EP0920312A4 - Apoptose induzioerende adamantyl-derivate und deren verwendung als antikrebsmittel - Google Patents

Apoptose induzioerende adamantyl-derivate und deren verwendung als antikrebsmittel

Info

Publication number: EP0920312A4
Authority: EP; European Patent Office
Prior art keywords: cancer; adamantyl; pct; sec; useful
Prior art date: 1996-07-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

EP97933256A

Other languages

English (en)

French (fr)

Other versions

EP0920312A1 (de

EP0920312B1 (de

Inventor

Magnus Pfahl

Xian-Ping Lu

Darryl Rideout

Hongyue Zhang

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Galderma Research and Development SNC

Original Assignee

Galderma Research and Development SNC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-08

Filing date

1997-07-08

Publication date

2000-11-02

1997-07-08 Application filed by Galderma Research and Development SNC filed Critical Galderma Research and Development SNC

1997-07-08 Priority to DK97933256T priority Critical patent/DK0920312T3/da

1999-06-09 Publication of EP0920312A1 publication Critical patent/EP0920312A1/de

2000-11-02 Publication of EP0920312A4 publication Critical patent/EP0920312A4/de

2004-12-08 Application granted granted Critical

2004-12-08 Publication of EP0920312B1 publication Critical patent/EP0920312B1/de

2017-07-08 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Emergency Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Oncology (AREA)
Cardiology (AREA)
Communicable Diseases (AREA)
Heart & Thoracic Surgery (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Cosmetics (AREA)

EP97933256A 1996-07-08 1997-07-08 Apoptose induzierende adamantyl-derivate und deren verwendung als antikrebsmittel Expired - Lifetime EP0920312B1 (de)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
DK97933256T DK0920312T3 (da)	1996-07-08	1997-07-08	Apoptoseinducerende adamantylderivater og deres anvendelse som anticancermidler

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US2128596P	1996-07-08	1996-07-08
US21285P		1996-07-08
PCT/US1997/011564 WO1998001132A1 (en)	1996-07-08	1997-07-08	Apoptosis inducing adamantyl derivatives and their usage as anti-cancer agents

Publications (3)

Publication Number	Publication Date
EP0920312A1 EP0920312A1 (de)	1999-06-09
EP0920312A4 true EP0920312A4 (de)	2000-11-02
EP0920312B1 EP0920312B1 (de)	2004-12-08

Family

ID=21803357

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP97933256A Expired - Lifetime EP0920312B1 (de)	1996-07-08	1997-07-08	Apoptose induzierende adamantyl-derivate und deren verwendung als antikrebsmittel

Country Status (21)

Country	Link
US (1)	US6127415A (de)
EP (1)	EP0920312B1 (de)
JP (1)	JP2000515506A (de)
KR (1)	KR20000023626A (de)
CN (1)	CN1279902C (de)
AT (1)	ATE284213T1 (de)
AU (1)	AU719311B2 (de)
BG (1)	BG103152A (de)
BR (1)	BR9710255A (de)
CA (1)	CA2259936C (de)
CZ (1)	CZ3499A3 (de)
DE (1)	DE69731885T2 (de)
ES (1)	ES2231877T3 (de)
HU (1)	HUP9903834A3 (de)
IL (1)	IL127946A0 (de)
NO (1)	NO990066L (de)
NZ (1)	NZ333800A (de)
PT (1)	PT920312E (de)
RU (1)	RU2209626C2 (de)
TR (1)	TR199900684T2 (de)
WO (1)	WO1998001132A1 (de)

Families Citing this family (44)

