EP0918555A2 - Mecanisme incrementiel destine en particulier a une seringue a membrane - Google Patents

Mecanisme incrementiel destine en particulier a une seringue a membrane

Info

Publication number
EP0918555A2
EP0918555A2 EP96904187A EP96904187A EP0918555A2 EP 0918555 A2 EP0918555 A2 EP 0918555A2 EP 96904187 A EP96904187 A EP 96904187A EP 96904187 A EP96904187 A EP 96904187A EP 0918555 A2 EP0918555 A2 EP 0918555A2
Authority
EP
European Patent Office
Prior art keywords
plunger
toothed wheel
rotation
incrementing
abutment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96904187A
Other languages
German (de)
English (en)
Inventor
Bernard Sams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP0918555A2 publication Critical patent/EP0918555A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/3152—Piston or piston-rod constructions, e.g. connection of piston with piston-rod including gearings to multiply or attenuate the piston displacing force
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A61M5/31541—Means preventing setting of a dose beyond the amount remaining in the cartridge
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31556—Accuracy improving means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31556—Accuracy improving means
    • A61M5/31558—Accuracy improving means using scaling up or down transmissions, e.g. gearbox
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/31573—Accuracy improving means
    • A61M5/31575—Accuracy improving means using scaling up or down transmissions, e.g. gearbox
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir

