EP0989062A1 - Dispositif pour remplir un liquide pharmaceutique sous pression dans un récipient - Google Patents

Dispositif pour remplir un liquide pharmaceutique sous pression dans un récipient Download PDF

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Publication number
EP0989062A1
EP0989062A1 EP99116465A EP99116465A EP0989062A1 EP 0989062 A1 EP0989062 A1 EP 0989062A1 EP 99116465 A EP99116465 A EP 99116465A EP 99116465 A EP99116465 A EP 99116465A EP 0989062 A1 EP0989062 A1 EP 0989062A1
Authority
EP
European Patent Office
Prior art keywords
filling
distributor
liquid
temperature
coolant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP99116465A
Other languages
German (de)
English (en)
Other versions
EP0989062B1 (fr
Inventor
Werner Mayer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Robert Bosch GmbH
Original Assignee
Robert Bosch GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robert Bosch GmbH filed Critical Robert Bosch GmbH
Publication of EP0989062A1 publication Critical patent/EP0989062A1/fr
Application granted granted Critical
Publication of EP0989062B1 publication Critical patent/EP0989062B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B63/00—Auxiliary devices, not otherwise provided for, for operating on articles or materials to be packaged
    • B65B63/08—Auxiliary devices, not otherwise provided for, for operating on articles or materials to be packaged for heating or cooling articles or materials to facilitate packaging
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
    • B67D—DISPENSING, DELIVERING OR TRANSFERRING LIQUIDS, NOT OTHERWISE PROVIDED FOR
    • B67D1/00—Apparatus or devices for dispensing beverages on draught
    • B67D1/08—Details
    • B67D1/0857—Cooling arrangements
    • B67D1/0858—Cooling arrangements using compression systems
    • B67D1/0861—Cooling arrangements using compression systems the evaporator acting through an intermediate heat transfer means
    • B67D1/0865—Cooling arrangements using compression systems the evaporator acting through an intermediate heat transfer means by circulating a cooling fluid along beverage supply lines, e.g. pythons
    • B67D1/0867—Cooling arrangements using compression systems the evaporator acting through an intermediate heat transfer means by circulating a cooling fluid along beverage supply lines, e.g. pythons the cooling fluid being a liquid

