EP0897283B1 - Analyse zum nachweis von degenerativen hirnerkrankungen - Google Patents

Analyse zum nachweis von degenerativen hirnerkrankungen Download PDF

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Publication number
EP0897283B1
EP0897283B1 EP97916578A EP97916578A EP0897283B1 EP 0897283 B1 EP0897283 B1 EP 0897283B1 EP 97916578 A EP97916578 A EP 97916578A EP 97916578 A EP97916578 A EP 97916578A EP 0897283 B1 EP0897283 B1 EP 0897283B1
Authority
EP
European Patent Office
Prior art keywords
animals
rsa
measure
respiratory
slaughter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP97916578A
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English (en)
French (fr)
Other versions
EP0897283A1 (de
Inventor
Christopher Pomfrett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Manchester
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Victoria University of Manchester
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Filing date
Publication date
Priority claimed from GB9607970A external-priority patent/GB9607970D0/en
Priority claimed from GB9623759A external-priority patent/GB9623759D0/en
Priority claimed from GB9704300A external-priority patent/GB9704300D0/en
Application filed by Victoria University of Manchester filed Critical Victoria University of Manchester
Priority to DK97916578T priority Critical patent/DK0897283T3/da
Publication of EP0897283A1 publication Critical patent/EP0897283A1/de
Application granted granted Critical
Publication of EP0897283B1 publication Critical patent/EP0897283B1/de
Anticipated expiration legal-status Critical
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/024—Measuring pulse rate or heart rate
    • A61B5/0245—Measuring pulse rate or heart rate by using sensing means generating electric signals, i.e. ECG signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
    • A61B5/4088—Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia

Definitions

  • BSE bovine spongiform encephalopathy
  • the invention also provides an animal carcass selection apparatus, comprising monitoring means for deriving a measure of the respiratory sinus arrhythmia of animals prior to slaughter, and means for comparing this measure with a reference value or range and hence producing an output indicating whether or not individual animals have normal RSA, the output being used to enable the selection of carcasses of only those animals for which the output indicates normal RSA.
  • the paper by Genovely and Pfeifer referred to above sets out various analysis methods including the "mean circular resultant" method which relies upon the degree of clustering of R-waves relative to the respiratory cycle. This is a suitable method to be used in measuring RSA in methods in accordance with the present invention.
  • RSA may also be measured in other ways, for example by fitting only an ECG monitor to the animal, and analysing the spectral components of an ECG tachygram derived from the monitor, i.e. the beat to beat variations in heart rate. RSA appears as a high frequency peak coincident with the respiratory frequency.
  • the lungs 1 expand and contract as a result of normal respiration. Stretch receptors in the wall of the lungs generate signals which are transmitted over nerves represented by line 2 to the brain stem or medulla 3. Signals from the medulla are transmitted on nerves represented by the line 4 to the heart 5. Damage to the medulla will also of course disrupt the transmission of signals from the cerebral cortex 6 but damage to the cerebral cortex will not directly affect the lungs/brain/heart control loop.
  • Figure 3 represents outputs which can be expected from a healthy mammal.
  • the regular line 12 represents the reference level.
  • the irregular line 13 represents the measured RSA. It will be noted that the two signals are of the same order of magnitude and that the signal 13 is sometimes greater than and sometime less than the reference level 12.
  • Figure 4 represents outputs which can be expected from a mammal in which the lung/brain/heart control loop has been disrupted for example as a result of diabetes, anaesthesia or the formation of lesions in the brain stem.
  • the line 12 remains much as it would be in a healthy subject. This indicates that good quality data is being assessed.
  • the line 13 indicates a greatly suppressed RSA level which is substantially constant over time. The two cases illustrated in Figures 3 and 4 are clearly distinguishable.
  • ECG electrocardiogram

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Physiology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Psychiatry (AREA)
  • Developmental Disabilities (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Neurosurgery (AREA)
  • Signal Processing (AREA)
  • Psychology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Claims (9)