Definitions

  • This invention relates to an incrementing mechanism for advancing a thrust member in response to advancement of an operating plunger.
  • the invention in particular - but not exclusively - relates to an incrementing mechanism adapted for use with a medical syringe, to permit the dispensing of a pre-set dose of medicament from a cartridge thereof.
  • a member is required to advance through a predetermined distance, pre-selected to suit the application, and there have been numerous proposals for mechanisms aimed at achieving this.
  • a particular problem exists in the case of the dispensing of a precise and predetermined quantity of medicament, from a syringe fitted with a hypodermic needle by means of which the medicament is injected into a body.
  • a simple and reliable device which may be pre-set to permit the precise dispensing of an accurately controlled quantity of insulin upon depression of an operating member.
  • an incrementing mechanism for advancing a thrust member in response to advancement of an operating plunger having a pre-set range of movement, in which mechanism the plunger is hollow and is formed with an internal rack, the plunger being movable axially away from and towards a fixed abutment, the thrust member is slidably supported within the plunger and carries a first toothed wheel engaged with the rack, a second toothed wheel is coupled to the first toothed wheel, and there is provided a fixed rack along which the second toothed wheel runs, the internal rack being disengageable from the first toothed wheel by rotation of the operating plunger whereafter the plunger may be moved away from the fixed abutment and then on subsequent engagement of the internal rack with the first toothed wheel and driving of the plunger to engage the abutment, the thrust member is correspondingly advanced.
  • the incre- menting mechanism of the present invention may find uses other than in connection with the dispensing of medicament from a syringe, that is the principal intended use of this mechanism and it will hereinafter be described solely with reference to that use.
  • the incrementing mechanism of this invention is to be used to dispense a precisely measured dose from a syringe, the syringe is either pre-filled with medicament or is loaded with a pre-filled cartridge of the medicament whereafter the mechanism is then coupled to the rear end of the syringe.
  • the plunger is turned to disengage its rack from the first toothed wheel associated with t e thrust member and is moved axially rearwardly away from the abutment through a distance suitable for the dose to be dispensed.
  • the plunger is driven forwardly to re-engage the abutment.
  • the first toothed wheel is rotated and so rotates the second toothed wheel which in turn runs along the fixed rack, so advancing the thrust member.
  • the velocity ratio (and so also the mechanical advantage) between the operating plunger and thrust member may be adjusted to give a manageable plunger movement for a relatively small thrust member movement for a typical dose to be dispensed.
  • that velocity ratio may be set to be of the order of 4:1 whereby the thrust member moves through one quarter of the distance moved by the plunger, on any one operating stroke.
  • the operating plunger has a plurality of parallel axially-extending internal racks disposed in an equi-spaced manner around the internal surface of the plunger, with channels formed therebetween and in which may be positioned the first toothed wheel, upon rotation of the plunger. In this way, the toothed wheel may be engaged with any one of the racks in order to perform an operating stroke, and so with the plunger in any one of a number of different angular settings. Typically, five such racks may be provided.
  • Axial movement of the plunger away from the abutment, to pre-set a medicament dose to be dispensed may be effected by drive means co-operating with the plunger upon the rotation thereof.
  • drive means may include a cam surface on one of the plunger and a fixed component (such as a body of the mechanism) and a cam follower on the other of the plunger and said fixed component.
  • the cam surface is configured to cause axial movement of the plunger only when the first toothed wheel is not engaged with the internal rack, or one of the internal racks, of the plunger. In this way, the toothed wheel - and also the thrust member - will not be moved axially as the plunger is moved axially away from the abutment.
  • the cam surface is formed externally of the plunger and is engaged by an axially-fixed resilient follower.
  • the cam follower may ride resiliently over the cam surface during axial movement of the plunger towards the abutment.
  • Ramped ratchet teeth may be provided on the cam surface which ratchet teeth co ⁇ operate with and are aligned with the follower when the (or a) plunger rack is engaged with the first toothed wheel. The teeth serve to prevent axial movement of the plunger away from the abutment other than when driven by the cam surfaces, upon plunger rotation.
  • the plunger preferably is formed with a series of index marks which successively are aligned with an indicator upon rotation of the plunger and its consequent movement away from the abutment.
  • the index marks are preferably formed in as many axial columns as there are racks and are arranged sequentially in a spiral manner around the plunger, so that successive index marks show at the indicator - which conveniently takes the form of a window through the mechanism body - as the plunger is rotated.