Definitions

  • the invention relates to a device for filling a pressurized pharmaceutical liquid in packaging container according to the preamble of claim 1, such as it is known from DE 43 41 934 A1.
  • the filling time for the liquid if necessary, taking into account the Distributor arranged temperature sensor detected temperature to calculate.
  • the device according to the invention for filling a Pressurized pharmaceutical liquid in packaging container with the characterizing features of claim 1 has the advantage that the filling accuracy also with a strongly temperature-dependent flow behavior of the to be filled Liquid is very high. This is achieved that the liquid according to the invention with a certain and in particular constant temperature of the filling valves is supplied so that the otherwise detectable Temperature fluctuations in the liquid, for example in the event of a batch change, after a break in production or when filling starts due to the heating of the Components of the filling device result, can be avoided can.
  • the device 10 shown in FIG. 1 is used for filling a pressurized pharmaceutical liquid 1 in packaging containers such as vials 2, ampoules or similar.
  • the device 10 has a product container 11, which by means of a quick release device 12 is replaceably attachable to a feed line 13.
  • a connector 14 which is connected to a pressure source, not shown.
  • the feed line 13 opens into a tubular in the filling area Distributor 15, from which fill lines 17 branch off, that lead directly to the individual vials 2.
  • a filling valve 18 is arranged, that can be controlled by the control device 20 of the device 10 is.
  • the ends of the filling lines facing the vials 2 17, which are designed as filling needles 21, are more common Arranged movable up and down to in one Standstill phase of the cycle by means of a conveyor pumped vials 2 for dispensing the liquid 1 in to be able to immerse the head openings of the vials 2.
  • the one required facilities are known per se and not essential to the invention, not shown.
  • the essential opening time with regard to the exact filling quantity the filling valve 18 is controlled by the control device 20 taking into account that of one arranged in the distributor 15 Pressure sensor 22 calculated pressure that with the control device 20 is connected. Furthermore, a first temperature sensor 23 is provided in the distributor 15, which is also connected to the control device 20.
  • the device expresses viscosity 10 specially furnished.
  • the basic idea is there in that the liquid 1 when filling, that is when Passing through the filling valves 18 always a very specific one Should have temperature, the viscosity thus known from the control device 20 when calculating the opening times the filling valve 18 is taken into account.
  • the distributor 15 and a section of each Filling lines 17 integrated in a block-shaped housing 24, which in turn is arranged on a console 25 of the device 10 is.
  • the housing 24 has an inlet connection 26 and an outlet port 27 for a coolant that by the housing 24 is passed.
  • the housing 24 is as Hollow housing formed, the interior 28 of one in Loops laid cooling line 29 is penetrated.
  • the cooling line 29 surrounds the distributor 15 in the housing 24, so that it is cooled by convection.
  • the temperature prevailing in the housing 24 can be determined by means of a second temperature sensor 31 can be detected with a Temperature control loop is coupled to the temperature in the housing to keep constant.
  • the distributor 15 is still at least part of the feed line 13 double-walled with an inlet 32 and an outlet 33 for coolant educated. Furthermore, the product container 11 can also be double-walled formed with an inlet 34 and an outlet 35 be to allow coolant to flow through.
  • the basic idea of the invention exists in the pharmaceutical liquid 1 with a possible constant temperature, here the one achieved by the coolant Liquid 1 temperature to be filled.
  • This means of the second temperature sensor 31 arranged in the housing 24 is monitored by means of the temperature control loop mentioned above kept consistent.
  • the goal is that Liquid 1 in the distributor 15 to a very specific temperature, their viscosity when calculating the opening time of the filling valves 18 on the basis of the control device 20 will cool down, and this during the filling processes to keep as constant as possible.
  • the volume the distributor 15 with respect to the number of filling lines 17 and that to be dispensed into the vials 2 with each filling process Filling volume and the target temperature of the liquid 1 decisive.
  • the liquid 1 tends to nucleate at a higher temperature, so that the trend basically goes to the total product volume and thus to cool the entire device 10.
  • the filling accuracy of the device 10 can be increased if the software the control device 20 is capable of opening time the filling valves 18 with slight temperature fluctuations the liquid 1 in the distributor 15, which from the first Temperature sensor 23 are detected to adapt. To do this corresponding temperature / viscosity characteristics of the liquid 1 stored in the control device 20. Because the temperature fluctuations the liquid 1 in relation to devices, which have no means of keeping the temperature constant the liquid 1 have, are less Fluctuations in filling times compared to conventional devices less.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Filling Of Jars Or Cans And Processes For Cleaning And Sealing Jars (AREA)
  • Basic Packing Technique (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
EP99116465A 1998-09-25 1999-08-21 Dispositif pour remplir un liquide pharmaceutique sous pression dans un récipient Expired - Lifetime EP0989062B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19844011 1998-09-25
DE19844011A DE19844011C1 (de) 1998-09-25 1998-09-25 Vorrichtung zum Abfüllen einer unter Druck stehenden pharmazeutischen Flüssigkeit in Verpackungsbehälter

Publications (2)

Publication Number Publication Date
EP0989062A1 true EP0989062A1 (fr) 2000-03-29
EP0989062B1 EP0989062B1 (fr) 2003-03-12

Family

ID=7882225

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99116465A Expired - Lifetime EP0989062B1 (fr) 1998-09-25 1999-08-21 Dispositif pour remplir un liquide pharmaceutique sous pression dans un récipient

Country Status (4)

