EP0762879A4 - Derives de wortmannine stereochimiques - Google Patents

Derives de wortmannine stereochimiques

Info

Publication number: EP0762879A4
Authority: EP; European Patent Office
Prior art keywords: stereochemical; wortmannin; derivatives; wortmannin derivatives; relates
Prior art date: 1994-07-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

EP95925483A

Other languages

German (de)

English (en)

Other versions

EP0762879B1 (fr

EP0762879A1 (fr

Inventor

Lawrence Camillo Creemer

Herbert Andrew Kirst

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Eli Lilly and Co

Original Assignee

Eli Lilly and Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-07-01

Filing date

1995-06-30

Publication date

1997-10-01

1995-06-30 Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co

1997-03-19 Publication of EP0762879A1 publication Critical patent/EP0762879A1/fr

1997-10-01 Publication of EP0762879A4 publication Critical patent/EP0762879A4/fr

2000-05-10 Application granted granted Critical

2000-05-10 Publication of EP0762879B1 publication Critical patent/EP0762879B1/fr

2015-06-30 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

QDLHCMPXEPAAMD-QAIWCSMKSA-N wortmannin Chemical class C1([C@]2(C)C3=C(C4=O)OC=C3C(=O)O[C@@H]2COC)=C4[C@@H]2CCC(=O)[C@@]2(C)C[C@H]1OC(C)=O QDLHCMPXEPAAMD-QAIWCSMKSA-N 0.000 title abstract 3
239000002246 antineoplastic agent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000002935 phosphatidylinositol 3 kinase inhibitor Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/06—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Steroid Compounds (AREA)
Compounds Of Unknown Constitution (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

EP95925483A 1994-07-01 1995-06-30 Derives de wortmannine stereochimiques Expired - Lifetime EP0762879B1 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/269,716 US5480906A (en)	1994-07-01	1994-07-01	Stereochemical Wortmannin derivatives
US269716		1994-07-01
PCT/US1995/008410 WO1996001108A1 (fr)	1994-07-01	1995-06-30	Derives de wortmannine stereochimiques

Publications (3)

Publication Number	Publication Date
EP0762879A1 EP0762879A1 (fr)	1997-03-19
EP0762879A4 true EP0762879A4 (fr)	1997-10-01
EP0762879B1 EP0762879B1 (fr)	2000-05-10

Family

ID=23028391

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP95925483A Expired - Lifetime EP0762879B1 (fr)	1994-07-01	1995-06-30	Derives de wortmannine stereochimiques

Country Status (10)

Country	Link
US (1)	US5480906A (fr)
EP (1)	EP0762879B1 (fr)
JP (1)	JPH10502373A (fr)
AT (1)	ATE192649T1 (fr)
AU (1)	AU2959995A (fr)
CA (1)	CA2193963A1 (fr)
DE (1)	DE69516866T2 (fr)
ES (1)	ES2145915T3 (fr)
WO (1)	WO1996001108A1 (fr)
ZA (1)	ZA955466B (fr)

Families Citing this family (59)

