EP0810882A4 - Verfahren und zusammensetzung für die regulation der cd28-expression - Google Patents

Verfahren und zusammensetzung für die regulation der cd28-expression

Info

Publication number
EP0810882A4
EP0810882A4 EP96909477A EP96909477A EP0810882A4 EP 0810882 A4 EP0810882 A4 EP 0810882A4 EP 96909477 A EP96909477 A EP 96909477A EP 96909477 A EP96909477 A EP 96909477A EP 0810882 A4 EP0810882 A4 EP 0810882A4
Authority
EP
European Patent Office
Prior art keywords
regulation
expression
compositions
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96909477A
Other languages
English (en)
French (fr)
Other versions
EP0810882A1 (de
Inventor
Robert C Tam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bausch Health Americas Inc
Original Assignee
ICN Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ICN Pharmaceuticals Inc filed Critical ICN Pharmaceuticals Inc
Publication of EP0810882A1 publication Critical patent/EP0810882A1/de
Publication of EP0810882A4 publication Critical patent/EP0810882A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/13—Decoys
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/15—Nucleic acids forming more than 2 strands, e.g. TFOs
    • C12N2310/151—Nucleic acids forming more than 2 strands, e.g. TFOs more than 3 strands, e.g. tetrads, H-DNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/18—Type of nucleic acid acting by a non-sequence specific mechanism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP96909477A 1995-02-09 1996-02-05 Verfahren und zusammensetzung für die regulation der cd28-expression Withdrawn EP0810882A4 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US38704195A 1995-02-09 1995-02-09
US387041 1995-02-09
PCT/US1996/001507 WO1996024380A1 (en) 1995-02-09 1996-02-05 Methods and compositions for regulation of cd28 expression
2003-03-28

Publications (2)

Publication Number Publication Date
EP0810882A1 EP0810882A1 (de) 1997-12-10
EP0810882A4 true EP0810882A4 (de) 1999-05-19

Family

ID=23528194

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96909477A Withdrawn EP0810882A4 (de) 1995-02-09 1996-02-05 Verfahren und zusammensetzung für die regulation der cd28-expression

Country Status (4)

Country Link
EP (1) EP0810882A4 (de)
HU (1) HUP9801629A3 (de)
PL (1) PL321711A1 (de)
WO (1) WO1996024380A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
IT1277025B1 (it) * 1995-12-04 1997-11-04 Cooperativa Centro Ricerche Po Classe di oligonucleotidi fosfodiesterici ad attivita' citotossica composizioni farmaceutiche che li contengono e loro uso
SK84599A3 (en) * 1996-12-27 2000-07-11 Icn Pharmaceuticals G-rich oligo aptamers and methods of modulating an immune response
EP1108017A2 (de) * 1998-09-03 2001-06-20 Coley Pharmaceutical GmbH Oligonukleotide mit einem g-motif und deren verwendungen
US6977245B2 (en) 1999-04-12 2005-12-20 The United States Of America As Represented By The Department Of Health And Human Services Oligodeoxynucleotide and its use to induce an immune response
EP1322655B1 (de) 2000-01-14 2007-11-14 The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services Oligodeoxynukleotide und ihre verwendung zur induktion einer immunreaktion
US7585847B2 (en) 2000-02-03 2009-09-08 Coley Pharmaceutical Group, Inc. Immunostimulatory nucleic acids for the treatment of asthma and allergy
JP2005500806A (ja) 2000-09-15 2005-01-13 コーリー ファーマシューティカル ゲーエムベーハー ＣｐＧに基づく免疫アゴニスト／免疫アンタゴニストの高スループットスクリーニングのためのプロセス
WO2003020884A2 (en) 2001-08-14 2003-03-13 The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services Method for rapid generation of mature dendritic cells
AU2002366710A1 (en) 2001-12-20 2003-07-09 The Government Of The United States Of America As Represented By The Secretary Of The Department Of USE OF CpG OLIGODEOXYNUCLEOTIDES TO INDUCE ANGIOGENESIS
US20120252869A1 (en) * 2009-07-24 2012-10-04 Opko Curna, Llc Treatment of sirtuin (sirt) related diseases by inhibition of natural antisense transcript to a sirtuin (sirt)
KR101802540B1 (ko) 2009-09-25 2017-11-28 큐알엔에이, 인크. Ｆｌｇ의 발현 및 활성을 조절함으로써 필라그린(ｆｌｇ)에 관련된 질환의 치료
EP2931893A1 (de) * 2012-12-13 2015-10-21 Universität Leipzig T-zellen-modulierung durch exon-skipping

