EP0862420A4 - Synthese de nanoparticules medicamenteuses par sechage par pulverisation - Google Patents

Synthese de nanoparticules medicamenteuses par sechage par pulverisation

Info

Publication number
EP0862420A4
EP0862420A4 EP96939455A EP96939455A EP0862420A4 EP 0862420 A4 EP0862420 A4 EP 0862420A4 EP 96939455 A EP96939455 A EP 96939455A EP 96939455 A EP96939455 A EP 96939455A EP 0862420 A4 EP0862420 A4 EP 0862420A4
Authority
EP
European Patent Office
Prior art keywords
synthesis
spray drying
drug nanoparticles
nanoparticles
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96939455A
Other languages
German (de)
English (en)
Other versions
EP0862420A1 (fr
Inventor
Ulagaraj Selvaraj
Gary L Messing
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Penn State Research Foundation
Original Assignee
Penn State Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Penn State Research Foundation filed Critical Penn State Research Foundation
Publication of EP0862420A1 publication Critical patent/EP0862420A1/fr
Publication of EP0862420A4 publication Critical patent/EP0862420A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0476—Particles, beads, capsules, spheres
    • A61K49/0485—Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP96939455A 1995-10-13 1996-10-11 Synthese de nanoparticules medicamenteuses par sechage par pulverisation Withdrawn EP0862420A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US519495P 1995-10-13 1995-10-13
US5194P 1995-10-13
PCT/US1996/016417 WO1997013503A1 (fr) 1995-10-13 1996-10-11 Synthese de nanoparticules medicamenteuses par sechage par pulverisation

Publications (2)

Publication Number Publication Date
EP0862420A1 EP0862420A1 (fr) 1998-09-09
EP0862420A4 true EP0862420A4 (fr) 1999-11-03

Family

ID=21714643

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96939455A Withdrawn EP0862420A4 (fr) 1995-10-13 1996-10-11 Synthese de nanoparticules medicamenteuses par sechage par pulverisation

Country Status (2)

