EP0812819A3 - Enantiomère enrichie d'un ester de l'acide malonique substitué par des restes d'hydrocarbures tertiaires et sa préparation - Google Patents

Enantiomère enrichie d'un ester de l'acide malonique substitué par des restes d'hydrocarbures tertiaires et sa préparation Download PDF

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Publication number
EP0812819A3
EP0812819A3 EP97106223A EP97106223A EP0812819A3 EP 0812819 A3 EP0812819 A3 EP 0812819A3 EP 97106223 A EP97106223 A EP 97106223A EP 97106223 A EP97106223 A EP 97106223A EP 0812819 A3 EP0812819 A3 EP 0812819A3
Authority
EP
European Patent Office
Prior art keywords
malonic acid
preparation
hydrocarbonrest
enantiomer
acid ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP97106223A
Other languages
German (de)
English (en)
Other versions
EP0812819B1 (fr
EP0812819A2 (fr
Inventor
Udo Dr. Jegelka
Wolfgang Dr. Kleemiss
Bruno Dr. Klotz--Berendes
Marcel Dr. Feld
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Huels AG
Degussa Huels AG
Chemische Werke Huels AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Huels AG, Degussa Huels AG, Chemische Werke Huels AG filed Critical Huels AG
Publication of EP0812819A2 publication Critical patent/EP0812819A2/fr
Publication of EP0812819A3 publication Critical patent/EP0812819A3/fr
Application granted granted Critical
Publication of EP0812819B1 publication Critical patent/EP0812819B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/34—Esters of acyclic saturated polycarboxylic acids having an esterified carboxyl group bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP97106223A 1996-06-10 1997-04-16 Enantiomère enrichie d'un ester de l'acide malonique substitué par des restes d'hydrocarbures tertiaires et sa préparation Expired - Lifetime EP0812819B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19623142A DE19623142A1 (de) 1996-06-10 1996-06-10 Enantiomerenangereicherte, durch einen tertiären Kohlenwasserstoffrest substituierte Malonsäuremonoester sowie deren Herstellung
DE19623142 1996-06-10

Publications (3)

Publication Number Publication Date
EP0812819A2 EP0812819A2 (fr) 1997-12-17
EP0812819A3 true EP0812819A3 (fr) 1999-11-03
EP0812819B1 EP0812819B1 (fr) 2001-11-28

Family

ID=7796548

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97106223A Expired - Lifetime EP0812819B1 (fr) 1996-06-10 1997-04-16 Enantiomère enrichie d'un ester de l'acide malonique substitué par des restes d'hydrocarbures tertiaires et sa préparation

Country Status (4)

