EP0853479A4 - ANTAGONISTES DU RECEPTEUR ADRENERGIQUE ALPHA 1b - Google Patents

ANTAGONISTES DU RECEPTEUR ADRENERGIQUE ALPHA 1b

Info

Publication number
EP0853479A4
EP0853479A4 EP96933093A EP96933093A EP0853479A4 EP 0853479 A4 EP0853479 A4 EP 0853479A4 EP 96933093 A EP96933093 A EP 96933093A EP 96933093 A EP96933093 A EP 96933093A EP 0853479 A4 EP0853479 A4 EP 0853479A4
Authority
EP
European Patent Office
Prior art keywords
alpha
receptor antagonists
adrenergic receptor
adrenergic
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96933093A
Other languages
German (de)
English (en)
Other versions
EP0853479A1 (fr
Inventor
Mark G Bock
William C Lumma
Michael A Patane
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9604288.2A external-priority patent/GB9604288D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0853479A1 publication Critical patent/EP0853479A1/fr
Publication of EP0853479A4 publication Critical patent/EP0853479A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP96933093A 1995-09-29 1996-09-24 ANTAGONISTES DU RECEPTEUR ADRENERGIQUE ALPHA 1b Withdrawn EP0853479A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US450195P 1995-09-29 1995-09-29
GBGB9604288.2A GB9604288D0 (en) 1996-02-29 1996-02-29 Alpha 1b adrenergic receptor antagonists
GB9604288 1996-02-29
PCT/US1996/015223 WO1997011698A1 (fr) 1995-09-29 1996-09-24 ANTAGONISTES DU RECEPTEUR ADRENERGIQUE ALPHA 1b
US4501P 1997-04-25

Publications (2)

Publication Number Publication Date
EP0853479A1 EP0853479A1 (fr) 1998-07-22
EP0853479A4 true EP0853479A4 (fr) 2001-04-11

Family

ID=26308827

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96933093A Withdrawn EP0853479A4 (fr) 1995-09-29 1996-09-24 ANTAGONISTES DU RECEPTEUR ADRENERGIQUE ALPHA 1b

Country Status (4)

Country Link
EP (1) EP0853479A4 (fr)
JP (1) JPH11512710A (fr)
CA (1) CA2232138A1 (fr)
WO (1) WO1997011698A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1312310B1 (it) * 1999-05-07 2002-04-15 Recordati Ind Chimica E Farma Uso di antagonisti selettivi del recettore adrenergico a 1b per ilmiglioramento della disfunzione sessuale
ATE309240T1 (de) 2000-08-31 2005-11-15 Hoffmann La Roche Chinazolin-derivate als alpha-1 adrenerge antagonisten
ES2345993T3 (es) 2004-09-14 2010-10-07 The Regents Of The University Of Colorado, A Body Corporate Metodo para el tratamiento con bucindolol basado en direccionamiento genetico.
EP2924033B1 (fr) * 2012-11-26 2019-02-27 Shenyang Haiwang Biotechnology Co., Ltd Utilisation d'hétérocycles azotés pentagonaux de type pipérazine ou pipéridine
JP6602181B2 (ja) * 2015-11-30 2019-11-06 公立大学法人横浜市立大学 血圧制御異常の新規治療法
CN109414441A (zh) 2016-06-27 2019-03-01 艾其林医药公司 治疗医学障碍的喹唑啉和吲哚化合物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4026894A (en) * 1975-10-14 1977-05-31 Abbott Laboratories Antihypertensive agents
US4101548A (en) * 1977-02-22 1978-07-18 Bristol-Myers Company 1,2,3-Thiadiazole amides
GB2171977A (en) * 1985-03-05 1986-09-10 Emi Plc Thorn Gripper

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5793977A (en) * 1980-11-26 1982-06-11 Sankyo Co Ltd Acylaminoquinazoline derivative and its preparation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4026894A (en) * 1975-10-14 1977-05-31 Abbott Laboratories Antihypertensive agents
US4101548A (en) * 1977-02-22 1978-07-18 Bristol-Myers Company 1,2,3-Thiadiazole amides
GB2171977A (en) * 1985-03-05 1986-09-10 Emi Plc Thorn Gripper

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
I.TAKAYANAGI, F.KONNO, H.ARAI, K. CHIMOTO AND T. KITADA: "Newly synthesized alpha1-adrenoceptor blockers (SM911 and SM2470) and characterization of alpha-adrenoceptors in rat aortic strips, rat vas deferens preparations and rabbit aortic strips", GEN.PHARMACOL., vol. 16, no. 6, 1985, pages 613 - 615, XP000973937 *
See also references of WO9711698A1 *
VALERIE A. ALABASTER, SIMON F.CAMPBELL, JOHN C. DANILEWICZ, COLIN W.GREENGRASS, AND RHONA M. PLEWS: "2,4-Diamino-6,7-dimethoxyquinazolines. 2. 2-(4-Carbamoylpiperidino) Derivatives as alpha1-Adrenoceptor Antagonists and Antihypertensive Agents", J.MED.CHEM., vol. 30, 1987, pages 999 - 1003, XP002159406 *

Also Published As

Publication number Publication date
JPH11512710A (ja) 1999-11-02
EP0853479A1 (fr) 1998-07-22
CA2232138A1 (fr) 1997-04-03
WO1997011698A1 (fr) 1997-04-03

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