EP0759984A4 - Modulatoren des superfamilie der tnf/ngf-rezeptoren und lösliche, oligone rezeptoren der tnf/ngf-superfamilie - Google Patents

Modulatoren des superfamilie der tnf/ngf-rezeptoren und lösliche, oligone rezeptoren der tnf/ngf-superfamilie

Info

Publication number
EP0759984A4
EP0759984A4 EP95919787A EP95919787A EP0759984A4 EP 0759984 A4 EP0759984 A4 EP 0759984A4 EP 95919787 A EP95919787 A EP 95919787A EP 95919787 A EP95919787 A EP 95919787A EP 0759984 A4 EP0759984 A4 EP 0759984A4
Authority
EP
European Patent Office
Prior art keywords
ngf
super
family
tnf
oligomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95919787A
Other languages
English (en)
French (fr)
Other versions
EP0759984A1 (de
Inventor
David Wallach
Mark Boldin
Igor Mett
Eugene Varfolomeev
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeda Research and Development Co Ltd
Original Assignee
Yeda Research and Development Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL109632A external-priority patent/IL109632A/en
Application filed by Yeda Research and Development Co Ltd filed Critical Yeda Research and Development Co Ltd
Publication of EP0759984A1 publication Critical patent/EP0759984A1/de
Publication of EP0759984A4 publication Critical patent/EP0759984A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP95919787A 1994-05-11 1995-05-11 Modulatoren des superfamilie der tnf/ngf-rezeptoren und lösliche, oligone rezeptoren der tnf/ngf-superfamilie Withdrawn EP0759984A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IL109632A IL109632A (en) 1994-05-11 1994-05-11 Modulators of the function of tnf receptors
IL10963294 1994-05-11
IL11112594 1994-10-02
IL11112594A IL111125A0 (en) 1994-05-11 1994-10-02 Soluble oligomeric tnf/ngf super family ligand receptors and their use
PCT/US1995/005854 WO1995031544A1 (en) 1994-05-11 1995-05-11 Modulator of tnf/ngf superfamily receptors and soluble oligomeric tnf/ngf superfamily receptors

Publications (2)

Publication Number Publication Date
EP0759984A1 EP0759984A1 (de) 1997-03-05
EP0759984A4 true EP0759984A4 (de) 2002-06-26

Family

ID=26322830

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95919787A Withdrawn EP0759984A4 (de) 1994-05-11 1995-05-11 Modulatoren des superfamilie der tnf/ngf-rezeptoren und lösliche, oligone rezeptoren der tnf/ngf-superfamilie

Country Status (10)