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US6462064B1 (en) *	1996-07-08	2002-10-08	Galderma Research & Development S.N.C.	Apoptosis inducing adamantyl derivatives and their usage as anti-cancer agents, especially for cervical cancers and dysplasias
FR2757852B1 (fr)	1996-12-31	1999-02-19	Cird Galderma	Composes stilbeniques a groupement adamantyl, compositions les contenant et utilisations
FR2759292B1 (fr) *	1997-02-10	2000-08-11	Cird Galderma	Utilisation de retinoides en tant qu'agents induisant la pigmentation
FR2779723B1 (fr) *	1998-06-12	2000-07-13	Cird Galderma	Composes biaryles heterocycliques aromatiques, compositions pharmaceutiques et cosmetiques les contenant et utilisations
CN1384825A (zh) *	1999-08-31	2002-12-11	马克西亚药品公司	亚苄基－噻唑烷二酮及其类似物以及它们在治疗糖尿病中的应用
BR0207846A (pt)	2001-03-07	2005-09-13	Incyte San Diego Inc	Derivados heterocìclicos para o tratamento de câncer e outras doenças proliferativas
JP2004523571A (ja) *	2001-03-08	2004-08-05	マキシア・ファーマシューティカルズ・インコーポレイテッド	Ｒｘｒ活性化分子
CA2340824A1 (en) *	2001-03-14	2002-09-14	Ibm Canada Limited-Ibm Canada Limitee	Method and system for application behavior analysis
US6613534B2 (en)	2001-03-20	2003-09-02	Wake Forest University Health Sciences	MAP-2 as a determinant of metastatic potential
ITRM20010464A1 (it) *	2001-07-31	2003-01-31	Sigma Tau Ind Farmaceuti	Derivati retinoidi ad attivita' antiangiogenica, antitumorale e pro-apoptotica.
EP1421061A4 (de) *	2001-08-17	2004-12-22	Incyte San Diego Inc	Oximderivate für die behandlung von dyslipidämie und hypercholesterinämie
ES2283649T3 (es) *	2001-10-31	2007-11-01	F. Hoffmann-La Roche Ag	Compuesto retinoides heterociclicos.
JP2005513026A (ja) *	2001-11-15	2005-05-12	インサイトサンディエゴインコーポレイテッド	高コレステロール血症、異脂肪血症および他の代謝障害；癌、および他の疾患を治療するｎ−置換複素環
WO2003048101A1 (en) *	2001-11-30	2003-06-12	The Burnham Institute	Induction of apoptosis in cancer cells
US7102000B2 (en) *	2002-03-08	2006-09-05	Incyte San Diego Inc.	Heterocyclic amide derivatives for the treatment of diabetes and other diseases
US7196108B2 (en) *	2002-03-08	2007-03-27	Incyte San Diego Inc.	Bicyclic heterocycles for the treatment of diabetes and other diseases
AU2003237790A1 (en) *	2002-05-14	2003-12-02	Baylor College Of Medicine	Small molecule inhibitors of her2 expression
US7449480B2 (en) *	2002-05-14	2008-11-11	Baylor College Of Medicine	Small molecule inhibitors of HER2 expression
US20040156799A1 (en) *	2002-06-04	2004-08-12	Zigang Dong	Cancer treatment method and compositions
US6864264B1 (en) *	2002-08-20	2005-03-08	Gloria L. Anderson	1-adamantyl chalcones for the treatment of proliferative disorders
US20050014767A1 (en) *	2003-01-29	2005-01-20	Magnus Pfahl	Benzoxazole, benzothiazole, and benzimidazole derivatives for the treatment of cancer and other diseases