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WO2000018885A1 (fr) *	1998-09-29	2000-04-06	Gamida Cell Ltd.	Procedes de regulation de la proliferation et de la differentiation de cellules souches et precurseurs
US6413773B1 (en)	1998-06-01	2002-07-02	The Regents Of The University Of California	Phosphatidylinositol 3-kinase inhibitors as stimulators of endocrine differentiation
EP1158985B1 (fr) *	1999-01-13	2011-12-28	Bayer HealthCare LLC	DIPHENYLE UREES A SUBSTITUTION OMEGA-CARBOXY ARYLE EN TANT QU'INHIBITEURS DE LA KINASE p38
US8124630B2 (en)	1999-01-13	2012-02-28	Bayer Healthcare Llc	ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
AU1330901A (en) *	1999-10-06	2001-05-10	Brigham And Women's Hospital	Compounds and methods for modulating non-transcriptional effects of steroid hormones
US6667300B2 (en) *	2000-04-25	2003-12-23	Icos Corporation	Inhibitors of human phosphatidylinositol 3-kinase delta
GEP20084317B (en)	2000-04-25	2008-02-25	Icos Corp	Inhibitors of human phosphatidyl-inositol 3-kinase delta
US7235523B2 (en) *	2001-04-13	2007-06-26	Children's Hospital Medical Center	Methods for the treatment of hepatic disorders
US7371763B2 (en) *	2001-04-20	2008-05-13	Bayer Pharmaceuticals Corporation	Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
GB0119865D0 (en)	2001-08-14	2001-10-10	Cancer Res Campaign Tech	DNA-PK inhibitors
GB0119863D0 (en)	2001-08-14	2001-10-10	Cancer Res Campaign Tech	DNA-PK inhibitors
US6703414B2 (en) *	2001-09-14	2004-03-09	Arizona Board Of Regents On Behalf Of The University Of Arizona	Device and method for treating restenosis
US7081475B2 (en) *	2001-09-14	2006-07-25	Prolx Pharmaceuticals Corp.	Wortmannin analogs and methods of using same
US20080108672A1 (en) *	2002-01-11	2008-05-08	Bernd Riedl	Omega-Carboxyaryl Substituted Diphenyl Ureas As Raf Kinase Inhibitors
IL152904A0 (en) *	2002-01-24	2003-06-24	Gamida Cell Ltd	Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations
WO2003062404A1 (fr) *	2002-01-25	2003-07-31	Gamida-Cell Ltd.	Methodes de developpement de cellules souches et de cellules precurseurs, populations de cellules multipliees obtenues a l'aide de ces methodes
SI1478358T1 (sl)	2002-02-11	2013-09-30	Bayer Healthcare Llc	Sorafenib tozilat za zdravljenje bolezni, značilnih po abnormalni angiogenezi
US7049313B2 (en)	2002-02-25	2006-05-23	Kudos Pharmaceuticals Ltd.	ATM inhibitors
US20050054097A1 (en) *	2002-11-17	2005-03-10	Tony Peled	EX-VIVO expansion of hematopoietic system cell populations in mononuclear cell cultures
US7230139B2 (en) *	2002-12-05	2007-06-12	Gemin X Biotechnologies	Diterpenoid compounds, compositions thereof and their use as anti-cancer or anti-fungal agents
US7557129B2 (en)	2003-02-28	2009-07-07	Bayer Healthcare Llc	Cyanopyridine derivatives useful in the treatment of cancer and other disorders
US20050054103A1 (en) *	2003-03-07	2005-03-10	Tony Peled	Expansion of renewable stem cell populations using modulators of PI 3-kinase
MXPA05011248A (es) *	2003-04-23	2005-12-14	Wyeth Corp	Derivados de wortmanina solubles en agua.
EP1636585B2 (fr) *	2003-05-20	2012-06-13	Bayer HealthCare LLC	Diaryl-urees presentant une activite d'inhibition des kinases
EP1663978B1 (fr) *	2003-07-23	2007-11-28	Bayer Pharmaceuticals Corporation	Omega-carboxyaryldiphenyluree fluoro-subtituee pour le traitement et la prevention de maladies et d'etats pathologiques
AU2004265149A1 (en)	2003-08-13	2005-02-24	Kudos Pharmaceuticals Limited	Aminopyrones and their use as ATM inhibitors
WO2005016348A1 (fr) *	2003-08-14	2005-02-24	Icos Corporation	Methodes d'inhibition de reponses immunes stimulees par un facteur endogene
