EP0689433A4 - Nouveaux agents de liaison des metaux, procedes et compositions permettant de les utiliser pour traiter la toxicite des metaux - Google Patents

Nouveaux agents de liaison des metaux, procedes et compositions permettant de les utiliser pour traiter la toxicite des metaux

Info

Publication number
EP0689433A4
EP0689433A4 EP93908352A EP93908352A EP0689433A4 EP 0689433 A4 EP0689433 A4 EP 0689433A4 EP 93908352 A EP93908352 A EP 93908352A EP 93908352 A EP93908352 A EP 93908352A EP 0689433 A4 EP0689433 A4 EP 0689433A4
Authority
EP
European Patent Office
Prior art keywords
compositions
methods
binding agents
toxicity
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP93908352A
Other languages
German (de)
English (en)
Other versions
EP0689433A1 (fr
Inventor
Patrick L Iversen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Nebraska Lincoln
University of Nebraska System
Original Assignee
University of Nebraska Lincoln
University of Nebraska System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Nebraska Lincoln, University of Nebraska System filed Critical University of Nebraska Lincoln
Publication of EP0689433A1 publication Critical patent/EP0689433A1/fr
Publication of EP0689433A4 publication Critical patent/EP0689433A4/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP93908352A 1993-03-16 1993-03-16 Nouveaux agents de liaison des metaux, procedes et compositions permettant de les utiliser pour traiter la toxicite des metaux Ceased EP0689433A4 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1993/002363 WO1994021243A1 (fr) 1993-03-16 1993-03-16 Nouveaux agents de liaison des metaux, procedes et compositions permettant de les utiliser pour traiter la toxicite des metaux

Publications (2)

Publication Number Publication Date
EP0689433A1 EP0689433A1 (fr) 1996-01-03
EP0689433A4 true EP0689433A4 (fr) 1999-10-20

Family

ID=22236405

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93908352A Ceased EP0689433A4 (fr) 1993-03-16 1993-03-16 Nouveaux agents de liaison des metaux, procedes et compositions permettant de les utiliser pour traiter la toxicite des metaux

Country Status (3)

Country Link
EP (1) EP0689433A4 (fr)
AU (1) AU3920293A (fr)
WO (1) WO1994021243A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6140305A (en) 1996-04-04 2000-10-31 Bio-Rad Laboratories, Inc. Hereditary hemochromatosis gene products
US7026116B1 (en) 1996-04-04 2006-04-11 Bio-Rad Laboratories, Inc. Polymorphisms in the region of the human hemochromatosis gene
US6849399B1 (en) 1996-05-23 2005-02-01 Bio-Rad Laboratories, Inc. Methods and compositions for diagnosis and treatment of iron misregulation diseases
WO1998056814A1 (fr) 1997-06-13 1998-12-17 Progenitor, Inc. Diagnostic et traitement des affections liees a la surcharge en fer et des affections ferriprives, procedes et compositions appropries
CN110105446B (zh) * 2019-04-11 2022-02-18 中国科学院遗传与发育生物学研究所农业资源研究中心 一种金属硫蛋白基因mt27、其编码得到的金属硫蛋白及其表达和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0134773A1 (fr) * 1983-08-08 1985-03-20 Smithkline Beckman Corporation Gène à levure-cuivre-métallothionéine
WO1989011486A1 (fr) * 1988-05-26 1989-11-30 University Patents, Inc. Composes de thiophosphoramidite et de phosphorodithioate de nucleosides et de polynucleotides et procedes
US5618796A (en) * 1991-09-12 1997-04-08 The Board Of Regents Of The University Of Nebraska Metal binding oligonucleotide and methods and compositions for their use to treat metal toxicity

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0134773A1 (fr) * 1983-08-08 1985-03-20 Smithkline Beckman Corporation Gène à levure-cuivre-métallothionéine
WO1989011486A1 (fr) * 1988-05-26 1989-11-30 University Patents, Inc. Composes de thiophosphoramidite et de phosphorodithioate de nucleosides et de polynucleotides et procedes
US5618796A (en) * 1991-09-12 1997-04-08 The Board Of Regents Of The University Of Nebraska Metal binding oligonucleotide and methods and compositions for their use to treat metal toxicity

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
IVERSEN, PATRICK L. ET AL: "Synthetic antisense oligonucleotide probes the essentiality of metallothionein gene", BIOL. SIGNALS (1993), VOLUME DATE 1992, 1(6), 293-9, XP002111176 *
See also references of WO9421243A1 *

Also Published As

Publication number Publication date
WO1994021243A1 (fr) 1994-09-29
EP0689433A1 (fr) 1996-01-03
AU3920293A (en) 1994-10-11

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