EP0996441A4 - Compositions pharmaceutiques constituees d'arglabine et de derives d'arglabine - Google Patents

Compositions pharmaceutiques constituees d'arglabine et de derives d'arglabine

Info

Publication number
EP0996441A4
EP0996441A4 EP98918509A EP98918509A EP0996441A4 EP 0996441 A4 EP0996441 A4 EP 0996441A4 EP 98918509 A EP98918509 A EP 98918509A EP 98918509 A EP98918509 A EP 98918509A EP 0996441 A4 EP0996441 A4 EP 0996441A4
Authority
EP
European Patent Office
Prior art keywords
arglabin
pharmaceutical compositions
derivatives
arglabin derivatives
pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98918509A
Other languages
German (de)
English (en)
Other versions
EP0996441A1 (fr
Inventor
Sergazy M Adekenov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PARACURE Inc dba KAZAK-PARACURE
PARACURE Inc dba KAZAK PARACUR
Original Assignee
PARACURE Inc dba KAZAK-PARACURE
PARACURE Inc dba KAZAK PARACUR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/934,229 external-priority patent/US5902809A/en
Priority claimed from US08/934,471 external-priority patent/US6693127B1/en
Application filed by PARACURE Inc dba KAZAK-PARACURE, PARACURE Inc dba KAZAK PARACUR filed Critical PARACURE Inc dba KAZAK-PARACURE
Publication of EP0996441A1 publication Critical patent/EP0996441A1/fr
Publication of EP0996441A4 publication Critical patent/EP0996441A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
EP98918509A 1997-04-26 1998-04-22 Compositions pharmaceutiques constituees d'arglabine et de derives d'arglabine Withdrawn EP0996441A4 (fr)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
KZ973971 1997-04-23
KZ970397 1997-04-26
US5168197P 1997-07-03 1997-07-03
US51681P 1997-07-03
US93422897A 1997-09-19 1997-09-19
US934228 1997-09-19
US934471 1997-09-19
US08/934,229 US5902809A (en) 1997-07-03 1997-09-19 Arglabin compounds and therapeutic uses thereof
US08/934,471 US6693127B1 (en) 1997-07-03 1997-09-19 Pharmaceutical compositions of arglabin and arglabin derivatives
US934229 1997-09-19
PCT/US1998/007989 WO1998048789A1 (fr) 1997-04-26 1998-04-22 Compositions pharmaceutiques constituees d'arglabine et de derives d'arglabine

Publications (2)

Publication Number Publication Date
EP0996441A1 EP0996441A1 (fr) 2000-05-03
EP0996441A4 true EP0996441A4 (fr) 2002-08-07

Family

ID=27532391

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98918509A Withdrawn EP0996441A4 (fr) 1997-04-26 1998-04-22 Compositions pharmaceutiques constituees d'arglabine et de derives d'arglabine

Country Status (5)

Country Link
EP (1) EP0996441A4 (fr)
JP (1) JP3507511B2 (fr)
AU (1) AU7141898A (fr)
CA (1) CA2287318A1 (fr)
WO (1) WO1998048789A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5994388A (en) 1997-03-18 1999-11-30 The Children's Medical Center Corporation Cytochalasin and isoindolinone derivatives as inhibitors of angiogenesis
US6051565A (en) * 1997-04-26 2000-04-18 International Phytochemistry Research Labs, Ltd. Farnesyl-protein transferase inhibitors
GB9809889D0 (en) * 1998-05-11 1998-07-08 Univ Strathclyde Prevention of restenosis
WO1999064003A1 (fr) * 1998-06-09 1999-12-16 Tovarischestvo S Ogranichennoi Otvetstvennostju 'tabifarm' Traitement precoce du cancer du foie
CA2356438A1 (fr) * 2001-09-05 2003-03-05 Andre Pichette Utilisation de terpenes et de leurs derives comme potentialisateurs d'agents antitumoraux dans le traitement de cancers
US7678904B2 (en) 2003-07-11 2010-03-16 University Of Kentucky Use of parthenolide derivatives as antileukemic and cytotoxic agents
WO2005007103A2 (fr) * 2003-07-11 2005-01-27 University Of Kentucky Research Foundation Utilisation de derives de parthenolide en tant qu'agents antileucemiques et cytotoxiques
CN102372723B (zh) * 2010-08-19 2014-03-26 石药集团中奇制药技术（石家庄）有限公司 一种从多花蒿中提取阿格拉宾的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995006476A1 (fr) * 1993-09-03 1995-03-09 Trustees Of Boston University Procedes et compositions pour traiter les neoplasies pathologiques

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995006476A1 (fr) * 1993-09-03 1995-03-09 Trustees Of Boston University Procedes et compositions pour traiter les neoplasies pathologiques

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BOTTEX-GAUTHIER C ET AL: "IN VITRO BIOLOGICAL ACTIVITIES OF ARGLABIN, A SESQUITERPENE LACTONE FROM THE CHINESE HERB Artemisi myriantha WALL. (ASTERACEAE)", BIOTECHNOLOGY THERAPEUTICS, MARCEL DEKKER, NEW YORK, NY, US, vol. 4, no. 1/2, 1993, pages 77 - 98, XP002114696, ISSN: 0898-2848 *
See also references of WO9848789A1 *

Also Published As

Publication number Publication date
AU7141898A (en) 1998-11-24
WO1998048789A1 (fr) 1998-11-05
EP0996441A1 (fr) 2000-05-03
CA2287318A1 (fr) 1998-11-05
JP2002509532A (ja) 2002-03-26
JP3507511B2 (ja) 2004-03-15

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Legal Events

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Effective date: 20030929

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Inventor name: ADEKENOV, SERGAZY M.

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Effective date: 20060124