EP0713869A3 - - Google Patents
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- Publication number
- EP0713869A3 EP0713869A3 EP95118473A EP95118473A EP0713869A3 EP 0713869 A3 EP0713869 A3 EP 0713869A3 EP 95118473 A EP95118473 A EP 95118473A EP 95118473 A EP95118473 A EP 95118473A EP 0713869 A3 EP0713869 A3 EP 0713869A3
- Authority
- EP
- European Patent Office
- Prior art keywords
- dsm
- concn
- oxo
- benzyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 abstract 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 229960002715 nicotine Drugs 0.000 abstract 2
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 abstract 2
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 abstract 2
- 229910019213 POCl3 Inorganic materials 0.000 abstract 1
- 241000589516 Pseudomonas Species 0.000 abstract 1
- 241000589540 Pseudomonas fluorescens Species 0.000 abstract 1
- 241000589776 Pseudomonas putida Species 0.000 abstract 1
- 241001478283 Variovorax Species 0.000 abstract 1
- 241001478284 Variovorax paradoxus Species 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH3537/94 | 1994-11-25 | ||
| CH3538/94 | 1994-11-25 | ||
| CH353794 | 1994-11-25 | ||
| CH353894 | 1994-11-25 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EP0713869A2 EP0713869A2 (fr) | 1996-05-29 |
| EP0713869A3 true EP0713869A3 (fr) | 1996-06-19 |
| EP0713869B1 EP0713869B1 (fr) | 1999-04-28 |
Family
ID=25693268
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP95118473A Expired - Lifetime EP0713869B1 (fr) | 1994-11-25 | 1995-11-23 | Derivés de pyridine di et trisubstitués et leur préparation |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US5760236A (fr) |
| EP (1) | EP0713869B1 (fr) |
| JP (1) | JPH08208610A (fr) |
| AT (1) | ATE179415T1 (fr) |
| CA (1) | CA2163602A1 (fr) |
| DE (1) | DE59505765D1 (fr) |
| DK (1) | DK0713869T3 (fr) |
| ES (1) | ES2132498T3 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5760236A (en) * | 1994-11-25 | 1998-06-02 | Lonza, Ltd. | Di and trisubstituted pyridines |
| CN100383253C (zh) * | 2005-04-29 | 2008-04-23 | 上海爱普香料有限公司 | 一种以尼古丁为底物生物转化制备6-羟基-3-琥珀酰-吡啶的方法 |
| US20180110274A1 (en) * | 2016-10-26 | 2018-04-26 | Lynell LaRue | Cushioned protective garment and a method for making such |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2634188A1 (de) * | 1975-11-17 | 1977-08-04 | British American Tobacco Co | Verfahren zur verminderung des nikotingehalts von tabak durch mikrobielle behandlung |
| US5089509A (en) * | 1988-09-15 | 1992-02-18 | Allergan, Inc. | Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity |
| EP0556465A2 (fr) * | 1991-12-05 | 1993-08-25 | Lonza Ag | Procédé microbiologique pour la préparation d'acides hétérocycliques aromatiques hydroxylés |
| WO1995006032A1 (fr) * | 1993-08-20 | 1995-03-02 | Banyu Pharmaceutical Co., Ltd. | Inhibiteur de la tyrosine kinase |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5098924A (en) * | 1989-09-15 | 1992-03-24 | E. R. Squibb & Sons, Inc. | Diol sulfonamide and sulfinyl renin inhibitors |
| US5760236A (en) * | 1994-11-25 | 1998-06-02 | Lonza, Ltd. | Di and trisubstituted pyridines |
-
1995
- 1995-11-21 US US08/561,230 patent/US5760236A/en not_active Expired - Fee Related
- 1995-11-23 CA CA002163602A patent/CA2163602A1/fr not_active Abandoned
- 1995-11-23 AT AT95118473T patent/ATE179415T1/de not_active IP Right Cessation
- 1995-11-23 DK DK95118473T patent/DK0713869T3/da active
- 1995-11-23 EP EP95118473A patent/EP0713869B1/fr not_active Expired - Lifetime
- 1995-11-23 ES ES95118473T patent/ES2132498T3/es not_active Expired - Lifetime
- 1995-11-23 DE DE59505765T patent/DE59505765D1/de not_active Expired - Fee Related
- 1995-11-24 JP JP7306233A patent/JPH08208610A/ja not_active Withdrawn
-
1998
- 1998-04-30 US US09/069,996 patent/US5994540A/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2634188A1 (de) * | 1975-11-17 | 1977-08-04 | British American Tobacco Co | Verfahren zur verminderung des nikotingehalts von tabak durch mikrobielle behandlung |
| US5089509A (en) * | 1988-09-15 | 1992-02-18 | Allergan, Inc. | Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity |
| EP0556465A2 (fr) * | 1991-12-05 | 1993-08-25 | Lonza Ag | Procédé microbiologique pour la préparation d'acides hétérocycliques aromatiques hydroxylés |
| WO1995006032A1 (fr) * | 1993-08-20 | 1995-03-02 | Banyu Pharmaceutical Co., Ltd. | Inhibiteur de la tyrosine kinase |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2163602A1 (fr) | 1996-05-26 |
| US5994540A (en) | 1999-11-30 |
| US5760236A (en) | 1998-06-02 |
| ES2132498T3 (es) | 1999-08-16 |
| EP0713869B1 (fr) | 1999-04-28 |
| DK0713869T3 (da) | 1999-10-25 |
| EP0713869A2 (fr) | 1996-05-29 |
| DE59505765D1 (de) | 1999-06-02 |
| JPH08208610A (ja) | 1996-08-13 |
| ATE179415T1 (de) | 1999-05-15 |
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