EP0812819A3 - Enantiomère enrichie d'un ester de l'acide malonique substitué par des restes d'hydrocarbures tertiaires et sa préparation - Google Patents

Enantiomère enrichie d'un ester de l'acide malonique substitué par des restes d'hydrocarbures tertiaires et sa préparation Download PDF

Info

Publication number
EP0812819A3
EP0812819A3 EP97106223A EP97106223A EP0812819A3 EP 0812819 A3 EP0812819 A3 EP 0812819A3 EP 97106223 A EP97106223 A EP 97106223A EP 97106223 A EP97106223 A EP 97106223A EP 0812819 A3 EP0812819 A3 EP 0812819A3
Authority
EP
European Patent Office
Prior art keywords
malonic acid
preparation
hydrocarbonrest
enantiomer
acid ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP97106223A
Other languages
German (de)
English (en)
Other versions
EP0812819A2 (fr
EP0812819B1 (fr
Inventor
Udo Dr. Jegelka
Wolfgang Dr. Kleemiss
Bruno Dr. Klotz--Berendes
Marcel Dr. Feld
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Huels AG
Degussa Huels AG
Chemische Werke Huels AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Huels AG, Degussa Huels AG, Chemische Werke Huels AG filed Critical Huels AG
Publication of EP0812819A2 publication Critical patent/EP0812819A2/fr
Publication of EP0812819A3 publication Critical patent/EP0812819A3/fr
Application granted granted Critical
Publication of EP0812819B1 publication Critical patent/EP0812819B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP97106223A 1996-06-10 1997-04-16 Enantiomère enrichie d'un ester de l'acide malonique substitué par des restes d'hydrocarbures tertiaires et sa préparation Expired - Lifetime EP0812819B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19623142 1996-06-10
DE19623142A DE19623142A1 (de) 1996-06-10 1996-06-10 Enantiomerenangereicherte, durch einen tertiären Kohlenwasserstoffrest substituierte Malonsäuremonoester sowie deren Herstellung

Publications (3)

Publication Number Publication Date
EP0812819A2 EP0812819A2 (fr) 1997-12-17
EP0812819A3 true EP0812819A3 (fr) 1999-11-03
EP0812819B1 EP0812819B1 (fr) 2001-11-28

Family

ID=7796548

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97106223A Expired - Lifetime EP0812819B1 (fr) 1996-06-10 1997-04-16 Enantiomère enrichie d'un ester de l'acide malonique substitué par des restes d'hydrocarbures tertiaires et sa préparation

Country Status (4)