  1. Verfahren zur Auswahl von Säugetierschlachtkörpern zur Einführung in die menschliche Nahrungskette, worin die respiratorische Sinusarrhythmie der zu schlachtenden Tiere vor dem Schlachten gemessen wird, und nur die Schlachtkörper von Tieren, bei denen die assoziierte RSA normal ist, ausgewählt werden.
  2. Verfahren nach Anspruch 1, worin Tiere ausgewählt werden, wenn die RSA innerhalb eines prädeterminierten Bereichs liegt.
  3. Verfahren zur Auswahl von Säugetieren zum Schlachten, worin die respiratorische Sinusarrhythmie der Tiere beurteilt wird, und die Tiere mit einer gemessenen abnormen RSA geschlachtet werden.
  4. Verfahren nach Anspruch 3, worin Tiere ausgewählt werden, wenn die gemessene RSA außerhalb eines prädeterminierten Bereichs liegt.
  5. Verfahren nach einem der vorangehenden Ansprüche, worin ein Messwert der RSA durch Analyse des Clustering-Grades einer Reihe von R-Zacken relativ zu den Atmungszyklen, in denen sie auftreten, berechnet wird, ein Test auf Zufälligkeit auf die analysierte Reihe von R-Zacken angewendet wird, um einen Bezugswert abzuleiten, der ein prädeterminiertes Signifikanzniveau für das Clustering der R-Zacken relativ zu den Atmungszyklen darstellt, und der gemessene Wert mit dem Bezugswert verglichen wird, wobei ein erheblicher Unterschied zwischen den Vergleichswerten zur Annahme führt, dass das Säugetier an einer degenerativen Himerkrankung leidet.
  6. Verfahren nach einem der Ansprüche 1 bis 4, worin ein Messwert der RSA durch Analyse eines EKG-Tachogramms zum Nachweis hochfrequenter Peaks, die mit der Atemfrequenz zusammenfallen, berechnet wird.
  7. Selektionsapparat für Tierschlachtkörper, umfassend Monitoring-Mittel zum Ableiten eines Messwertes der respiratorischen Sinusarrhythmie von Tieren vor dem Schlachten und Mittel zum Vergleich dieses Messwertes mit einem Bezugswert oder -bereich und folglich Herbeiführung eines Outputs, der anzeigt, ob einzelne Tiere eine normale RSA aufweisen oder nicht, wobei der Output zur Ermöglichung der Auswahl von Schlachtkörpern von nur den Tieren, für die der Output eine normale RSA anzeigt, verwendet wird.
  8. Selektionsapparat zur Auswahl von Tieren zum Schlachten, umfassend ein Monitoring-Mittel zum Ableiten eines Messwertes der respiratorischen Sinusarrhythmie der Tiere und Mittel zum Vergleich dieses Messwertes mit einem Bezugswert oder -bereich und folglich Herbeiführung eines Outputs, der anzeigt, welche Tiere eine gemessene abnorme RSA aufweisen, um das Schlachten solcher Tiere zu ermöglichen.
  9. Apparat nach Ansprüchen 7 oder 8, umfassend einen EKG-Monitor und einen Atmungsmonitor.
EP97916578A 1996-04-17 1997-04-15 Analyse zum nachweis von degenerativen hirnerkrankungen Expired - Lifetime EP0897283B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK97916578T DK0897283T3 (da) 1996-04-17 1997-04-15 Analyse for tilstedeværelse af degenerativ hjernesygdom

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB9607970A GB9607970D0 (en) 1996-04-17 1996-04-17 Analysis for the presence of degenerative brain diseasse
GB9607970 1996-04-17
GB9623759A GB9623759D0 (en) 1996-11-15 1996-11-15 Analysis for the presence of degenerative brain disease
GB9623759 1996-11-15
GB9704300 1997-03-01
GB9704300A GB9704300D0 (en) 1997-03-01 1997-03-01 Analysis for the presence of degenerative brain disease
PCT/GB1997/001043 WO1997038627A1 (en) 1996-04-17 1997-04-15 Analysis for the presence of degenerative brain disease

Publications (2)

Publication Number Publication Date
EP0897283A1 EP0897283A1 (de) 1999-02-24
EP0897283B1 true EP0897283B1 (de) 2004-10-13

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EP97916578A Expired - Lifetime EP0897283B1 (de) 1996-04-17 1997-04-15 Analyse zum nachweis von degenerativen hirnerkrankungen

Country Status (11)

Country Link
US (1) US6217521B1 (de)
EP (1) EP0897283B1 (de)
JP (1) JP2001502193A (de)
AT (1) ATE279143T1 (de)
AU (1) AU736454B2 (de)
CA (1) CA2251831A1 (de)
DE (1) DE69731194T2 (de)
DK (1) DK0897283T3 (de)
ES (1) ES2230599T3 (de)
PT (1) PT897283E (de)
WO (1) WO1997038627A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9624280D0 (en) * 1996-11-22 1997-01-08 Univ Glasgow Apparatus and method for measuring cardiac vagal tone
US6591991B2 (en) * 2001-08-06 2003-07-15 Luce Belle Collapsible tire stand
US7045297B2 (en) * 2001-11-14 2006-05-16 Prion Developmental Laboratories, Inc. Rapid prion-detection assay
US20030092090A1 (en) * 2001-11-14 2003-05-15 Kiamars Hajizadeh Rapid prion-detection device, system, and test kit
GB2399886A (en) * 2003-03-26 2004-09-29 Secr Defence Identifying degenerative brain disease using EEG or EMG measurements

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4510944A (en) * 1982-12-30 1985-04-16 Porges Stephen W Method and apparatus for evaluating rhythmic oscillations in aperiodic physiological response systems
GB9022623D0 (en) * 1990-10-18 1990-11-28 Univ Manchester Depth of anaesthesia monitoring
GB9307523D0 (en) * 1993-04-13 1993-06-02 Mini Agriculture & Fisheries Detection of cns gases

Also Published As

Publication number Publication date
US6217521B1 (en) 2001-04-17
ES2230599T3 (es) 2005-05-01
WO1997038627A1 (en) 1997-10-23
JP2001502193A (ja) 2001-02-20
DK0897283T3 (da) 2005-02-14
EP0897283A1 (de) 1999-02-24
AU2518997A (en) 1997-11-07
CA2251831A1 (en) 1997-10-23
DE69731194T2 (de) 2005-10-20
ATE279143T1 (de) 2004-10-15
DE69731194D1 (de) 2004-11-18
PT897283E (pt) 2005-02-28
AU736454B2 (en) 2001-07-26

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