EP0855911A4 - Namenamicin, ein endiyn-antitumor-antibiotikum aus der meeresascidiacea polysyncraton lithostrotum - Google Patents

Namenamicin, ein endiyn-antitumor-antibiotikum aus der meeresascidiacea polysyncraton lithostrotum

Info

Publication number: EP0855911A4
Authority: EP; European Patent Office
Prior art keywords: namenamicin; antitumor antibiotic; enediyne antitumor; polysyncraton; lithostrotum
Prior art date: 1995-10-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP96936663A

Other languages

English (en)

French (fr)

Other versions

EP0855911A1 (de

Inventor

Chris M Ireland

William M Maiese

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Wyeth LLC

University of Utah Research Foundation Inc

Original Assignee

Wyeth LLC

University of Utah Research Foundation Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-10-20

Filing date

1996-10-18

Publication date

1998-10-14

1996-10-18 Application filed by Wyeth LLC, University of Utah Research Foundation Inc filed Critical Wyeth LLC

1998-08-05 Publication of EP0855911A1 publication Critical patent/EP0855911A1/de

1998-10-14 Publication of EP0855911A4 publication Critical patent/EP0855911A4/de

Status Withdrawn legal-status Critical Current

Links

241000827422 Polysyncraton Species 0.000 title 1
239000003972 antineoplastic antibiotic Substances 0.000 title 1
PYODOXNMJUJHHR-UHFFFAOYSA-N namenamicin Natural products O1CC(NC(C)C)C(OC)CC1OC1C(O)C(SC)(C(CO)OC2OC(C)C(SC)C(O)C2)C(C)OC1OC1C(C2=CCSSSC)=C(NC(=O)OC)C(=O)CC2(O)C#CC=CC#C1 PYODOXNMJUJHHR-UHFFFAOYSA-N 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Oncology (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Communicable Diseases (AREA)
Microbiology (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EP96936663A 1995-10-20 1996-10-18 Namenamicin, ein endiyn-antitumor-antibiotikum aus der meeresascidiacea polysyncraton lithostrotum Withdrawn EP0855911A4 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US575695P	1995-10-20	1995-10-20
US5756P		1995-10-20
PCT/US1996/016689 WO1997014421A1 (en)	1995-10-20	1996-10-18	Namenamicin, an enediyne antitumor antibiotic from the marine ascidian polysyncraton lithostrotum

Publications (2)

Publication Number	Publication Date
EP0855911A1 EP0855911A1 (de)	1998-08-05
EP0855911A4 true EP0855911A4 (de)	1998-10-14

Family

ID=21717578

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP96936663A Withdrawn EP0855911A4 (de)	1995-10-20	1996-10-18	Namenamicin, ein endiyn-antitumor-antibiotikum aus der meeresascidiacea polysyncraton lithostrotum

Country Status (3)

Country	Link
EP (1)	EP0855911A4 (de)
JP (1)	JPH11513690A (de)
WO (1)	WO1997014421A1 (de)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5079233A (en) *	1987-01-30	1992-01-07	American Cyanamid Company	N-acyl derivatives of the LL-E33288 antitumor antibiotics, composition and methods for using the same
US5037651A (en) *	1987-01-30	1991-08-06	American Cyanamid Company	Dihydro derivatives of LL-E33288 antibiotics
US4996305A (en) *	1988-02-29	1991-02-26	American Cyanamid Company	Process for producing the antibiotic and antitumor agents LL-E33288.epsilon.ε-Br

1996
- 1996-10-18 EP EP96936663A patent/EP0855911A4/de not_active Withdrawn
- 1996-10-18 WO PCT/US1996/016689 patent/WO1997014421A1/en not_active Ceased
- 1996-10-18 JP JP9516021A patent/JPH11513690A/ja active Pending

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO9714421A1 *

Also Published As

Publication number	Publication date
EP0855911A1 (de)	1998-08-05
WO1997014421A1 (en)	1997-04-24
JPH11513690A (ja)	1999-11-24

Legal Events

Date	Code	Title	Description
1998-06-19	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1998-08-05	17P	Request for examination filed	Effective date: 19980427
1998-08-05	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
1998-10-14	A4	Supplementary search report drawn up and despatched	Effective date: 19980831
1998-10-14	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
2000-09-01	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2000-10-18	18D	Application deemed to be withdrawn	Effective date: 20000503

Publication	Publication Date	Title
EP0606610A3 (de)	1995-04-05	Elektroplattiersystem mit mehreren Abteilungen.
ZA961444B (en)	1997-08-25	Pyrazolylbenzoyl derivatives.
ZA967315B (en)	1998-03-02	Biphenylamides.
EP0643543A3 (de)	1996-03-13	Nahbereichfunktelefonsystem.
ZA969158B (en)	1997-09-03	Communication system.
MX213417B (es)	2003-03-27	Fenilpiridazinonas.
ZA961446B (en)	1997-08-25	Phenyldiketone derivates.
ZA964468B (en)	1997-02-06	Triazolylmethyl-cyclopentanols.
ZA961955B (en)	1997-09-11	Indazolecarboxamides.
ZA961449B (en)	1997-08-25	Isoxazolylbenzoyl derivatives.
ZA986874B (en)	2000-01-31	Alatrofloxacin parenteral compositions.
ZA969973B (en)	1998-05-27	2-thioxo-imidazolidin-4-one derivatives.
DE69610844D1 (en)	2000-12-07	Hydroformylierungsverfahren.
AU6921596A (en)	1997-04-09	Coordinating telephones or adjuncts on the same loop
ZA966773B (en)	1997-02-19	Sulfonyl-or sulfinyl-benzoylguanidin derivate.
ZA967741B (en)	1998-03-13	Diarylalkenylamine derivatives.
ZA964209B (en)	1997-11-24	Benzopyrans.
ZA962821B (en)	1997-10-09	4-indolylpiperazinyl derivatives.
ZA969625B (en)	1997-05-22	25-Hydroxy-16-ene-26, 27-bishomo-cholecalciferols
ZA963787B (en)	1997-11-13	Antibiotics.
ZA967087B (en)	1997-02-24	Solid sucralose.
ZA966399B (en)	1997-02-19	Endothelin-receptor-antagonists.
ZA967357B (en)	1998-03-02	Pyrazol-4-ylbenzoyl derivatives.
ZA969923B (en)	1998-05-26	Antioxidant.
ZA966933B (en)	1997-02-19	Endothelin-receptor-antagonists.