EP0807116A4 - Kationische amphiphile - Google Patents

Kationische amphiphile

Info

Publication number
EP0807116A4
EP0807116A4 EP94924449A EP94924449A EP0807116A4 EP 0807116 A4 EP0807116 A4 EP 0807116A4 EP 94924449 A EP94924449 A EP 94924449A EP 94924449 A EP94924449 A EP 94924449A EP 0807116 A4 EP0807116 A4 EP 0807116A4
Authority
EP
European Patent Office
Prior art keywords
cationic amphiphiles
amphiphiles
cationic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94924449A
Other languages
English (en)
French (fr)
Other versions
EP0807116A1 (de
Inventor
Timothy D Heath
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Megabios Corp
Original Assignee
Megabios Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Megabios Corp filed Critical Megabios Corp
Publication of EP0807116A1 publication Critical patent/EP0807116A1/de
Publication of EP0807116A4 publication Critical patent/EP0807116A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP94924449A 1994-06-22 1994-06-22 Kationische amphiphile Withdrawn EP0807116A4 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1994/007071 WO1995035301A1 (en) 1994-06-22 1994-06-22 Cationic amphiphiles

Publications (2)

Publication Number Publication Date
EP0807116A1 EP0807116A1 (de) 1997-11-19
EP0807116A4 true EP0807116A4 (de) 1998-01-07

Family

ID=22242692

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94924449A Withdrawn EP0807116A4 (de) 1994-06-22 1994-06-22 Kationische amphiphile

Country Status (6)

Country Link
EP (1) EP0807116A4 (de)
JP (1) JPH10506093A (de)
AU (1) AU696881B2 (de)
CA (1) CA2194221C (de)
NO (1) NO970172L (de)
WO (1) WO1995035301A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2231819T3 (es) * 1995-06-07 2005-05-16 Inex Pharmaceuticals Corp Particulas de lipido-acido nucleico preparadas a traves de un intermedio complejo de lipido-acido nucleico hidrofobo y uso para transferir genes.
US7422902B1 (en) 1995-06-07 2008-09-09 The University Of British Columbia Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
US6235310B1 (en) 1997-04-04 2001-05-22 Valentis, Inc. Methods of delivery using cationic lipids and helper lipids
ES2278597T3 (es) 1999-02-22 2007-08-16 Georgetown University Inmunoliposomas dirigidos mediante un fragmento de anticuerpo para la administracion sistematica de genes.
US9034329B2 (en) 1999-02-22 2015-05-19 Georgetown University Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
US7780882B2 (en) 1999-02-22 2010-08-24 Georgetown University Simplified and improved method for preparing an antibody or an antibody fragment targeted immunoliposome for systemic administration of a therapeutic or diagnostic agent
US9034330B2 (en) 1999-02-22 2015-05-19 Georgetown University Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
AU2002307035A1 (en) * 2001-04-02 2002-10-15 Georgetown University A simplified and improved method for preparing an antibody or an antibody fragment targeted immunoliposome or polyplex for systemic administration of a therapeutic or diagnostic agent
DE10207178A1 (de) * 2002-02-19 2003-09-04 Novosom Ag Komponenten für die Herstellung amphoterer Liposomen
DE60334618D1 (de) 2002-06-28 2010-12-02 Protiva Biotherapeutics Inc Verfahren und vorrichtung zur herstellung von liposomen
KR101168440B1 (ko) 2003-07-16 2012-07-27 프로티바 바이오쎄라퓨틱스, 인코포레이티드 지질 캡슐화된 간섭 ｒｎａ
NZ581166A (en) 2003-09-15 2011-06-30 Protiva Biotherapeutics Inc Polyethyleneglycol-modified lipid compounds and uses thereof
ATE536418T1 (de) 2004-06-07 2011-12-15 Protiva Biotherapeutics Inc Lipidverkapselte interferenz-rna
CA2569645C (en) 2004-06-07 2014-10-28 Protiva Biotherapeutics, Inc. Cationic lipids and methods of use
AU2005259799A1 (en) 2004-07-02 2006-01-12 Protiva Biotherapeutics, Inc. Immunostimulatory siRNA molecules and uses therefor
WO2007051303A1 (en) 2005-11-02 2007-05-10 Protiva Biotherapeutics, Inc. MODIFIED siRNA MOLECULES AND USES THEREOF
US7915399B2 (en) 2006-06-09 2011-03-29 Protiva Biotherapeutics, Inc. Modified siRNA molecules and uses thereof
PL2279254T3 (pl) 2008-04-15 2017-11-30 Protiva Biotherapeutics Inc. Nowe preparaty lipidowe do dostarczania kwasów nukleinowych
EP2743265B1 (de) 2008-10-09 2017-03-15 Arbutus Biopharma Corporation Verbesserte Aminolipide und Verfahren zur Freisetzung von Nukleinsäuren
US9018187B2 (en) 2009-07-01 2015-04-28 Protiva Biotherapeutics, Inc. Cationic lipids and methods for the delivery of therapeutic agents
WO2011000107A1 (en) 2009-07-01 2011-01-06 Protiva Biotherapeutics, Inc. Novel lipid formulations for delivery of therapeutic agents to solid tumors
US8569256B2 (en) 2009-07-01 2013-10-29 Protiva Biotherapeutics, Inc. Cationic lipids and methods for the delivery of therapeutic agents
WO2012000104A1 (en) 2010-06-30 2012-01-05 Protiva Biotherapeutics, Inc. Non-liposomal systems for nucleic acid delivery
US9301980B2 (en) 2013-07-16 2016-04-05 The Board Of Trustees Of The Leland Stanford Junio Enhancement of osteogenic potential of bone grafts
CN117098541A (zh) 2020-11-25 2023-11-21 阿卡格拉医药公司 用于递送核酸的脂质纳米粒及相关使用方法
AU2023275780B2 (en) 2022-05-25 2026-03-05 Akagera Medicines, Inc. Lipid nanoparticles for delivery of nucleic acids and methods of use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0099068A1 (de) * 1982-07-06 1984-01-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Neue Glycerinderivate zur Synthese von Phospholipiden
WO1991016024A1 (en) * 1990-04-19 1991-10-31 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
WO1994005624A1 (en) * 1992-08-28 1994-03-17 Life Technologies, Inc. Cationic lipids
WO1995026356A1 (en) * 1994-03-29 1995-10-05 Northwestern University Novel cationic phospholipids for transfection