Country Link
US (1) US6176277B1 (fr)
EP (1) EP0989062B1 (fr)
JP (1) JP2000109190A (fr)
DE (2) DE19844011C1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103482099A (zh) * 2013-09-03 2014-01-01 立白日化有限公司 膏体灌装中准确定量控制系统及其控制方法
CN105174167A (zh) * 2015-10-09 2015-12-23 光明乳业股份有限公司 灌装装置

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7161787B2 (en) * 2004-05-04 2007-01-09 Millipore Corporation Low power solenoid driver circuit
US8101244B2 (en) * 2004-06-09 2012-01-24 Smithkline Beecham Corporation Apparatus and method for producing or processing a product or sample
TWI428271B (zh) * 2004-06-09 2014-03-01 Smithkline Beecham Corp 生產藥物之裝置及方法
US20060002594A1 (en) * 2004-06-09 2006-01-05 Clarke Allan J Method for producing a pharmaceutical product
US7182110B2 (en) * 2005-04-25 2007-02-27 Roebuck John T Fluid dispensing system with timed sequence fill cycle
DE102009006795A1 (de) * 2009-01-30 2010-08-05 Krones Ag Befülleinrichtung
JP6271717B2 (ja) 2013-05-24 2018-01-31 ザ プロクター アンド ギャンブル カンパニー 濃縮界面活性剤組成物
EP2810877A1 (fr) * 2013-06-04 2014-12-10 The Procter & Gamble Company Méthode pour emballager du détergent
CN110844138A (zh) * 2019-11-27 2020-02-28 山东新华医疗器械股份有限公司 一种灌装设备
TWI895352B (zh) 2020-02-14 2025-09-01 瑞士商赫孚孟拉羅股份公司 用於液體藥物產物之時間-壓力-充填系統與方法以及其用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2199503A (en) * 1937-12-11 1940-05-07 Michael A Martin Beer cooling system and apparatus
FR1028773A (fr) * 1950-05-19 1953-05-27 Machine à doser les produits liquides
DE4341934A1 (de) 1993-12-09 1995-06-14 Bosch Gmbh Robert Verfahren und Vorrichtung zum Dosieren und Abfüllen einer Flüssigkeit in Verpackungsbehälter

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4216879A (en) * 1978-08-16 1980-08-12 The Cornelius Company Method of and apparatus for dispensing a high volumetric flow rate of carbonated beverage, having partial reversal of a circulating flow
SE9203330D0 (sv) * 1992-11-09 1992-11-09 Kabi Pharmacia Ab Fluid distribution system
JP2633820B2 (ja) * 1995-06-16 1997-07-23 ボッシュ包装機株式会社 液体の圧力充填方法
DE19633970A1 (de) * 1995-09-08 1997-03-13 Fuji Electric Co Ltd Bierverkaufsmaschine und Verfahren zum Unter-Druck-Setzen eines Bierfasses

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2199503A (en) * 1937-12-11 1940-05-07 Michael A Martin Beer cooling system and apparatus
FR1028773A (fr) * 1950-05-19 1953-05-27 Machine à doser les produits liquides
DE4341934A1 (de) 1993-12-09 1995-06-14 Bosch Gmbh Robert Verfahren und Vorrichtung zum Dosieren und Abfüllen einer Flüssigkeit in Verpackungsbehälter

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103482099A (zh) * 2013-09-03 2014-01-01 立白日化有限公司 膏体灌装中准确定量控制系统及其控制方法
CN103482099B (zh) * 2013-09-03 2016-06-08 立白日化有限公司 膏体灌装中准确定量控制系统及其控制方法
CN105174167A (zh) * 2015-10-09 2015-12-23 光明乳业股份有限公司 灌装装置
CN105174167B (zh) * 2015-10-09 2018-09-18 光明乳业股份有限公司 灌装装置

Also Published As

Publication number Publication date
US6176277B1 (en) 2001-01-23
EP0989062B1 (fr) 2003-03-12
DE59904519D1 (de) 2003-04-17
JP2000109190A (ja) 2000-04-18
DE19844011C1 (de) 2000-03-09

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