EP0923372A4 - Inhibiteurs de pyridinone thrombine - Google Patents
Inhibiteurs de pyridinone thrombineInfo
- Publication number
- EP0923372A4 EP0923372A4 EP97906633A EP97906633A EP0923372A4 EP 0923372 A4 EP0923372 A4 EP 0923372A4 EP 97906633 A EP97906633 A EP 97906633A EP 97906633 A EP97906633 A EP 97906633A EP 0923372 A4 EP0923372 A4 EP 0923372A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- pyridinone
- thrombine
- inhibitors
- thrombine inhibitors
- pyridinone thrombine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1205896P | 1996-02-22 | 1996-02-22 | |
| US12058P | 1996-02-22 | ||
| GB9605643 | 1996-03-18 | ||
| GBGB9605643.7A GB9605643D0 (en) | 1996-03-18 | 1996-03-18 | Pyridinone thrombin inhibitors |
| PCT/US1997/002408 WO1997030708A1 (fr) | 1996-02-22 | 1997-02-18 | Inhibiteurs de pyridinone thrombine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP0923372A1 EP0923372A1 (fr) | 1999-06-23 |
| EP0923372A4 true EP0923372A4 (fr) | 2001-09-05 |
Family
ID=26308947
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP97906633A Withdrawn EP0923372A4 (fr) | 1996-02-22 | 1997-02-18 | Inhibiteurs de pyridinone thrombine |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0923372A4 (fr) |
| JP (1) | JP2000512616A (fr) |
| AU (1) | AU720616B2 (fr) |
| CA (1) | CA2245811A1 (fr) |
| WO (1) | WO1997030708A1 (fr) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0971891A4 (fr) * | 1997-01-22 | 2000-04-19 | Merck & Co Inc | Inhibiteurs de thrombine |
| CN1125051C (zh) * | 1997-11-26 | 2003-10-22 | 三维药物公司 | 杂环氨基胍和烷氧基胍及其作为蛋白酶抑制剂的用途 |
| WO1999026926A1 (fr) | 1997-11-26 | 1999-06-03 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl aminoguanidines et alcoxyguanidines et leur utilisation en tant qu'inhibiteurs de protease |
| EP1039907A4 (fr) * | 1997-12-01 | 2001-09-19 | Merck & Co Inc | Inhibiteurs de thrombine |
| NZ508669A (en) | 1998-06-11 | 2003-06-30 | Dimensional Pharm Inc | Pyrazinone protease inhibitors |
| PT997474E (pt) | 1998-08-14 | 2004-01-30 | Pfizer | Agentes antitromboticos |
| CA2348740A1 (fr) | 1998-12-23 | 2000-07-06 | Ruth R. Wexler | Inhibiteurs de la thrombine ou du facteur xa |
| AR023510A1 (es) | 1999-04-21 | 2002-09-04 | Astrazeneca Ab | Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina. |
| US6653316B1 (en) | 1999-05-19 | 2003-11-25 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| US7015230B1 (en) | 1999-05-19 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
| US6867217B1 (en) | 1999-05-19 | 2005-03-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
| US6716838B1 (en) | 1999-05-19 | 2004-04-06 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents |
| US6664255B1 (en) | 1999-05-19 | 2003-12-16 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
| US6750342B1 (en) | 1999-05-19 | 2004-06-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| IL146244A0 (en) * | 1999-05-19 | 2002-07-25 | Pharmacia Corp | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
| US6458952B1 (en) | 1999-05-19 | 2002-10-01 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
| MXPA01011956A (es) * | 1999-05-27 | 2002-06-21 | Dimensional Pharm Inc | Oxazaheterociclos como inhibidores de proteasas. |
| FR2795072B1 (fr) * | 1999-06-15 | 2001-07-27 | Adir | Nouveaux derives bicycliques d'amino-pyrazinones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| EP1194428B1 (fr) | 1999-07-09 | 2003-09-17 | 3-Dimensional Pharmaceuticals, Inc. | Inhibiteurs de protease heteroaryle et agents d'imagerie diagnostique |
| PL354265A1 (en) | 1999-09-13 | 2003-12-29 | 3-Dimensional Pharmaceuticals, Inc.3-Dimensional Pharmaceuticals, Inc. | Azacycloalkanone serine protease inhibitors |
| WO2001068605A1 (fr) | 2000-03-13 | 2001-09-20 | Pharmacia Corporation | Benzenes polycycliques substitues aryle et heteroaryle utiles pour l'inhibition selective de la cascade de coagulation |
