EP0792190A1 - Tubulure a vide pour le traitement en laboratoire d'echantillons liquides multiples - Google Patents

Tubulure a vide pour le traitement en laboratoire d'echantillons liquides multiples

Info

Publication number
EP0792190A1
EP0792190A1 EP96930585A EP96930585A EP0792190A1 EP 0792190 A1 EP0792190 A1 EP 0792190A1 EP 96930585 A EP96930585 A EP 96930585A EP 96930585 A EP96930585 A EP 96930585A EP 0792190 A1 EP0792190 A1 EP 0792190A1
Authority
EP
European Patent Office
Prior art keywords
receptacle
base
vacuum
adapter frame
dimensioned
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96930585A
Other languages
German (de)
English (en)
Inventor
Glenn C. Sasaki
Barry K. Hanamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beckman Coulter Inc
Original Assignee
Beckman Instruments Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beckman Instruments Inc filed Critical Beckman Instruments Inc
Publication of EP0792190A1 publication Critical patent/EP0792190A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B01L3/50255—Multi-well filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/18—Apparatus therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators

Definitions

  • This invention relates generally to vacuum manifold devices, and specifically, to vacuum manifold devices useful in the simultaneous laboratory processing of multiple liquid samples.
  • the simultaneous testing of multiple liquid samples in a single apparatus is conducted with apparatus especially designed for this purpose.
  • the most common piece of apparatus is a disposable tray having multiple individual “wells. " These trays, commonly called “microtitre dishes,” are made by a large number of manufacturers in a variety of sizes and shapes.
  • microtitre dishes are made by a large number of manufacturers in a variety of sizes and shapes.
  • an individual liquid sample is placed within each of the wells, where it is manipulated as part of the testing process.
  • a third problem is that, because of the relative inflexibility of present-day vacuum manifolds, and the excessive amount of area required by present-day multiple testing operations, present-day vacuum manifolds are not easily incorporated into fully automated machines capable of carrying out a multiplicity of laboratory procedures using a relatively small amount of work space.
  • the invention satisfies these needs.
  • the invention is a vacuum manifold useful in combination with first and second liquid receptacles, such as microtitre dishes.
  • the invention comprises:
  • a base which is sized and dimensioned to accept and retain the first receptacle, the base having a bottom wall and side walls, the side walls having uppermost portions which cooperate to form a base wall perimeter;
  • an adapter frame which is sized and dimensioned to accept and retain the second receptacle, the adapter frame being further sized and dimensioned to attach to the base wall perimeter in substantially sealed relationship such that the first receptacle can be fully enclosed within a chamber formed by the base, the adapter frame and the second receptacle;
  • the vacuum means comprises a port defined within the base.
  • Both the base and the adapter frame can be sized and dimensioned to handle a wide variety of liquid receptacles.
  • the second receptacle is adapted for filtration, its bottom comprising a filtration material.
  • both the first and second liquid receptacles complies a plurality of separate "wells.” This facilitates the simultaneous processing of a large number of individual liquid samples in a single step.
  • the invention can also comprise stacking trays for retaining unused liquid receptacles and frames when not in use.
  • the invention is easily adaptable in a semi-automated or fully- automated machine having a computerized mechanical manipulator.
  • the mechanical manipulator is programmed to robotically configure and reconfigure the various elements of the vacuum manifold to serially carry out a number of laboratory manipulations of a large number of individual liquid samples.
  • the invention can be conveniently and easily used to perform a wide variety of vacuum-assisted laboratory procedures, such as filtration, drying, column purification and column chromatography.
  • the invention is inexpensive and simple to manufacture and operate, and its use conserves valuable laboratory work space.
  • FIGURE 1 is an exploded perspective view showing a vacuum manifold having features of the invention and adapted for use with a narrow dish microtitre tray;
  • FIGURE 2 is an exploded cross-sectional view of the vacuum manifold shown in FIG. 1 ;
  • FIGURE 3 is a cross-sectional side view of the fully assembled vacuum manifold shown in FIG. 1 ;
  • FIGURE 4 is an exploded perspective view showing a vacuum manifold having features of the invention and adapted for use with a deep dish microtitre tray;
  • FIGURE 5 is an exploded cross-sectional view of the vacuum manifold shown in FIG. 4;
  • FIGURE 6 is a cross-sectional side view of the fully assembled vacuum manifold shown in FIG. 4;
  • FIGURE 7 is an exploded perspective view of a stacking tray assembly having features of the invention.
  • FIGURE 8 is an exploded cross-sectional view of the stacking tray assembly shown in FIG. 7;
  • FIGURE 9 is a cross-sectional view of the fully assembled stacking tray assembly shown in FIG. 7;
  • FIGURE 10 is a perspective view of a machine and a kit having features of the invention.
  • the vacuum manifold of the invention 10 comprises a base 12, an adapter frame 14 and a means for drawing a vacuum.
  • the base has a bottom wall 16 and side walls 18.
  • the side walls 18 have uppermost portions 20 which cooperate to form a base wall perimeter 22.
  • the base 12 is sized and dimensioned to accept and retain a first liquid receptacle 24.
  • the base 12 has a foot print with an area smaller than about 200 square centimeters.
  • footprint is meant to indicate the horizontal area and dimensions of various elements of the invention
  • the base 12 further comprises a vacuum port 26 capable of attachment to an external source of vacuum, such as a laboratory vacuum line.
  • the vacuum port 26 is defined in the side walls 18 proximate to the bottom wall 16.
  • a discontinuous lip 28 is provided to support the first receptacle 24 above and spaced-apart from the bottom wall 16. This allows a vacuum generated using the vacuum port 26 to be uniform across the bottom wall 16.
  • the base 12 can be made out of a wide variety of suitable materials, such as metals and plastics. For ease and inexpense of manufacture, the base 12 is typically made from a plastic.
  • the base 12 has a rectangular footprint with the width between about 1 0 and about 1 3 centimeters and a length between about 1 2 and about 1 6 centimeters.
  • the base 12 is inexpensively made with dimensions capable of accepting and retaining the footprint of any first receptacle 24 having a footprint smaller than the footprint of the base 12.
  • the adapter frame 14 is sized and dimensioned to accept a second liquid receptacle 30. Typically, this is accomplished by providing the adapter frame 14 with an interior lip 32 capable of supporting the second receptacle 30 in a horizontal position. In the embodiments shown in the drawings, a sealing gasket 34 is disposed around the perimeter of the lip 28 to provide sufficient sealing of the second receptacle 30 to the adapter frame 14 when a vacuum is applied to the bottom side 36 of the second receptacle 30.