US20050054614A1 (en) *	2003-08-14	2005-03-10	Diacovo Thomas G.	Methods of inhibiting leukocyte accumulation
WO2005113556A1 (fr)	2004-05-13	2005-12-01	Icos Corporation	Quinazolinones utilisees en tant qu'inhibiteurs de la phosphatidylinositol 3-kinase delta humaine
WO2005117889A1 (fr) *	2004-05-25	2005-12-15	Icos Corporation	Methodes de traitement et/ou de prevention de la proliferation aberrante des cellules hematopoietiques
JP5371426B2 (ja)	2004-07-09	2013-12-18	プロルックスファーマシューティカルズコープ．	ワートマニン類似体及び化学療法薬と組み合わせた同一物を使用する方法
WO2006030442A2 (fr) *	2004-09-16	2006-03-23	Gamida-Cell Ltd.	Methodes de culture ex vivo de cellules souches et de precurseur par co-culture avec des cellules mesenchymales
BRPI0515498A (pt)	2004-09-20	2008-07-29	Kudos Pharm Ltd	inibidores de dna-pk
EP1799699A1 (fr) *	2004-10-13	2007-06-27	Wyeth	Analogues de la 17-hydroxywortmannine employés en tant qu inhibiteurs de pi3k
EP1848712A1 (fr)	2005-02-09	2007-10-31	Kudos Pharmaceuticals Ltd	Inhibiteurs d'atm
WO2006089106A2 (fr) *	2005-02-17	2006-08-24	Icos Corporation	Procede d'inhibition d'accumulation de leucocytes
AR053358A1 (es)	2005-04-15	2007-05-02	Cancer Rec Tech Ltd	Inhibidores de adn - pk
AU2006243000B2 (en) *	2005-05-05	2011-05-26	Macrophage Pharma Limited	Alpha aminoacid ester-drug conjugates hydrolysable by carboxylesterase
EP1886138A4 (fr) *	2005-05-11	2009-04-15	Genetic Technologies Ltd	Procédés d'enrichissement de cellules fétales
US8846393B2 (en)	2005-11-29	2014-09-30	Gamida-Cell Ltd.	Methods of improving stem cell homing and engraftment
EP1965790B1 (fr)	2005-12-30	2011-12-07	Arizona Board of Regents, Acting on Behalf of The University of Arizona	Metabolites des analogues de la wortmannine et leurs procedes d'utilisation
KR20160091440A (ko)	2008-11-13	2016-08-02	길리아드 칼리스토가 엘엘씨	혈액 종양에 대한 요법
US9492449B2 (en)	2008-11-13	2016-11-15	Gilead Calistoga Llc	Therapies for hematologic malignancies
US20100233733A1 (en) *	2009-02-10	2010-09-16	Nodality, Inc., A Delaware Corporation	Multiple mechanisms for modulation of the pi3 kinase pathway
BRPI1012333A2 (pt)	2009-03-24	2016-03-29	Gilead Calistoga Llc	atropisômeros de derivados de 2-purinil-3-tolil-quinazolinonas e métodos de uso
AP2011005956A0 (en) *	2009-04-20	2011-10-31	Gilead Calistoga Llc	Methods of treatment for solid tumors.
CA2768843A1 (fr)	2009-07-21	2011-01-27	Gilead Calistoga Llc	Traitement de troubles du foie par des inhibiteurs de pi3k
SG193494A1 (en)	2011-03-21	2013-10-30	Vivolux Ab	Treatment of solid tumours
HK1202581A1 (en)	2012-02-13	2015-10-02	Gamida-Cell Ltd.	Mesenchymal stem cells conditioned medium and methods of generating and using the same
NZ629684A (en)	2012-03-05	2016-10-28	Gilead Calistoga Llc	Polymorphic forms of (s)-2-(1-(9h-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3h)-one
US9175266B2 (en)	2012-07-23	2015-11-03	Gamida Cell Ltd.	Enhancement of natural killer (NK) cell proliferation and activity
US9567569B2 (en)	2012-07-23	2017-02-14	Gamida Cell Ltd.	Methods of culturing and expanding mesenchymal stem cells
WO2014046589A1 (fr)	2012-09-21	2014-03-27	Vivolux Ab	Moyens et procédé pour traiter des tumeurs solides
WO2014203129A1 (fr)	2013-06-19	2014-12-24	Olema Pharmaceuticals, Inc.	Combinaisons de composés benzopyrane, leurs compositions et utilisations
NZ736970A (en)	2013-12-20	2018-11-30	Gilead Calistoga Llc	Process methods for phosphatidylinositol 3-kinase inhibitors
WO2015095605A1 (fr)	2013-12-20	2015-06-25	Gilead Calistoga Llc	Formes polymorphes d'un sel chlorhydrate de la (s)-2-(9h-purine-6-ylamino)propyl)-5-fluoro-3-phénylquinazolin-4(3h)-one
MA40059A (fr)	2014-06-13	2015-12-17	Gilead Sciences Inc	Inhibiteurs de la phosphatidylinositol 3-kinase