Country Link
EP (1) EP0862420A4 (fr)
WO (1) WO1997013503A1 (fr)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5747001A (en) * 1995-02-24 1998-05-05 Nanosystems, L.L.C. Aerosols containing beclomethazone nanoparticle dispersions
US20020039594A1 (en) * 1997-05-13 2002-04-04 Evan C. Unger Solid porous matrices and methods of making and using the same
GB9710604D0 (en) * 1997-05-22 1997-07-16 Nycomed Imaging As Contrast media
US6433154B1 (en) 1997-06-12 2002-08-13 Bristol-Myers Squibb Company Functional receptor/kinase chimera in yeast cells
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6946117B1 (en) 1997-09-29 2005-09-20 Nektar Therapeutics Stabilized preparations for use in nebulizers
CA2217095A1 (fr) * 1997-10-22 1999-04-22 Hydro-Quebec Nanocomposites a interfaces activees prepares par broyage mecanique d'hydrures de magnesium et usage de ceux-ci pour le stockage d'hydrogene
DE19920555B4 (de) * 1999-05-05 2004-08-26 Cognis Deutschland Gmbh & Co. Kg Verwendung von nanoskaligen Metallseifen
JP2003518038A (ja) * 1999-12-20 2003-06-03 ニコラス， ジェイ カークホフ， 流動床噴霧乾燥によるナノ粒子製造方法
US8771740B2 (en) * 1999-12-20 2014-07-08 Nicholas J. Kerkhof Process for producing nanoparticles by spray drying
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US6764720B2 (en) 2000-05-16 2004-07-20 Regents Of The University Of Minnesota High mass throughput particle generation using multiple nozzle spraying
DE10026698A1 (de) 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
JP2004509739A (ja) * 2000-09-27 2004-04-02 ベリオン　インコーポレイテッド 即時水溶解性カプセルおよびその製法
WO2002082900A1 (fr) 2001-03-30 2002-10-24 Rhodia Inc. Suspension aqueuse de nanoparticules comprenant un ingredient agrochimique actif
KR100463167B1 (ko) * 2001-04-13 2004-12-23 주식회사 태평양 고분자 나노입자를 이용한 경피흡수제 및 이를 함유한외용제 조성물
US7247338B2 (en) 2001-05-16 2007-07-24 Regents Of The University Of Minnesota Coating medical devices
WO2003032959A1 (fr) * 2001-10-15 2003-04-24 Bosch William H Compositions nanoparticulaires comprenant des noyaux inorganiques
TW200300696A (en) 2001-11-01 2003-06-16 Inhale Therapeutic Syst Spray drying methods and related compositions
US7368102B2 (en) 2001-12-19 2008-05-06 Nektar Therapeutics Pulmonary delivery of aminoglycosides
GB0216700D0 (en) 2002-07-18 2002-08-28 Astrazeneca Ab Process
AU2003249474A1 (en) 2002-08-12 2004-02-25 Pfizer Products Inc. Pharmaceutical compositions of semi-ordered drugs and polymers
GB0302673D0 (en) 2003-02-06 2003-03-12 Astrazeneca Ab Pharmaceutical formulations
GB0310300D0 (en) * 2003-05-06 2003-06-11 Univ Belfast Nanocomposite drug delivery composition
KR20060015316A (ko) 2003-05-28 2006-02-16 넥타르 테라퓨틱스 아미노산 및/또는 인지질로 부분 또는 완전 코팅된수불용성 활성제 미립자의 제조를 위한 알코올성 수용액의분무 건조법
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
DE10351004A1 (de) 2003-10-30 2005-05-25 Basf Ag Nanopartikuläre Wirkstoffformulierungen
WO2006083326A2 (fr) * 2004-08-07 2006-08-10 Cabot Corporation Fabrication d'une dispersion gazeuse de nanoparticules, et produits contenant des nanoparticules et traitement de ceux-ci
US7829000B2 (en) 2005-02-25 2010-11-09 Hewlett-Packard Development Company, L.P. Core-shell solid freeform fabrication
WO2006102494A2 (fr) * 2005-03-23 2006-09-28 Elan Pharma International Limited Formulations d'un corticosteroide nanoparticulaire et d'un antihistamine
CN101272848B (zh) 2005-07-28 2013-03-13 Isp投资有限公司 改进喷雾干燥的粉末和颗粒材料性质的方法，以及由此生产的产品
FR2891275B1 (fr) * 2005-09-26 2007-11-16 Commissariat Energie Atomique Procede de fabrication de compositions comprenant des nanoparticules d'un elememnt ou compose chimique dispersees dans une matrice organique
US7951428B2 (en) 2006-01-31 2011-05-31 Regents Of The University Of Minnesota Electrospray coating of objects
US9108217B2 (en) 2006-01-31 2015-08-18 Nanocopoeia, Inc. Nanoparticle coating of surfaces
EP2529761B1 (fr) 2006-01-31 2017-06-14 Nanocopoeia, Inc. Revêtement de nanoparticule des surfaces
GB0613925D0 (en) 2006-07-13 2006-08-23 Unilever Plc Improvements relating to nanodispersions
CN101516357A (zh) 2006-09-22 2009-08-26 米维塔尔股份公司 包含阿拉伯胶的乳剂
US9040816B2 (en) 2006-12-08 2015-05-26 Nanocopoeia, Inc. Methods and apparatus for forming photovoltaic cells using electrospray
US8613946B2 (en) 2006-12-21 2013-12-24 Isp Investment Inc. Carotenoids of enhanced bioavailability
US10189957B2 (en) 2007-01-26 2019-01-29 Isp Investments Llc Formulation process method to produce spray dried products
US8703204B2 (en) * 2007-05-03 2014-04-22 Bend Research, Inc. Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer
US8309129B2 (en) 2007-05-03 2012-11-13 Bend Research, Inc. Nanoparticles comprising a drug, ethylcellulose, and a bile salt
WO2008149230A2 (fr) 2007-06-04 2008-12-11 Pfizer Products Inc. Nanoparticules comprenant un médicament, un polymère cellulosique non ionisable et du tocophéryl polyéthylène glycol succinate
EP2162120B1 (fr) 2007-06-04 2016-05-04 Bend Research, Inc Nanoparticules comportant un polymère cellulosique non ionisable et un copolymère bloc amphiphile non ionisable
EP2231169B1 (fr) 2007-12-06 2016-05-04 Bend Research, Inc. Compositions pharmaceutiques comprenant des nanoparticules et une matière de remise en suspension
EP2240162A4 (fr) 2007-12-06 2013-10-09 Bend Res Inc Nanoparticules comprenant un polymère non ionisable et un copolymère de méthacrylate fonctionnalisé par amine
WO2010079036A2 (fr) * 2008-12-18 2010-07-15 Basf Se Dispersion aqueuse contenant des particules de pesticides et un saccharide en solution
US8877746B2 (en) * 2009-08-25 2014-11-04 Cardioklne, Inc Compositions for delivery of insoluble agents
WO2013132457A2 (fr) 2012-03-07 2013-09-12 National Institute Of Pharmaceutical Education And Research (Niper) Compositions de dispersions de solides nanocristallins et leur procédé de préparation
RU2561686C1 (ru) * 2014-04-01 2015-08-27 Александр Александрович Кролевец Способ инкапсуляции аспирина в ксантановой камеди
EP3586827A1 (fr) 2018-06-29 2020-01-01 Consejo Superior de Investigaciones Cientificas (CSIC) Formulation pharmaceutique présentant une solubilité et une biodisponibilité améliorées
CN114886856A (zh) * 2022-06-09 2022-08-12 山西辅仁恒峰药业有限公司 一种奥司他韦纳米干混悬剂的制备方法及应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4952402A (en) * 1984-10-30 1990-08-28 Elan Corporation, P.L.C. Controlled release powder and process for its preparation
WO1994009898A1 (fr) * 1992-10-26 1994-05-11 Schwarz Pharma Ag Procede de fabrication de microcapsules