Country Link
US (1) US6613934B1 (fr)
EP (1) EP0812819B1 (fr)
JP (1) JPH1081648A (fr)
DE (2) DE19623142A1 (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022725A1 (es) * 1999-02-26 2002-09-04 Schering Corp Hidrolisis enzimatica enantioselectiva de esteres 3-sustituidos de acido glutarico
CN102102114B (zh) * 2004-06-21 2013-08-14 沃尼尔·朗伯有限责任公司 普瑞巴林和相关化合物的制备
WO2006128590A1 (fr) * 2005-05-31 2006-12-07 Dsm Ip Assets B.V. Hydrolases, acides nucleiques codant pour ces hydrolases et methodes de fabrication et d'utilisation
US9249265B1 (en) 2014-09-08 2016-02-02 Sirrus, Inc. Emulsion polymers including one or more 1,1-disubstituted alkene compounds, emulsion methods, and polymer compositions
US10414839B2 (en) 2010-10-20 2019-09-17 Sirrus, Inc. Polymers including a methylene beta-ketoester and products formed therefrom
US9828324B2 (en) 2010-10-20 2017-11-28 Sirrus, Inc. Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom
KR20140020236A (ko) 2010-10-20 2014-02-18 바이오포믹스, 인크. 열 전달제 존재하에서의 빠른 회수를 사용하는 메틸렌 말로네이트의 합성
US9279022B1 (en) 2014-09-08 2016-03-08 Sirrus, Inc. Solution polymers including one or more 1,1-disubstituted alkene compounds, solution polymerization methods, and polymer compositions
EP3517523A1 (fr) 2011-10-19 2019-07-31 Sirrus, Inc. Monomères multifonctionnels et leurs procédés de production
US9181365B2 (en) 2012-03-30 2015-11-10 Sirrus, Inc. Methods for activating polymerizable compositions, polymerizable systems, and products formed thereby
JP6345644B2 (ja) 2012-03-30 2018-06-20 シラス・インコーポレイテッド インク配合物およびコーティング配合物ならびにこれらを作製するための重合性の系
EP3153530B1 (fr) 2012-03-30 2021-02-24 Sirrus, Inc. Articles composites et laminés et systèmes polymérisables pour leur production
WO2013181600A2 (fr) 2012-06-01 2013-12-05 Bioformix Inc. Matériau optique et objets formés à partir de celui-ci
WO2014078689A1 (fr) 2012-11-16 2014-05-22 Bioformix Inc. Systèmes et procédés de liaison de matières plastiques
US10607910B2 (en) 2012-11-30 2020-03-31 Sirrus, Inc. Composite compositions for electronics applications
CN105008321A (zh) 2013-01-11 2015-10-28 瑟拉斯公司 经过双(羟甲基)丙二酸酯的途径获得亚甲基丙二酸酯的方法
US9315597B2 (en) 2014-09-08 2016-04-19 Sirrus, Inc. Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures
US9416091B1 (en) 2015-02-04 2016-08-16 Sirrus, Inc. Catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US10501400B2 (en) 2015-02-04 2019-12-10 Sirrus, Inc. Heterogeneous catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US9334430B1 (en) 2015-05-29 2016-05-10 Sirrus, Inc. Encapsulated polymerization initiators, polymerization systems and methods using the same
US9217098B1 (en) 2015-06-01 2015-12-22 Sirrus, Inc. Electroinitiated polymerization of compositions having a 1,1-disubstituted alkene compound
CN108289866B (zh) * 2015-10-23 2025-10-28 纳维托制药有限公司 Sestrin-gator2相互作用的调节剂和其用途
US9518001B1 (en) 2016-05-13 2016-12-13 Sirrus, Inc. High purity 1,1-dicarbonyl substituted-1-alkenes and methods for their preparation
US9567475B1 (en) 2016-06-03 2017-02-14 Sirrus, Inc. Coatings containing polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
US10196481B2 (en) 2016-06-03 2019-02-05 Sirrus, Inc. Polymer and other compounds functionalized with terminal 1,1-disubstituted alkene monomer(s) and methods thereof
US9617377B1 (en) 2016-06-03 2017-04-11 Sirrus, Inc. Polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
US10428177B2 (en) 2016-06-03 2019-10-01 Sirrus, Inc. Water absorbing or water soluble polymers, intermediate compounds, and methods thereof
TWI776886B (zh) 2017-04-26 2022-09-11 美商奈維特製藥公司 Sestrin-gator2交互作用之調節劑及其用途
CN110656134B (zh) * 2018-06-29 2023-03-28 广东东阳光药业有限公司 一种单酯的制备方法
CA3117336A1 (fr) 2018-10-24 2020-04-30 Navitor Pharmaceuticals, Inc. Polymorphies d'acide (s)-2-amino-5,5-difluoro-4,4-dimethylpentanoique pour la modulation de mtorc1
JP2022554276A (ja) 2019-11-01 2022-12-28 ナビター ファーマシューティカルズ， インコーポレイテッド Ｍｔｏｒｃ１モジュレーターを使用する処置方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0050799A1 (fr) * 1980-10-21 1982-05-05 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Procédés de production de di-esters alcoyliques et de mono-esters alcoyliques optiquement actifs de l'acide 3-amino-glutarique
SE453599B (sv) * 1985-04-26 1988-02-15 Karl Hult Enantiomert rena monoestrar av malonsyra och ett enzymatiskt forfarande liksom mellanprodukter for framstellning derav

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1138324A (zh) * 1993-12-21 1996-12-18 贝林格尔·英格海姆公司 增环的二氢吡啶及其在制备药物制剂中的应用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0050799A1 (fr) * 1980-10-21 1982-05-05 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Procédés de production de di-esters alcoyliques et de mono-esters alcoyliques optiquement actifs de l'acide 3-amino-glutarique
SE453599B (sv) * 1985-04-26 1988-02-15 Karl Hult Enantiomert rena monoestrar av malonsyra och ett enzymatiskt forfarande liksom mellanprodukter for framstellning derav

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 8224, Derwent World Patents Index; Class B05, AN 82-004555, XP002114667 *
KITAZUME, TOMOYA ET AL: "Microbial approach to the practical monofluorinated chiral synthons", J. ORG. CHEM. (1986), 51(7), 1003-6, XP002114665 *
KLOTZ-BERENDES, BRUNO ET AL: "Enzymic synthesis of optically active monoalkylated malonic monoesters", TETRAHEDRON: ASYMMETRY (1997), 8(11), 1821-1823, XP002114677 *
REGIS LEUNG-TOUNG ET AL.: "Flash vacuum pyrolysis of tert-butyl beta-ketoesters:Sterically protected alpha oxoketenes", TETRAHEDRON., vol. 48, no. 36, 1992, OXFORD GB, pages 7641 - 7654, XP002114666 *