| CA2405306A1 (fr) | 2000-04-05 | 2001-10-18 | Pharmacia Corporation | Pyridones polycycliques 4-aryl et heteroaryl substituees utiles pour l'inhibition selective de la cascade de coagulation |
| AU2001249870A1 (en) | 2000-04-05 | 2001-10-23 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 4-pyrones useful for selective inhibition of the coagulation cascade |
| WO2001079195A2 (fr) * | 2000-04-14 | 2001-10-25 | Corvas International, Inc. | Nouveaux inhibiteurs de thrombine de type non covalent |
| CA2405684A1 (fr) | 2000-04-17 | 2001-10-25 | Pharmacia Corporation | 1,4-quinones polycycliques substituees par aryle et heteroaryles utiles pour l'inhibition selective des reactions en cascade provoquant la coagulation |
| US6476016B2 (en) | 2000-07-17 | 2002-11-05 | 3-Dimensional Pharmaceuticals, Inc. | Cyclic oxyguanidine pyrazinones as protease inhibitors |
| MXPA03000963A (es) | 2000-08-04 | 2004-04-05 | Dimensional Pharm Inc | Inhibidores de oxiguanidina ciclica proteasa. |
| US6710058B2 (en) | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
| US7119094B1 (en) | 2000-11-20 | 2006-10-10 | Warner-Lambert Company | Substituted polycyclic aryl and heteroarpyl pyrazinones useful for selective inhibition of the coagulation cascade |
| MXPA03004458A (es) | 2000-11-20 | 2005-01-25 | Pharmacia Corp | Arilpiridinas y heteroarilpiridinas sustituidas utiles para inhibicion selectiva de la cascada de coagulacion. |
| US7015223B1 (en) | 2000-11-20 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl 1,2,4-triazinones useful for selective inhibition of the coagulation cascade |
| EP1438292A1 (fr) | 2001-10-03 | 2004-07-21 | Pharmacia Corporation | Composes heterocycliques a 6 chainons utiles dans l'inhibition selective de la cascade de la coagulation |
| AU2002367752A1 (en) | 2001-10-03 | 2003-11-17 | Pharmacia Corporation | Substituted 5-membered polycyclic compounds useful for selective inhibition of the coagulation cascade |
| SI21097A (sl) * | 2001-12-04 | 2003-06-30 | Univerza V Ljubljani | Inhibitorji trombina |
| ATE448784T1 (de) | 2002-02-14 | 2009-12-15 | Pharmacia Corp | Substituierte pyridinone als modulatoren für p38 map kinase |
| FR2867780B1 (fr) | 2004-03-19 | 2006-05-19 | Servier Lab | Nouveaux derives de 4-oxo-4,6,7,8-tetrahydropyrrolo (1,2-a) pyrazine-6-carboxamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| KR100854584B1 (ko) | 2006-03-20 | 2008-08-27 | 주식회사 엘지생명과학 | 피리다지논, 피리미돈 또는 피리돈 구조를 포함하는선택적인 트롬빈 억제제 |
| JP6901054B1 (ja) * | 2020-03-13 | 2021-07-14 | 三菱電機株式会社 | エレベーターのドアパネル構造 |
-
1997
- 1997-02-18 EP EP97906633A patent/EP0923372A4/fr not_active Withdrawn
- 1997-02-18 JP JP09530260A patent/JP2000512616A/ja active Pending
- 1997-02-18 AU AU21274/97A patent/AU720616B2/en not_active Ceased
- 1997-02-18 CA CA 2245811 patent/CA2245811A1/fr not_active Abandoned
- 1997-02-18 WO PCT/US1997/002408 patent/WO1997030708A1/fr not_active Ceased
Non-Patent Citations (2)
| Title |
|---|
| No further relevant documents disclosed * |
| See also references of WO9730708A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0923372A1 (fr) | 1999-06-23 |
| WO1997030708A1 (fr) | 1997-08-28 |
| JP2000512616A (ja) | 2000-09-26 |
| AU2127497A (en) | 1997-09-10 |
| CA2245811A1 (fr) | 1997-08-28 |
| AU720616B2 (en) | 2000-06-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 19980922 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE |
|
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20010719 |
|
| AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE |
|
| RIC1 | Information provided on ipc code assigned before grant |
Free format text: 7C 07K 5/06 A, 7A 61K 38/05 B, 7A 61K 31/44 B, 7C 07D 213/72 B |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
|
| 18W | Application withdrawn |
Effective date: 20031017 |