EP0923372A4 - PYRIDINONE THROMBINE INHIBITORS - Google Patents

PYRIDINONE THROMBINE INHIBITORS

Info

Publication number
EP0923372A4
EP0923372A4 EP97906633A EP97906633A EP0923372A4 EP 0923372 A4 EP0923372 A4 EP 0923372A4 EP 97906633 A EP97906633 A EP 97906633A EP 97906633 A EP97906633 A EP 97906633A EP 0923372 A4 EP0923372 A4 EP 0923372A4
Authority
EP
European Patent Office
Prior art keywords
pyridinone
thrombine
inhibitors
thrombine inhibitors
pyridinone thrombine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97906633A
Other languages
German (de)
French (fr)
Other versions
EP0923372A1 (en
Inventor
Philip E Sanderson
Terry A Lyle
Joseph P Vacca
William C Lumma
Stephen F Brady
Thomas J Tucker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9605643.7A external-priority patent/GB9605643D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0923372A1 publication Critical patent/EP0923372A1/en
Publication of EP0923372A4 publication Critical patent/EP0923372A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP97906633A 1996-02-22 1997-02-18 PYRIDINONE THROMBINE INHIBITORS Withdrawn EP0923372A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1205896P 1996-02-22 1996-02-22
US12058P 1996-02-22
GB9605643 1996-03-18
GBGB9605643.7A GB9605643D0 (en) 1996-03-18 1996-03-18 Pyridinone thrombin inhibitors
PCT/US1997/002408 WO1997030708A1 (en) 1996-02-22 1997-02-18 Pyridinone thrombin inhibitors

Publications (2)

Publication Number Publication Date
EP0923372A1 EP0923372A1 (en) 1999-06-23
EP0923372A4 true EP0923372A4 (en) 2001-09-05

Family

ID=26308947

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97906633A Withdrawn EP0923372A4 (en) 1996-02-22 1997-02-18 PYRIDINONE THROMBINE INHIBITORS

Country Status (5)

Country Link
EP (1) EP0923372A4 (en)
JP (1) JP2000512616A (en)
AU (1) AU720616B2 (en)
CA (1) CA2245811A1 (en)
WO (1) WO1997030708A1 (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0971891A4 (en) * 1997-01-22 2000-04-19 Merck & Co Inc THROMBIN INHIBITORS
CN1125051C (en) * 1997-11-26 2003-10-22 三维药物公司 Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors
WO1999026926A1 (en) 1997-11-26 1999-06-03 3-Dimensional Pharmaceuticals, Inc. Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors
EP1039907A4 (en) * 1997-12-01 2001-09-19 Merck & Co Inc THROMBIN INHIBITORS
NZ508669A (en) 1998-06-11 2003-06-30 Dimensional Pharm Inc Pyrazinone protease inhibitors
PT997474E (en) 1998-08-14 2004-01-30 Pfizer ANTITROMBOTIC AGENTS
CA2348740A1 (en) 1998-12-23 2000-07-06 Ruth R. Wexler Thrombin or factor xa inhibitors
AR023510A1 (en) 1999-04-21 2002-09-04 Astrazeneca Ab A TEAM OF PARTS, PHARMACEUTICAL FORMULATION AND USE OF A THROMBIN INHIBITOR.
US6653316B1 (en) 1999-05-19 2003-11-25 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
US7015230B1 (en) 1999-05-19 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
US6867217B1 (en) 1999-05-19 2005-03-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
US6716838B1 (en) 1999-05-19 2004-04-06 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents
US6664255B1 (en) 1999-05-19 2003-12-16 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade
US6750342B1 (en) 1999-05-19 2004-06-15 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade
IL146244A0 (en) * 1999-05-19 2002-07-25 Pharmacia Corp Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
US6458952B1 (en) 1999-05-19 2002-10-01 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
MXPA01011956A (en) * 1999-05-27 2002-06-21 Dimensional Pharm Inc Oxazaheterocycles as protease inhibitors.
FR2795072B1 (en) * 1999-06-15 2001-07-27 Adir NOVEL BICYCLIC DERIVATIVES OF AMINO-PYRAZINONES, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
EP1194428B1 (en) 1999-07-09 2003-09-17 3-Dimensional Pharmaceuticals, Inc. Heteroaryl protease inhibitors and diagnostic imaging agents
PL354265A1 (en) 1999-09-13 2003-12-29 3-Dimensional Pharmaceuticals, Inc.3-Dimensional Pharmaceuticals, Inc. Azacycloalkanone serine protease inhibitors
WO2001068605A1 (en) 2000-03-13 2001-09-20 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade
CA2405306A1 (en) 2000-04-05 2001-10-18 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade
AU2001249870A1 (en) 2000-04-05 2001-10-23 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted 4-pyrones useful for selective inhibition of the coagulation cascade
WO2001079195A2 (en) * 2000-04-14 2001-10-25 Corvas International, Inc. Pyridine and pyrazine derivatives as thrombin inhibitors
CA2405684A1 (en) 2000-04-17 2001-10-25 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted 1,4-quinones useful for selective inhibition of the coagulation cascade
US6476016B2 (en) 2000-07-17 2002-11-05 3-Dimensional Pharmaceuticals, Inc. Cyclic oxyguanidine pyrazinones as protease inhibitors
MXPA03000963A (en) 2000-08-04 2004-04-05 Dimensional Pharm Inc Cyclic oxyguanidine protease inhibitors.
US6710058B2 (en) 2000-11-06 2004-03-23 Bristol-Myers Squibb Pharma Company Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
US7119094B1 (en) 2000-11-20 2006-10-10 Warner-Lambert Company Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade
MXPA03004458A (en) 2000-11-20 2005-01-25 Pharmacia Corp Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade.
US7015223B1 (en) 2000-11-20 2006-03-21 Pharmacia Corporation Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade
EP1438292A1 (en) 2001-10-03 2004-07-21 Pharmacia Corporation 6-membered heterocyclic compounds useful for selective inhibition of the coagulation cascade
AU2002367752A1 (en) 2001-10-03 2003-11-17 Pharmacia Corporation Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade
SI21097A (en) * 2001-12-04 2003-06-30 Univerza V Ljubljani Thrombine inhibitors
ATE448784T1 (en) 2002-02-14 2009-12-15 Pharmacia Corp SUBSTITUTED PYRIDINONES AS MODULATORS FOR P38 MAP KINASE
FR2867780B1 (en) 2004-03-19 2006-05-19 Servier Lab NOVEL 4-OXO-4,6,7,8-TETRAHYDROPYRROLO (1,2-A) PYRAZINE-6-CARBOXAMIDE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
KR100854584B1 (en) 2006-03-20 2008-08-27 주식회사 엘지생명과학 Selective thrombin inhibitors including pyridazinone, pyrimidone or pyridone structures
JP6901054B1 (en) * 2020-03-13 2021-07-14 三菱電機株式会社 Elevator door panel structure

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO9730708A1 *

Also Published As

Publication number Publication date
EP0923372A1 (en) 1999-06-23
WO1997030708A1 (en) 1997-08-28
JP2000512616A (en) 2000-09-26
AU2127497A (en) 1997-09-10
CA2245811A1 (en) 1997-08-28
AU720616B2 (en) 2000-06-08

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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