EP0807116A4 - Cationic amphiphiles - Google Patents

Cationic amphiphiles

Info

Publication number
EP0807116A4
EP0807116A4 EP94924449A EP94924449A EP0807116A4 EP 0807116 A4 EP0807116 A4 EP 0807116A4 EP 94924449 A EP94924449 A EP 94924449A EP 94924449 A EP94924449 A EP 94924449A EP 0807116 A4 EP0807116 A4 EP 0807116A4
Authority
EP
European Patent Office
Prior art keywords
cationic amphiphiles
amphiphiles
cationic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94924449A
Other languages
German (de)
French (fr)
Other versions
EP0807116A1 (en
Inventor
Timothy D Heath
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Megabios Corp
Original Assignee
Megabios Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Megabios Corp filed Critical Megabios Corp
Publication of EP0807116A1 publication Critical patent/EP0807116A1/en
Publication of EP0807116A4 publication Critical patent/EP0807116A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
EP94924449A 1994-06-22 1994-06-22 Cationic amphiphiles Withdrawn EP0807116A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1994/007071 WO1995035301A1 (en) 1994-06-22 1994-06-22 Cationic amphiphiles

Publications (2)

Publication Number Publication Date
EP0807116A1 EP0807116A1 (en) 1997-11-19
EP0807116A4 true EP0807116A4 (en) 1998-01-07

Family

ID=22242692

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94924449A Withdrawn EP0807116A4 (en) 1994-06-22 1994-06-22 Cationic amphiphiles

Country Status (6)

Country Link
EP (1) EP0807116A4 (en)
JP (1) JPH10506093A (en)
AU (1) AU696881B2 (en)
CA (1) CA2194221C (en)
NO (1) NO970172D0 (en)
WO (1) WO1995035301A1 (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7422902B1 (en) 1995-06-07 2008-09-09 The University Of British Columbia Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
US5976567A (en) * 1995-06-07 1999-11-02 Inex Pharmaceuticals Corp. Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
US6235310B1 (en) 1997-04-04 2001-05-22 Valentis, Inc. Methods of delivery using cationic lipids and helper lipids
JP4799736B2 (en) 1999-02-22 2011-10-26 ジョージタウン・ユニバーシティ Antibody fragment targeted immunoliposomes for systemic gene delivery
US9034329B2 (en) 1999-02-22 2015-05-19 Georgetown University Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
US7780882B2 (en) 1999-02-22 2010-08-24 Georgetown University Simplified and improved method for preparing an antibody or an antibody fragment targeted immunoliposome for systemic administration of a therapeutic or diagnostic agent
US9034330B2 (en) 1999-02-22 2015-05-19 Georgetown University Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
AU2002307035A1 (en) * 2001-04-02 2002-10-15 Georgetown University A simplified and improved method for preparing an antibody or an antibody fragment targeted immunoliposome or polyplex for systemic administration of a therapeutic or diagnostic agent
DE10207178A1 (en) * 2002-02-19 2003-09-04 Novosom Ag Components for the production of amphoteric liposomes
EP1519714B1 (en) 2002-06-28 2010-10-20 Protiva Biotherapeutics Inc. Method and apparatus for producing liposomes
CA2532228C (en) 2003-07-16 2017-02-14 Protiva Biotherapeutics, Inc. Lipid encapsulated interfering rna
EP1664316B1 (en) 2003-09-15 2012-08-29 Protiva Biotherapeutics Inc. Polyethyleneglycol-modified lipid compounds and uses thereof
JP4764426B2 (en) 2004-06-07 2011-09-07 プロチバ バイオセラピューティクス インコーポレイティッド Cationic lipids and methods of use
CA2569664C (en) 2004-06-07 2013-07-16 Protiva Biotherapeutics, Inc. Lipid encapsulated interfering rna
EP1773857A4 (en) 2004-07-02 2009-05-13 Protiva Biotherapeutics Inc Immunostimulatory sirna molecules and uses therefor
CN101346393B (en) 2005-11-02 2015-07-22 普洛体维生物治疗公司 Modified siRNA molecules and uses thereof
US7915399B2 (en) 2006-06-09 2011-03-29 Protiva Biotherapeutics, Inc. Modified siRNA molecules and uses thereof
CA2721333C (en) 2008-04-15 2020-12-01 Protiva Biotherapeutics, Inc. Novel lipid formulations for nucleic acid delivery
CA2740000C (en) 2008-10-09 2017-12-12 Tekmira Pharmaceuticals Corporation Improved amino lipids and methods for the delivery of nucleic acids
US9018187B2 (en) 2009-07-01 2015-04-28 Protiva Biotherapeutics, Inc. Cationic lipids and methods for the delivery of therapeutic agents
US8569256B2 (en) 2009-07-01 2013-10-29 Protiva Biotherapeutics, Inc. Cationic lipids and methods for the delivery of therapeutic agents
WO2011000107A1 (en) 2009-07-01 2011-01-06 Protiva Biotherapeutics, Inc. Novel lipid formulations for delivery of therapeutic agents to solid tumors
US9006417B2 (en) 2010-06-30 2015-04-14 Protiva Biotherapeutics, Inc. Non-liposomal systems for nucleic acid delivery
CA2916898A1 (en) 2013-07-16 2015-01-22 The Board Of Trustees Of The Leland Stanford Junior University Enhancement of osteogenic potential of bone grafts
WO2022115645A1 (en) 2020-11-25 2022-06-02 Akagera Medicines, Inc. Lipid nanoparticles for delivery of nucleic acids, and related methods of use
CA3256897A1 (en) 2022-05-25 2023-11-30 Akagera Medicines, Inc. Lipid nanoparticles for delivery of nucleic acids and methods of use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0099068A1 (en) * 1982-07-06 1984-01-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Glycerine derivatives for phospholipids synthesis
WO1991016024A1 (en) * 1990-04-19 1991-10-31 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
WO1994005624A1 (en) * 1992-08-28 1994-03-17 Life Technologies, Inc. Cationic lipids
WO1995026356A1 (en) * 1994-03-29 1995-10-05 Northwestern University Novel cationic phospholipids for transfection

