EP0871444A4 - Pyrroles d'aryle substitues en position 2 et 5, compositions contenant de tels composes et leurs modes d'utilisation - Google Patents

Pyrroles d'aryle substitues en position 2 et 5, compositions contenant de tels composes et leurs modes d'utilisation

Info

Publication number
EP0871444A4
EP0871444A4 EP96928099A EP96928099A EP0871444A4 EP 0871444 A4 EP0871444 A4 EP 0871444A4 EP 96928099 A EP96928099 A EP 96928099A EP 96928099 A EP96928099 A EP 96928099A EP 0871444 A4 EP0871444 A4 EP 0871444A4
Authority
EP
European Patent Office
Prior art keywords
compounds
methods
substituted aryl
compositions containing
aryl pyrroles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96928099A
Other languages
German (de)
English (en)
Other versions
EP0871444A1 (fr
Inventor
Laszlo Stephen E De
Nathan B Mantlo
Gerald S Ponticello
Harold G Selnick
Nigel J Liverton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9607253.3A external-priority patent/GB9607253D0/en
Priority claimed from GBGB9608472.8A external-priority patent/GB9608472D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0871444A1 publication Critical patent/EP0871444A1/fr
Publication of EP0871444A4 publication Critical patent/EP0871444A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP96928099A 1995-08-10 1996-08-06 Pyrroles d'aryle substitues en position 2 et 5, compositions contenant de tels composes et leurs modes d'utilisation Withdrawn EP0871444A4 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US209495P 1995-08-10 1995-08-10
US2094 1995-08-10
US1418296P 1996-03-26 1996-03-26
US14182 1996-03-26
GBGB9607253.3A GB9607253D0 (en) 1996-04-04 1996-04-04 2,5-Substituted aryl pyrroles, compositions containing such compounds of use
GB9607253 1996-04-04
GB9608472 1996-04-25
GBGB9608472.8A GB9608472D0 (en) 1996-04-25 1996-04-25 2,5-Substituted aryl pyrroles,compositions containing such compounds and methods of use
PCT/US1996/012922 WO1997005878A1 (fr) 1995-08-10 1996-08-06 Pyrroles d'aryle substitues en position 2 et 5, compositions contenant de tels composes et leurs modes d'utilisation

Publications (2)

Publication Number Publication Date
EP0871444A1 EP0871444A1 (fr) 1998-10-21
EP0871444A4 true EP0871444A4 (fr) 1999-01-13

Family

ID=27451430

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96928099A Withdrawn EP0871444A4 (fr) 1995-08-10 1996-08-06 Pyrroles d'aryle substitues en position 2 et 5, compositions contenant de tels composes et leurs modes d'utilisation

Country Status (5)

Country Link
EP (1) EP0871444A4 (fr)
JP (1) JPH11510511A (fr)
AU (1) AU699148B2 (fr)
CA (1) CA2228050A1 (fr)
WO (1) WO1997005878A1 (fr)