  • the adapter frame 14 is further sized and dimensioned to attach to the base wall perimeter 22 of the base in a substantially sealed relationship such that, when a first receptacle 24 is disposed within the base 12 and a second receptacle 30 is disposed within the adapter frame 14, the first receptacle 24 is fully enclosed within a chamber 38 formed by the base 12, the adapter frame 14 and the second receptacle 30.
  • the adapter frame 14 is rectangular with substantially the same footprint as that of the base 12.
  • the adapter frame 14 defines a central opening 40 which is sized and dimensioned to accept and retain the footprint of a particular second receptacle 30.
  • the invention allows the use of a second receptacle 30 which has a different footprint than that of the first receptacle 24. In the invention, this is easily accomplished by adapting the base 12 to accept and retain the footprint of the first receptacle 24 and adapting the adaptor frame 14 to accept and retain the different footprint of the second receptacle 30.
  • the invention makes it easy to use liquid receptacles 24 and 30 of differing height.
  • the base 12 is sized and dimensioned to accept and retain the first receptacle 24 having a given height while the adapter frame 14 is sized and dimensioned to accept a second receptacle 30 having a different height.
  • Figures 4-6 illustrate the invention using an adapter frame 14 sized and dimensioned to accept and retain a typical deep well microtitre plate.
  • the adapter frame 14 can be made from a wide variety of suitable materials. Metals and plastics are easily used. Plastics are generally the preferred material because of the ease and inexpense of its use in the manufacturing process.
  • locator pins 42 are disposed within the base 12 and adapted to cooperate with matching holes 44 within the adapter frame 14 to facilitate the proper alignment and sealing of the adapter frame 14 to the base 12.
  • the base 12 and the adapter frame 14 have matching beveled walls so that the adapter frame 14 "nests" with the base 12.
  • the invention 10 can further comprise a first receptacle 24, such as a microtitre dish, disposed within the base 12.
  • the invention 10 can comprise a second receptacle 30, such as a microtitre dish, disposed within the adapter frame 14 above the first receptacle 24.
  • the receptacles 24 and 30 are microtitre dishes having a plurality of separate wells 46 disposed in fixed arrays.
  • the fixed array of the second receptacle 30 is similar in layout to the fixed array of the first receptacle 24. This allows each well 46 in the second receptacle 30 to discharge liquid into a corresponding well 46 in the first receptacle 24.
  • the bottoms 48 of each separate well 46 of the second receptacle 30 comprise a filter material, such as a filtering membrane. As liquid is filtered from a well 46 in the second receptacle 30 across the filter membrane in the well bottom 48, the liquid drops by gravity into the corresponding well 46 in the first receptacle 24.
  • the vacuum means is for drawing a vacuum on the bottom side 36 of the second receptacle 30 when the second receptacle 30 is disposed within the adapter frame 14 and the first receptacle 24 is disposed within the base 12.
  • the vacuum means is typically one or more ports disposed within the base 12 or adapter frame 14. As discussed above, the embodiments illustrated in the drawings define a vacuum port 26 near the bottom wall 16 of the base 12. In this embodiment, when the vacuum manifold of the invention 10 is fully assembled with first and second liquid receptacles 24 and 30 are in place, a uniform vacuum is drawn across the bottom wall 16 of the base 12. This uniform vacuum propagates around the first receptacle 24 so as to result in a uniform vacuum across the bottom side 36 of the second receptacle 30.
  • the distance between the first receptacle 24 and the second receptacle 30 must be carefully chosen in conjunction with the degree of vacuum to be used within the vacuum manifold 10 so as not to horizontally divert liquid dripping from the second receptacle 30 to the first receptacle 24.
  • the degree of vacuum must be sufficiently small, given the distance between the bottom side 36 of the second receptacle 30 and the uppermost portion of the first receptacle 24, so that liquid dripping from a specific well 46 in the second receptacle 30 falls precisely vertically into the corresponding well 46 within the first receptacle 24. Should the degree of vacuum be excessive, liquid falling from the second receptacle 30 towards the first receptacle 24 may be diverted horizontally into a non-corresponding well 46 within the first receptacle 24.
  • the invention is also a kit 50 comprising the vacuum manifold 10 described above, together with one or more stacking trays 52 which are sized and dimensioned to accept at least one of the receptacles 24 and 30.
  • the stacking trays 52 are similar in design and construction to the base 12. The stacking trays, however, have no vacuum ports 26.
  • the purpose of the stacking trays 52 is to allow receptacles 24 and
  • the kit can also provide additional adapter frames 14, each sized and dimensioned to accept and retain receptacles 24 and 30 having different footprints and/or differing heights.
  • the invention 10 is conveniently used with semi-automated DNA purification equipment, such as BioMek 2000 purification equipment sold by Beckman Instruments, Inc. of Fullerton, California.
  • the vacuum manifold of the invention 10 is also conveniently adapted to a fully automatic machine 54 capable of robotically carrying out a number of laboratory manipulations to a plurality of individual liquid samples.
  • a machine 54 comprises the vacuum manifold 10 described above and a computerized mechanical manipulator 56 having a moveable gripper tool 58.
  • the mechanical manipulator 56 is basically a computerized robotic device programmed to robotically manipulate the various elements of the vacuum manifold 10 to perform first one laboratory manipulation on a plurality of liquid samples, then reconfigure the vacuum manifold 10 to perform a second or more laboratory manipulations on those liquid samples.
  • one or more stacking trays 52 described above can be conveniently used to stack various elements of the invention 10 in between use. For example, as shown in
  • a machine of the invention 54 comprises a vacuum manifold 10 and two stacking trays 52. Such a machine 54 can conveniently perform five or more different laboratory manipulations using the vacuum manifold 10.
  • One of skill in the art will appreciate the relative lack of space required by the machine 54 because of the stacking capabilities of the component elements.
  • the machine of the invention 54 is relatively easy and inexpensive to construct and maintain. Because of the simplicity of its construction and operation, such a machine 54 has a very high reliability factor Any process that can use vacuum as a driving force can generally be adapted for use in the invention. Such processes include column chromatography, column-based purification methods, vacuum drawing and filtration. For example, the invention can be easily adapted to carrying out chromatography procedures. In this case, the second liquid receptacle would have a plurality of chromatography columns, each having a semi-permeable bottom to allow a vacuum below the bottom to operate on liquid within each column.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Water Supply & Treatment (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Robotics (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Manipulator (AREA)
  • Details Of Rigid Or Semi-Rigid Containers (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