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0099068A1 (de) * 1982-07-06 1984-01-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Neue Glycerinderivate zur Synthese von Phospholipiden
WO1991016024A1 (en) * 1990-04-19 1991-10-31 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US5264618A (en) * 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
WO1994005624A1 (en) * 1992-08-28 1994-03-17 Life Technologies, Inc. Cationic lipids
WO1995026356A1 (en) * 1994-03-29 1995-10-05 Northwestern University Novel cationic phospholipids for transfection

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HARRIS D J ET AL: "THE DEVELOPMENT OF IMPROVED CATIONIC LIPIDS FOR GENE TRANSFER INTO CYSTIC FIBROSIS AIRWAY EPITHELIAL CELLS", PHOSPHORUS, SULPHUR AND SILICON AND THE RELATED ELEMENTS, vol. 109/110, no. 1/04, 1996, pages 289 - 292, XP000676977 *
See also references of WO9535301A1 *
SOLODIN I ET AL: "SYNTHESIS OF PHOSPHOTRIESTER CATIONIC PHOSPHOLIPIDS, CATIONIC LIPIDS 2", SYNLETT, no. 5, May 1996 (1996-05-01), pages 457/458, XP000645321 *

Also Published As

Publication number Publication date
JPH10506093A (ja) 1998-06-16
CA2194221C (en) 2001-01-02
AU7471194A (en) 1996-01-15
NO970172D0 (no) 1997-01-15
EP0807116A1 (de) 1997-11-19
AU696881B2 (en) 1998-09-24
NO970172L (no) 1997-01-15
WO1995035301A1 (en) 1995-12-28
CA2194221A1 (en) 1995-12-28

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Legal Events

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