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GB9816837D0 (en) 1998-08-04 1998-09-30 Zeneca Ltd Amide derivatives
US7772432B2 (en) 1991-09-19 2010-08-10 Astrazeneca Ab Amidobenzamide derivatives which are useful as cytokine inhibitors
US5916891A (en) 1992-01-13 1999-06-29 Smithkline Beecham Corporation Pyrimidinyl imidazoles
US6046208A (en) * 1996-01-11 2000-04-04 Smithkline Beecham Corporation Substituted imidazole compounds
CA2260213C (fr) * 1996-07-11 2005-03-29 Pfizer Inc. Composes de pyridylpyrrole utiles comme antagonistes de l'interleukine et du facteur tnf
WO1998047899A1 (fr) * 1997-04-24 1998-10-29 Ortho-Mcneil Corporation, Inc. Pyrrolopyridines substituees utilisees dans le traitement des maladies inflammatoires
EP0988301B1 (fr) 1997-06-12 2006-08-09 Aventis Pharma Limited Acetals cycliques imidazolyle
US7301021B2 (en) 1997-07-02 2007-11-27 Smithkline Beecham Corporation Substituted imidazole compounds
CN1271279A (zh) 1997-09-23 2000-10-25 普尼卡有限公司 用于治疗细胞因子介导性疾病的酰胺类衍生物
CA2306870A1 (fr) 1997-10-20 1999-04-29 David Michael Goldstein Inhibiteurs bicycliques d'une kinase
US6022884A (en) 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
EP1031572A4 (fr) * 1997-11-14 2001-09-19 Sankyo Co Derives de pyridylpyrrole
EP2017266A1 (fr) 1997-11-19 2009-01-21 Kowa Co., Ltd. Dérivés de pyridazine et medicaments les contenant comme principe actif
US6335340B1 (en) 1997-12-19 2002-01-01 Smithkline Beecham Corporation compounds of heteroaryl substituted imidazole, their pharmaceutical compositons and uses
DE69839278T2 (de) * 1997-12-19 2008-09-11 Amgen Inc., Thousand Oaks Substituierte pyridin- und pyridazinderivate und ihre pharmazeutische verwendung
US6174901B1 (en) 1998-12-18 2001-01-16 Amgen Inc. Substituted pyridine and pyridazine compounds and methods of use
ES2232137T3 (es) 1998-05-15 2005-05-16 Astrazeneca Ab Derivados de benzamida para el tratamiento de enfermedades mediadas por citoquinas.
CN1188389C (zh) 1998-05-15 2005-02-09 阿斯特拉曾尼卡有限公司 用于治疗由细胞因子引起的疾病的苯甲酰胺衍生物
US6858617B2 (en) 1998-05-26 2005-02-22 Smithkline Beecham Corporation Substituted imidazole compounds
CN1142912C (zh) 1998-08-04 2004-03-24 阿斯特拉曾尼卡有限公司 用作细胞因子产生的抑制剂的酰胺衍生物
ES2211172T3 (es) 1998-09-25 2004-07-01 Astrazeneca Ab Derivados de benzamida y su utilizacion como inhibidores de citoquinas.
DK1117653T3 (da) 1998-10-01 2003-05-26 Astrazeneca Ab Quinolin- og quinazolinderivater og deres anvendelse som inhibitorer af cykokin-merierede sygdomme
CA2346665A1 (fr) 1998-10-07 2000-04-13 Smithkline Beecham Corporation Nouveau traitement pour la gestion des accidents vasculaires cerebraux
US6548503B1 (en) 1998-11-04 2003-04-15 Smithkline Beecham Corporation Pyridin-4-yl or pyrimidin-4-yl substituted pyrazines
JP2000247959A (ja) 1999-02-26 2000-09-12 Kowa Co ピリダジン−３−オン誘導体及びこれを含有する医薬
WO2000055153A1 (fr) 1999-03-17 2000-09-21 Astrazeneca Ab Derives amides
WO2000066124A1 (fr) * 1999-04-28 2000-11-09 Sankyo Company, Limited Agents preventifs ou inhibiteurs destines a une hepatopathie
KR20010114267A (ko) * 1999-05-14 2001-12-31 오르토-맥네일 파마슈티칼, 인코퍼레이티드 치환된 3-피리딜-4-아릴피롤과 관련 치료방법 및 예방방법
US7122666B2 (en) 1999-07-21 2006-10-17 Sankyo Company, Limited Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses
AU7922900A (en) 1999-10-27 2001-05-08 Novartis Ag Thiazole and imidazo (4,5-b) pyridine compounds and their pharmaceutical use
JP2003528043A (ja) 1999-11-23 2003-09-24 スミスクライン・ビーチャム・コーポレイション ＣＳＢＰ／ｐ３８キナーゼ阻害剤としての３，４‐ジヒドロ−（１Ｈ）キナゾリン−２−オン化合物
US6759410B1 (en) 1999-11-23 2004-07-06 Smithline Beecham Corporation 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
WO2001038314A1 (fr) 1999-11-23 2001-05-31 Smithkline Beecham Corporation Composes de 3,4-dihydro-(1h)quinazolin-2-one utilises comme inhibiteurs de kinase csbp/p38
US7235551B2 (en) 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
US6664256B1 (en) 2000-07-10 2003-12-16 Kowa Co., Ltd. Phenylpyridazine compounds and medicines containing the same
KR20030076612A (ko) * 2001-01-18 2003-09-26 상꾜 가부시키가이샤 간장해를 예방 또는 치료하기 위한 조성물
WO2002057255A1 (fr) * 2001-01-22 2002-07-25 Sankyo Company, Limited Derives du pyrrole substitues en 4 ou 5
EG23054A (en) * 2001-01-22 2004-02-29 Sankyo Co Pyrrole derivatives their preparation and their therapeutic uses
MY130778A (en) 2001-02-09 2007-07-31 Vertex Pharma Heterocyclic inhibitiors of erk2 and uses thereof
GB0112348D0 (en) 2001-05-19 2001-07-11 Smithkline Beecham Plc Compounds
EP1432699A1 (fr) * 2001-09-05 2004-06-30 Smithkline Beecham Plc Pyridylfurans et pyrroles inhibiteurs de la kinase raf
WO2004029040A1 (fr) * 2002-09-27 2004-04-08 Janssen Pharmaceutica N.V. Pyrroles 3,4-disubstitues et utilisation de ceux-ci pour le traitement de maladies inflammatoires
BRPI0408359A (pt) 2003-03-18 2006-03-21 Kowa Co derivados de fenilpiridazina solúveis em água e medicamentos contendo os mesmos
GB0324790D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Amide derivatives
PE20090362A1 (es) 2007-06-08 2009-04-04 Janssen Pharmaceutica Nv Derivados de piperidina/piperazina como moduladores de dgat
WO2008148840A1 (fr) 2007-06-08 2008-12-11 Janssen Pharmaceutica N.V. Dérivés de piperidine/piperazine
AU2008258560C1 (en) 2007-06-08 2014-04-10 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
JO2972B1 (en) 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine / piperazine derivatives
PE20140572A1 (es) 2008-06-05 2014-05-16 Janssen Pharmaceutica Nv Combinaciones de drogas que comprenden un inhibidor de dgat y un agonista de ppar
US8088817B2 (en) * 2008-08-25 2012-01-03 Santen Pharmaceutical Co., Ltd. Pyrrole derivative having, as substituents, ureido group, aminocarbonly group and bicyclic group which may have substituent
SI2716684T1 (sl) * 2011-05-17 2019-11-29 Pharmasyntez Spojine za profilakso in postopek za zdravljenje adhezijskega postopka
CN102863371B (zh) * 2011-07-06 2016-04-13 中国科学院上海有机化学研究所 氟代二氢吡咯或氟代吡咯
CN111662239B (zh) * 2019-03-06 2023-07-28 中国医学科学院药物研究所 1,2,4-三唑类化合物及其制法和药物用途
CN113354616B (zh) * 2020-03-05 2024-03-26 中国医学科学院药物研究所 二芳基-1,2,4-三唑类化合物及其制法和药物用途
CN114394934B (zh) * 2022-01-06 2023-06-13 苏州大学 吡唑苯甲酰胺类化合物及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997016441A1 (fr) * 1995-10-31 1997-05-09 Merck & Co., Inc. Pyrroles aryliques de substitution, compositions renfermant de telles composes et methodes d'utilisation de ces substances