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0099068A1 (en) * 1982-07-06 1984-01-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Glycerine derivatives for phospholipids synthesis
WO1991016024A1 (en) * 1990-04-19 1991-10-31 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US5264618A (en) * 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
WO1994005624A1 (en) * 1992-08-28 1994-03-17 Life Technologies, Inc. Cationic lipids
WO1995026356A1 (en) * 1994-03-29 1995-10-05 Northwestern University Novel cationic phospholipids for transfection

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HARRIS D J ET AL: "THE DEVELOPMENT OF IMPROVED CATIONIC LIPIDS FOR GENE TRANSFER INTO CYSTIC FIBROSIS AIRWAY EPITHELIAL CELLS", PHOSPHORUS, SULPHUR AND SILICON AND THE RELATED ELEMENTS, vol. 109/110, no. 1/04, 1996, pages 289 - 292, XP000676977 *
See also references of WO9535301A1 *
SOLODIN I ET AL: "SYNTHESIS OF PHOSPHOTRIESTER CATIONIC PHOSPHOLIPIDS, CATIONIC LIPIDS 2", SYNLETT, no. 5, May 1996 (1996-05-01), pages 457/458, XP000645321 *

Also Published As

Publication number Publication date
AU696881B2 (en) 1998-09-24
NO970172L (en) 1997-01-15
WO1995035301A1 (en) 1995-12-28
EP0807116A1 (en) 1997-11-19
CA2194221C (en) 2001-01-02
JPH10506093A (en) 1998-06-16
CA2194221A1 (en) 1995-12-28
NO970172D0 (en) 1997-01-15
AU7471194A (en) 1996-01-15

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Legal Events

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