EP0814845A4 - Behandlungsmethode gegen tumoren bestehend aus transduktion mit negativ-selektiven markern, anwendung interaktiver agenzien und anschliessender bestrahlung - Google Patents

Behandlungsmethode gegen tumoren bestehend aus transduktion mit negativ-selektiven markern, anwendung interaktiver agenzien und anschliessender bestrahlung

Info

Publication number
EP0814845A4
EP0814845A4 EP96902097A EP96902097A EP0814845A4 EP 0814845 A4 EP0814845 A4 EP 0814845A4 EP 96902097 A EP96902097 A EP 96902097A EP 96902097 A EP96902097 A EP 96902097A EP 0814845 A4 EP0814845 A4 EP 0814845A4
Authority
EP
European Patent Office
Prior art keywords
transduction
tumors
radiation
treatment
application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96902097A
Other languages
English (en)
French (fr)
Other versions
EP0814845A1 (de
Inventor
Jae Ho Kim
Svend Freytag
San Hie Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Henry Ford Hospital
Original Assignee
Henry Ford Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Henry Ford Hospital filed Critical Henry Ford Hospital
Publication of EP0814845A1 publication Critical patent/EP0814845A1/de
Publication of EP0814845A4 publication Critical patent/EP0814845A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
EP96902097A 1995-01-04 1996-01-04 Behandlungsmethode gegen tumoren bestehend aus transduktion mit negativ-selektiven markern, anwendung interaktiver agenzien und anschliessender bestrahlung Withdrawn EP0814845A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36860295A 1995-01-04 1995-01-04
US368602 1995-01-04
PCT/US1996/000148 WO1996020733A1 (en) 1995-01-04 1996-01-04 Treatment of tumors by transduction with negative selective markers, application of interaction agents and subsequent radiation exposure

Publications (2)

Publication Number Publication Date
EP0814845A1 EP0814845A1 (de) 1998-01-07
EP0814845A4 true EP0814845A4 (de) 2001-08-08

Family

ID=23451926

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96902097A Withdrawn EP0814845A4 (de) 1995-01-04 1996-01-04 Behandlungsmethode gegen tumoren bestehend aus transduktion mit negativ-selektiven markern, anwendung interaktiver agenzien und anschliessender bestrahlung

Country Status (5)

Country Link
EP (1) EP0814845A4 (de)
JP (1) JPH10511853A (de)
AU (1) AU714896B2 (de)
CA (1) CA2207974A1 (de)
WO (1) WO1996020733A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9924981D0 (en) 1999-10-21 1999-12-22 Univ Manchester Gene therapy
GB2397063A (en) * 1999-10-21 2004-07-14 Cedars Sinai Medical Center A medicament comprising a cytotoxic pro drug activated by HSV TK
EP1786474B1 (de) 2004-08-12 2011-06-01 Cedars-Sinai Medical Center Kombinierte gentherapie zur behandlung makroskopischer glioma
US8883493B2 (en) 2007-01-30 2014-11-11 Cedars-Sinai Medical Center Adenoviral vector comprising herpes simplex virus type 1 thymidine kinase and a transgene for increasing the expression of the transgene

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996026743A1 (en) * 1995-03-01 1996-09-06 Human Gene Therapy Research Institute Radiation enhanced gene therapy for treatment of tumors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996026743A1 (en) * 1995-03-01 1996-09-06 Human Gene Therapy Research Institute Radiation enhanced gene therapy for treatment of tumors

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CULVER K W ET AL: "IN VIVO GENE TRANSFER WITH RETROVIRAL VECTOR-PRODUCER CELLS FOR TREATMENT OF EXPERIMENTAL BRAIN TUMORS", SCIENCE,US,AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, vol. 256, 12 June 1992 (1992-06-12), pages 1550 - 1552, XP002045618, ISSN: 0036-8075 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1995, KIM JAE HO ET AL: "Selective enhancement of radiation response of herpes simplex virus thymidine kinase transduced 9L gliosarcoma cells in vitro and in vivo by antiviral agents.", XP002168823, Database accession no. PREV199698596634 *
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, vol. 33, no. 4, November 1995 (1995-11-01), pages 861 - 868, ISSN: 0360-3016 *
KIM J H ET AL: "Use of retroviral gene transfer and antiviral agents as radiation sensitizers in cultured brain tumor cells.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, vol. 35, 1994, 85th Annual Meeting of the American Association for Cancer Research;San Francisco, California, USA; April 10-13, 1994, 1994, pages 637, XP002168822, ISSN: 0197-016X *
KIM, JAE HO ET AL: "Selective enhancement by an antiviral agent of the radiation -induced cell killing of human glioma cells transduced with HSV-tk gene", CANCER RES. (1994), 54(23), 6053-6, XP002168821 *
See also references of WO9620733A1 *

Also Published As

Publication number Publication date
EP0814845A1 (de) 1998-01-07
AU714896B2 (en) 2000-01-13
WO1996020733A1 (en) 1996-07-11
CA2207974A1 (en) 1996-07-11
JPH10511853A (ja) 1998-11-17
AU4654096A (en) 1996-07-24

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Legal Events

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Ipc: A61K 48/00 20060101AFI20110923BHEP