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997016441A1 (fr) * 1995-10-31 1997-05-09 Merck & Co., Inc. Pyrroles aryliques de substitution, compositions renfermant de telles composes et methodes d'utilisation de ces substances

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 124, no. 19, 6 May 1996, Columbus, Ohio, US; abstract no. 260752x, J. LEHUEDE ET AL: "Preparation of 1H-2,3,4,5-tetraarylpyrroles by oxidation of heterocyclic imine-enamines" page 1241; XP002084087 *
D. BHATTACHARJEE ET AL: "Reissert compound studies. XXXV. Acid-catalyzed condensations of the phthalazine Reissert compound and condensations of phthalazine Reissert compound salt", JOURNAL OF HETEROCYCLIC CHEMISTRY., vol. 17, 1980, PROVO US, pages 1035 - 1040, XP002084079 *
D. M. PERRINE ET AL: "Four novel phenyldithienoindole isomers from the oxidative photocyclization of dithienylpyrroles", JOURNAL OF ORGANIC CHEMISTRY, vol. 52, no. 11, 1987, EASTON US, pages 2213 - 2216, XP002084077 *
H. STETTER ET AL: "Addition von Aldehyden an aktivierte Doppelbindungen. XV (1. Synthese von gamma-Diketonen mit heterocyclischen Substituenteh und deren Umsetzung zu N-Methylpyrrolen und Chinolizidin bzw. Indolizidin Systemen", JOURNAL OF HETEROCYCLIC CHEMISTRY., vol. 14, 1977, PROVO US, pages 573 - 581, XP002084080 *
K. T. POTTS ET AL: "The pyrrolo(3,4-c)pyrazole system, a new 10pi-electron heteropentalene", JOURNAL OF ORGANIC CHEMISTRY, vol. 44, no. 4, 1979, EASTON US, pages 622 - 626, XP002084076 *
See also references of WO9705878A1 *
SYNTH. COMMUN., vol. 26, no. 4, 1996, pages 793 - 802 *
V. GIRIDHAR ET AL: "Base and acid-catalyzed condensation reactions of Resissert compounds with vinylpyridines", JOURNAL OF HETEROCYCLIC CHEMISTRY., vol. 8, 1971, PROVO US, pages 121 - 123, XP002084078 *

Also Published As

Publication number Publication date
AU6769196A (en) 1997-03-05
AU699148B2 (en) 1998-11-26
CA2228050A1 (fr) 1997-02-20
WO1997005878A1 (fr) 1997-02-20
JPH11510511A (ja) 1999-09-14
EP0871444A1 (fr) 1998-10-21

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