EP0674705A4 - Antisense-oligonukleotide zur hemmung der expression mutierter gene und wildtypgene des collagens. - Google Patents

Antisense-oligonukleotide zur hemmung der expression mutierter gene und wildtypgene des collagens.

Info

Publication number
EP0674705A4
EP0674705A4 EP94901327A EP94901327A EP0674705A4 EP 0674705 A4 EP0674705 A4 EP 0674705A4 EP 94901327 A EP94901327 A EP 94901327A EP 94901327 A EP94901327 A EP 94901327A EP 0674705 A4 EP0674705 A4 EP 0674705A4
Authority
EP
European Patent Office
Prior art keywords
mutated
collagen
wild type
antisense oligonucleotides
inhibit expression
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94901327A
Other languages
English (en)
French (fr)
Other versions
EP0674705A1 (de
Inventor
Darwin Prockop
Alain Colige
Renato Baserga
Paul Nugent
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thomas Jefferson University
Original Assignee
Thomas Jefferson University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomas Jefferson University filed Critical Thomas Jefferson University
Publication of EP0674705A1 publication Critical patent/EP0674705A1/de
Publication of EP0674705A4 publication Critical patent/EP0674705A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
EP94901327A 1992-11-09 1993-11-09 Antisense-oligonukleotide zur hemmung der expression mutierter gene und wildtypgene des collagens. Withdrawn EP0674705A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97333292A 1992-11-09 1992-11-09
US973332 1992-11-09
PCT/US1993/010756 WO1994011494A1 (en) 1992-11-09 1993-11-09 Antisense oligonucleotides to inhibit expression of mutated and wild type genes for collagen

Publications (2)

Publication Number Publication Date
EP0674705A1 EP0674705A1 (de) 1995-10-04
EP0674705A4 true EP0674705A4 (de) 1997-11-26

Family

ID=25520770

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94901327A Withdrawn EP0674705A4 (de) 1992-11-09 1993-11-09 Antisense-oligonukleotide zur hemmung der expression mutierter gene und wildtypgene des collagens.

Country Status (4)

Country Link
EP (1) EP0674705A4 (de)
JP (1) JPH08503366A (de)
CA (1) CA2148687A1 (de)
WO (1) WO1994011494A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5808037A (en) * 1995-09-15 1998-09-15 Ramareddy Venkata Guntaka Oligomers which inhibit expression of collagen genes
US6156513A (en) * 1995-09-15 2000-12-05 Ramareddy V. Guntaka Oligmers which inhibit expression of collagen genes
US5780611A (en) * 1995-09-15 1998-07-14 Ramareddy Venkata Guntaka Oligomers which inhibit expression of collagen genes
GB9519299D0 (en) 1995-09-21 1995-11-22 Farrar Gwyneth J Genetic strategy
GB9604449D0 (en) * 1996-03-01 1996-05-01 Farrar Gwyneth J Genetic strategy ii
US8551970B2 (en) 1996-04-02 2013-10-08 Optigen Patents Limited Genetic suppression and replacement
GB9606961D0 (en) 1996-04-02 1996-06-05 Farrar Gwyneth J Genetic strategy III
US5814500A (en) * 1996-10-31 1998-09-29 The Johns Hopkins University School Of Medicine Delivery construct for antisense nucleic acids and methods of use
WO1998041648A2 (en) * 1997-03-20 1998-09-24 Variagenics, Inc. Target genes for allele-specific drugs
US6200754B1 (en) 1998-03-19 2001-03-13 Variagenics, Inc. Inhibitors of alternative alleles of genes encoding products that mediate cell response to environmental changes
US6939712B1 (en) * 1998-12-29 2005-09-06 Impedagen, Llc Muting gene activity using a transgenic nucleic acid
GB9929487D0 (en) 1999-12-15 2000-02-09 Zeneca Ltd Antisense oligonucleotides

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990006934A1 (en) * 1988-12-20 1990-06-28 Baylor College Of Medicine Triple stranded nucleic acid and methods of use
WO1993004701A1 (en) * 1991-09-05 1993-03-18 University Of Connecticut Targeted delivery of poly- or oligonucleotides to cells

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990006934A1 (en) * 1988-12-20 1990-06-28 Baylor College Of Medicine Triple stranded nucleic acid and methods of use
WO1993004701A1 (en) * 1991-09-05 1993-03-18 University Of Connecticut Targeted delivery of poly- or oligonucleotides to cells

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
COLIGE, A. ET AL.: "Use of an antisense oligonucleotide to inhibit expression of a mutated human procollagen gene ( COL1A1 ) in transfected mouse 3T3 cells.", BIOCHEMISTRY, (1993 JAN 12) 32 (1) 7-11., XP002032408 *
COLIGE, A. ET AL.: "USE OF AN ANTISENSE OLIGONUCLEOTIDE TO INHIBIT EXPRESSION OF A MUTATED HUMAN PROCOLLAGEN GENE (COL1A1) IN TRANSFECTED MOUSE 3T3 CELLS.", MATRIX 13 (1). 1993. 30., XP002032407 *
FOURTH INTERNATIONAL CONFERENCE ON THE MOLECULAR BIOLOGY AND PATHOLOGY OF MATRIX, JUNE 10-13, 1992. *
See also references of WO9411494A1 *

Also Published As

Publication number Publication date
EP0674705A1 (de) 1995-10-04
WO1994011494A1 (en) 1994-05-26
CA2148687A1 (en) 1994-05-26
JPH08503366A (ja) 1996-04-16

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