EP0738154A4 - Analogues de lhrh a extremite n-terminale modifiee - Google Patents

Analogues de lhrh a extremite n-terminale modifiee

Info

Publication number
EP0738154A4
EP0738154A4 EP19940924100 EP94924100A EP0738154A4 EP 0738154 A4 EP0738154 A4 EP 0738154A4 EP 19940924100 EP19940924100 EP 19940924100 EP 94924100 A EP94924100 A EP 94924100A EP 0738154 A4 EP0738154 A4 EP 0738154A4
Authority
EP
European Patent Office
Prior art keywords
lhrh
modified analogs
terminus modified
terminus
analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19940924100
Other languages
German (de)
English (en)
Other versions
EP0738154A1 (fr
Inventor
Fortuna Haviv
Timothy D Fitzpatrick
Rolf E Swenson
Charles J Nichols
Nicholas A Mort
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/103,022 external-priority patent/US5413990A/en
Priority claimed from US08/279,677 external-priority patent/US5502035A/en
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of EP0738154A4 publication Critical patent/EP0738154A4/fr
Publication of EP0738154A1 publication Critical patent/EP0738154A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP94924100A 1993-08-06 1994-07-29 Analogues de lhrh a extremite n-terminale modifiee Withdrawn EP0738154A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US103022 1993-08-06
US08/103,022 US5413990A (en) 1993-08-06 1993-08-06 N-terminus modified analogs of LHRH
US08/279,677 US5502035A (en) 1993-08-06 1994-07-27 N-terminus modified analogs of LHRH
US279677 1994-07-27
PCT/US1994/008678 WO1995004541A1 (fr) 1993-08-06 1994-07-29 Analogues de lhrh a extremite n-terminale modifiee

Publications (2)

Publication Number Publication Date
EP0738154A4 true EP0738154A4 (fr) 1996-04-12
EP0738154A1 EP0738154A1 (fr) 1996-10-23

Family

ID=26799998

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94924100A Withdrawn EP0738154A1 (fr) 1993-08-06 1994-07-29 Analogues de lhrh a extremite n-terminale modifiee

Country Status (4)

Country Link
EP (1) EP0738154A1 (fr)
JP (2) JP3662926B2 (fr)
CA (1) CA2167834A1 (fr)
WO (1) WO1995004541A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994013313A1 (fr) * 1992-12-04 1994-06-23 Abbott Laboratories Antagonistes de l'hormone liberant l'hormone luteinisante (lhrh) de decapeptides modifies en position 6
US5635161A (en) * 1995-06-07 1997-06-03 Abbott Laboratories Aerosol drug formulations containing vegetable oils
DE19544212A1 (de) * 1995-11-28 1997-06-05 Asta Medica Ag Neue LH-RH-Antagonisten mit verbesserter Wirkung
FR2797441B1 (fr) * 1999-07-30 2001-10-12 Centre Nat Rech Scient Derives des cyclohexane, cyclohexene, cyclohexadiene et benzene pour la preparation de ligands du recepteur du mannose
US6462062B1 (en) 2000-09-26 2002-10-08 The Procter & Gamble Company Compounds and methods for use thereof in the treatment of cancer or viral infections
GB0307777D0 (en) 2003-04-04 2003-05-07 Medical Res Council Conjugate compounds
WO2005105829A2 (fr) 2004-04-30 2005-11-10 Theraptosis S.A. Inhibiteurs de caspase-2 et leurs applications biologiques
JP6880352B1 (ja) 2019-11-07 2021-06-02 中外製薬株式会社 Ｋｒａｓ阻害作用を有する環状ペプチド化合物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2233652A (en) * 1986-10-13 1991-01-16 Sandoz Ltd Synthesis of peptide alcohols

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4690916A (en) * 1984-11-13 1987-09-01 Syntex (U.S.A.) Inc. Nona and decapeptide analogs of LHRH useful as LHRH antagonists
US4800191A (en) * 1987-07-17 1989-01-24 Schally Andrew Victor LHRH antagonists
US5110904A (en) * 1989-08-07 1992-05-05 Abbott Laboratories Lhrh analogs

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2233652A (en) * 1986-10-13 1991-01-16 Sandoz Ltd Synthesis of peptide alcohols

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
A.JANECKA ET AL: "The structural features of effective antagonists of the LHRH", AMINO ACIDS, vol. 6, no. 2, pages 111 - 130, XP000566196, DOI: doi:10.1007/BF00805840 *
AMINO ACIDS, vol. 5, no. 3, pages 359 - 365 *
K.CHANNBASAVAIAH ET AL: "New analogs of lulliberin which inhibit ovulation in the rat", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 86, no. 4, ORLANDO, FL US, pages 1266 - 1273, XP024844257, DOI: doi:10.1016/0006-291X(79)90253-5 *
K.FOLKERS ET AL: "Activities of antagonists of LHRH...", ZEITSCHRIFT FUR NATURFORSCHUNG, TEIL B: ANORGANISCHE CHEMIE, ORGANISCHE CHEMIE, vol. 42b, TUBINGEN DE, pages 101 - 106 *
K.FOLKERS ET AL: "Synthesis and bioassay of antagonists of LHRH...", ZEITSCHRIFT FUR NATURFORSCHUNG, TEIL B: ANORGANISCHE CHEMIE, ORGANISCHE CHEMIE, vol. 37b, no. 8, TUBINGEN DE, pages 1075 - 1081 *
S BAJUSZ ET AL: "New antagonists of LHRH", INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH, vol. 32, COPENHAGEN DK, pages 425 - 435, XP008026213 *
See also references of WO9504541A1 *

Also Published As

Publication number Publication date
WO1995004541A1 (fr) 1995-02-16
CA2167834A1 (fr) 1995-02-16
JPH09501913A (ja) 1997-02-25
JP3662926B2 (ja) 2005-06-22
JP2005170950A (ja) 2005-06-30
EP0738154A1 (fr) 1996-10-23

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