EP0871480A4 - Lymphocytes t declenchant une reaction immunitaire et methodes d'utilisation - Google Patents

Lymphocytes t declenchant une reaction immunitaire et methodes d'utilisation

Info

Publication number
EP0871480A4
EP0871480A4 EP97912648A EP97912648A EP0871480A4 EP 0871480 A4 EP0871480 A4 EP 0871480A4 EP 97912648 A EP97912648 A EP 97912648A EP 97912648 A EP97912648 A EP 97912648A EP 0871480 A4 EP0871480 A4 EP 0871480A4
Authority
EP
European Patent Office
Prior art keywords
lymphocytes
triggering
methods
immune reaction
immune
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97912648A
Other languages
German (de)
English (en)
Other versions
EP0871480A1 (fr
Inventor
David Berd
Giorgio Parmiani
Andrea Anichini
Marialuisa Sensi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thomas Jefferson University
Original Assignee
Thomas Jefferson University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomas Jefferson University filed Critical Thomas Jefferson University
Publication of EP0871480A1 publication Critical patent/EP0871480A1/fr
Publication of EP0871480A4 publication Critical patent/EP0871480A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4271—Melanoma antigens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/57—Skin; melanoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP97912648A 1996-10-04 1997-10-02 Lymphocytes t declenchant une reaction immunitaire et methodes d'utilisation Withdrawn EP0871480A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2700296P 1996-10-04 1996-10-04
US27002P 1996-10-04
PCT/US1997/015741 WO1998014206A1 (fr) 1996-10-04 1997-10-02 Lymphocytes t declenchant une reaction immunitaire et methodes d'utilisation

Publications (2)

Publication Number Publication Date
EP0871480A1 EP0871480A1 (fr) 1998-10-21
EP0871480A4 true EP0871480A4 (fr) 2001-04-04

Family

ID=21835095

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97912648A Withdrawn EP0871480A4 (fr) 1996-10-04 1997-10-02 Lymphocytes t declenchant une reaction immunitaire et methodes d'utilisation

Country Status (7)

Country Link
EP (1) EP0871480A4 (fr)
AU (1) AU4976697A (fr)
CA (1) CA2242590A1 (fr)
IL (1) IL125747A0 (fr)
NZ (1) NZ330995A (fr)
PL (1) PL328790A1 (fr)
WO (1) WO1998014206A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3482199A (en) * 1998-04-09 1999-11-01 Thomas Jefferson University A method of inducing an anti-tumor response against a lung metastasis in a melanoma patient
JP2002513772A (ja) * 1998-05-04 2002-05-14 トーマス・ジェファーソン・ユニバーシティ 腫瘍細胞および抽出物を含む組成物、ならびにそれらの使用方法
AU757980B2 (en) 1999-03-16 2003-03-13 Thomas Jefferson University Hapten-conjugated mammalian cells and methods of making and using thereof
US7297330B2 (en) * 2000-02-04 2007-11-20 Thomas Jefferson University Low dose haptenized tumor cell and tumor cell extract immunotherapy
JP2005528901A (ja) 2002-06-10 2005-09-29 アバクス・テクノロジーズ・インコーポレーテッド ハプテン化腫瘍細胞の凍結保存
WO2005059179A1 (fr) * 2003-12-12 2005-06-30 Bayer Pharmaceutical Corporation Procede de prediction et de pronostic du cancer, et surveillance de traitement anticancereux
US12247060B2 (en) 2018-01-09 2025-03-11 Marengo Therapeutics, Inc. Calreticulin binding constructs and engineered T cells for the treatment of diseases
JP7554742B2 (ja) 2018-07-03 2024-09-20 マレンゴ・セラピューティクス，インコーポレーテッド 抗ｔｃｒ抗体分子およびその使用
EP3906057A4 (fr) * 2019-01-04 2022-09-14 Marengo Therapeutics, Inc. Molécules d'anticorps anti-tcr et leurs utilisations
GB2597851B (en) 2019-02-21 2024-05-29 Marengo Therapeutics Inc Antibody molecules that bind to NKP30 and uses thereof
AU2020226893B2 (en) 2019-02-21 2025-02-27 Marengo Therapeutics, Inc. Multifunctional molecules that bind to T cell related cancer cells and uses thereof
GB2609554B (en) 2020-01-03 2025-08-20 Marengo Therapeutics Inc Anti-TCR antibody molecules and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0668350A1 (fr) * 1994-02-16 1995-08-23 Akzo Nobel N.V. Antigène associé au mélanome, épitopes de cet antigène et vaccins contre le mélanome

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3806565A1 (de) * 1988-03-01 1989-09-14 Deutsches Krebsforsch Virusmodifizierte tumorvakzinen fuer die immuntherapie von tumormetastasen
IE922233A1 (en) * 1991-07-10 1993-01-13 Augusto C Ochoa Short-term anti-cd3 stimulation of lymphocytes to increase¹their in vivo activity
IL122455A0 (en) * 1995-06-07 1998-06-15 Univ Jefferson Hapten modified tumor cell extract and methods of treating or screening for cancer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0668350A1 (fr) * 1994-02-16 1995-08-23 Akzo Nobel N.V. Antigène associé au mélanome, épitopes de cet antigène et vaccins contre le mélanome

