EP0959886A4 - Imidazoles a substitution triaryle en tant qu'antagonistes du glucagon - Google Patents

Imidazoles a substitution triaryle en tant qu'antagonistes du glucagon

Info

Publication number
EP0959886A4
EP0959886A4 EP97948343A EP97948343A EP0959886A4 EP 0959886 A4 EP0959886 A4 EP 0959886A4 EP 97948343 A EP97948343 A EP 97948343A EP 97948343 A EP97948343 A EP 97948343A EP 0959886 A4 EP0959886 A4 EP 0959886A4
Authority
EP
European Patent Office
Prior art keywords
substituted imidazoles
glucagon antagonists
triaryl substituted
triaryl
glucagon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97948343A
Other languages
German (de)
English (en)
Other versions
EP0959886A1 (fr
Inventor
Linda L Chang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9700540.9A external-priority patent/GB9700540D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0959886A1 publication Critical patent/EP0959886A1/fr
Publication of EP0959886A4 publication Critical patent/EP0959886A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
EP97948343A 1996-11-20 1997-11-17 Imidazoles a substitution triaryle en tant qu'antagonistes du glucagon Withdrawn EP0959886A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US3146696P 1996-11-20 1996-11-20
GB9700540 1997-01-13
GBGB9700540.9A GB9700540D0 (en) 1997-01-13 1997-01-13 Triaryl substituted imidazoles as glucagon antagonists
PCT/US1997/021020 WO1998022109A1 (fr) 1996-11-20 1997-11-17 Imidazoles a substitution triaryle en tant qu'antagonistes du glucagon
US31466P 2008-02-26

Publications (2)

Publication Number Publication Date
EP0959886A1 EP0959886A1 (fr) 1999-12-01
EP0959886A4 true EP0959886A4 (fr) 2001-05-02

Family

ID=26310783

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97948343A Withdrawn EP0959886A4 (fr) 1996-11-20 1997-11-17 Imidazoles a substitution triaryle en tant qu'antagonistes du glucagon

Country Status (5)

