EP0858455A4 - 4-oxa- und 4-thia-steroide - Google Patents

4-oxa- und 4-thia-steroide

Info

Publication number
EP0858455A4
EP0858455A4 EP96936811A EP96936811A EP0858455A4 EP 0858455 A4 EP0858455 A4 EP 0858455A4 EP 96936811 A EP96936811 A EP 96936811A EP 96936811 A EP96936811 A EP 96936811A EP 0858455 A4 EP0858455 A4 EP 0858455A4
Authority
EP
European Patent Office
Prior art keywords
thia
oxa
steroids
thia steroids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96936811A
Other languages
English (en)
French (fr)
Other versions
EP0858455A1 (de
Inventor
Raman K Bakshi
Gool F Patel
Gary H Rasmusson
Richard L Tolman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9602905.3A external-priority patent/GB9602905D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0858455A1 publication Critical patent/EP0858455A1/de
Publication of EP0858455A4 publication Critical patent/EP0858455A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/006—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by sulfur as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/003—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by oxygen as hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
EP96936811A 1995-10-26 1996-10-22 4-oxa- und 4-thia-steroide Withdrawn EP0858455A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US600195P 1995-10-26 1995-10-26
US6001P 1995-10-26
GBGB9602905.3A GB9602905D0 (en) 1996-02-13 1996-02-13 4-oxa and 4-thia steroids
GB9602905 1996-02-13
PCT/US1996/016883 WO1997015564A1 (en) 1995-10-26 1996-10-22 4-oxa and 4-thia steroids

Publications (2)

Publication Number Publication Date
EP0858455A1 EP0858455A1 (de) 1998-08-19
EP0858455A4 true EP0858455A4 (de) 2000-04-12

Family

ID=26308677

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96936811A Withdrawn EP0858455A4 (de) 1995-10-26 1996-10-22 4-oxa- und 4-thia-steroide

Country Status (5)

Country Link
EP (1) EP0858455A4 (de)
JP (1) JPH11513981A (de)
AU (1) AU713582B2 (de)
CA (1) CA2233966A1 (de)
WO (1) WO1997015564A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2462456C (en) * 2001-10-03 2010-05-04 Merck & Co., Inc. Androstane 17-beta-carboxamides as androgen receptor modulators
CA2524409C (en) * 2003-05-07 2011-12-20 Merck & Co., Inc. Androgen receptor modulators and methods of use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1805857A1 (de) * 1967-11-03 1969-06-26 Hoffmann La Roche Verfahren zur Herstellung von 4-Oxaandrostanen
US3644421A (en) * 1968-12-02 1972-02-22 Syntex Corp 4-oxa-3-keto-delta**1-pregnene derivatives
EP0298652A2 (de) * 1987-06-29 1989-01-11 Merck & Co. Inc. Dehydrierungsverfahren und Zwischenprodukte

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1805857A1 (de) * 1967-11-03 1969-06-26 Hoffmann La Roche Verfahren zur Herstellung von 4-Oxaandrostanen
US3644421A (en) * 1968-12-02 1972-02-22 Syntex Corp 4-oxa-3-keto-delta**1-pregnene derivatives
EP0298652A2 (de) * 1987-06-29 1989-01-11 Merck & Co. Inc. Dehydrierungsverfahren und Zwischenprodukte

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9715564A1 *

Also Published As

Publication number Publication date
WO1997015564A1 (en) 1997-05-01
JPH11513981A (ja) 1999-11-30
AU713582B2 (en) 1999-12-02
AU7464496A (en) 1997-05-15
EP0858455A1 (de) 1998-08-19
CA2233966A1 (en) 1997-05-01

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19980526

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A4 Supplementary search report drawn up and despatched

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Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20010703