EP0907375A4 - Neuartige substanz - Google Patents

Neuartige substanz

Info

Publication number
EP0907375A4
EP0907375A4 EP97922354A EP97922354A EP0907375A4 EP 0907375 A4 EP0907375 A4 EP 0907375A4 EP 97922354 A EP97922354 A EP 97922354A EP 97922354 A EP97922354 A EP 97922354A EP 0907375 A4 EP0907375 A4 EP 0907375A4
Authority
EP
European Patent Office
Prior art keywords
novel compounds
novel
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97922354A
Other languages
English (en)
French (fr)
Other versions
EP0907375A1 (de
Inventor
Elizabeth Jane Lawlor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Ltd
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd, SmithKline Beecham Corp filed Critical SmithKline Beecham Ltd
Publication of EP0907375A1 publication Critical patent/EP0907375A1/de
Publication of EP0907375A4 publication Critical patent/EP0907375A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/46—Streptococcus ; Enterococcus; Lactococcus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
EP97922354A 1996-04-18 1997-04-18 Neuartige substanz Withdrawn EP0907375A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9607991.8A GB9607991D0 (en) 1996-04-18 1996-04-18 Novel compounds
GB9607991 1996-04-18
PCT/US1997/006553 WO1997038720A1 (en) 1996-04-18 1997-04-18 Novel compounds

Publications (2)

Publication Number Publication Date
EP0907375A1 EP0907375A1 (de) 1999-04-14
EP0907375A4 true EP0907375A4 (de) 2000-06-28

Family

ID=10792235

Family Applications (6)

Application Number Title Priority Date Filing Date
EP97922354A Withdrawn EP0907375A4 (de) 1996-04-18 1997-04-18 Neuartige substanz
EP97921273A Withdrawn EP0904105A4 (de) 1996-04-18 1997-04-18 Neuartige zusammensetzungen
EP97922370A Withdrawn EP0914328A4 (de) 1996-04-18 1997-04-18 STREPTOCOCCUS PNEUMONIAE ALANYL tRNS SYNTHETASE
EP97918781A Withdrawn EP0914327A4 (de) 1996-04-18 1997-04-18 NEUE LysS-PROTEINE AUS STREPTOCOCCUS PNEUMONIAE
EP97922405A Withdrawn EP0907376A4 (de) 1996-04-18 1997-04-18 Neue verbindungen
EP97920430A Withdrawn EP0954331A4 (de) 1996-04-18 1997-04-18 Neuartige verbindungen

Family Applications After (5)

Application Number Title Priority Date Filing Date
EP97921273A Withdrawn EP0904105A4 (de) 1996-04-18 1997-04-18 Neuartige zusammensetzungen
EP97922370A Withdrawn EP0914328A4 (de) 1996-04-18 1997-04-18 STREPTOCOCCUS PNEUMONIAE ALANYL tRNS SYNTHETASE
EP97918781A Withdrawn EP0914327A4 (de) 1996-04-18 1997-04-18 NEUE LysS-PROTEINE AUS STREPTOCOCCUS PNEUMONIAE
EP97922405A Withdrawn EP0907376A4 (de) 1996-04-18 1997-04-18 Neue verbindungen
EP97920430A Withdrawn EP0954331A4 (de) 1996-04-18 1997-04-18 Neuartige verbindungen

Country Status (5)