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4107288A (en) * 1974-09-18 1978-08-15 Pharmaceutical Society Of Victoria Injectable compositions, nanoparticles useful therein, and process of manufacturing same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4952402A (en) * 1984-10-30 1990-08-28 Elan Corporation, P.L.C. Controlled release powder and process for its preparation
US5354556A (en) * 1984-10-30 1994-10-11 Elan Corporation, Plc Controlled release powder and process for its preparation
WO1994009898A1 (fr) * 1992-10-26 1994-05-11 Schwarz Pharma Ag Procede de fabrication de microcapsules

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9713503A1 *

Also Published As

Publication number Publication date
EP0862420A1 (fr) 1998-09-09
WO1997013503A1 (fr) 1997-04-17

Similar Documents

Publication Publication Date Title
ATE196463T1 (de) Assymetrische synthese von (-) 6-chloro-4-
DE69924930D1 (de) Synthese von Oligonukleotiden
NO974701D0 (no) Syntese av tale-bölgeformer
DE69424151D1 (de) Automatisierte synthese von oligonukleotiden
ATE186903T1 (de) Synthese von cyclopropylacetylen
NO973938L (no) Farmasöytisk preparat av piperidinoalkanolforbindelser
DE69327427D1 (de) Synthese von Epoxysiliconen
DE69611442D1 (de) Enzymatische synthese von glykosidischen verbindungen
DE69620240D1 (de) Herstellung von levulinsäure aus kohlenhydrathaltigen materialien
EP0833863A4 (fr) Formation de nanocomposites polymeres par synthese en emulsion
DE69916582D1 (de) Synthese von zsm-48
ATE123037T1 (de) Synthese von carbonylverbindungen.
DE69501534D1 (de) Synthese von 1,1,1,3,3-Pentafluorpropan
DE69126089D1 (de) Synthese von Trans-1,4-Polybutadien
DE69310372D1 (de) Synthesereaktionssäule
DE69603269D1 (de) Derivate von inulin
EP1169466A4 (fr) Synthese de 1,2,3,4-tetrahydroxybenzenes et de 1,2,3-trihydroxybenzenes au moyen de myo-inositol-1phosphate synthase et de myo-inositol 2-dehydrogenase
FI973591A0 (fi) Nya syntetiserade kryptofysiner
EP0823255A4 (fr) Composition pharmaceutique contenant du sucralfate
DE69602937D1 (de) Verbesserte synthese von racemischen metallocenen
DE69801344D1 (de) Synthese von Bis(Phthalocyanylalumino)tetraphenyldisiloxanen
DE69627349D1 (de) Einrichtung zur synthese von oligonukleotiden
DE69802453D1 (de) Herstellung von bioaktiven Verbindungen durch Plasmasynthese
DE69722585D1 (de) Synthese von wellenformen
FI962603L (fi) Hydroksihapon tai sitä sisältävän tuotteen käyttö sekä siitä tehty valmiste

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19980424

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 19990921

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

RIC1 Information provided on ipc code assigned before grant

Free format text: 6A 61K 9/16 A, 6B 29B 9/00 B, 6B 29B 9/12 B, 6A 61K 9/51 B, 6A 61K 9/50 B

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN

18W Application withdrawn

Withdrawal date: 20011115