  • limiting means may be provided to prevent pre-setting of the plunger to a position which, on the subsequent driving thereof to the abutment, would require the thrust member to move beyond its maximum advanced position, corresponding to the exhaustion of medicament from the syringe.
  • a clutch may be formed between one of the toothed wheels and the thrust member to hold the wheels and so also the thrust member stationary other than when the plunger is driven towards the abutment.
  • a sleeve which surrounds at least part of the plunger and which obscures the window when in an initial position. Rotation of the plunger may release the sleeve to expose the zero mark only when the plunger has properly been aligned to initialise the mechanism. Thereafter, the indicated dose on further rotating the plunger will be the dose which will be dispensed upon subsequent actuation of the mechanism.
  • Rotation of the plunger may be performed by means of an external pre-setting knob, which is also used to effect axial driving movement of the plunger, to dispense medicament.
  • a knob may be connected to the plunger through a slip-clutch, arranged to slip when the rotary force applied to the knob exceeds some predetermined value.
  • This invention extends to an incrementing mechanism of this invention as described above, in combination with a syringe for injecting a medicament, the mechanism being connected to the rear end of the syringe whereby doses of medicament may be dispensed by cycling the incrementing mechanism.
  • the syringe may directly hold the medicament, or a cartridge of the medicament may be contained within the syringe. Either way, the medicament-dispensing piston of the syringe or cartridge is driven by the thrust member through a precisely controlled distance, upon cycling of the operating plunger.
  • FIG. 1 is a longitudinal sectional view through the incrementing mechanism, coupled to a syringe body containing a cartridge of medicament:
  • Figure 2 is a partially cut-away isometric view of the mechanism of Figure 1;
  • Figure 3 is a side view of the operating plunger of the mechanism;
  • Figures 4A and 4B are cross-sections through the mechanism on line IV-IV marked on Figure 1, with the operating plunger in two different angular settings;
  • Figure 5 is a detail view of the wheel assembly and support;
  • Figures 6A and 6B show the operation of a zero sleeve, in two different positions;
  • Figures 7A and 7B are respectively a cross-section through and a cut-away isometric view through the central part of the plunger and the co-operating part of the zero sleeve;
  • Figure 8 is an enlarged view of part of the plunger and the cam follower engageable therewith;
  • Figure 9 shows the operating button separated from the plunger
  • Figure 10 shows the plunger in conjunction with a dose-limiting nut
  • Figure 11 is a cross-section through the forward end of the plunger and the nut taken on line XI-XI marked on Figure 1;
  • Figure 12 is an external view of a pen-like self- injection device incorporating the incrementing mechanism of Figures 1 to 11.
  • forward refers to the direction of the needle-end of the syringe, and to the left in Figures 1 and 2; and the term “backward” refers to the direction away from the syringe, and so to the right in Figures 1 and 2.
  • the incrementing mechanism shown in the drawings is configured for use with a syringe including a housing 10 containing a cartridge 11 of a medicament, the cartridge having a dispensing piston 12 which, when moved axially along the cartridge 11, dispenses medicament therefrom, through a needle (not shown) at the forward end of the syringe housing.
  • a syringe including a housing 10 containing a cartridge 11 of a medicament, the cartridge having a dispensing piston 12 which, when moved axially along the cartridge 11, dispenses medicament therefrom, through a needle (not shown) at the forward end of the syringe housing.
  • the mechanism has a hollow body 13 in the forward end of which is provided a stop member 14 including an inwardly-directed rib 15 by means of which the body 13 may be mounted on the syringe housing 10, the rib 15 engaging in an external groove around that housing 10.
  • a stop member 14 including an inwardly-directed rib 15 by means of which the body 13 may be mounted on the syringe housing 10, the rib 15 engaging in an external groove around that housing 10.
  • Both rotatably and axially slidably mounted within the body 13 is an operating plunger 17 having formed along a forward portion 18 thereof columns of dose-indicating markings, and along a rearward portion thereof a cam surface 19 (see particularly Figures 3 and 8).
  • a window 20 is formed in the body 13 to permit viewing of the index marks on the forward portion 18 of the plunger, an enlarging lens 21 being fitted in that window 20.
  • the lens 21 is a part of a cam follower 22, which may resiliently engage with cams and ratchet teeth 24 formed on the cam surface 19.
  • rotation of the plunger 17 in the appropriate sense will cause the plunger to move backward (rightwards in Figures 1 and 2) as the follower threads along the cams on the cam surface 19, so successively displaying the index marks through the window 20.
  • the plunger may be thrust forward until its forward end engages radial face 23 of the stop member 14, the cam follower 22 riding over the ratchet teeth 24 of the cam surface 19 during this action.
  • the ratchet teeth 24 are ramped ( Figure 8), which teeth are arranged in five aligned columns, so that the plunger may be thrust forward only when follower 22 is aligned with one of the columns of teeth 24.
  • a zero sleeve 25 ( Figures 6A and 6B), the plunger 17 being rotatably received within the sleeve 25.