Country Link
EP (1) EP0959886A4 (fr)
JP (1) JP2000514088A (fr)
AU (1) AU730295B2 (fr)
CA (1) CA2271893A1 (fr)
WO (1) WO1998022109A1 (fr)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5916891A (en) 1992-01-13 1999-06-29 Smithkline Beecham Corporation Pyrimidinyl imidazoles
TR199801361T2 (xx) * 1996-01-11 1998-10-21 Smithkline Beecham Corporation Yeni ikameli imidazol bile�imleri.
AP9700912A0 (en) 1996-01-11 1997-01-31 Smithkline Beecham Corp Novel cycloalkyl substituted imidazoles
US6046208A (en) * 1996-01-11 2000-04-04 Smithkline Beecham Corporation Substituted imidazole compounds
WO1997035856A1 (fr) * 1996-03-25 1997-10-02 Smithkline Beecham Corporation Nouveau traitement des lesions du systeme nerveux central
WO1998007425A1 (fr) 1996-08-21 1998-02-26 Smithkline Beecham Corporation Composes d'imidazole, compositions les contenant et leur utilisation
US5929076A (en) * 1997-01-10 1999-07-27 Smithkline Beecham Corporation Cycloalkyl substituted imidazoles
WO1998056377A1 (fr) 1997-06-13 1998-12-17 Smithkline Beecham Corporation Nouveaux composes de pyrazole et de pyrazoline substitues
WO1998057966A1 (fr) 1997-06-19 1998-12-23 Smithkline Beecham Corporation Nouveaux composes imidazole a substitution d'aryloxypymiridine
US6562832B1 (en) 1997-07-02 2003-05-13 Smithkline Beecham Corporation Substituted imidazole compounds
US6489325B1 (en) 1998-07-01 2002-12-03 Smithkline Beecham Corporation Substituted imidazole compounds
US7301021B2 (en) 1997-07-02 2007-11-27 Smithkline Beecham Corporation Substituted imidazole compounds
TW517055B (en) 1997-07-02 2003-01-11 Smithkline Beecham Corp Novel substituted imidazole compounds
WO1999001452A1 (fr) 1997-07-02 1999-01-14 Smithkline Beecham Corporation Nouveaux imidazoles cycloalkyle-substitues
WO1999017776A1 (fr) 1997-10-08 1999-04-15 Smithkline Beecham Corporation Nouveaux composes substitues de cycloalcenyle
US6335340B1 (en) 1997-12-19 2002-01-01 Smithkline Beecham Corporation compounds of heteroaryl substituted imidazole, their pharmaceutical compositons and uses
NZ526958A (en) 1998-05-22 2004-12-24 Smithkline Beecham Corp Novel 2-alkyl substituted imidazole compounds
US6858617B2 (en) 1998-05-26 2005-02-22 Smithkline Beecham Corporation Substituted imidazole compounds
US6548503B1 (en) 1998-11-04 2003-04-15 Smithkline Beecham Corporation Pyridin-4-yl or pyrimidin-4-yl substituted pyrazines
JP2002541253A (ja) 1999-04-09 2002-12-03 スミスクライン・ビーチャム・コーポレイション トリアリールイミダゾール
US6503949B1 (en) 1999-05-17 2003-01-07 Noro Nordisk A/S Glucagon antagonists/inverse agonists
JP2003528043A (ja) 1999-11-23 2003-09-24 スミスクライン・ビーチャム・コーポレイション ＣＳＢＰ／ｐ３８キナーゼ阻害剤としての３，４‐ジヒドロ−（１Ｈ）キナゾリン−２−オン化合物
US6759410B1 (en) 1999-11-23 2004-07-06 Smithline Beecham Corporation 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
WO2001038314A1 (fr) 1999-11-23 2001-05-31 Smithkline Beecham Corporation Composes de 3,4-dihydro-(1h)quinazolin-2-one utilises comme inhibiteurs de kinase csbp/p38
DK1248604T4 (da) 2000-01-21 2012-05-21 Novartis Ag Kombinationer indeholdende dipeptidylpeptidase-IV-inhibitorer og antidiabetiske midler
US7235551B2 (en) 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
US6562807B2 (en) 2000-06-23 2003-05-13 Novo Nordisk A/S Glucagon antagonists/inverse agonists
US6821960B2 (en) 2000-11-17 2004-11-23 Noyo Nordisk Pharmaceuticals, Inc. Glucagon antagonists/inverse agonists
US6706744B2 (en) 2000-11-17 2004-03-16 Novo Nordisk A/S Glucagon antagonists/inverse agonists
JP2004513935A (ja) 2000-11-17 2004-05-13 ノボ　ノルディスク　アクティーゼルスカブ グルカゴンアンタゴニスト／逆アゴニスト
US6762318B2 (en) 2001-12-03 2004-07-13 Novo Nordisk A/S Glucagon antagonists
US6881746B2 (en) 2001-12-03 2005-04-19 Novo Nordick A/S Glucagon antagonists/inverse agonists
WO2004004725A2 (fr) 2002-07-09 2004-01-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Nouvelles compositions pharmaceutiques a base de nouveaux anticholinergiques et d'inhibiteurs de la kinase p38
WO2004063147A1 (fr) * 2003-01-10 2004-07-29 Novo Nordisk A/S Sels et solvates d'antagonistes de glucagon
US7572922B2 (en) 2003-01-27 2009-08-11 Merck & Co., Inc. Substituted pyrazoles, compositions containing such compounds and methods of use
US7301036B2 (en) 2003-12-19 2007-11-27 Merck & Co., Inc. Cyclic guanidines, compositions containing such compounds and methods of use
CN1964947A (zh) 2004-06-04 2007-05-16 默克公司 吡唑衍生物、包含其的组合物及其用法
JP2008505905A (ja) 2004-07-07 2008-02-28 メルク　エンド　カムパニー　インコーポレーテッド ピラゾールアミド誘導体、こうした化合物を含有する組成物および使用方法
CA2574147A1 (fr) 2004-07-22 2006-02-09 Linda Brockunier Pyrazoles substitues, compositions contenant de tels composes et leurs methodes d'utilisation
US20060035893A1 (en) 2004-08-07 2006-02-16 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
PE20060777A1 (es) 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
CN101146762A (zh) 2005-03-21 2008-03-19 默克公司 取代的芳基和杂芳基衍生物
WO2006104826A2 (fr) 2005-03-30 2006-10-05 Merck & Co., Inc. Composes antagonistes du recepteur du glucagon, compositions renfermant de tels composes et methodes d'utilisation
WO2007015999A2 (fr) 2005-07-26 2007-02-08 Merck & Co., Inc. Procede de synthese d'un pyrazole substitue
PL1931350T5 (pl) 2005-09-14 2021-11-15 Takeda Pharmaceutical Company Limited Podanie inhibitorów dipeptydylo-peptydazy
TW200745031A (en) 2005-10-13 2007-12-16 Merck & Co Inc Acyl indoles, compositions containing such compounds and methods of use
EP2001472A2 (fr) 2006-03-23 2008-12-17 Merck and Co., Inc. Composes antagonistes du recepteur du glucagon, compositions contenant de tels composes et procedes d'utilisation
JP2009537525A (ja) 2006-05-16 2009-10-29 メルク エンド カムパニー インコーポレーテッド グルカゴン受容体アンタゴニスト化合物、このような化合物を含む組成物及び使用方法
TW200821284A (en) 2006-10-03 2008-05-16 Merck & Co Inc Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
EP1992344A1 (fr) 2007-05-18 2008-11-19 Institut Curie P38 alpha comme cible therapeutique pour les maladies associées á une mutation de FGFR3
WO2011041293A1 (fr) 2009-09-30 2011-04-07 Takeda Pharmaceutical Company Limited Dérivés pyrazolo [1, 5—a] pyrimidines comme inhibiteurs de kinase 1 régulatrice de signal d'apoptose
WO2011097079A1 (fr) 2010-02-03 2011-08-11 Takeda Pharmaceutical Company Limited Inhibiteurs de kinase 1 régulant le signal d'apoptose
MX2013006768A (es) 2010-12-23 2013-07-22 Pfizer Moduladores de receptor de glucagon.
ES2597972T3 (es) 2011-02-08 2017-01-24 Pfizer Inc Modulador del receptor de glucagón
RU2013157388A (ru) 2011-07-22 2015-08-27 Пфайзер Инк. Хинолинильные модуляторы глюкагонового рецептора
EP3065736B1 (fr) 2013-11-04 2018-11-14 Merck Sharp & Dohme Corp. Composés antagonistes du récepteur du glucagon, compositions correspodantes et méthodes d'utilisation

