EP0876480A4 - Animaux a deletion ciblee de gene - Google Patents

Animaux a deletion ciblee de gene

Info

Publication number
EP0876480A4
EP0876480A4 EP96936753A EP96936753A EP0876480A4 EP 0876480 A4 EP0876480 A4 EP 0876480A4 EP 96936753 A EP96936753 A EP 96936753A EP 96936753 A EP96936753 A EP 96936753A EP 0876480 A4 EP0876480 A4 EP 0876480A4
Authority
EP
European Patent Office
Prior art keywords
animals
targeted gene
gene deletion
deletion
targeted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96936753A
Other languages
German (de)
English (en)
Other versions
EP0876480A1 (fr
Inventor
Margaret L Hibbs
Ashley R Dunn
Dianne Graill
George Hodgson
David M Tarlington
Jane Armes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Walter and Eliza Hall Institute of Medical Research
Austin and Repatriation Medical Centre
Ludwig Institute for Cancer Research Ltd
Ludwig Cancer Research
Original Assignee
Walter and Eliza Hall Institute of Medical Research
Austin and Repatriation Medical Centre
Ludwig Institute for Cancer Research Ltd
Ludwig Cancer Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Walter and Eliza Hall Institute of Medical Research, Austin and Repatriation Medical Centre, Ludwig Institute for Cancer Research Ltd, Ludwig Cancer Research filed Critical Walter and Eliza Hall Institute of Medical Research
Publication of EP0876480A1 publication Critical patent/EP0876480A1/fr
Publication of EP0876480A4 publication Critical patent/EP0876480A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0325—Animal model for autoimmune diseases

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Environmental Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP96936753A 1995-10-20 1996-10-18 Animaux a deletion ciblee de gene Withdrawn EP0876480A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US575895P 1995-10-20 1995-10-20
US5758P 1995-10-20
PCT/US1996/016807 WO1997014791A1 (fr) 1995-10-20 1996-10-18 Animaux a deletion ciblee de gene

Publications (2)

Publication Number Publication Date
EP0876480A1 EP0876480A1 (fr) 1998-11-11
EP0876480A4 true EP0876480A4 (fr) 1999-10-20

Family

ID=21717589

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96936753A Withdrawn EP0876480A4 (fr) 1995-10-20 1996-10-18 Animaux a deletion ciblee de gene

Country Status (2)

Country Link
EP (1) EP0876480A4 (fr)
WO (1) WO1997014791A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3453348B2 (ja) 2000-08-24 2003-10-06 科学技術振興事業団 Ｉｉｉ型アレルギー炎症モデル動物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4736866B1 (en) * 1984-06-22 1988-04-12 Transgenic non-human mammals
US5464764A (en) * 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
COREY, S.ET AL.: "Granulocyte macrophage-colony stimulating factor stimulates both association and activation of phosphoinositide 3-OH-Kinase and src-related tyrosine kinase(s) in human myeloid derived cells", THE EMBO JOURNAL, vol. 12, no. 7, July 1993 (1993-07-01), pages 2681 - 2690, XP002101405 *
HIBBS, M.L. ET AL.: "Identification of a duplication of the mouse lyn gene", GENE, vol. 156, no. 2, 24 April 1995 (1995-04-24), pages 175 - 181, XP004042352 *
HIBBS, M.L. ET AL.: "Multiple defects in the immune system of lyn-deficient mice, culminating in autoimmune disease", CELL, vol. 83, no. 2, 20 October 1995 (1995-10-20), pages 301 - 311, XP002101398 *
KEFALAS, P. ET AL.: "Signalling by the p60c-src family of protein tyrosine kinases", INT.J.BIOCHEM.CELL.BIOL, vol. 27, no. 6, June 1995 (1995-06-01), pages 551 - 563, XP002101406 *
MOLINA, T.J. ET AL.: "Profound block in thymocyte development in mice lacking p56lck", NATURE, vol. 357, 14 May 1992 (1992-05-14), pages 161 - 164, XP002101402 *
NISHIZUMI, H. ET AL.: "Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice", IMMUNITY, vol. 3, no. 5, November 1995 (1995-11-01), pages 549 - 560, XP002101400 *
See also references of WO9714791A1 *
STEIN, P.L. ET AL.: "pp59fyn-mutant mice display differential signaling in thymocytes and peripheral T cell.", CELL, vol. 70, 1992, pages 741 - 750, XP002101403 *
TAKATA, M. ET AL.: "Tyrosine kinsases lyn and syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways", THE EMBO JOURNAL, vol. 13, 1994, pages 1341 - 1349, XP002101401 *
TORIGOE, T. ET AL.: "Regulation of src-family protein tyrosine kinases by interleukins, IL-2 and IL-3", LEUKEMIA, vol. 6, no. Suppl. 3, 1992, pages 94S - 97S, XP002101404 *
WANG, J. ET AL.: "Altered antigen receptor signaling and impaired fas-mediated apoptosis of B cells in lyn-deficient mice", JOURNAL OF EXPERIMENTAL MEDECINE, vol. 184, no. 3, 1 September 1996 (1996-09-01), pages 831 - 838, XP002101399 *

Also Published As

Publication number Publication date
WO1997014791A1 (fr) 1997-04-24
EP0876480A1 (fr) 1998-11-11

Similar Documents

Publication Publication Date Title
DE69636832D1 (de) Lauf mit axial hintereinander angeordneten projektilen
PT101950A (pt) 5-AMINO-4-ETILSULFINIL-1-ARILPIRAZóIS COM ACTIVIDADE PESTICIDA
DE69627322D1 (de) Rakete mit gitterruder
EP0791061A4 (fr) Animaux a rupture genique ciblee
FI972255L (fi) Kasvualusta
EP0876480A4 (fr) Animaux a deletion ciblee de gene
ES1032204Y (es) Lavabo-retrete-resindencia para animales.
KR970053552U (ko) 동물용 연속주사기
DE69604024D1 (de) Haustiergarten
NO960982D0 (no) Fiskeredskap
AU6803396A (en) Animals with targeted gene deletion
AUPN605495A0 (en) Animals with targeted gene deletion
KR970020417U (ko) 수족관용 히타장치
DE59604346D1 (de) Selbstfahrender Mähdrescher
KR970000060U (ko) 가축용 급수기
KR970020436U (ko) 낚시용 밑밥 투이구
NL1003888A1 (nl) Verbeterde sleepketting.
KR970050593U (ko) 수족관
KR960028006U (ko) 양식장용 부구
ES1024681Y (es) Mingitorio canino.
IT1289882B1 (it) Sistema di controllo dell'accensione
KR940026243U (ko) 동물 주사용 화살
KR960030677U (ko) 먹통
KR960033465U (ko) 소육기
KR950001823U (ko) 농업용 난방기 완전연소 촉진장치

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19980515

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 19990907

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN

18W Application withdrawn

Withdrawal date: 20010517