329 - 332, XP000613059 *
ROCHFORD J. ET AL.: "Intrathecal administation of dynorphin A and its fragments increase heart rate and arteria pressure in the urethane anesthetized rat: mediation by a nonopioid mechanism", BRAIN RESEARCH, vol. 565, no. 1, 1991, pages 67 - 77, XP000612957 *
See also references of WO9325217A1 *
TAKEMORI A. ET AL.: "Suppression by Dynorphin A and des-Tyr-Dynorphin A peptides of the expression of opiate withdrawl and tolerance in morphine-depedent mice", J.PHARMACOL.EXP.THER., vol. 266, no. 1, 1993, pages 121 - 124, XP000612554 *
XIE, GUO-XI ET AL.: "Expression of cDNA encoding a seven-helix receptor from human placenta with affinity for opioid ligands", PROC.NATL.ACAD.SCI., vol. 89, 1992, USA, pages 4124 - 4128, XP002022035 *

Also Published As

Publication number	Publication date
AU4399093A (en)	1994-01-04
FI945811A7 (fi)	1995-02-06
CZ281630B6 (cs)	1996-11-13
WO1993025217A1 (fr)	1993-12-23
HUT70160A (en)	1995-09-28
CA2137916A1 (fr)	1993-12-23
JPH08501075A (ja)	1996-02-06
NO944778D0 (no)	1994-12-09
KR950701818A (ko)	1995-05-17
HU9403563D0 (en)	1995-02-28
FI945811L (fi)	1995-02-06
NO944778L (no)	1995-02-10
FI945811A0 (fi)	1994-12-09
RU95106651A (ru)	1996-12-27
CZ313194A3 (en)	1995-08-16
EP0652765A1 (fr)	1995-05-17

Legal Events

Date	Code	Title	Description
1995-03-31	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1995-05-17	17P	Request for examination filed	Effective date: 19950109
1995-05-17	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
1996-01-10	RHK1	Main classification (correction)	Ipc: A61K 38/00
1997-03-26	RHK1	Main classification (correction)	Ipc: C07K 5/00
1997-04-09	A4	Supplementary search report drawn up and despatched
1997-04-09	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
1998-02-25	17Q	First examination report despatched	Effective date: 19980113
1999-08-27	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
1999-10-13	18D	Application deemed to be withdrawn	Effective date: 19990416

Publication	Publication Date	Title
EP0652765A4 (fr)	1997-04-09	Analogues de dynophine des-tyr.
FI921647A0 (fi)	1992-04-13	Spetsdelpipett.
FR2693752B1 (fr)	1996-08-02	Barrage-clapet.
FI921391A0 (fi)	1992-03-30	Friktionsfast staol.
FI920146A0 (fi)	1992-01-13	Stroemskensystem.
FI922100A0 (fi)	1992-05-08	Traedkvistare -kapare.
ES1021196Y (es)	1994-01-01	Cubre-cajas pefeccionado.
ES1020184Y (es)	1993-03-16	Conjunto soporte-envase.
FI920064A0 (fi)	1992-01-08	Kompostor.
ES1022971Y (es)	1994-04-16	Perinola.
ES1020075Y (es)	1993-03-01	Columbario.
ES1020335Y (es)	1993-01-16	Estuche-escribania.
ES1023265Y (es)	1994-01-01	Cabina fotografica.
ES1023634Y (es)	1994-03-01	Poste-corta-trafico.
FI920681A0 (fi)	1992-02-18	Lyftvagn.
FI921605A0 (fi)	1992-04-10	Lager- och transportenhet foer mineralullsskivor.
FI920252A0 (fi)	1992-01-21	Bockningsmaskin.
FI920315A0 (fi)	1992-01-24	Skjutlave.
FI920454A0 (fi)	1992-02-03	Fjaederram.
FI920476A0 (fi)	1992-02-04	Snabbkopplings- och kraengnings- anordning foer graevmaskinsredskap.
FI920512A0 (fi)	1992-02-07	Ytfarkost.
FI920541A0 (fi)	1992-02-10	Hoernlist foer panelvaegg.
FI920603A0 (fi)	1992-02-13	Knappsatsskydd foer ficktelefon.
FI920622A0 (fi)	1992-02-14	Foerbraenningssystem foer miljoefarliga gasutslaepp.
FI920016A0 (fi)	1992-01-02	Kameraenhet foer en feldetekteringsanordning foer plattytor.