EP0845045A4 - Regulation de fonctions cellulaires a l'aide d'une expression ectopique de recepteurs non endogenes de signalisation de cellule - Google Patents

Regulation de fonctions cellulaires a l'aide d'une expression ectopique de recepteurs non endogenes de signalisation de cellule

Info

Publication number
EP0845045A4
EP0845045A4 EP96928135A EP96928135A EP0845045A4 EP 0845045 A4 EP0845045 A4 EP 0845045A4 EP 96928135 A EP96928135 A EP 96928135A EP 96928135 A EP96928135 A EP 96928135A EP 0845045 A4 EP0845045 A4 EP 0845045A4
Authority
EP
European Patent Office
Prior art keywords
ektopic
regulation
expression
cell signaling
cellular functions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96928135A
Other languages
German (de)
English (en)
Other versions
EP0845045A1 (fr
Inventor
Marvin C Gershengorn
Erik S Falck-Pedersen
Ronald G Crystal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cornell Research Foundation Inc
Original Assignee
Cornell Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornell Research Foundation Inc filed Critical Cornell Research Foundation Inc
Publication of EP0845045A1 publication Critical patent/EP0845045A1/fr
Publication of EP0845045A4 publication Critical patent/EP0845045A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP96928135A 1995-08-14 1996-08-12 Regulation de fonctions cellulaires a l'aide d'une expression ectopique de recepteurs non endogenes de signalisation de cellule Withdrawn EP0845045A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US225495P 1995-08-14 1995-08-14
US2254 1995-08-14
PCT/US1996/013077 WO1997007233A1 (fr) 1995-08-14 1996-08-12 Regulation de fonctions cellulaires a l'aide d'une expression ectopique de recepteurs non endogenes de signalisation de cellule

Publications (2)

Publication Number Publication Date
EP0845045A1 EP0845045A1 (fr) 1998-06-03
EP0845045A4 true EP0845045A4 (fr) 1999-11-24

Family

ID=21699924

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96928135A Withdrawn EP0845045A4 (fr) 1995-08-14 1996-08-12 Regulation de fonctions cellulaires a l'aide d'une expression ectopique de recepteurs non endogenes de signalisation de cellule

Country Status (5)

Country Link
EP (1) EP0845045A4 (fr)
JP (1) JPH11510704A (fr)
AU (1) AU716407B2 (fr)
CA (1) CA2229287A1 (fr)
WO (1) WO1997007233A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994010322A1 (fr) * 1992-10-29 1994-05-11 Board Of Regents, The University Of Texas System Transfert et ciblage du gene recepteur ldl induit par l'adenovirus
WO1994026915A1 (fr) * 1993-05-10 1994-11-24 The Regents Of The University Of Michigan Transfert de genes dans les cellules epitheliales pancreatiques et biliaires
WO1994029447A2 (fr) * 1993-06-09 1994-12-22 Medical Research Council Adn codant le recepteur humain de l'hormone liberant la thyrotrophine
WO1995016772A1 (fr) * 1993-12-14 1995-06-22 Cornell Research Foundation, Inc. Systeme d'expression du gene d'adenovirus

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166320A (en) * 1987-04-22 1992-11-24 University Of Connecticut Carrier system and method for the introduction of genes into mammalian cells
WO1989007136A2 (fr) * 1988-02-05 1989-08-10 Whitehead Institute For Biomedical Research Hepatocytes modifies et leurs utilisations
US5462856A (en) * 1990-07-19 1995-10-31 Bunsen Rush Laboratories, Inc. Methods for identifying chemicals that act as agonists or antagonists for receptors and other proteins involved in signal transduction via pathways that utilize G-proteins
US5401629A (en) * 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994010322A1 (fr) * 1992-10-29 1994-05-11 Board Of Regents, The University Of Texas System Transfert et ciblage du gene recepteur ldl induit par l'adenovirus
WO1994026915A1 (fr) * 1993-05-10 1994-11-24 The Regents Of The University Of Michigan Transfert de genes dans les cellules epitheliales pancreatiques et biliaires
WO1994029447A2 (fr) * 1993-06-09 1994-12-22 Medical Research Council Adn codant le recepteur humain de l'hormone liberant la thyrotrophine
WO1995016772A1 (fr) * 1993-12-14 1995-06-22 Cornell Research Foundation, Inc. Systeme d'expression du gene d'adenovirus