La présente invention concerne une tubulure à vide qui peut être utilisée commodément, sur des machines de laboratoire semi-automatiques ou entièrement automatiques, pour exécuter une succession de manipulations de laboratoire avec l'aide du vide, sur un grand nombre d'échantillons liquides distincts. L'invention comporte une base (12) dont la taille et les dimensions lui permettent d'accepter et de maintenir un premier récipient (24) pour liquide, comme une boîte de microtitrage. D'une manière générale, la base (12) a un fond (16) et des parois latérales (18), et le premier récipient (24) est conçu pour demeurer à l'intérieur des parois latérales (18). L'invention comporte aussi un cadre d'adaptation (14) dont la taille et les dimensions lui permettent d'accepter et de conserver un deuxième récipient (30) pour liquide, comme une deuxième boîte de microtitrage. Dans un cas typique, le cadre d'adaptation (14) est une structure en cadre rectangulaire ayant une lèvre (32) qui porte le deuxième récipient (30). La base (12) a généralement un orifice (26) qui peut être fixé à une source de vide. En fonctionnement, le premier récipient (24) pour liquide est placé à l'intérieur de la base (12), le cadre d'adaptation (14) est placé par-dessus la base (12) et le deuxième récipient (30) pour liquide est placé sur le cadre d'adaptation (14), de telle sorte qu'un deuxième récipient (30) est situé directement au-dessus du premier (24). Quand on applique le vide à la base (12) en utilisant l'orifice à vide (26), un vide uniforme est établi sur le fond du deuxième récipient (30) pour liquide, ce qui donne une force d'entraînement agissant sur le liquide qui se trouve dans le deuxième récipient (30). Dans un mode de fonctionnement typique, le fond du deuxième récipient (30) est une membrane filtrante et le vide est utilisé pour faire passer du liquide du deuxième récipient (30) dans le premier (24) à travers la membrane. Du fait de sa construction modulaire, les différents éléments du cadre à vide s'empilent facilement dans des châssis d'empilage placés d'un côté de la tubulure à vide. Cette capacité d'empilage permet d'exécuter un grand nombre d'opérations de laboratoire avec assistance par le vide, sur des ensembles multiples d'échantillons liquides, sans la nécessité de disposer d'une grande superficie de paillasse horizontale. Elle facilite aussi l'adaptation de l'invention à un équipement robotisé, pour donner un outil entièrement automatisé de traitement en laboratoire.
EP96930585A 1995-09-15 1996-08-23 Tubulure a vide pour le traitement en laboratoire d'echantillons liquides multiples Withdrawn EP0792190A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US52874195A 1995-09-15 1995-09-15
US528741 1995-09-15
PCT/US1996/013668 WO1997010055A1 (fr) 1995-09-15 1996-08-23 Tubulure a vide pour le traitement en laboratoire d'echantillons liquides multiples