Also Published As

Publication number Publication date
EP0812819A2 (fr) 1997-12-17
US6613934B1 (en) 2003-09-02
EP0812819B1 (fr) 2001-11-28
JPH1081648A (ja) 1998-03-31
DE59705498D1 (de) 2002-01-10
DE19623142A1 (de) 1997-12-11

Similar Documents

Publication Publication Date Title
EP0812819A3 (fr) Enantiomère enrichie d'un ester de l'acide malonique substitué par des restes d'hydrocarbures tertiaires et sa préparation
EP0343427A3 (fr) Hydrogels préparés en utilisant des esters d'acides alcényl-phosphoniques ou phosphiniques comme reticulants.
EP0280222A3 (fr) Produits d'addition à partir d'acrylates et d'amines et leur utilisation dans des masses durcissables par rayons
ATE147062T1 (de) Verfahren zur herstellung von eicosapentaensäure oder von einem esterderivat davon
AT366400B (de) Verfahren zur herstellung kathodisch abscheidbarer lackbindemittel
DE19681532T1 (de) Verfahren zur Herstellung von L-Glutaminsäure durch Fermentation
AT361142B (de) Verfahren zur herstellung eines neuen tetra- decapeptids und seiner saeureadditionssalze
EP1083197A3 (fr) Composition de caoutchouc pour revêtement de rouleaux
AT362347B (de) Verfahren zur herstellung von neuen 3-phenoxy-3 -phenylpropanaminen sowie deren saeureadditions- salzen
ATA380178A (de) Verfahren zur herstellung von neuen n-acetyl-paminophenyl-n'acetylaminothioalkansaeureestern
EP0291804A3 (fr) Protéines à effet de TNF
EP1231203A3 (fr) Procédé de préparation d'esters acylés d'acide citrique
DE3672967D1 (de) Verfahren zur herstellung eines gepfropften aethylen-acrylsaeure-ester-copolymerisats.
DE3886677D1 (de) Verfahren zur Herstellung eines Acrylsäureester-Vinylchlorid-Pfropfpolymerisates.
DE69714681D1 (de) Verfahren zur Herstellung von Sophorolipiden durch zyklische Fermentation mit Zuführung von Fettsäureestern oder Ölen
DE3579064D1 (de) Triterpene ester von organischer saeure, verfahren zu ihrer herstellung und hypolipeinische zusammenstellungen die sie enthalten.
DE63764T1 (de) Verfahren zur aenderung eines mikroorganismus.
ATA476480A (de) Verfahren zur herstellung von neuen estern eines harzsaeure-maleinsaeurenanhydrid-addukts
AT368138B (de) Verfahren zur herstellung von 3-hydroxy-6-phenyl1,2,3,4-tetrahydro-1,5-benzodiazocinen sowie von deren saeureadditionssalzen
EP1024199A3 (fr) Procédé d'obtention d'acide gamma-linolenique de protozoaires du genre Colpidium
ATA799578A (de) Verfahren zur herstellung eines margarinefettes
EP1043351A3 (fr) Esters d'acide (méth)acrylique contenant des groupes d'uréthane, procédé pour leur préparation et leur utilisation ainsi que de revêtements durcissables par irradiation les contenant
DE3774354D1 (de) Metallprodukt mit verbessertem glanz nach der lackierung und verfahren zu dessen herstellung.
EP0315018A3 (fr) Fluorométhoxyphényl-dihydropyridines, leurs procédés de préparation et leur utilisation dans des médicaments
EP0302826A3 (fr) Procédé de préparation de composés d'amino-acides non saturés

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): CH DE FR GB LI

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: DEGUSSA-HUELS AKTIENGESELLSCHAFT

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): CH DE FR GB LI

17P Request for examination filed

Effective date: 20000408

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: DEGUSSA AG

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

17Q First examination report despatched

Effective date: 20010423

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): CH DE FR GB LI

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: CH

Ref legal event code: NV

Representative=s name: SCHMAUDER & PARTNER AG PATENTANWALTSBUERO

REG Reference to a national code

Ref country code: GB

Ref legal event code: IF02

REF Corresponds to:

Ref document number: 59705498

Country of ref document: DE

Date of ref document: 20020110

GBT Gb: translation of ep patent filed (gb section 77(6)(a)/1977)

Effective date: 20020128

ET Fr: translation filed
PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20020916

Year of fee payment: 6

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 20020918

Year of fee payment: 6

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20020919

Year of fee payment: 6

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed
PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20030331

Year of fee payment: 7

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20030416

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20030430

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20030430

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20030416

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20031231

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20041103