EP0944394A4 - Behandlung einer hiv-infektion durch beeinträchtigung der cyclophilinrezeptor-aktivität innerhalb der wirtszelle - Google Patents

Behandlung einer hiv-infektion durch beeinträchtigung der cyclophilinrezeptor-aktivität innerhalb der wirtszelle

Info

Publication number
EP0944394A4
EP0944394A4 EP97917517A EP97917517A EP0944394A4 EP 0944394 A4 EP0944394 A4 EP 0944394A4 EP 97917517 A EP97917517 A EP 97917517A EP 97917517 A EP97917517 A EP 97917517A EP 0944394 A4 EP0944394 A4 EP 0944394A4
Authority
EP
European Patent Office
Prior art keywords
action
treatment
host cell
hiv infection
cyclophilin receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97917517A
Other languages
English (en)
French (fr)
Other versions
EP0944394A1 (de
Inventor
Michael Bukrinsky
Barbara A Sherry
Peter C Ulrich
Anthony Cerami
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Picower Institute for Medical Research
Original Assignee
Picower Institute for Medical Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/615,933 external-priority patent/US5840305A/en
Application filed by Picower Institute for Medical Research filed Critical Picower Institute for Medical Research
Publication of EP0944394A1 publication Critical patent/EP0944394A1/de
Publication of EP0944394A4 publication Critical patent/EP0944394A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/52—Isomerases (5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP97917517A 1996-03-12 1997-03-12 Behandlung einer hiv-infektion durch beeinträchtigung der cyclophilinrezeptor-aktivität innerhalb der wirtszelle Withdrawn EP0944394A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US1318596P 1996-03-12 1996-03-12
US613185P 1996-03-12
US08/615,933 US5840305A (en) 1996-03-14 1996-03-14 Treatment of HIV-Infection by interfering with host cell cyclophilin receptor activity
US615933 1996-03-14
PCT/US1997/003819 WO1997033604A1 (en) 1996-03-12 1997-03-12 Treatment of hiv-infection by interfering with host cell cyclophilin receptor activity

Publications (2)

Publication Number Publication Date
EP0944394A1 EP0944394A1 (de) 1999-09-29
EP0944394A4 true EP0944394A4 (de) 2003-05-14

Family

ID=26684543

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97917517A Withdrawn EP0944394A4 (de) 1996-03-12 1997-03-12 Behandlung einer hiv-infektion durch beeinträchtigung der cyclophilinrezeptor-aktivität innerhalb der wirtszelle

Country Status (5)

Country Link
EP (1) EP0944394A4 (de)
JP (1) JP2000510097A (de)
AU (1) AU723905B2 (de)
CA (1) CA2248192A1 (de)
WO (1) WO1997033604A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030220234A1 (en) 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
US7141648B2 (en) 2001-10-19 2006-11-28 Isotechnika Inc. Synthesis of cyclosporin analogs
HRP20040354B1 (en) 2001-10-19 2012-10-31 Isotechnika Inc. Novel cyclosporin analog microemulsion preconcentrates
AU2002347102A1 (en) * 2001-10-25 2003-05-12 Hans Will Means for inhibition of the synthesis of viral proteins
US7108988B2 (en) 2001-11-02 2006-09-19 The J. David Gladstone Institutes Methods of identifying agents for inhibiting lentivirus replication
US10365280B2 (en) 2014-10-02 2019-07-30 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating malignancies
ES2990218T3 (es) * 2018-08-22 2024-11-29 Bacainn Biotherapeutics Ltd Composiciones de ciclosporina y métodos de uso

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0484281A2 (de) * 1990-11-02 1992-05-06 Sandoz Ltd. Zyklosporine
WO1993023081A1 (en) * 1992-05-15 1993-11-25 The Rockefeller University Methods and agents for modulating immune response, and uses thereof
WO1995007468A1 (en) * 1993-09-08 1995-03-16 Sandoz Ltd. Assay kit

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0484281A2 (de) * 1990-11-02 1992-05-06 Sandoz Ltd. Zyklosporine
WO1993023081A1 (en) * 1992-05-15 1993-11-25 The Rockefeller University Methods and agents for modulating immune response, and uses thereof
WO1995007468A1 (en) * 1993-09-08 1995-03-16 Sandoz Ltd. Assay kit

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ALLAIN F ET AL: "Selective assay for CyPA and CyPB in human blood using highly specific anti-peptide antibodies", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 178, no. 1, 13 January 1995 (1995-01-13), pages 113 - 120, XP004021130, ISSN: 0022-1759 *
BILLICH A ET AL: "MODE OF ACTION OF SDZ NIM 811, A NONIMMUNOSUPPRESSIVE CYCLOSPORIN A ANALOG WITH ACTIVITY AGAINST HUMAN IMMUNODEFICIENCY VIRUS (HIV) TYPE 1: INTERFERENCE WITH HIV PROTEIN-CYCLOPHILIN A INTERACTIONS", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 69, no. 4, 1 April 1995 (1995-04-01), pages 2451 - 2461, XP002022423, ISSN: 0022-538X *
ROYDON PRICE E ET AL: "CYCLOPHILIN B TRAFFICKING THROUGH THE SECRETORY PATHWAY IS ALTERED BY BINDING OF CYCLOSPORIN A", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 91, April 1994 (1994-04-01), pages 3931 - 3935, XP002931337, ISSN: 0027-8424 *
See also references of WO9733604A1 *

Also Published As

Publication number Publication date
JP2000510097A (ja) 2000-08-08
AU2581197A (en) 1997-10-01
EP0944394A1 (de) 1999-09-29
AU723905B2 (en) 2000-09-07
CA2248192A1 (en) 1997-09-18
WO1997033604A1 (en) 1997-09-18

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Ipc: 7A 61K 39:00 K

Ipc: 7A 61K 39/39 K

Ipc: 7A 61K 38:13 J

Ipc: 7A 61K 47/48 J

Ipc: 7A 61K 47/48 B

Ipc: 7C 12N 9/90 B

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