Publications (1)

Publication Number Publication Date
EP0792190A1 true EP0792190A1 (fr) 1997-09-03

Family

ID=24106971

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96930585A Withdrawn EP0792190A1 (fr) 1995-09-15 1996-08-23 Tubulure a vide pour le traitement en laboratoire d'echantillons liquides multiples

Country Status (3)

Country Link
EP (1) EP0792190A1 (fr)
JP (1) JPH10510501A (fr)
WO (1) WO1997010055A1 (fr)

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US6357141B1 (en) * 2000-03-13 2002-03-19 Zymark Corporation Evaporator with hot air bath and method of use
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DE10238630A1 (de) * 2002-08-19 2004-03-04 Macherey, Nagel Gmbh & Co. Handelsgesellschaft Verfahren zur Isolierung biologischer Makromoleküle sowie Vorrichtung zur Durchführung dieses Verfahrens
EP1491258B1 (fr) * 2003-06-24 2008-12-03 Millipore Corporation Systeme de vide multifonctionnelle
US7824623B2 (en) * 2003-06-24 2010-11-02 Millipore Corporation Multifunctional vacuum manifold
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DE102009040180A1 (de) * 2009-09-07 2011-03-17 Dionex Benelux B.V. Strömungssteuerung bei der räumlichen Chromatografie
JP2011209084A (ja) * 2010-03-30 2011-10-20 Sumitomo Bakelite Co Ltd マイクロプレート
CA2979850C (fr) 2015-03-24 2020-07-21 Illumina, Inc. Procedes, ensembles de support, et systemes pour l'imagerie d'echantillons pour une analyse biologique ou chimique
JP6472698B2 (ja) * 2015-03-30 2019-02-20 テルモ株式会社 保持具ハンド、保持具移載装置、及び保持具の移載方法
CN110193216A (zh) * 2019-06-12 2019-09-03 江苏睿玻生物科技有限公司 负压收集装置及负压收集方法

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Publication number Priority date Publication date Assignee Title
CN106081368A (zh) * 2016-06-07 2016-11-09 安徽宏远职业卫生技术服务有限公司 一种密封性好的食品检测样品保存装置

Also Published As

Publication number Publication date
JPH10510501A (ja) 1998-10-13
WO1997010055A1 (fr) 1997-03-20

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