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3707475A (en) * 1970-11-16 1972-12-26 Pfizer Antiinflammatory imidazoles
US3929807A (en) * 1971-05-10 1975-12-30 Ciba Geigy Corp 2-Substituted-4(5)-(aryl)-5(4)-(2,3 or -4-pyridyl)-imidazoles
WO1993014081A1 (fr) * 1992-01-13 1993-07-22 Smithkline Beecham Corporation Derives imidazole et leur utilisation comme inhibiteurs de cytokine
WO1995003297A1 (fr) * 1993-07-21 1995-02-02 Smithkline Beecham Corporation Imidazoles actives contre les maladies transmises par la cytokine
WO1996018626A1 (fr) * 1994-12-13 1996-06-20 F. Hoffmann-La Roche Ag Derives imidazoles utilises comme inhibiteurs de la proteine kinase, notamment de la tyrosine kinase du recepteur du facteur de croissance de l'epiderme (egf-r)
WO1996021654A1 (fr) * 1995-01-12 1996-07-18 Smithkline Beecham Corporation Nouveaux composes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5620999A (en) * 1994-07-28 1997-04-15 Weier; Richard M. Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3707475A (en) * 1970-11-16 1972-12-26 Pfizer Antiinflammatory imidazoles
US3929807A (en) * 1971-05-10 1975-12-30 Ciba Geigy Corp 2-Substituted-4(5)-(aryl)-5(4)-(2,3 or -4-pyridyl)-imidazoles
WO1993014081A1 (fr) * 1992-01-13 1993-07-22 Smithkline Beecham Corporation Derives imidazole et leur utilisation comme inhibiteurs de cytokine
WO1995003297A1 (fr) * 1993-07-21 1995-02-02 Smithkline Beecham Corporation Imidazoles actives contre les maladies transmises par la cytokine
WO1996018626A1 (fr) * 1994-12-13 1996-06-20 F. Hoffmann-La Roche Ag Derives imidazoles utilises comme inhibiteurs de la proteine kinase, notamment de la tyrosine kinase du recepteur du facteur de croissance de l'epiderme (egf-r)
WO1996021654A1 (fr) * 1995-01-12 1996-07-18 Smithkline Beecham Corporation Nouveaux composes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GALLAGHER T F ET AL: "2,4,5- Triarylimidazole inhibitors of IL-1 biosynthesis", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,GB,OXFORD, vol. 5, no. 11, 8 June 1995 (1995-06-08), pages 1171 - 1176, XP004135499, ISSN: 0960-894X *
See also references of WO9822109A1 *

