EP0946556A4 - Kombinatorisches verfahren zur herstellung von hydrofurrochinolin-bibliotheken - Google Patents

Kombinatorisches verfahren zur herstellung von hydrofurrochinolin-bibliotheken

Info

Publication number
EP0946556A4
EP0946556A4 EP97954102A EP97954102A EP0946556A4 EP 0946556 A4 EP0946556 A4 EP 0946556A4 EP 97954102 A EP97954102 A EP 97954102A EP 97954102 A EP97954102 A EP 97954102A EP 0946556 A4 EP0946556 A4 EP 0946556A4
Authority
EP
European Patent Office
Prior art keywords
hydrofuroquinoline
libraries
preparing
combinatorial process
combinatorial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97954102A
Other languages
English (en)
French (fr)
Other versions
EP0946556A1 (de
Inventor
Jose S Mendoza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of EP0946556A1 publication Critical patent/EP0946556A1/de
Publication of EP0946556A4 publication Critical patent/EP0946556A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP97954102A 1996-12-18 1997-12-15 Kombinatorisches verfahren zur herstellung von hydrofurrochinolin-bibliotheken Withdrawn EP0946556A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3366596P 1996-12-18 1996-12-18
US33665P 1996-12-18
PCT/US1997/022870 WO1998027093A1 (en) 1996-12-18 1997-12-15 Combinatorial process for preparing hydrofuroquinoline libraries

Publications (2)

Publication Number Publication Date
EP0946556A1 EP0946556A1 (de) 1999-10-06
EP0946556A4 true EP0946556A4 (de) 2001-07-04

Family

ID=21871728

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97954102A Withdrawn EP0946556A4 (de) 1996-12-18 1997-12-15 Kombinatorisches verfahren zur herstellung von hydrofurrochinolin-bibliotheken

Country Status (5)

Country Link
EP (1) EP0946556A4 (de)
JP (1) JP2001508050A (de)
AU (1) AU5797098A (de)
CA (1) CA2273884A1 (de)
WO (1) WO1998027093A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7250423B2 (en) * 2001-09-24 2007-07-31 Chao-Jun Li Methods for synthesizing heterocycles and therapeutic use of the heterocycles for cancers
DE10236910A1 (de) * 2002-08-12 2004-03-11 Grünenthal GmbH Substituierte 1,2,3,4-Tetrahydrochinolinderivate
WO2005016255A2 (en) * 2003-07-16 2005-02-24 Ligand Pharmaceuticals Incorporated Substituted tetrahydroquinolines, phenylacetic acids and benzoic acids as hepatocyte nuclear factor 4 (hnf-4 ) modulator compounds
DE102004031656A1 (de) * 2004-06-30 2006-01-19 Merck Patent Gmbh Tetrahydrochinoline
DE102005027170A1 (de) * 2005-06-13 2006-12-14 Merck Patent Gmbh Substituierte Tetrahydrochinoline
EP2647638A1 (de) * 2012-04-02 2013-10-09 Almirall, S.A. Substituierte tricyclische Verbindungen mit Aktivität gegenüber EP1-Rezeptoren

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3632852A (en) * 1969-03-17 1972-01-04 Parke Davis & Co Hexahydrobenzofurofuro(3 2-c) quinoline compounds
WO1994008051A1 (en) * 1992-10-01 1994-04-14 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2650226A (en) * 1950-05-24 1953-08-25 Schenley Ind Inc Furo and thieno quinaldines and process for making same
US2650227A (en) * 1950-05-27 1953-08-25 Schenley Ind Inc Derivatives of 2:3-dihydro-4-methylfuro (3:2-c) quinoline and preparation thereof
US2650229A (en) * 1950-05-27 1953-08-25 Schenley Ind Inc Derivatives of 2:3-dihydro-4-methyltfuro(3:2-c) quinoline and preparation thereof
US3631050A (en) * 1968-11-13 1971-12-28 Parke Davis & Co Hexahydro-9b-methylfuro(3 2-c) quinoline compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3632852A (en) * 1969-03-17 1972-01-04 Parke Davis & Co Hexahydrobenzofurofuro(3 2-c) quinoline compounds
WO1994008051A1 (en) * 1992-10-01 1994-04-14 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BORRIONE E ET AL: "SYNTHESIS AND CYCLOADDITION REACTIONS OF ETHYL GLYOXYLATE IMINES. SYNTHESIS OF SUBSTITUTED FURO-U3,2-CQUINOLINES AND 7H-INDENO U2,1-CQUINOLINES", JOURNAL OF HETEROCYCLIC CHEMISTRY,US,HETEROCORPORATION. PROVO, vol. 25, 1 November 1988 (1988-11-01), pages 1831 - 1835, XP000670083, ISSN: 0022-152X *
ELSLAGER E. F., WORTH D. F.: "1,4-Cycloaddition Reactions. I.", J. HETEROCYCL. CHEM, vol. 6, 1969, pages 597 - 598, XP000994873 *
LUCCHINI V., PRATO M., SCORRANO G., STIVANELLO M., VALLE G.: "Acid-catalysed Addition of N-Aryl Imines to Dihydrofuran.", J. CHEM. SOC. PERKIN TRANS., vol. 2, 1992, pages 259 - 266, XP000994883 *
MIKHAILOV,B.M. ET AL.: "Reaction of Dihydrosylvan with Schiff Bases", BULL. ACAD. SCI. USSR DIV. CHEM. SCI. (ENGL.TRANSL.), 1964, pages 1597 - 1599, XP000995275 *
PERRICONE S. C., WORTH F. D., ELSLAGER E. F.: "1,4-Cycloaddition Reactions. III.", J. HETEROCYCL. CHEM., vol. 7, 1970, pages 537 - 542, XP000995005 *
See also references of WO9827093A1 *
WORTH F. D., PERRICONE S. C., ELSLAGER E. F.: "1,4-Cycloaddition Reactions. IV.", J. HETEROCYCL. CHEM., vol. 7, 1970, pages 1353 - 1356, XP000995219 *
WORTH,D.F. ET AL.: "1,4-Cycloaddition Reactions. V.", J. HETEROCYCL. CHEM., vol. 11, 1974, pages 69 - 70, XP000994879 *

Also Published As

Publication number Publication date
WO1998027093A1 (en) 1998-06-25
AU5797098A (en) 1998-07-15
JP2001508050A (ja) 2001-06-19
CA2273884A1 (en) 1998-06-25
EP0946556A1 (de) 1999-10-06

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