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CAIGNARD A ET AL: "In situ demonstration of renal-cell-carcinoma-specific T-cell clones.", INTERNATIONAL JOURNAL OF CANCER, vol. 66, no. 4, 1996, pages 564 - 570, XP002159122 *
SATO T: "Active specific immunotherapy with hapten-modified autologous melanoma cell vaccine.", CANCER IMMUNOLOGY IMMUNOTHERAPY, vol. 43, no. 3, 1996, pages 174 - 179, XP000953008 *
See also references of WO9814206A1 *
SENSI M ET AL.: "Clonal expansion of T lymphocytes in human melanoma metastases after treatment with a hapten-modified autologous tumor vaccine.", JOURNAL OF CLINICAL INVESTIGATION, vol. 99, no. 4, 15 February 1997 (1997-02-15), pages 710 - 717, XP000953042 *
SENSI M ET AL.: "Cytotoxic T-lymphocyte clones from different patients display limited T-cell-receptor variable-region gene usage in HLA-A2-restricted recognition of the melanoma antigen Melan-A/MART-1.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 92, no. 12, 1 June 1995 (1995-06-01), pages 5674 - 5678, XP002143225 *
WEIDMANN E ET AL.: "Evidence for oligoclonal T-cell response in a metastasis of renal cell carcinoma responding to vaccination with autologous tumor cells and transfer of in vitro-sensitized vaccine-draining lymph node lymphocytes.", CANCER RESEARCH, vol. 53, no. 20, 1993, pages 4745 - 4749, XP002150949 *

Also Published As

Publication number Publication date
IL125747A0 (en) 1999-04-11
AU4976697A (en) 1998-04-24
WO1998014206A1 (fr) 1998-04-09
NZ330995A (en) 2000-12-22
PL328790A1 (en) 1999-02-15
CA2242590A1 (fr) 1998-04-09
EP0871480A1 (fr) 1998-10-21

Similar Documents

Publication Publication Date Title
EP1018987A4 (fr) Neocartilage et ses methodes d'utilisation
PL329930A1 (en) Antigens of human lymphocytes b and related reagents
ID21085A (id) Perkaitan dan bidang pemisah listrik untuk perlengkapan komunikasi pemakaian pribadi
IT1290006B1 (it) Alchilfenilbisacilfosfinossidi e miscele di fotoiniziatori
DE69803199D1 (de) Erkennung und entfernung von makroviren
ID17767A (id) Vaksin dan polipeptida-polipeptida sampul hiv
MA21131A1 (fr) Copolymeres d'esters terephthalate et leur utilisation dans des compositions de blanchissement .
EP0760014A4 (fr) Identification et utilisation de composes antiviraux
DK0634216T3 (da) Agglutinationsreaktions- og separationsbeholder
ID19769A (id) Sintase isoprenoid kimerik dan penggunaannya
EP0871480A4 (fr) Lymphocytes t declenchant une reaction immunitaire et methodes d'utilisation
MA24273A1 (fr) (4-arylthiazol-2yl) sulfonamides et leur utilisation
ID22672A (id) Piringan dan peralatan perekaman piringan
GB2267973B (en) Metallic block for detecting force operating on metallic V-belt and system for detection of operating force using the same
EP1012279A4 (fr) Genes de mitofusine et leur utilisation
EP0888267A4 (fr) Nouveaux composes de pyruvate et procedes d'utilisation
BR9700847A (pt) Vaso de separação e reação de aglutinação
MA23794A1 (fr) Utilisation de phenylcyclohexylcarboxamides
FR2770050B1 (fr) Dispositif de securite d'un accumulateur electrochimique
GB2330727B (en) Tone and periodical signal detection
IT1298175B1 (it) Procedimento migliorato per la polimerizzazione e la copolimerizzazione di olefine
ITMI932136A0 (it) Interfaccia di processore di segnali e digitali
ZA939756B (en) Monocional antibodies and anti-idiotypic antibodies to hepatitits c virus
KR970706592A (ko) 축을 벗어난 입력들을 감지할 수 있는 적분 가속도계(integrating accelerometer capable of sensing off-axis inputs)
ID18913A (id) Turunan turunan tienopiridin dan penggunaannya

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

AX Request for extension of the european patent

Free format text: AL PAYMENT 980714;LT PAYMENT 980714;LV PAYMENT 980714;RO PAYMENT 980714;SI PAYMENT 980714

17P Request for examination filed

Effective date: 19981001

RIC1 Information provided on ipc code assigned before grant

Free format text: 7C 12N 5/06 A, 7G 01N 33/574 B, 7C 07K 14/705 B

A4 Supplementary search report drawn up and despatched

Effective date: 20010215

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN

18W Application withdrawn

Withdrawal date: 20010615