Country Link
US (4) US5747314A (de)
EP (6) EP0907375A4 (de)
JP (6) JP2001519651A (de)
GB (1) GB9607991D0 (de)
WO (6) WO1997039013A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968777A (en) * 1996-04-18 1999-10-19 Smithkline Beecham Corporation DNA encoding seryl t-RNA synthetase
US6348328B1 (en) * 1997-05-14 2002-02-19 Smithkline Beecham Corporation Compounds
EP0894858A3 (de) * 1997-07-29 1999-11-03 Smithkline Beecham Corporation Prolyl tRNA synthetase von Streptococcus pneumoniae
EP0909818A1 (de) * 1997-10-17 1999-04-21 Smithkline Beecham Corporation Valyl tRNA synthetase (EC 6.1.1.9) aus Streptococcus pneumoniae
CN1309720A (zh) 1997-11-25 2001-08-22 综合医院公司 毒性相关核酸序列及其应用
US7112716B2 (en) 2000-04-06 2006-09-26 The General Hospital Corporation Methods for screening and identifying host pathogen defense genes
US8470417B2 (en) * 2004-04-02 2013-06-25 Curwood, Inc. Packaging inserts with myoglobin blooming agents, packages and methods for packaging
WO2010099477A2 (en) 2009-02-27 2010-09-02 Atyr Pharma, Inc. Polypeptide structural motifs associated with cell signaling activity
US8980253B2 (en) 2010-04-26 2015-03-17 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase
CA2797362C (en) 2010-04-27 2020-12-08 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl trna synthetases
EP2563382B1 (de) 2010-04-27 2017-06-07 aTyr Pharma, Inc. Innovative entdeckung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen im zusammenhang mit proteinfragmenten von threonyl-trna-synthetasen
WO2011139853A2 (en) 2010-04-28 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl trna synthetases
CA2797393C (en) 2010-04-29 2020-03-10 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl trna synthetases
CA2797374C (en) 2010-04-29 2021-02-16 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of asparaginyl trna synthetases
CN103096912A (zh) 2010-05-03 2013-05-08 Atyr医药公司 与苯丙氨酰-α-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
CA2797799C (en) 2010-05-03 2020-12-08 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of seryl-trna synthetases
CN103140233B (zh) 2010-05-03 2017-04-05 Atyr 医药公司 与甲硫氨酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现
US8961961B2 (en) 2010-05-03 2015-02-24 a Tyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of arginyl-tRNA synthetases
US9062301B2 (en) 2010-05-04 2015-06-23 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutamyl-prolyl-tRNA synthetases
JP6008844B2 (ja) 2010-05-04 2016-10-19 エータイアー ファーマ， インコーポレイテッド ｐ３８ＭＵＬＴＩ−ｔＲＮＡ合成酵素複合体のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
EP2568996B1 (de) 2010-05-14 2017-10-04 aTyr Pharma, Inc. Therapeutische, diagnostische und antikörperhaltige zusammensetzungen im zusammenhang mit proteinfragmenten von phenylalanyl-beta-trna-synthetasen
CN103096914B (zh) 2010-05-17 2015-08-12 Atyr医药公司 与亮氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
CA2800375C (en) 2010-05-27 2021-03-09 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-trna synthetases
EP2575857B1 (de) 2010-06-01 2018-01-24 aTyr Pharma, Inc. Innovative erkennung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen in zusammenhang mit proteinfragmenten von lysyl-trna-synthetasen
WO2012009289A2 (en) 2010-07-12 2012-01-19 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of aspartyl-trna synthetases
EP2593125B1 (de) 2010-07-12 2017-11-01 aTyr Pharma, Inc. Innovative erkennung therapeutischer, diagnostischer und antikörperhaltiger zusammensetzungen in zusammenhang mit proteinfragmenten von glycyl-trna-synthetasen
US20130202576A1 (en) 2010-07-12 2013-08-08 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-trna synthetases
US8999321B2 (en) 2010-07-12 2015-04-07 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases
AU2011293294B2 (en) 2010-08-25 2016-03-24 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Tyrosyl-tRNA synthetases
CA2812795C (en) 2010-10-06 2021-08-31 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related protein fragments of tryptophanyl trna synthetases
US9714419B2 (en) 2011-08-09 2017-07-25 Atyr Pharma, Inc. PEGylated tyrosyl-tRNA synthetase polypeptides
US9816084B2 (en) 2011-12-06 2017-11-14 Atyr Pharma, Inc. Aspartyl-tRNA synthetases
US9822353B2 (en) 2011-12-06 2017-11-21 Atyr Pharma, Inc. PEGylated aspartyl-tRNA synthetase polypeptides
WO2013115926A2 (en) 2011-12-29 2013-08-08 Atyr Pharma, Inc. Aspartyl-trna synthetase-fc conjugates
CN105378075B (zh) 2013-03-15 2022-04-05 Atyr 医药公司 组氨酰-trna合成酶-fc缀合物
CN110536694A (zh) 2017-04-20 2019-12-03 Atyr 医药公司 用于治疗肺部炎症的组合物和方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994028139A1 (en) * 1993-05-28 1994-12-08 Massachusetts Institute Of Technology tRNA BINDING-DEPENDENT INHIBITION OF MICROBIAL PATHOGEN GROWTH
EP0785270A1 (de) * 1996-01-19 1997-07-23 Smithkline Beecham Plc Seryl-tRNA Synthetase von Staphylococcus aureus
EP0786519A2 (de) * 1996-01-05 1997-07-30 Human Genome Sciences, Inc. Polynukleotide und Sequenzen aus Staphylococcus aureus
WO1998018931A2 (en) * 1996-10-31 1998-05-07 Human Genome Sciences, Inc. Streptococcus pneumoniae polynucleotides and sequences