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
ATHARI A. & JUNGERMANN K.: "Direct activation by prostaglandin F2a but not thromboxane a2 of glycogenolysis via an increase in inositol 1,4,5-triphosphate in rat hepatocytes.", BIOCHEM. BIOPHYS. RES. COMM., vol. 163, no. 3, 29 September 1989 (1989-09-29), pages 1235 - 1242, XP002105455 *
DIPALMA J.R. ET AL., EDS.: "Basic pharmacology in medicine, 4th ed.", 1994, MEDICAL SURVEILLANCE IN., WEST CHESTER, PA, XP002105459 *
FALCK-PEDERSEN E. ET AL.: "Expression of thyrotropin-releasing hormone receptors by adenovirus-mediated gene transfer reveals that thyrotropin releasing hormone desensitization is cell-specific.", MOLECULAR PHARMACOLOGY, vol. 45, no. 4, April 1994 (1994-04-01), pages 684 - 689, XP002105449 *
GANDHI C.R. ET AL.: "Endothelin, a potent peptide agonist in the liver.", J. BIOL. CHEM., vol. 265, no. 29, 15 October 1990 (1990-10-15), pages 17432 - 17435, XP002105452 *
GERSHENGORN M.C. ET AL.: "Thyrotropin-releasing hormone (TRH) receptor number determines the size of the TRH-responsive phosphoinositide pool.", J. BIOL. CHEM., vol. 269, no. 9, 4 March 1994 (1994-03-04), pages 6779 - 6783, XP002105450 *
HEINFLINK M. ET AL.: "Thyrotropin-releasing hormone receptor activation does not elevate intracellular cyclic adenosine 3'5'-monophosphate in cells expressing high levels of receptors", J. CLIN. ENDOCRIN. METAB., vol. 79, no. 2, August 1994 (1994-08-01), pages 650 - 652, XP002105451 *
MINE T. ET AL.: "Calcium rather than cyclic AMP is an intracellular messenger of parathyroid hormone action on glycogen metabolism in rat hepatocytes.", BIOCHEM. J., vol. 258, 15 March 1989 (1989-03-15), pages 889 - 894, XP002105456 *
See also references of WO9707233A1 *
TOHKIN M. ET AL.: "Mastoparan, a peptide toxin from wasp venom, stimulates glycogenolysis mediated by an increase of the cytosolic Ca++ concentration but not by an increase of cAMP in rat hepatocytes", FEBS LETTERS, vol. 260, no. 2, January 1990 (1990-01-01), pages 179 - 182, XP002105454 *
WAKELAM M.J.O. ET AL.: "Activation of two signal-transduction systems in hepatocytes by glucagon.", NATURE, vol. 323, no. 4, 4 September 1986 (1986-09-04), pages 68 - 71, XP002105453 *
WOLFF G. ET AL.: "Ectopic expression of thyrptropin releasing hormone (TRH) receptors in liver modulates organ function to regulate blood glucose by TRH.", NATURE GENETICS, vol. 12, no. 3, March 1996 (1996-03-01), pages 274 - 279, XP002105457 *

Also Published As

Publication number Publication date
CA2229287A1 (fr) 1997-02-27
EP0845045A1 (fr) 1998-06-03
WO1997007233A1 (fr) 1997-02-27
JPH11510704A (ja) 1999-09-21
AU716407B2 (en) 2000-02-24
AU6772196A (en) 1997-03-12

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