EP0817630A4 - Inhibitoren der farnesyl-protein transferase - Google Patents

Inhibitoren der farnesyl-protein transferase

Info

Publication number
EP0817630A4
EP0817630A4 EP96910528A EP96910528A EP0817630A4 EP 0817630 A4 EP0817630 A4 EP 0817630A4 EP 96910528 A EP96910528 A EP 96910528A EP 96910528 A EP96910528 A EP 96910528A EP 0817630 A4 EP0817630 A4 EP 0817630A4
Authority
EP
European Patent Office
Prior art keywords
farnesyl
protein transferase
transferase inhibitors
inhibitors
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96910528A
Other languages
English (en)
French (fr)
Other versions
EP0817630A1 (de
Inventor
Terrence M Ciccarone
Theresa M Williams
Suzanne C Mactough
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/412,830 external-priority patent/US5534537A/en
Priority claimed from US08/413,137 external-priority patent/US5578629A/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0817630A1 publication Critical patent/EP0817630A1/de
Publication of EP0817630A4 publication Critical patent/EP0817630A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP96910528A 1995-03-29 1996-03-25 Inhibitoren der farnesyl-protein transferase Withdrawn EP0817630A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US413137 1989-09-27
US08/412,830 US5534537A (en) 1995-03-29 1995-03-29 Prodrugs of inhibitors of farnesyl-protein transferase
US412830 1995-03-29
US08/413,137 US5578629A (en) 1995-03-29 1995-03-29 Benzamide-containing inhibitors of farnesyl-protein transferase
PCT/US1996/003980 WO1996030015A1 (en) 1995-03-29 1996-03-25 Inhibitors of farnesyl-protein transferase

Publications (2)

Publication Number Publication Date
EP0817630A1 EP0817630A1 (de) 1998-01-14
EP0817630A4 true EP0817630A4 (de) 1999-01-27

Family

ID=27021935

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96910528A Withdrawn EP0817630A4 (de) 1995-03-29 1996-03-25 Inhibitoren der farnesyl-protein transferase

Country Status (5)

Country Link
EP (1) EP0817630A4 (de)
JP (1) JPH11503419A (de)
AU (1) AU706008B2 (de)
CA (1) CA2216564A1 (de)
WO (1) WO1996030015A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221865B1 (en) 1995-11-06 2001-04-24 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
US6693123B2 (en) 1995-11-06 2004-02-17 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
US6204293B1 (en) 1995-11-06 2001-03-20 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
US6310095B1 (en) 1995-11-06 2001-10-30 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
JP2000504014A (ja) * 1996-01-30 2000-04-04 メルク エンド カンパニー インコーポレーテッド ファルネシル―タンパク質転移酵素の阻害剤
JP2000507589A (ja) * 1996-04-03 2000-06-20 メルク エンド カンパニー インコーポレーテッド ファルネシル―タンパク質転移酵素の阻害剤
AU717298B2 (en) * 1996-04-03 2000-03-23 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
DE19613691A1 (de) * 1996-04-05 1997-10-09 Boehringer Ingelheim Int Arzneimittel für die Behandlung von Tumorerkrankungen
JP2002518985A (ja) * 1997-05-07 2002-06-25 ユニバーシティー・オブ・ピッツバーグ タンパク質イソプレニルトランスフェラーゼの阻害剤
FR2766819B1 (fr) * 1997-07-31 1999-10-29 Pf Medicament Nouvelles sulfonamides derivees d'anilines substituees utiles comme medicaments
WO1999020612A1 (en) * 1997-10-22 1999-04-29 Astrazeneca Uk Limited Imidazole derivatives and their use as farnesyl protein transferase inhibitors
DK1025088T3 (da) 1997-10-22 2001-11-12 Astrazeneca Ab Imidazolderivater og deres anvendelse som farnesylproteintransferaseinhibitorer
AU1872900A (en) * 1998-12-23 2000-07-31 Astrazeneca Ab Chemical compounds
GB9930318D0 (en) 1999-12-22 2000-02-09 Zeneca Ltd Novel compounds
HN2001000008A (es) 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
JP2008528604A (ja) 2005-01-25 2008-07-31 グラクソ グループ リミテッド 抗菌剤

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8827308D0 (en) * 1988-11-23 1988-12-29 British Bio Technology Compounds

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CICCARONE, T. M. ET AL.: "Non-Thiol 3-Aminomethylbenzamide Inhibitors of Farnesyl-Protein Transferase", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, no. 9, 1999, pages 1991 - 1996 *
See also references of WO9630015A1 *
VOGT, A. ET AL.: "A Non-peptide Mimetic of Ras-CAAX : ...", THE JOURNAL OF BOILOGICAL CHEMISTRY, vol. 270, no. 2, 13 January 1995 (1995-01-13), pages 660 - 664, XP002080788 *
YIMIN, Q. ET AL.: "Peptidomimetic Inhibitors of P21RAS Farnesyltransferase...", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 4, no. 21, 1994, pages 2579 - 2584, XP002080787 *

Also Published As

Publication number Publication date
AU706008B2 (en) 1999-06-03
EP0817630A1 (de) 1998-01-14
CA2216564A1 (en) 1996-10-03
AU5370196A (en) 1996-10-16
JPH11503419A (ja) 1999-03-26
WO1996030015A1 (en) 1996-10-03

Similar Documents

Publication Publication Date Title
EP0817629A4 (de) Farnesylprotein transferase inhibitoren
EP0862435A4 (de) Inhibitoren der farnesyl-protein-transferase
EP1003374A4 (de) Inhibitoren von farnesyl-protein-transferase
EP0725650A4 (de) Inhibitoren der farnesyl-proteintransferase
EP0833633A4 (de) Inhibitoren der farnesyl-protein-transferase
EP0618221A3 (de) Heterozyklische Farnesyl-Protein-Transferase-Inhibitoren.
FI973492L (fi) NO-syntaasin estäjät
EP0841919A4 (de) Inhibitoren der farnesyl-protein transferase
EP0794789A4 (de) Prenyltransferase inhibitoren
FI963597A0 (fi) Isoprenyylitransferaasi-inhibiittoreita
EP0891350A4 (de) Inhibioten der farnesylprotein-transferase
PT858464E (pt) Inibidores de trombina
GB9604311D0 (en) Inhibitors of farnesyl-protein transferase
EP0777475A4 (de) Inhibitoren der farnesyl-protein-transferase
EP0891349A4 (de) Inhibitoren von farnesylprotein-transferase
EP1045844A4 (de) Inhibitoren von farnesyl-protein-transferase
EP0904080A4 (de) Inhibitoren der farnesyl-protein transferase
EP0817630A4 (de) Inhibitoren der farnesyl-protein transferase
EP0783305A4 (de) Inhibitoren der farnesyl-protein-transferase
EP0812203A4 (de) Inhibitoren der geranylgeranyl-protein transferase
EP0760813A4 (de) Inhibitoren von farnesyl-protein-transferase
EP0891335A4 (de) Inhibitoren von farnesylprotein-transferase
PT863916E (pt) Tripeptidos de polifluoroalquil triptofano inibidores de trombina
EP0891353A4 (de) Farnesyl-protein transferase inhibitoren
EP0787123A4 (de) Farnesyl-protein transferase inhibitoren

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19971029

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 19981208

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

17Q First examination report despatched

Effective date: 19991203

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20010323