  • a slot 26 is formed axially along the sleeve 25, arm 27 connecting lens 21 to the cam follower 22 extending along that slot and restraining the sleeve against rotation.
  • the forward end of the sleeve is provided with a shutter blade 28 which obscures (Figure 6A) or opens ( Figure 6B) the window 20 through the body 13, the index marks on portion 18 not being visible when the sleeve is in the position of Figure 6A.
  • an inwardly-directed catch 29 ( Figures 7A and 7B), the sleeve having axial slits to each side of the catch to allow outward springing thereof.
  • An annular rib 30 ( Figures 3, 7A and 7B) extends around the plunger 17 between the forward portion 18 and the cam surface 19, the rib 30 having a notch 31 through which the catch may pass.
  • a helical compression spring 32 acts between the forward end of sleeve 25 and an internal shoulder in the body 13, urging the sleeve to the right
  • the sleeve 25 may be moved to the left relative to the plunger 17 by springing the catch 29 over the rib 30; the catch will then hold the sleeve in the position illustrated in Figure 6A and 7B, with the shutter blade 28 closing the window 20. Rotation of the sleeve 25 relative to the plunger 17 will bring the catch 29 into alignment with the notch 31, whereby the sleeve may move to the position shown in Figure 6B under the action of spring 32.
  • An operating button 33 is engaged with the rearward end of the sleeve 25 by means of a rotatable coupling 34.
  • the button has two internal lugs 35 each of which has a projection 36, the projections 36 being slidingly engaged in splines 37 formed at the rearward end of the plunger 17.
  • the plunger will normally be driven by rotation of the button 33, but should the torque applied to the button 33 exceed some predetermined value, then the button may rotate with respect to the plunger by the projections 36 springing inwardly to ride over the splines 37.
  • the plunger 17 is formed internally with five axially-extending equi-spaced toothed racks 40, grooves 41 being formed between those racks.
  • a support 42 formed integrally with stop member 14, is disposed within the plunger 17 and is held stationary with respect thereto, the racks 40 running on the outer surface of that support during plunger movement.
  • a channel 43 is formed in the support 42, in which channel is slidably mounted a thrust rod 44 the forward end of which engages the piston 12 to cause axial movement thereof.
  • the rearward end of the rod 44 defines a housing 45 having arcuate surfaces and within which is located a wheel assembly 46 including a first toothed wheel 47 which fits closely (but rotatably) to the arcuate surfaces of the housing 45.
  • a second toothed wheel 48 engaged with a rack 49 formed on the support 42.
  • the first toothed wheel 47 successively comes into engagement with each of the racks 40 formed in the plunger. Between each such engagement, the first toothed wheel 47 lies in a groove 41 of the plunger and so is free of the racks 40.
  • the cam profile of the cam surface 19 is arranged so that upon rotation of the plunger, the plunger moves rearwardly only when the first toothed wheel 47 lies within a groove 41; whenever that toothed wheel 47 is engaged with a rack 40, no axial movement of the plunger takes place.
  • the columns of ramped ratchet teeth 24 ( Figures 3 and 8) are aligned with follower 22 when the toothed wheel 47 is so engaged, then to permit the forward movement of the plunger. In this way, rotation of the plunger will gradually also move the plunger to the right, whilst both the wheel assembly 46 and the thrust rod 44 remain stationary.
  • the cam surface 19 is shown in greater detail in Figure 8. Between the columns of ramped ratchet teeth 24 are formed individual cams 52 which, on being engaged by the cam follower 22, drive the plunger 17 axially, as the plunger is rotated. Each cam 52 is profiled to move the plunger through a suitable distance to dispense one dose unit, on thrusting the plunger to the left. The ratchet teeth serve to prevent an operator partially pushing the plunger to the left when the cam follower is aligned with a column of teeth 24, and then pulling the plunger back to continue rotation.
  • the operator must push the plunger forward at least until the follower can re-engage in the next pitch of cams 52, nearer the front of the plunger, or the operator may push the plunger fully forwardly, and start again.
  • the ratchet teeth serve to prevent the plunger being moved out of the body 13 other than by being threaded, on being turned by button 33.
  • the ratchet tooth 53 at the end of the cam surface 19 is almost continuous and is of a greater height between the aligned columns of teeth 24. This tooth 53 is engaged by follower 22 when the mechanism is in its initial state as shown in Figures 1 and 6A, and prevents the spring 32 pushing the plunger outwardly until the zero orientation has been selected.
  • the initial starting position for the mechanism is as shown in Figures 1, 2 and 6A, when a fresh cartridge has been inserted in the syringe housing.
  • the button 33 is rotated until catch 29 passes through notch 31 in rib 30, under the action of spring 32, at which point the blade 28 exposes the plunger, mid-way between the "0" and "1" index marks.
  • Continued rotation of the button 33 winds the plunger 17 to the right, both the wheel assembly 46 and the thrust rod 44 remaining stationary.
  • the index marks are appropriately aligned with the racks 40, so that each time a selected dose is displayed, a rack is engaged with the first toothed wheel 47.
  • the button 33 is thrust to the left, so driving the sleeve 25 to the left.