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06505396A (ja) * 1991-03-08 1994-06-23 サイトメッド，インコーポレイテッド 可溶性ｃｄ２８タンパク質およびそれを用いる治療方法
US6664107B1 (en) * 1993-05-26 2003-12-16 Ontario Cancer Institute, University Health Network CD45 disrupted nucleic acid

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
MACAYA R F ET AL: "THROMBIN-BINDING DNA APTAMER FORMS A UNIMOLECULAR QUADRUPLEX STRUCTURE IN SOLUTION", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 90, April 1993 (1993-04-01), pages 3745 - 3749, XP002043117 *
See also references of WO9624380A1 *
TAM R C ET AL: "BIOLOGICAL AVAILABILITY AND NUCLEASE RESISTANCE EXTEND THE IN-VITRO ACTIVITY OF A PHOSPHOROTHIOATE-3'HYDROXYPROPYLAMINE OLIGONUCLEOTIDE", NUCLEIC ACIDS RESEARCH, (25 MAR 1994) VOL. 22, NO. 6, PP. 977-986., XP002096884 *
TAM R C ET AL: "Oligonucleotide-mediated inhibition of CD28 expression induces human T cell hyporesponsiveness and manifests impaired contact hypersensitivity in mice.", JOURNAL OF IMMUNOLOGY, (1997 JAN 1) 158 (1) 200-8., XP002096885 *

Also Published As

Publication number Publication date
PL321711A1 (en) 1997-12-22
HUP9801629A3 (en) 2000-10-30
WO1996024380A1 (en) 1996-08-15
HUP9801629A2 (hu) 1998-10-28
EP0810882A1 (de) 1997-12-10

Similar Documents

Publication Publication Date Title
AU5529596A (en) Methods and compositions related to stereolithography
PL323736A1 (en) Composition maintaining release of non-aggregable erythropoietin
IL117872A0 (en) Herbicidal compositions and method of their use
AU7471096A (en) Compositions and methods for treating bone deficit conditions
AU5439996A (en) Compositions and methods for treating pain
ZA96737B (en) Cosmetic compositions for reducing or preventing signs of cullulite
AU4751296A (en) Method of suspending inclusions and compositions produced thereby
AU6485996A (en) Methods and compositions for modulation and inhibition of teomerase
HUP9801629A3 (en) Methods and compositions for regulation of cd28 expression
GB9508791D0 (en) Compositions of matter
EP0777473A4 (de) Präparate und verfahren zur kontrolle des rauchens
AU3117600A (en) Composition and method for regulation of body weight and associated conditions
PL324461A1 (en) Synergic herbicidal composition and method of using same
HUP9603529A3 (en) Femoral part of hip-joint-prothesis
AU4468093A (en) Composition and methods for the generation of bone
IL110887A0 (en) Method for regulation of NF-AlphaB
GB9517111D0 (en) Surface-coating composition and method of application
ZA963073B (en) Coating compositions and methods of using them
GB9507297D0 (en) New composition of matter
EP0821576A4 (de) Verhütungsverfahren
IL113057A0 (en) Compositions for the treatment of dandruff
GB9524575D0 (en) Thickener for cosmetic composition
GB9510162D0 (en) Compositions for the treatment of skin conditions
CZ250097A3 (cs) Způsoby a kompozice k regulaci exprese CD28
ZA963825B (en) Composition of matter

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19970908

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: SI PAYMENT 970908

A4 Supplementary search report drawn up and despatched

Effective date: 19990401

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN

18W Application withdrawn

Withdrawal date: 20000809