EP0859862A4 - Nouveau marqueur diagnostique pour l'epissage de genes associes a la fonction neurologique - Google Patents

Nouveau marqueur diagnostique pour l'epissage de genes associes a la fonction neurologique

Info

Publication number
EP0859862A4
EP0859862A4 EP96937747A EP96937747A EP0859862A4 EP 0859862 A4 EP0859862 A4 EP 0859862A4 EP 96937747 A EP96937747 A EP 96937747A EP 96937747 A EP96937747 A EP 96937747A EP 0859862 A4 EP0859862 A4 EP 0859862A4
Authority
EP
European Patent Office
Prior art keywords
splice variants
genes associated
diagnostic marker
new diagnostic
neurological function
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96937747A
Other languages
German (de)
English (en)
Other versions
EP0859862A1 (fr
Inventor
John A Hardy
Alison M Goate
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
University of South Florida
Washington University in St Louis WUSTL
University of South Florida St Petersburg
Original Assignee
University of Washington
University of South Florida
Washington University in St Louis WUSTL
University of South Florida St Petersburg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington, University of South Florida, Washington University in St Louis WUSTL, University of South Florida St Petersburg filed Critical University of Washington
Publication of EP0859862A1 publication Critical patent/EP0859862A1/fr
Publication of EP0859862A4 publication Critical patent/EP0859862A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP96937747A 1995-10-25 1996-10-25 Nouveau marqueur diagnostique pour l'epissage de genes associes a la fonction neurologique Withdrawn EP0859862A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US704595P 1995-10-25 1995-10-25
US7045P 1995-10-25
PCT/US1996/017128 WO1997015688A1 (fr) 1995-10-25 1996-10-25 Nouveau marqueur diagnostique pour l'epissage de genes associes a la fonction neurologique

Publications (2)

Publication Number Publication Date
EP0859862A1 EP0859862A1 (fr) 1998-08-26
EP0859862A4 true EP0859862A4 (fr) 1998-11-11

Family

ID=21723903

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96937747A Withdrawn EP0859862A4 (fr) 1995-10-25 1996-10-25 Nouveau marqueur diagnostique pour l'epissage de genes associes a la fonction neurologique

Country Status (5)

Country Link
EP (1) EP0859862A4 (fr)
JP (1) JPH11513570A (fr)
AU (1) AU7521696A (fr)
WO (1) WO1997015688A1 (fr)
ZA (1) ZA968899B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0814157A3 (fr) * 1996-06-18 1998-01-07 Smithkline Beecham Corporation Marqueur diagnostique pour variations des gènes codant presenilin en association avec la maladie d'Alzheimer et familial adulte apparition de la maladie d'Alzheimer
GB9902776D0 (en) * 1999-02-08 1999-03-31 Marie Curie Cancer Care Materials and methods relating to a cancer cell marker

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0791660A1 (fr) * 1996-02-22 1997-08-27 Smithkline Beecham Corporation Nouveau marqueur diagnostique pour variations d'épissage de gènes en association avec fonctions neurologiques
EP0814157A2 (fr) * 1996-06-18 1997-12-29 Smithkline Beecham Corporation Marqueur diagnostique pour variations des gènes codant presenilin en association avec la maladie d'Alzheimer et familial adulte apparition de la maladie d'Alzheimer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0791660A1 (fr) * 1996-02-22 1997-08-27 Smithkline Beecham Corporation Nouveau marqueur diagnostique pour variations d'épissage de gènes en association avec fonctions neurologiques
EP0814157A2 (fr) * 1996-06-18 1997-12-29 Smithkline Beecham Corporation Marqueur diagnostique pour variations des gènes codant presenilin en association avec la maladie d'Alzheimer et familial adulte apparition de la maladie d'Alzheimer

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BATESON A N ET AL: "GAMMA-AMINOBUTYRIC ACIDA RECEPTOR HETEROGENEITY IS INCREASED BY ALTERNATIVE SPLICING OF A NOVEL BETA-SUBUNIT GENE TRANSCRIPT", JOURNAL OF NEUROCHEMISTRY, vol. 56, no. 4, April 1991 (1991-04-01), pages 1437 - 1440, XP002045954 *
CLARK R F ET AL: "THE STRUCTURE OF THE PRESENILIN 1 (S182) GENE AND IDENTIFICATION OFSIX NOVEL MUTATIONS IN EARLY ONSET AD FAMILIES", NATURE GENETICS, vol. 11, no. 2, October 1995 (1995-10-01), pages 219 - 222, XP002042861 *
KOBAYASHI K ET AL: "STRUCTURE OF THE HUMAN TYROSINE HYDROXYLASE GENE: ALTERNATIVE SPLICING FROM A SINGLE GENE ACCOUNTS FOR GENERATION OF FOUR MRNA TYPES", JOURNAL OF BIOCHEMISTRY, vol. 103, no. 6, June 1988 (1988-06-01), pages 907 - 912, XP002020413 *
See also references of WO9715688A1 *

Also Published As

Publication number Publication date
JPH11513570A (ja) 1999-11-24
AU7521696A (en) 1997-05-15
EP0859862A1 (fr) 1998-08-26
WO1997015688A1 (fr) 1997-05-01
ZA968899B (en) 1998-07-23

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