  • the catch 29 engages rib 30 to drive the plunger to the left, the catch being restrained against outward movement by a co-operating rib within the body 13, until the left hand end of the plunger engages the radial face 23 of the stop member 14; then, the catch 29 comes free of the body rib and may spring outwardly and over rib 30.
  • the wheel assembly 46 is rotated by the action of the rack 40 on the first toothed wheel 47.
  • the relative diameters of the first and second toothed wheels, and the pitch of the teeth, are selected such that the velocity ratio of the plunger movement to the rod movement is 4:1.
  • a limiting mechanism is provided for the plunger 17, as the thrust rod 44 approaches its extreme leftward (in Figure 1) movement.
  • This mechanism comprises a nut 55 ( Figures 2, 10 and 11) having axial tines 56 frictionally engaged with corresponding splines formed internally within the forward end of the plunger 17; the nut 55 is in this way non-rotatably coupled to the plunger 17 but may slide axially with respect thereto.
  • the nut 55 has an internal segmented thread 54, there being axial grooves through the thread in alignment with the tines 56.
  • the forward end of the support 42 is of reduced diameter and is formed with a segmented screw-thread 57 co-operating with the segmented thread of the nut 55.
  • the pitch of these co-operating threads is one quarter of the pitch of the cam surface 19, so that the nut moves rearwardly as the plunger is rotated to set a dose.
  • the rightward movement of the nut before thrusting the plunger to the left thus corresponds to the leftward movement of the rod 44, on driving the plunger into engagement with the radial face 23.
  • a rib 58 is formed on the rod 44, and eventually a point is reached at which an abutment 59 on the nut 55 engages that rib 58 during plunger rotation to set a dose to be dispensed.
  • This dose may then be dispensed in the usual way, by thrusting the button 33 to the left.
  • the nut 55 is moved back to its initial position with its end face against radial face 23, by interaction between the tines of the nut and the plunger.
  • the mechanism may be re-set by removing the spent cartridge and piston, turning the button 33 until the wheel assembly is free of racks 40 ( Figure 4B) and then pushing the thrust rod back into the body 13. The mechanism is then ready for connecting to a fresh cartridge.
  • the mechanism may be regarded as a non-reusable throw- away item, further medicament being dispensed from a new cartridge connected to a new mechanism.
  • the above-described mechanism may be assembled into a pen-like housing, as shown in Figure 12.
  • the cap 60 of the housing is removable to expose the syringe housing 10 and a hypodermic needle attached thereto, and to give access to the housing to permit the changing of the cartridge of medicament.
  • the cap is replaced and the complete assembly may easily and conveniently be carried for use whenever required.
  • a cam follower separate from a pawl engageable with the ratchet teeth may be provided, the cam follower being specifically adapted to interact with the cams 52, and the pawl with the ratchet teeth.
  • the cam follower need be arranged as a part of the lens; this has been done in the case of the described embodiment merely for convenience of manufacture and assembly.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Cette invention concerne un mécanisme permettant de distribuer avec précision des quantités prédéterminées de médicament à partir d'une seringue. Ce mécanisme a un piston (17) qui peut tourner à l'intérieur d'un logement (13) et qui possède une surface de came (19) en contact avec un suiveur fixe (22) de telle sorte que la rotation du piston (17) éloigne celui-ci de la seringue. A l'intérieur du piston se trouve un certain nombre de crémaillères parallèles (40) qui, à leur tour, entrent toutes en contact avec une première roue dentée (47) lors de la rotation du piston. La première roue dentée (47) est reliée à une seconde roue dentée (48) qui se déplace sur une crémaillère fixe (49) intérieure au piston et parallèle à l'axe de celui-ci. La première roue dentée (47) est couplée à une tige de commande (44) destinée au piston de la seringue. Après présélection de la dose requise effectuée par rotation du piston (17), ce dernier est alors poussé vers la seringue, entraînant ainsi la rotation des première et seconde roues dentées (47 et 48). Ceci a pour effet de diriger la tige de commande vers l'intérieur de la seringue mais grâce à la sélection appropriée des diamètres des roues dentées et de leur pas dentaire, il est possible d'obtenir un rapport de vitesse favorable entre les mouvements du piston et de la tige de commande.
EP96904187A 1995-02-28 1996-02-28 Mecanisme incrementiel destine en particulier a une seringue a membrane Withdrawn EP0918555A2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9503969 1995-02-28
GBGB9503969.9A GB9503969D0 (en) 1995-02-28 1995-02-28 Incrementing mechanism
PCT/GB1996/000446 WO1996026754A2 (fr) 1995-02-28 1996-02-28 Mecanisme incrementiel destine en particulier a une seringue a membrane

Publications (1)

Publication Number Publication Date
EP0918555A2 true EP0918555A2 (fr) 1999-06-02

Family

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EP96904187A Withdrawn EP0918555A2 (fr) 1995-02-28 1996-02-28 Mecanisme incrementiel destine en particulier a une seringue a membrane

Country Status (3)

Country Link
EP (1) EP0918555A2 (fr)
GB (1) GB9503969D0 (fr)
WO (1) WO1996026754A2 (fr)

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Also Published As

Publication number Publication date
GB9503969D0 (en) 1995-04-19
WO1996026754A2 (fr) 1996-09-06
WO1996026754A3 (fr) 1996-10-17

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