EP0825870A4 - Modulation de sequences cytokiniques de clones de lymphocytes t humains autoreactifs - Google Patents

Modulation de sequences cytokiniques de clones de lymphocytes t humains autoreactifs

Info

Publication number
EP0825870A4
EP0825870A4 EP96920109A EP96920109A EP0825870A4 EP 0825870 A4 EP0825870 A4 EP 0825870A4 EP 96920109 A EP96920109 A EP 96920109A EP 96920109 A EP96920109 A EP 96920109A EP 0825870 A4 EP0825870 A4 EP 0825870A4
Authority
EP
European Patent Office
Prior art keywords
cytokinic
sequences
modulation
reactive
self
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96920109A
Other languages
German (de)
English (en)
Other versions
EP0825870A1 (fr
Inventor
David A Hafler
Howard L Weiner
Vijay K Kuchroo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brigham and Womens Hospital Inc
Original Assignee
Brigham and Womens Hospital Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham and Womens Hospital Inc filed Critical Brigham and Womens Hospital Inc
Publication of EP0825870A1 publication Critical patent/EP0825870A1/fr
Publication of EP0825870A4 publication Critical patent/EP0825870A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Rehabilitation Therapy (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP96920109A 1995-04-20 1996-04-19 Modulation de sequences cytokiniques de clones de lymphocytes t humains autoreactifs Withdrawn EP0825870A4 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US42678495A 1995-04-20 1995-04-20
US426784 1995-04-20
US54545695A 1995-10-19 1995-10-19
US545456 1995-10-19
US54657195A 1995-10-20 1995-10-20
PCT/US1996/005783 WO1996032957A1 (fr) 1995-04-20 1996-04-19 Modulation de sequences cytokiniques de clones de lymphocytes t humains autoreactifs
US546571 2006-10-12

Publications (2)

Publication Number Publication Date
EP0825870A1 EP0825870A1 (fr) 1998-03-04
EP0825870A4 true EP0825870A4 (fr) 2002-09-25

Family

ID=27411523

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96920109A Withdrawn EP0825870A4 (fr) 1995-04-20 1996-04-19 Modulation de sequences cytokiniques de clones de lymphocytes t humains autoreactifs

Country Status (5)

Country Link
EP (1) EP0825870A4 (fr)
AU (1) AU5851196A (fr)
CA (1) CA2216936A1 (fr)
IL (1) IL117976A0 (fr)
WO (1) WO1996032957A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU711303B2 (en) * 1996-03-13 1999-10-07 Shionogi & Co., Ltd. Human T cell clones specific for rheumatoid arthritis
DK1918298T3 (da) * 2000-08-21 2010-11-29 Apitope Technology Bristol Ltd Peptid
WO2003063759A2 (fr) 2002-01-31 2003-08-07 Peptor Ltd. Peptides de hsp et analogues pour la modulation des reponses immunitaires par l'intermediaire des cellules presentant l'antigene
US20050272097A1 (en) * 2004-02-18 2005-12-08 Emanuel Calenoff Methods and compositions for detecting and treating autoimmune diseases
GB201300683D0 (en) * 2013-01-15 2013-02-27 Apitope Int Nv Peptide

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993025661A1 (fr) * 1992-06-10 1993-12-23 President And Fellows Of Harvard College Clones heterogenes de cellules t specifiques contre le peptide proteolipidique 139-151

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993025661A1 (fr) * 1992-06-10 1993-12-23 President And Fellows Of Harvard College Clones heterogenes de cellules t specifiques contre le peptide proteolipidique 139-151

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MCRAE, BRADFOR L. ET AL: "Fine specificity of CD4+ T cell responses to the dominant encephalitogeni PLP 139-151 peptide in SJL/J mice", XP002206878, retrieved from STN Database accession no. 121:132104 CA *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; NICHOLSON, LINDSAY B. ET AL: "An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis", XP002206877, retrieved from STN Database accession no. 123:312138 CA *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; VAN DER VEEN, ROEL C. ET AL: "Fine-specificity differences in the recognition of an encephalitogenic peptide by T helper 1 and 2 cells", XP002206879, retrieved from STN Database accession no. 120:215143 CA *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; WUCHERPFENNIG, KAI W. ET AL: "Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones", XP002206894, retrieved from STN Database accession no. 120:104298 CA *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; KHOURY S J ET AL: "Acquired tolerance to experimental autoimmune encephalomyelitis by intrathymic injection of myelin basic protein or its major encephalitogenic peptide.", XP002206881, retrieved from STN Database accession no. 93340632 *
IMMUNITY (1995), 3(4), 397-405, 1995 *
J. EXP. MED. (1994), 179(1), 279-90, 1994 *
J. NEUROIMMUNOL. (1993), 48(2), 221-6, 1993 *
JOURNAL OF EXPERIMENTAL MEDICINE, (1993 AUG 1) 178 (2) 559-66. *
NEUROCHEM. RES. (1994), 19(8), 997-1004, 1994 *
See also references of WO9632957A1 *
V K KUCHROO ET AL.: "A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse cell repertoire", JOURNAL OF IMMUNOLOGY, vol. 153, no. 7, 1994, BALTIMORE US, pages 3326 - 3336, XP002206876 *

Also Published As

Publication number Publication date
WO1996032957A1 (fr) 1996-10-24
EP0825870A1 (fr) 1998-03-04
AU5851196A (en) 1996-11-07
IL117976A0 (en) 1996-08-04
CA2216936A1 (fr) 1996-10-24

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