Country Link
EP (1) EP0759984A4 (de)
JP (1) JP3966387B2 (de)
KR (1) KR100404737B1 (de)
CN (2) CN1329512C (de)
AU (1) AU703919B2 (de)
CA (1) CA2189983A1 (de)
FI (1) FI964509L (de)
IL (1) IL111125A0 (de)
NO (1) NO321514B1 (de)
WO (1) WO1995031544A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5663070A (en) * 1993-11-15 1997-09-02 Lxr Biotechnology Inc. Recombinant production of a soluble splice variant of the Fas (Apo-1) antigen, fas TM
US5712381A (en) * 1994-10-19 1998-01-27 Genetics Institute, Inc. MADD, a TNF receptor death domain ligand protein
US5849501A (en) * 1994-10-19 1998-12-15 Genetics Institute, Inc. TNF receptor death domain ligand proteins and method to identify inhibitors of ligand binding
US5852173A (en) * 1994-10-19 1998-12-22 Genetics Institute, Inc. TNF receptor death ligand proteins and inhibitors of ligand binding
US5847099A (en) * 1994-10-19 1998-12-08 Genetics Institute, Inc. TNF receptor death domain ligand proteins
IL114615A0 (en) 1995-07-16 1995-11-27 Yeda Res & Dev Modulators of the function of fas receptors and other proteins
US7097972B1 (en) 1995-02-13 2006-08-29 Regents Of The University Of Michigan Method and composition for regulating apoptosis
US6015665A (en) * 1995-02-13 2000-01-18 The Regents Of The University Of Michigan Method and composition for regulating apoptosis
US6060238A (en) * 1995-02-13 2000-05-09 The Regents Of The University Of Michigan Method and composition for regulating apoptosis
WO1996025941A1 (en) * 1995-02-22 1996-08-29 Yeda Research And Development Co. Ltd. Modulators of regulatory proteins
US6355780B1 (en) 1995-02-22 2002-03-12 Yeda Research And Development Co. Ltd. Antibodies to the death domain motifs of regulatory proteins
US6747138B1 (en) 1995-04-03 2004-06-08 Regents Of The University Of Michigan Methods and compositions for regulating Fas-associated apoptosis
US7807783B1 (en) 1995-04-03 2010-10-05 The Regents Of The University Of Michigan Methods and compositions for regulating FAS-associated apoptosis
US6399327B1 (en) 1995-07-16 2002-06-04 Yeda Research And Development Co. Ltd. Modulators of the function of FAS receptors and other proteins
US6030945A (en) * 1996-01-09 2000-02-29 Genentech, Inc. Apo-2 ligand
US6998116B1 (en) 1996-01-09 2006-02-14 Genentech, Inc. Apo-2 ligand
SI0894141T1 (en) 1996-02-20 2005-10-31 Applied Research Systems Ars Holding N.V. Hybrid proteins which form heterodimers
BR9707589A (pt) 1996-02-20 2000-01-04 Applied Research Systems Proteìna hìbrida, molécula de dna, vetor de expressão, célula hospedeira, composição farmacêutica e processos para produzir proteìna hìbrida e para induzir maturação folicular.
CA2249206A1 (en) 1996-04-01 1997-10-09 Genentech, Inc. Apo-2li and apo-3 apoptosis polypeptides
WO1998006839A1 (en) * 1996-07-15 1998-02-19 Human Genome Sciences, Inc. Cd44-like protein
US6462176B1 (en) 1996-09-23 2002-10-08 Genentech, Inc. Apo-3 polypeptide
CA2273185A1 (en) 1996-11-05 1998-05-14 Board Of Regents, The University Of Texas System Compositions and uses for sentrin, a cell-death protecting protein
US6930084B1 (en) 1996-11-06 2005-08-16 The Regents Of The University Of California Treating arthritis with TNF receptor releasing enzyme
JP2001508648A (ja) 1996-11-06 2001-07-03 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 腫瘍壊死因子レセプター放出酵素、酵素を含む組成物、およびその使用方法
US6593456B1 (en) 1996-11-06 2003-07-15 The Regents Of The University Of California Tumor necrosis factor receptor releasing enzyme
US5858990A (en) * 1997-03-04 1999-01-12 St. Elizabeth's Medical Center Fas ligand compositions for treatment of proliferative disorders
US6342369B1 (en) 1997-05-15 2002-01-29 Genentech, Inc. Apo-2-receptor
US7001992B2 (en) 1997-05-30 2006-02-21 Human Genome Sciences, Inc. Antibodies to secreted protein HEMCM42
ATE487737T1 (de) * 1997-05-30 2010-11-15 Human Genome Sciences Inc 32 humane sekretierte proteine
IL121746A0 (en) * 1997-06-05 1998-02-22 Yeda Res & Dev Modulators of intracellular cell death and cell survival pathways
US6051385A (en) * 1997-10-22 2000-04-18 The Regents Of The University Of Michigan Compositions and methods for identifying and testing therapeutics against HSV infection
WO1999028465A2 (en) * 1997-11-28 1999-06-10 The Regents Of The University Of California Pias molecules that recognize and bind stat proteins and uses thereof
JP2002508962A (ja) 1998-01-15 2002-03-26 ジェネンテク・インコーポレイテッド Ａｐｏ−２リガンド
US6207422B1 (en) * 1998-04-17 2001-03-27 The Metrohealth System Protein that enhances expression of potassium channels on cell surfaces and nucleic acids that encode the same
EP1022027A1 (de) * 1999-01-22 2000-07-26 Applied Research Systems ARS Holding N.V. Antagonisten von Tumornecrosefaktor und ihre Verwendungen gegen Endometriose
JP2001078776A (ja) 1999-09-14 2001-03-27 Inst Of Physical & Chemical Res Ｎａｄｅ結合蛋白質
ES2706403T3 (es) 2008-12-10 2019-03-28 Joslin Diabetes Center Inc Métodos para diagnosticar y predecir una enfermedad renal
WO2014127835A1 (en) 2013-02-22 2014-08-28 Christian-Albrechts-Universität Zu Kiel Plant-derived resistance gene