BRPI0409501A (pt) *	2003-04-18	2006-04-18	Incyte San Diego Inc	compostos isocromanos substituìdos para o tratamento de desordens metabólicas, de cáncer e de outras doenças
RU2257894C1 (ru) *	2003-12-03	2005-08-10	Государственный научный центр-Институт биофизики	Противоопухолевое средство бензамид
EP1993986B1 (de) *	2005-12-02	2010-07-14	Finorga Sas	Verfahren zur herstellung aromatischer derivate von 1-adamantan
US9486467B2 (en) *	2006-06-12	2016-11-08	Ramot At Tel-Aviv University Ltd.	Method of treating colorectal cancer that expresses a mutated APC gene by administering erythromycin or tylosin
CN107652212B (zh)	2007-01-15	2019-11-15	于崇曦	维生素a酸类和类维生素a酸化合物的前药
ES2569660T3 (es)	2007-06-08	2016-05-12	Mannkind Corporation	Inhibidores de la IRE-1alfa
RU2360692C1 (ru) *	2007-12-21	2009-07-10	Тихоокеанский Институт Биоорганической Химии Дальневосточного Отделения Российской Академии Наук (Тибох Дво Ран)	Средство, стимулирующее апоптоз клеток лейкемии человека
CN102241678B (zh) *	2011-04-26	2014-10-29	辽宁利锋科技开发有限公司	含有脂环结构化合物的抗肿瘤作用与应用
KR101604053B1 (ko) *	2011-08-05	2016-03-16	(주)아모레퍼시픽	신규 벤조산아미드 화합물
CN103923107B (zh) *	2014-04-11	2016-06-01	安徽师范大学	金刚烷基吡啶配合物、中间体及其制备方法和应用
CN103936770B (zh) *	2014-04-11	2016-06-01	安徽师范大学	金刚烷基吡啶酰胺配合物、中间体及其制备方法和应用
CN103936771B (zh) *	2014-04-11	2016-06-01	安徽师范大学	金刚烷基吡啶甲酰胺配合物、中间体及其制备方法和应用
US11707442B2 (en)	2015-09-25	2023-07-25	The General Hospital Corporation	Antibacterial and antifungal compounds
US20170181988A1 (en) *	2015-12-23	2017-06-29	Cipla Limited	Methods for the treatment of bladder cancer
EP3301085A1 (de)	2016-09-29	2018-04-04	Biogem S.Ca.R.L.	Retinoidderivate mit antitumorwirkung
US11278025B2 (en)	2017-05-17	2022-03-22	The General Hospital Corporation	Antibiotic compounds
IT201900003343A1 (it)	2019-03-07	2020-09-07	Special Product’S Line S P A	Derivati fenolici per uso come antimicrobici, antibatterici, battericidi
JP2022525186A (ja)	2019-03-15	2022-05-11	ザジェネラルホスピタルコーポレイション	Ｔｅａｄ転写因子新規小分子阻害剤
CN112341406B (zh) *	2020-11-18	2023-02-10	韶远科技（上海)有限公司	反式-4-[4-(3-甲氧基-4-硝基苯基)-1-哌嗪基]金刚烷-1-醇合成方法
IT202000029912A1 (it)	2020-12-04	2022-06-04	Special Product’S Line S P A	Derivati fenolici per uso come antimicrobici, antibatterici, battericidi
IT202000029882A1 (it)	2020-12-04	2022-06-04	Special Product’S Line S P A	Derivati fenolici per uso come antimicrobici, antibatterici, battericidi
IT202000029906A1 (it)	2020-12-04	2022-06-04	Special Product’S Line S P A	Derivati fenolici per uso come antimicrobici, antibatterici, battericidi.
WO2022229017A1 (en)	2021-04-27	2022-11-03	Biogem S.C.A R.L.	Adamantyl retinoid derivative with anticancer activity