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5429921A (en) * 1988-04-04 1995-07-04 The Salk Institute Biotechnology/Industrial Assoc. Inc. Assays for agonists and antagonists of recombinant human calcium channels
US5476929A (en) * 1991-02-15 1995-12-19 Uab Research Foundation Structural gene of pneumococcal protein
GB9320563D0 (en) * 1993-10-06 1993-11-24 Zeneca Ltd Assay procedure and application in identification of herbicides
US5474905A (en) * 1993-11-24 1995-12-12 Research Corporation Technologies Antibodies specific for streptococcus pneumoniae hemin/hemoglobin-binding antigens
EP0785272A1 (de) * 1996-01-19 1997-07-23 Smithkline Beecham Plc Prolyl-tRNA Synthetase aus Staphylococcus aureus
WO1997037026A1 (en) * 1996-04-02 1997-10-09 Smithkline Beecham Corporation Novel compounds
US6294661B1 (en) * 1996-05-14 2001-09-25 Smithkline Beecham Corporation Compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994028139A1 (en) * 1993-05-28 1994-12-08 Massachusetts Institute Of Technology tRNA BINDING-DEPENDENT INHIBITION OF MICROBIAL PATHOGEN GROWTH
EP0786519A2 (de) * 1996-01-05 1997-07-30 Human Genome Sciences, Inc. Polynukleotide und Sequenzen aus Staphylococcus aureus
EP0785270A1 (de) * 1996-01-19 1997-07-23 Smithkline Beecham Plc Seryl-tRNA Synthetase von Staphylococcus aureus
WO1998018931A2 (en) * 1996-10-31 1998-05-07 Human Genome Sciences, Inc. Streptococcus pneumoniae polynucleotides and sequences

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
EMBL Database, Heidelberg, FRG Empro1 accession number D26185 05 February 1994 Ogasawara, N.: "B. subtilis DNA, 180 kilobase region of replication origin" *
LASKE, R. ET AL.: "Investigations on the Antiproliferative Effects of Amino Acid Antagonists Targeting for Aminoacyl-tRNA Synthetases. Part I--The Antibacterial Effect", ARCHIV DER PHARMAZIE, vol. 322, no. 12, December 1989 (1989-12-01), pages 847 - 852, XP002113352 *
OGASAWARA, N. ET AL.: "Systematic Sequencing of the 180 Kilobase Region of the Bacillus Subtilis Chromosome Containing the Replication Origin", DNA RESEARCH, vol. 1, no. 1, 1994, pages 1 - 14, XP000647993 *
See also references of WO9738720A1 *
VON DER HAAR, F. ET AL.: "Target Directed Drug Synthesis: The Aminoacyl-tRNA Synthetases as Possible Targets", ANGEWANDTE CHEMIE, vol. 20, no. 3, March 1981 (1981-03-01), pages 217 - 223, XP002112772 *

Also Published As

Publication number Publication date
EP0904105A1 (de) 1999-03-31
WO1997038715A1 (en) 1997-10-23
EP0914328A4 (de) 1999-11-03
EP0907376A4 (de) 1999-10-20
WO1997038721A1 (en) 1997-10-23
US6087142A (en) 2000-07-11
JP2000515365A (ja) 2000-11-21
WO1997038714A1 (en) 1997-10-23
WO1997038720A1 (en) 1997-10-23
JP2000511405A (ja) 2000-09-05
EP0907375A1 (de) 1999-04-14
EP0904105A4 (de) 1999-10-20
WO1997039016A1 (en) 1997-10-23
EP0954331A1 (de) 1999-11-10
EP0914327A4 (de) 1999-11-03
EP0954331A4 (de) 2000-01-12
JP2000509262A (ja) 2000-07-25
US5747314A (en) 1998-05-05
US5753480A (en) 1998-05-19
WO1997039013A1 (en) 1997-10-23
JP2002515871A (ja) 2002-05-28
JP2001519651A (ja) 2001-10-23
EP0914328A1 (de) 1999-05-12
US5863777A (en) 1999-01-26
EP0907376A1 (de) 1999-04-14
EP0914327A1 (de) 1999-05-12
JP2000509974A (ja) 2000-08-08
GB9607991D0 (en) 1996-06-19

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