EP0796252A4 - Bicyclische fibrinogen antagonisten - Google Patents

Bicyclische fibrinogen antagonisten

Info

Publication number
EP0796252A4
EP0796252A4 EP95942590A EP95942590A EP0796252A4 EP 0796252 A4 EP0796252 A4 EP 0796252A4 EP 95942590 A EP95942590 A EP 95942590A EP 95942590 A EP95942590 A EP 95942590A EP 0796252 A4 EP0796252 A4 EP 0796252A4
Authority
EP
European Patent Office
Prior art keywords
fibrinogen antagonists
bicyclic fibrinogen
bicyclic
antagonists
fibrinogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP95942590A
Other languages
English (en)
French (fr)
Other versions
EP0796252A1 (de
Inventor
James Francis Callahan
James Martin Samanen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0796252A1 publication Critical patent/EP0796252A1/de
Publication of EP0796252A4 publication Critical patent/EP0796252A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP95942590A 1994-12-09 1995-12-07 Bicyclische fibrinogen antagonisten Withdrawn EP0796252A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35304594A 1994-12-09 1994-12-09
US353045 1994-12-09
PCT/US1995/015932 WO1996017833A1 (en) 1994-12-09 1995-12-07 Bicyclic fibrinogen antagonists

Publications (2)

Publication Number Publication Date
EP0796252A1 EP0796252A1 (de) 1997-09-24
EP0796252A4 true EP0796252A4 (de) 1998-02-04

Family

ID=23387541

Family Applications (1)

Application Number Title Priority Date Filing Date
EP95942590A Withdrawn EP0796252A4 (de) 1994-12-09 1995-12-07 Bicyclische fibrinogen antagonisten

Country Status (3)

Country Link
EP (1) EP0796252A4 (de)
JP (1) JPH11505509A (de)
WO (1) WO1996017833A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ525513A (en) 1998-08-07 2004-09-24 Pont Pharmaceuticals Du Succinoylamino lactams as inhibitors of Abeta protein production
HRP990246A2 (en) 1998-08-07 2000-06-30 Du Pont Pharm Co Succinoylamino benzodiazepines as inhibitors of a beta protein production
CN1636011A (zh) 1998-12-24 2005-07-06 杜邦药品公司 作为Aβ蛋白产生抑制剂的琥珀酰氨基苯并二氮杂䓬
US6503902B2 (en) 1999-09-13 2003-01-07 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production
US6960576B2 (en) 1999-09-13 2005-11-01 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production
EP1222176A1 (de) 1999-10-08 2002-07-17 Bristol-Myers Squibb Pharma Company Amino-laktam-sulfonamide als inhibitoren der bildung von a-beta-protein
EP1261610A2 (de) 2000-02-17 2002-12-04 Bristol-Myers Squibb Pharma Company Succinoylamino-carbocyclen und -heterocyclen als hemmer der a-beta-proteinbildung
US6495540B2 (en) 2000-03-28 2002-12-17 Bristol - Myers Squibb Pharma Company Lactams as inhibitors of A-β protein production
MXPA02009755A (es) 2000-04-03 2003-03-27 Bristol Myers Squibb Pharma Co Lactamas ciclicas como inhibidores de la produccion de proteina a-beta.
EP1268434A1 (de) 2000-04-03 2003-01-02 Bristol-Myers Squibb Pharma Company Zyklische lactame als a-beta proteinproduktionsinhibitoren
WO2001077086A1 (en) 2000-04-11 2001-10-18 Dupont Pharmaceuticals Company SUBSTITUTED LACTAMS AS INHIBITORS OF Aβ PROTEIN PRODUCTION
IL147629A0 (en) 2000-06-01 2002-08-14 Bristol Myers Squibb Pharma Co LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Aβ PROTEIN PRODUCTION
DE60144284D1 (de) 2000-11-01 2011-05-05 Millennium Pharm Inc Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung
US6858592B2 (en) 2001-06-29 2005-02-22 Genzyme Corporation Aryl boronic acids for treating obesity
US7041280B2 (en) 2001-06-29 2006-05-09 Genzyme Corporation Aryl boronate functionalized polymers for treating obesity

