EP0717843A1 - Support code utilise en chromatographie en couche mince - Google Patents

Support code utilise en chromatographie en couche mince

Info

Publication number
EP0717843A1
EP0717843A1 EP94926223A EP94926223A EP0717843A1 EP 0717843 A1 EP0717843 A1 EP 0717843A1 EP 94926223 A EP94926223 A EP 94926223A EP 94926223 A EP94926223 A EP 94926223A EP 0717843 A1 EP0717843 A1 EP 0717843A1
Authority
EP
European Patent Office
Prior art keywords
layer chromatography
thin
code
support material
laser
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94926223A
Other languages
German (de)
English (en)
Inventor
Andrea Junker-Buchheit
Heinz Emil Hauck
Willi Jost
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of EP0717843A1 publication Critical patent/EP0717843A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/90—Plate chromatography, e.g. thin layer or paper chromatography
    • G01N30/92—Construction of the plate
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06K—GRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
    • G06K1/00—Methods or arrangements for marking the record carrier in digital fashion
    • G06K1/12—Methods or arrangements for marking the record carrier in digital fashion otherwise than by punching
    • G06K1/126—Methods or arrangements for marking the record carrier in digital fashion otherwise than by punching by photographic or thermographic registration

Definitions

  • the invention relates to a coded carrier for thin layer chromatography ("DC”) and a method for its production.
  • DC thin layer chromatography
  • Such a marking should have the highest possible density of information and should be able to be applied quickly to or into the respective layer. Above all, however, it should be resistant to all organic and inorganic solvents, bases and acids commonly used in TLC (not only in liquid form, but also in the case of gaseous effects due to vapor deposition) and thus neither disturb the chromatographic development nor the result of the separation or influenced. In addition, the marking should not only be legible in daylight, but also when exposed to UV radiation (e.g. 254 and 366 nm).
  • the previously usual markings for example by sticking labels or by scratching into the carrier layer, only partially or not at all meet these requirements and are also cumbersome. Due to the manual transmission of data, transmission errors can make the entries unusable. Labels can peel off and get lost.
  • the object of the invention was to provide labeled (coded) DC carriers which do not have the stated disadvantages or only have them to a lesser extent.
  • Irradiation of the carrier can be achieved with laser light, using an appropriate template (e.g. numbers and / or letters or lines for bar coding) or controlling the laser via a computer.
  • an appropriate template e.g. numbers and / or letters or lines for bar coding
  • the invention accordingly relates to a carrier for the DC, characterized by a coding applied with the aid of laser light, and to a method for its production, characterized in that a conventional carrier for the DC is irradiated with laser light.
  • Glass carriers and foils e.g. aluminum or plastic foils, e.g. those made of polyterephthalate
  • Sorberis Glass carriers and foils that are coated with Sorberis and contain a binder and optionally a fluorescence indicator and / or other additives are primarily suitable as supports.
  • Suitable as sorbent are all stationary phases usually used in DC, preferably modified or unmodified silica gels, furthermore e.g. Cellulose, polyamides, diatomaceous earth, aluminum oxides.
  • Polymeric organic substances are preferably used as binders, e.g. Polyacrylic acid or polymethacrylic acid and their amides.
  • a pulsed or unpulsed CO2 laser (wavelength 1.06 ⁇ m) or a Yag laser (solid-state laser, wavelength 10.6 ⁇ m) is preferably used as the laser source.
  • the exposure time is 5-50 nanoseconds per character.
  • the coding obtained can contain any data, e.g. lettering from the manufacturer, article number, batch number, date of manufacture, individual, unique numbering (consecutive numbers).
  • the coding is preferably carried out by irradiating the sorbent layer which contains a binder.
  • a laser it is also possible to mark the uncoated back of a carrier glass plate or a coated plastic film.
  • fine thermal stress cracks occur during the irradiation, which cause the glass surface to become cloudy in the wavelength range of visible light.
  • a ready-made HPTLC plate (E. Merck Kieselgel 60 F254, Item No. 5642, 100 x 200 mm) is used with a pulsed CO 2 laser, wavelength
  • HPTLC prefabricated plate (E. Merck Kieselgel 60, Art. No. 5641, 100 x 200 mm) is labeled with an unpulsed CO 2 laser (wavelength 10.6 ⁇ m, power consumption 10 watts, feed speed 100 mm / sec).
  • the laser is controlled by a computer.

Landscapes

  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Theoretical Computer Science (AREA)
  • Laser Beam Processing (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

L'invention concerne un support utilisé en chromatographie en couche mince, caractérisé par un codage appliqué à l'aide d'une lumière laser.
EP94926223A 1993-09-09 1994-08-30 Support code utilise en chromatographie en couche mince Withdrawn EP0717843A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4330564 1993-09-09
DE4330564A DE4330564B4 (de) 1993-09-09 1993-09-09 Codierter Träger für die Dünnschichtchromatographie
PCT/EP1994/002871 WO1995007459A1 (fr) 1993-09-09 1994-08-30 Support code utilise en chromatographie en couche mince

Publications (1)

Publication Number Publication Date
EP0717843A1 true EP0717843A1 (fr) 1996-06-26

Family

ID=6497274

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94926223A Withdrawn EP0717843A1 (fr) 1993-09-09 1994-08-30 Support code utilise en chromatographie en couche mince

Country Status (6)

Country Link
US (1) US5773576A (fr)
EP (1) EP0717843A1 (fr)
JP (1) JPH09503292A (fr)
CN (1) CN1095544C (fr)
DE (1) DE4330564B4 (fr)
WO (1) WO1995007459A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100481650B1 (ko) * 1996-09-05 2005-08-23 삼성전자주식회사 굴곡형액정표시장치의백라이트
WO2013105572A1 (fr) * 2012-01-11 2013-07-18 株式会社ダイセル Milieu chromatographique
JP6118271B2 (ja) 2012-02-03 2017-04-19 株式会社ダイセル クロマトグラフ媒体
CN110850020B (zh) * 2019-11-11 2022-03-29 中国药科大学 一种基于人工智能的中药识别方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4126554A (en) * 1977-09-02 1978-11-21 Analtech, Inc. Selectively marked thin-layer chromatographic plate
US4323755A (en) * 1979-09-24 1982-04-06 Rca Corporation Method of making a machine-readable marking in a workpiece
US4960691A (en) * 1986-09-29 1990-10-02 Abbott Laboratories Chromatographic test strip for determining ligands or receptors
JPS63285930A (ja) * 1987-05-18 1988-11-22 Sanyo Electric Co Ltd 超微細管の形成方法
BG46808A1 (en) * 1988-05-27 1990-03-15 Univ Plovdivski Device for laser engraving
US5439826A (en) * 1988-12-02 1995-08-08 Bio-Tek Instruments, Inc. Method of distinguishing among strips for different assays in an automated instrument

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9507459A1 *

Also Published As

Publication number Publication date
WO1995007459A1 (fr) 1995-03-16
DE4330564A1 (de) 1995-03-16
CN1095544C (zh) 2002-12-04
CN1130424A (zh) 1996-09-04
DE4330564B4 (de) 2005-03-17
JPH09503292A (ja) 1997-03-31
US5773576A (en) 1998-06-30

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Legal Events

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