EP0733122A4 - Proteines de fusion contenant une proteine rep de virus associe a l'adenovirus et proteine bacterienne - Google Patents

Proteines de fusion contenant une proteine rep de virus associe a l'adenovirus et proteine bacterienne

Info

Publication number
EP0733122A4
EP0733122A4 EP94919252A EP94919252A EP0733122A4 EP 0733122 A4 EP0733122 A4 EP 0733122A4 EP 94919252 A EP94919252 A EP 94919252A EP 94919252 A EP94919252 A EP 94919252A EP 0733122 A4 EP0733122 A4 EP 0733122A4
Authority
EP
European Patent Office
Prior art keywords
adeno
bacteria
proteins
associated virus
rep protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94919252A
Other languages
German (de)
English (en)
Other versions
EP0733122A1 (fr
Inventor
Robert Kotin
Brian Safer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetic Therapy Inc
US Department of Health and Human Services
Original Assignee
Genetic Therapy Inc
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetic Therapy Inc, US Department of Health and Human Services filed Critical Genetic Therapy Inc
Publication of EP0733122A1 publication Critical patent/EP0733122A1/fr
Publication of EP0733122A4 publication Critical patent/EP0733122A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/24—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a MBP (maltose binding protein)-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
EP94919252A 1993-05-26 1994-05-26 Proteines de fusion contenant une proteine rep de virus associe a l'adenovirus et proteine bacterienne Withdrawn EP0733122A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6723693A 1993-05-26 1993-05-26
US67236 1993-05-26
PCT/US1994/005940 WO1994028157A1 (fr) 1993-05-26 1994-05-26 Proteines de fusion contenant une proteine rep de virus associe a l'adenovirus et proteine bacterienne

Publications (2)

Publication Number Publication Date
EP0733122A1 EP0733122A1 (fr) 1996-09-25
EP0733122A4 true EP0733122A4 (fr) 1998-06-10

Family

ID=22074622

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94919252A Withdrawn EP0733122A4 (fr) 1993-05-26 1994-05-26 Proteines de fusion contenant une proteine rep de virus associe a l'adenovirus et proteine bacterienne

Country Status (4)

Country Link
EP (1) EP0733122A4 (fr)
JP (1) JPH09501309A (fr)
CA (1) CA2162271A1 (fr)
WO (1) WO1994028157A1 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6342390B1 (en) 1994-11-23 2002-01-29 The United States Of America As Represented By The Secretary Of Health And Human Services Lipid vesicles containing adeno-associated virus rep protein for transgene integration and gene therapy
US5843742A (en) * 1994-12-16 1998-12-01 Avigen Incorporated Adeno-associated derived vector systems for gene delivery and integration into target cells
US6281010B1 (en) 1995-06-05 2001-08-28 The Trustees Of The University Of Pennsylvania Adenovirus gene therapy vehicle and cell line
US5756283A (en) * 1995-06-05 1998-05-26 The Trustees Of The University Of Pennsylvania Method for improved production of recombinant adeno-associated viruses for gene therapy
DE19545126A1 (de) 1995-12-04 1997-06-05 Hoechst Ag ATP- und Nukleinsäure-bindendes Protein mit Helikase-Eigenschaften
US6521225B1 (en) * 1996-09-06 2003-02-18 Chiron Corporation AAV vectors
US6544523B1 (en) 1996-11-13 2003-04-08 Chiron Corporation Mutant forms of Fas ligand and uses thereof
EP1900818A3 (fr) 1997-11-06 2008-06-11 Novartis Vaccines and Diagnostics S.r.l. Antigènes de Neisserial
WO1999036544A2 (fr) 1998-01-14 1999-07-22 Chiron S.P.A. Antigenes du $i(neisseria meningitidis)
EP2261347A3 (fr) 1998-05-01 2012-01-11 Novartis Vaccines and Diagnostics, Inc. Antigènes de Neisseria meningitidis et compositions
CA2372235A1 (fr) 1999-04-30 2000-11-09 Rino Rappuoli Antigenes de neisseria conserves
GB9911683D0 (en) 1999-05-19 1999-07-21 Chiron Spa Antigenic peptides
GB9916529D0 (en) 1999-07-14 1999-09-15 Chiron Spa Antigenic peptides
EP1226253A2 (fr) 1999-10-29 2002-07-31 Chiron S.P.A. Peptides antigeniques de neisseria
CA2871789C (fr) 2000-01-17 2017-04-04 Novartis Vaccines And Diagnostics S.R.L. Vaccin a base de vesicule de membrane externe (omv) comprenant des proteines de membrane externe du serogroupe b de n. meningitis
ATE439372T1 (de) 2000-10-27 2009-08-15 Novartis Vaccines & Diagnostic Nukleinsäuren und proteine von gruppen a und b- streptokokken
GB0107658D0 (en) 2001-03-27 2001-05-16 Chiron Spa Streptococcus pneumoniae
GB0107661D0 (en) 2001-03-27 2001-05-16 Chiron Spa Staphylococcus aureus
EP2168596B1 (fr) 2001-12-12 2012-05-23 Novartis Vaccines and Diagnostics S.r.l. Immunisation contre la chlamydia trachomatis
GB0308198D0 (en) 2003-04-09 2003-05-14 Chiron Srl ADP-ribosylating bacterial toxin
US8268324B2 (en) 2004-03-29 2012-09-18 Galpharma Co., Ltd. Modified galectin 9 proteins and use thereof
ATE522541T1 (de) 2006-06-09 2011-09-15 Novartis Ag Bakterielle adhäsine konformere
BR112020002394A2 (pt) 2017-08-09 2020-07-28 Bioverativ Therapeutics Inc. moléculas de ácidos nucleicos e usos das mesmas
KR102925832B1 (ko) 2018-08-09 2026-02-11 바이오버라티브 테라퓨틱스 인크. 핵산 분자 및 비바이러스 유전자 치료를 위한 이의 용도