Country Link
US (1) US6613934B1 (fr)
EP (1) EP0812819B1 (fr)
JP (1) JPH1081648A (fr)
DE (2) DE19623142A1 (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022725A1 (es) * 1999-02-26 2002-09-04 Schering Corp Hidrolisis enzimatica enantioselectiva de esteres 3-sustituidos de acido glutarico
AP2466A (en) * 2004-06-21 2012-09-17 Warner Lambert Co Preparation of pregabalin and related compounds
WO2006128590A1 (fr) * 2005-05-31 2006-12-07 Dsm Ip Assets B.V. Hydrolases, acides nucleiques codant pour ces hydrolases et methodes de fabrication et d'utilisation
JP2014503474A (ja) 2010-10-20 2014-02-13 バイオフオーミツクス・インコーポレイテツド エネルギー移動手段の存在下での急速回収を用いたメチレンマロナートの合成
US9279022B1 (en) 2014-09-08 2016-03-08 Sirrus, Inc. Solution polymers including one or more 1,1-disubstituted alkene compounds, solution polymerization methods, and polymer compositions
US10414839B2 (en) 2010-10-20 2019-09-17 Sirrus, Inc. Polymers including a methylene beta-ketoester and products formed therefrom
US9249265B1 (en) 2014-09-08 2016-02-02 Sirrus, Inc. Emulsion polymers including one or more 1,1-disubstituted alkene compounds, emulsion methods, and polymer compositions
US9828324B2 (en) 2010-10-20 2017-11-28 Sirrus, Inc. Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom
EP2768917B1 (fr) 2011-10-19 2018-12-05 Sirrus, Inc. Monomères multifonctionnels et leurs procédés de production
JP6345644B2 (ja) 2012-03-30 2018-06-20 シラス・インコーポレイテッド インク配合物およびコーティング配合物ならびにこれらを作製するための重合性の系
US10913875B2 (en) 2012-03-30 2021-02-09 Sirrus, Inc. Composite and laminate articles and polymerizable systems for producing the same
CA2869108A1 (fr) 2012-03-30 2013-10-03 Bioformix Inc. Procedes d'activation de compositions polymerisables, systemes polymerisables, et produits formes
WO2013181600A2 (fr) 2012-06-01 2013-12-05 Bioformix Inc. Matériau optique et objets formés à partir de celui-ci
CN105008438B (zh) 2012-11-16 2019-10-22 拜奥福米克斯公司 塑料粘结体系及方法
WO2014085570A1 (fr) 2012-11-30 2014-06-05 Bioformix, Inc. Compositions composites pour des applications électroniques
WO2014110388A1 (fr) 2013-01-11 2014-07-17 Bioformix Inc. Procédé d'obtention de malonate de méthylène par l'intermédiaire de la voie du bis(hydroxyméthyl)malonate
US9416091B1 (en) 2015-02-04 2016-08-16 Sirrus, Inc. Catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US9315597B2 (en) 2014-09-08 2016-04-19 Sirrus, Inc. Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures
US10501400B2 (en) 2015-02-04 2019-12-10 Sirrus, Inc. Heterogeneous catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US9334430B1 (en) 2015-05-29 2016-05-10 Sirrus, Inc. Encapsulated polymerization initiators, polymerization systems and methods using the same
US9217098B1 (en) 2015-06-01 2015-12-22 Sirrus, Inc. Electroinitiated polymerization of compositions having a 1,1-disubstituted alkene compound
AU2016342027B2 (en) 2015-10-23 2021-05-13 Navitor Pharmaceuticals, Inc. Modulators of Sestrin-GATOR2 interaction and uses thereof
US9518001B1 (en) 2016-05-13 2016-12-13 Sirrus, Inc. High purity 1,1-dicarbonyl substituted-1-alkenes and methods for their preparation
US9617377B1 (en) 2016-06-03 2017-04-11 Sirrus, Inc. Polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
US9567475B1 (en) 2016-06-03 2017-02-14 Sirrus, Inc. Coatings containing polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
US10428177B2 (en) 2016-06-03 2019-10-01 Sirrus, Inc. Water absorbing or water soluble polymers, intermediate compounds, and methods thereof
US10196481B2 (en) 2016-06-03 2019-02-05 Sirrus, Inc. Polymer and other compounds functionalized with terminal 1,1-disubstituted alkene monomer(s) and methods thereof
TWI776886B (zh) 2017-04-26 2022-09-11 美商奈維特製藥公司 Sestrin-gator2交互作用之調節劑及其用途
CN110656134B (zh) * 2018-06-29 2023-03-28 广东东阳光药业有限公司 一种单酯的制备方法
JP7644002B2 (ja) 2018-10-24 2025-03-11 ナビター ファーマシューティカルズ， インコーポレイテッド 多形化合物およびその使用
EP4051259A4 (fr) 2019-11-01 2023-11-22 Navitor Pharmaceuticals, Inc. Méthodes de traitement à l'aide d'un modulateur de mtorc1

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0050799A1 (fr) * 1980-10-21 1982-05-05 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Procédés de production de di-esters alcoyliques et de mono-esters alcoyliques optiquement actifs de l'acide 3-amino-glutarique
SE453599B (sv) * 1985-04-26 1988-02-15 Karl Hult Enantiomert rena monoestrar av malonsyra och ett enzymatiskt forfarande liksom mellanprodukter for framstellning derav

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2152379T3 (es) * 1993-12-21 2001-02-01 Boehringer Ingelheim Pharma Dihidropiridinas condensadas y su utilizacion para la produccion de preparados farmaceuticos.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0050799A1 (fr) * 1980-10-21 1982-05-05 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Procédés de production de di-esters alcoyliques et de mono-esters alcoyliques optiquement actifs de l'acide 3-amino-glutarique
SE453599B (sv) * 1985-04-26 1988-02-15 Karl Hult Enantiomert rena monoestrar av malonsyra och ett enzymatiskt forfarande liksom mellanprodukter for framstellning derav

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 8224, Derwent World Patents Index; Class B05, AN 82-004555, XP002114667 *
KITAZUME, TOMOYA ET AL: "Microbial approach to the practical monofluorinated chiral synthons", J. ORG. CHEM. (1986), 51(7), 1003-6, XP002114665 *
KLOTZ-BERENDES, BRUNO ET AL: "Enzymic synthesis of optically active monoalkylated malonic monoesters", TETRAHEDRON: ASYMMETRY (1997), 8(11), 1821-1823, XP002114677 *
REGIS LEUNG-TOUNG ET AL.: "Flash vacuum pyrolysis of tert-butyl beta-ketoesters:Sterically protected alpha oxoketenes", TETRAHEDRON., vol. 48, no. 36, 1992, OXFORD GB, pages 7641 - 7654, XP002114666 *

Also Published As

Publication number Publication date
DE59705498D1 (de) 2002-01-10
DE19623142A1 (de) 1997-12-11
EP0812819B1 (fr) 2001-11-28
EP0812819A2 (fr) 1997-12-17
JPH1081648A (ja) 1998-03-31
US6613934B1 (en) 2003-09-02

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