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WO1997003682A1 (en) *	1995-07-17	1997-02-06	Centre International De Recherches Dermatologiques C.I.R.D. Galderma	Method for treating cancers using 6-[3-[1-adamantyl]-4-hydroxyphenyl]

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DE3026579A1 (de) *	1980-07-14	1982-02-11	Kali-Chemie Pharma Gmbh, 3000 Hannover	2,9-dioxatricyclo (4,3,1,o(pfeil hoch)3,7(pfeil hoch)) decane
LU85544A1 (fr) *	1984-09-19	1986-04-03	Cird	Derives heterocycliques aromatiques,leur procede de preparation et leur application dans les domaines therapeutique et cosmetique
LU85849A1 (fr) *	1985-04-11	1986-11-05	Cird	Derives benzonaphtaleniques,leur procede de preparation et leur application dans les domaines pharmaceutiques et cosmetiques
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1997
- 1997-07-08 US US09/214,422 patent/US6127415A/en not_active Expired - Fee Related
- 1997-07-08 CN CNB971977437A patent/CN1279902C/zh not_active Expired - Fee Related
- 1997-07-08 WO PCT/US1997/011564 patent/WO1998001132A1/en not_active Ceased
- 1997-07-08 IL IL12794697A patent/IL127946A0/xx unknown
- 1997-07-08 ES ES97933256T patent/ES2231877T3/es not_active Expired - Lifetime
- 1997-07-08 EP EP97933256A patent/EP0920312B1/de not_active Expired - Lifetime
- 1997-07-08 CZ CZ9934A patent/CZ3499A3/cs unknown
- 1997-07-08 BR BR9710255A patent/BR9710255A/pt not_active Application Discontinuation
- 1997-07-08 TR TR1999/00684T patent/TR199900684T2/xx unknown
- 1997-07-08 NZ NZ333800A patent/NZ333800A/xx unknown
- 1997-07-08 JP JP10505270A patent/JP2000515506A/ja not_active Ceased
- 1997-07-08 AT AT97933256T patent/ATE284213T1/de active
- 1997-07-08 RU RU99102174/14A patent/RU2209626C2/ru not_active IP Right Cessation
- 1997-07-08 DE DE69731885T patent/DE69731885T2/de not_active Expired - Lifetime
- 1997-07-08 CA CA002259936A patent/CA2259936C/en not_active Expired - Fee Related
- 1997-07-08 HU HU9903834A patent/HUP9903834A3/hu unknown
- 1997-07-08 PT PT97933256T patent/PT920312E/pt unknown
- 1997-07-08 AU AU36485/97A patent/AU719311B2/en not_active Ceased
1999
- 1999-01-07 NO NO990066A patent/NO990066L/no unknown
- 1999-01-08 KR KR1019997000075A patent/KR20000023626A/ko not_active Ceased
- 1999-02-05 BG BG103152A patent/BG103152A/xx unknown

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1997003682A1 (en) *	1995-07-17	1997-02-06	Centre International De Recherches Dermatologiques C.I.R.D. Galderma	Method for treating cancers using 6-[3-[1-adamantyl]-4-hydroxyphenyl]

Non-Patent Citations (3)

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Title
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EP0920312A1 (de)	1999-06-09
IL127946A0 (en)	2000-02-17
HUP9903834A2 (hu)	2000-05-28
BG103152A (bg)	1999-09-30
CA2259936C (en)	2009-02-03
BR9710255A (pt)	1999-08-10
CA2259936A1 (en)	1998-01-15
RU2209626C2 (ru)	2003-08-10
ATE284213T1 (de)	2004-12-15
HUP9903834A3 (en)	2001-02-28
KR20000023626A (ko)	2000-04-25
CN1230111A (zh)	1999-09-29
US6127415A (en)	2000-10-03
AU719311B2 (en)	2000-05-04
ES2231877T3 (es)	2005-05-16
NZ333800A (en)	2000-08-25
EP0920312B1 (de)	2004-12-08
DE69731885T2 (de)	2005-12-22
NO990066D0 (no)	1999-01-07
DE69731885D1 (de)	2005-01-13
CN1279902C (zh)	2006-10-18
AU3648597A (en)	1998-02-02
TR199900684T2 (xx)	1999-07-21
WO1998001132A1 (en)	1998-01-15
PT920312E (pt)	2005-04-29
CZ3499A3 (cs)	1999-11-17
JP2000515506A (ja)	2000-11-21
NO990066L (no)	1999-03-08

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