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0486917A2 (fr) * 1990-11-17 1992-05-27 BEHRINGWERKE Aktiengesellschaft Activité antivirale du gène rep codé par l'AAV-2

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5139941A (en) * 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0486917A2 (fr) * 1990-11-17 1992-05-27 BEHRINGWERKE Aktiengesellschaft Activité antivirale du gène rep codé par l'AAV-2

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHIORINI J A ET AL: "BIOLOGICALLY ACTIVE REP PROTEINS OF ADENO-ASSOCIATED VIRUS TYPE 2 PRODUCED AS FUSION PROTEINS IN ESCHERICHIA COLI", JOURNAL OF VIROLOGY, vol. 68, no. 2, February 1994 (1994-02-01), pages 797 - 804, XP000608411 *
IM D.S: & MUZYCZKA N.: "The AAV origin bvinding protein Rep68 is an ATP-dependent site-specific endonuclease with DNA helicase activity.", CELL, vol. 61, 4 May 1990 (1990-05-04), pages 447 - 457, XP002060793 *
NEW ENGLAND BIOLABS CATALOG, 1992, pages 96 - 97, XP002061117 *
See also references of WO9428157A1 *

Also Published As

Publication number Publication date
WO1994028157A1 (fr) 1994-12-08
CA2162271A1 (fr) 1994-12-08
JPH09501309A (ja) 1997-02-10
EP0733122A1 (fr) 1996-09-25

Similar Documents

Publication Publication Date Title
ITTO950367A0 (it) Proteine di prrsv ricombinanti, corredi diagnostici e vaccini contenenti tali proteine di prrsv ricombinanti.
DE69723254D1 (de) Protein der ausseren membran von moraxella catarrhalis omp-106, dessen gensequenz und dessen verwendung
EP0571442A4 (fr) Proteine tsg-14 induite par la cytokine, adn codant cette proteine et ses utilisations.
DE3680322D1 (de) Antibioticahaltiges mittel und seine verwendung als chirurgisches kunststoffmaterial.
DE69628791D1 (de) Absorbierende Zusammensetzung, absorbierendes Material, und ein, das absorbierende Material enthaltende, absorbierendes Produkt.
DE69230670D1 (de) Zusammensetzungen, die eine blutgerinnselpolymermatrix zur verabreichung von osteogenen proteinen enthalten
FI964311L (fi) Bifunktionaalinen proteiini, valmistus ja käyttö
DE69631065D1 (de) Verbessertes mittel zur verringerung des fliesswiederstandes von schlamm
MY102472A (en) Preparation of funtional human urokinase proteins.
NO307707B1 (no) Spiroazabicykliske forbindelser, farmasøytisk preparat inneholdende slike forbindelser og anvendelse derav
DE69715482D1 (de) Herstellung von 1,1,1,3,3-Pentachlorbutan und von 1,1,1,3,3-Pentafluorbutan
DE3861132D1 (de) Dismulgierendes und reinigungsmittel, verwendbar zur trennung von erdoel-wasser-gemischen, gegebenenfalls emulsionen und anwendungen dieses mittels.
FI892408L (fi) Fibronektinbindande protein.
DE69531958D1 (de) (1-3)-beta-d-glukon-bindungsprotein, antikörper der dieses protein erkennt undverwendung des proteins und antikörper
DE3788807D1 (de) Fusionsproteine und -partikel.
DE69634489D1 (de) Adenovirus dodekahedrischer proteinkomplex, dieser enthaltende zusammensetzung und verwendungen davon
DE3850433D1 (de) Allergiebehandlung und Zusammensetzung dafür.
DE69727240D1 (de) Kombinationen enthaltend vx478, zidovudin und 3tc zur behandlung von hiv
EP0749312A4 (fr) PROTEINES Gp29 DE -i(DIROFILARIA IMMITIS), MOLECULES D'ACIDE NUCLEIQUE ET LEURS UTILISATIONS
DE69624042D1 (de) TiO2 dotiertes, Ta2O5 enthaltendes dielektrisches Material und dieses enthaltende Bauteile
BR9709406B1 (pt) fluorenonas alquiloxiamino substituìdas e composição farmacêutica contendo as mesmas.
DE3852625D1 (de) Vektoren und Verbindungen zur Expression von Zymogen-Formen von menschlichem Protein C.
BR9605046B1 (pt) compostos n-(pirimidinl)-benzenossulfonamida e preparação farmacêutica contendo as mesmas.
DE69722433D1 (de) Pharmazeutische zubereitungen, welche zidovudin und lamivudine enthalten
AU3698595A (en) Dna sequence and protein of the non-structural reading frame i of the human parvovirus b19

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19951202

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

RHK1 Main classification (correction)

Ipc: C12N 15/62

A4 Supplementary search report drawn up and despatched

Effective date: 19980428

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19980723