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0417563A2 (de) * 1989-09-12 1991-03-20 F. Hoffmann-La Roche Ag TNF-bindende Proteine
EP0418014A1 (de) * 1989-09-11 1991-03-20 Immunex Corporation Rezeptoren für Tumornekrosisfaktor-alpha und -beta

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2067031C (en) * 1991-04-26 2003-02-18 Shigekazu Nagata Dna coding for human cell surface antigen

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0418014A1 (de) * 1989-09-11 1991-03-20 Immunex Corporation Rezeptoren für Tumornekrosisfaktor-alpha und -beta
EP0417563A2 (de) * 1989-09-12 1991-03-20 F. Hoffmann-La Roche Ag TNF-bindende Proteine

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
CLEMENT M-V ET AL: "FAS AND TUMOR NECROSIS FACTOR RECEPTOR-MEDIATED CELL DEATH: SIMILARITIES AND DISTINCTIONS", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, vol. 180, no. 2, 1 August 1994 (1994-08-01), pages 557 - 567, XP000983917, ISSN: 0022-1007 *
EVANS T J ET AL: "PROTECTIVE EFFECT OF 55- BUT NOT 75-KF SOLUBLE TUMOR NECROSIS FACTOR RECEPTOR-IMMUNOGLOBULIN G FUSION PROTEINS IN AN ANIMAL MODELOF GRAM-NEGATIVE SEPSIS", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, vol. 180, 1 December 1994 (1994-12-01), pages 2173 - 2179, XP000615869, ISSN: 0022-1007 *
HSU K C ET AL: "DIFFERENTIAL EXPRESSION AND LIGAND BINDING PROPERTIES OF TUMOR NECROSIS FACTOR RECEPTOR CHIMERIC MUTANTS", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 268, no. 22, 5 August 1993 (1993-08-05), pages 16430 - 16436, XP000942148, ISSN: 0021-9258 *
MORIMOTO H ET AL: "OVERCOMING TUMOR NECROSIS FACTOR AND DRUG RESISTANCE OF HUMAN TUMORCELL LINES BY COMBINATION TREATMENT WITH ANTI-FAS ANTIBODY AND DRUGS OR TOXINS", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 53, no. 11, 1 June 1993 (1993-06-01), pages 2591 - 2596, XP000942154, ISSN: 0008-5472 *
See also references of WO9531544A1 *
SUDA T ET AL: "MOLECULAR CLONING AND EXPRESSION OF THE FAS LIGAND, A NOVEL MEMBER OF THE TUMOR NECROSIS FACTOR FAMILY", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 75, 17 December 1993 (1993-12-17), pages 1169 - 1178, XP000579690, ISSN: 0092-8674 *
TARTAGLIA L A ET AL: "TUMOR NECROSIS FACTOR RECEPTOR SIGNALING", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 267, no. 7, 5 March 1992 (1992-03-05), pages 4304 - 4307, XP002056559, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
CA2189983A1 (en) 1995-11-23
AU2546995A (en) 1995-12-05
CN1173033C (zh) 2004-10-27
WO1995031544A1 (en) 1995-11-23
CN1616661A (zh) 2005-05-18
NO321514B1 (no) 2006-05-15
FI964509A0 (fi) 1996-11-08
CN1329512C (zh) 2007-08-01
AU703919B2 (en) 1999-04-01
FI964509L (fi) 1997-01-09
FI964509A7 (fi) 1997-01-08
CN1152937A (zh) 1997-06-25
EP0759984A1 (de) 1997-03-05
JPH10500568A (ja) 1998-01-20
NO964741D0 (no) 1996-11-08
JP3966387B2 (ja) 2007-08-29
KR100404737B1 (ko) 2004-05-03
NO964741L (no) 1997-01-09
IL111125A0 (en) 1994-12-29
KR970703419A (ko) 1997-07-03

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