Also Published As

Publication number Publication date
EP0959886A1 (fr) 1999-12-01
AU730295B2 (en) 2001-03-01
AU5442898A (en) 1998-06-10
WO1998022109A1 (fr) 1998-05-28
CA2271893A1 (fr) 1998-05-28
JP2000514088A (ja) 2000-10-24

Similar Documents

Publication Publication Date Title
EP0934305A4 (fr) Antagonistes de l'integrine
EP0946164A4 (fr) Antagonistes de l'integrine
FI942432L (fi) Järjestely hissikoneiston liittämiseksi rakennukseen
PT805813E (pt) Antagonistas de vasopressina triciclicos
EP0758238A4 (fr) Azacycles spiro-substitues utilises en tant qu'antagonistes de neurokinine-3
FI970523A7 (fi) (Atsetidin-1-yylialkyyli)laktaamit takykiniiniantagonisteina
FI955258L (fi) Takykiniiniantagonisteina käyttökelpoisia substituoituja pyrrolidiini-3-yl-alkyyli-piperidiineja
DE69715421D1 (de) Konzentrierte flüssige mikrobizid-enthaltende zusammensetzungen
FI960840A7 (fi) Indolijohdannaisia tromboksaani-A2-antagonisteina
FI960156A7 (fi) Bentsyylioksikinuklidiinit aineet P antagonisteina
PT738150E (pt) Antagonistas biciclicos de fibrinogenio
FI933810L (fi) Reseptorantagonister av exiterbara aminosyror
FI960516L (fi) Substituoituja bifenyylisulfonamidiendoteliiniantagonisteja
EP0866705A4 (fr) Antagonistes du recepteur de fibrinogene
DE59606460D1 (de) Bohrstange
PT831697E (pt) Composicoes microbicidas
DE69626556D1 (de) Biozide Zusammensetzungen
MX9100717A (es) Antagonistas de la bradiquinina
NO953290D0 (no) Grohemmende maling
FI953916L (fi) Fibrinogeenireseptoriantagonisteja
FI945807A7 (fi) 2,5-diokso-2,5-dihydro-1H-bents/b/atsepiinit NMDA-reseptorin antagonisteina
DE69622731D1 (de) Tetrahydrochinoline als nmda antagonisten
EP0708765A4 (fr) Derives de piperazinylcamphre substitues en tant qu'antagonistes de l'ocytocine
DE59206461D1 (de) Sizing-Gerüst Gruppe
EP0966479A4 (fr) Polyprolyl agissant en tant qu'inhibiteur de la cyclophiline

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19990621

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 20010321

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

RIC1 Information provided on ipc code assigned before grant

Free format text: 7A 61K 31/44 A, 7C 07D 401/04 B

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20040602