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1923821A1 (de) * 1969-05-09 1970-11-19 Wuelfing J A Fa 1,2,4,5-Tetrahydro-[3H]-benzo-1,4-diazepin-2,5-dion-Derivate,Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneipraeparaten
US3898214A (en) * 1974-07-22 1975-08-05 Squibb & Sons Inc Benzazepine diones
US4746657A (en) * 1987-07-13 1988-05-24 A. H. Robins Company, Incorporated Fused aromatic tetrahydroazepinones (and thiones)
EP0444924A1 (de) * 1990-02-28 1991-09-04 Suntory Limited Kondensierte 7-gliedrige zyklische Verbindungen und diese enthaltende antipsychotische Zubereitung
WO1993000095A2 (en) * 1991-06-28 1993-01-07 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
WO1993008174A1 (en) * 1991-10-18 1993-04-29 Genentech, Inc. NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPIIbIIIa RECEPTOR
WO1994014776A2 (en) * 1992-12-21 1994-07-07 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
US5389631A (en) * 1991-10-29 1995-02-14 Merck & Co., Inc. Fibrinogen receptor antagonists
US5441952A (en) * 1993-04-05 1995-08-15 Merck & Co., Inc. Fibrinogen receptor antagonists

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1923821A1 (de) * 1969-05-09 1970-11-19 Wuelfing J A Fa 1,2,4,5-Tetrahydro-[3H]-benzo-1,4-diazepin-2,5-dion-Derivate,Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneipraeparaten
US3898214A (en) * 1974-07-22 1975-08-05 Squibb & Sons Inc Benzazepine diones
US4746657A (en) * 1987-07-13 1988-05-24 A. H. Robins Company, Incorporated Fused aromatic tetrahydroazepinones (and thiones)
EP0444924A1 (de) * 1990-02-28 1991-09-04 Suntory Limited Kondensierte 7-gliedrige zyklische Verbindungen und diese enthaltende antipsychotische Zubereitung
WO1993000095A2 (en) * 1991-06-28 1993-01-07 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
WO1993008174A1 (en) * 1991-10-18 1993-04-29 Genentech, Inc. NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPIIbIIIa RECEPTOR
WO1994014776A2 (en) * 1992-12-21 1994-07-07 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
M. REIFFEN ET AL.: "Specific bradycardic agents. 1. Chemistry, pharmacology, and structure-activity relationships of substituted benzazepinones, a new class of compounds exerting antiischemic properties", JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, no. 5, May 1990 (1990-05-01), WASHINGTON DC, US, pages 1496 - 1504, XP002047919 *
See also references of WO9617833A1 *

Also Published As

Publication number Publication date
EP0796252A1 (de) 1997-09-24
JPH11505509A (ja) 1999-05-21
WO1996017833A1 (en) 1996-06-13

Similar Documents

Publication Publication Date Title
AP9500710A0 (en) Bicyclic fibrinogen antagonists
EP0702671A4 (de) Bicyclische fibrinogen-antagonisten
GB9405317D0 (en) Fibrinogen receptor antagonists
EP0912175A4 (de) Antagonisten des fibrinogenrezeptors
EP0799189A4 (de) Bicyclische fibrinogen-antagonisten
HU9603082D0 (en) Neurokinine (tachykinine) antagonists
AU3665793A (en) Fibrinogen receptor antagonists
AU1441695A (en) Fibrinogen receptor antagonists
PL312426A1 (en) Bicyclic tetrahydropyrazolepyridines
EP0796098A4 (de) Fibrinogenrezeptor-antagonisten
EP0885213A4 (de) Fibrinogenrezeptor antagonisten
HU9502028D0 (en) Fibrinogen receptor antagonists
EP0801650A4 (de) Fibrinogenrezeptor-antagonisten
HU9503191D0 (en) Adhesion-receptor antagonists
AU5322994A (en) Fibrinogen receptor antagonists
EP0794779A4 (de) Fibrinogenrezeptorantagonisten
GB9320799D0 (en) Fibrinogen receptor antagonists
GB9515852D0 (en) Fibrinogen receptor antagonists
EP0800395A4 (de) Antagonisten der fibrinogen-rezeptoren
GB9516643D0 (en) Fibrinogen receptor antagonists
SI0738150T1 (en) Bicyclic fibrinogen antagonists
ZA944019B (en) Bicyclic fibrinogen antagonists
ZA939515B (en) Bicyclic fibrinogen antagonists
AU7508598A (en) Bicyclic fibrinogen antagonists
HK1012390A (en) Bicyclic fibrinogen antagonists

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19970702

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): BE CH DE DK FR GB IT LI NL

A4 Supplementary search report drawn up and despatched

Effective date: 19971218

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): BE CH DE DK FR GB IT LI NL

17Q First examination report despatched

Effective date: 19981021

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20010731

R18D Application deemed to be withdrawn (corrected)

Effective date: 20010810