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0658343A1 (fr) *	1993-08-25	1995-06-21	Eli Lilly And Company	Utilisation d'hydroxywortmannine-17-bêta et de ses analogues pour la fabrication d'un médicament pour le traitement de maladies dépendant de la phosphatidylinositole-3-kinase

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3668222A (en) *	1969-05-14	1972-06-06	Sandoz Ltd	11-desacetoxy-wortmannin
US4988682A (en) *	1989-02-03	1991-01-29	University Of Pittsburgh	Myo-inositol analogs and method for their use

1994
- 1994-07-01 US US08/269,716 patent/US5480906A/en not_active Expired - Fee Related
1995
- 1995-06-30 ES ES95925483T patent/ES2145915T3/es not_active Expired - Lifetime
- 1995-06-30 DE DE69516866T patent/DE69516866T2/de not_active Expired - Fee Related
- 1995-06-30 AU AU29599/95A patent/AU2959995A/en not_active Abandoned
- 1995-06-30 WO PCT/US1995/008410 patent/WO1996001108A1/fr not_active Ceased
- 1995-06-30 ZA ZA955466A patent/ZA955466B/xx unknown
- 1995-06-30 JP JP8503967A patent/JPH10502373A/ja not_active Ceased
- 1995-06-30 AT AT95925483T patent/ATE192649T1/de not_active IP Right Cessation
- 1995-06-30 CA CA002193963A patent/CA2193963A1/fr not_active Abandoned
- 1995-06-30 EP EP95925483A patent/EP0762879B1/fr not_active Expired - Lifetime

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0658343A1 (fr) *	1993-08-25	1995-06-21	Eli Lilly And Company	Utilisation d'hydroxywortmannine-17-bêta et de ses analogues pour la fabrication d'un médicament pour le traitement de maladies dépendant de la phosphatidylinositole-3-kinase

Also Published As

Publication number	Publication date
AU2959995A (en)	1996-01-25
US5480906A (en)	1996-01-02
JPH10502373A (ja)	1998-03-03
ATE192649T1 (de)	2000-05-15
ZA955466B (en)	1996-12-30
CA2193963A1 (fr)	1996-01-18
WO1996001108A1 (fr)	1996-01-18
EP0762879B1 (fr)	2000-05-10
EP0762879A1 (fr)	1997-03-19
DE69516866D1 (de)	2000-06-15
DE69516866T2 (de)	2000-10-05
ES2145915T3 (es)	2000-07-16

Legal Events

Date	Code	Title	Description
1997-01-31	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1997-03-19	17P	Request for examination filed	Effective date: 19961227
1997-03-19	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
1997-03-19	AX	Request for extension of the european patent	Free format text: LT PAYMENT 961227;LV PAYMENT 961227;SI PAYMENT 961227
1997-10-01	A4	Supplementary search report drawn up and despatched	Effective date: 19970819
1997-10-01	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE
1998-10-28	17Q	First examination report despatched	Effective date: 19980910
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1999-12-16	GRAH	Despatch of communication of intention to grant a patent	Free format text: ORIGINAL CODE: EPIDOS IGRA
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Publication	Publication Date	Title
ZA955466B (en)	1996-12-30	Stereochemical wortmannin derivatives
BG101833A (bg)	1998-04-30	Гуаниново производно
MX9703564A (es)	1997-08-30	Inhibidores de proteasa multicatalitica.
ZA981080B (en)	1998-08-12	Bicyclic inhibitors of protein farnesyl transferase
GB2301106B (en)	1999-10-06	Synergistic stabilizer mixture
BG102474A (en)	1999-06-30	(-)-cis-6(s)-phenyl-5(r)-[4-(2-pyrrolidine-1-yletoxi)phenyl)-5,6,7 ,8-tetrahydronaphthalen-2-ol-d-tartarate
AU3631197A (en)	1998-02-02	N-benzylpiperidine and tetrahydropyridine derivatives
GB9003939D0 (en)	1990-04-18	Sulphatase inhibitors
IL114294A0 (en)	1995-10-31	Sterol derivatives
EP0674643A4 (fr)	1995-08-08	Derives de coumarine utilises comme inhibiteurs de retrovirus.
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