EP1003500A4 - Intramurale verabreichung von stickstoff monoxid zur hemmung der läsionsbildung nach einer gefässverletzung - Google Patents

Intramurale verabreichung von stickstoff monoxid zur hemmung der läsionsbildung nach einer gefässverletzung

Info

Publication number
EP1003500A4
EP1003500A4 EP97938163A EP97938163A EP1003500A4 EP 1003500 A4 EP1003500 A4 EP 1003500A4 EP 97938163 A EP97938163 A EP 97938163A EP 97938163 A EP97938163 A EP 97938163A EP 1003500 A4 EP1003500 A4 EP 1003500A4
Authority
EP
European Patent Office
Prior art keywords
nitrogen monoxide
vascular injury
intramural administration
lesions
inhibit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97938163A
Other languages
English (en)
French (fr)
Other versions
EP1003500A1 (de
Inventor
John P Cooke
Sverin Schwarzacher
Tai T Lim
Alan C Yeung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/695,792 external-priority patent/US5852058A/en
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Publication of EP1003500A1 publication Critical patent/EP1003500A1/de
Publication of EP1003500A4 publication Critical patent/EP1003500A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP97938163A 1996-08-12 1997-08-07 Intramurale verabreichung von stickstoff monoxid zur hemmung der läsionsbildung nach einer gefässverletzung Withdrawn EP1003500A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US695792 1996-08-12
US08/695,792 US5852058A (en) 1993-06-11 1996-08-12 Intramural delivery of nitric oxide enhancer for inhibiting lesion formation after vascular injury
PCT/US1997/013905 WO1998006389A1 (en) 1996-08-12 1997-08-07 Intramural delivery of nitric oxide enhancer for inhibiting lesion formation after vascular injury

Publications (2)

Publication Number Publication Date
EP1003500A1 EP1003500A1 (de) 2000-05-31
EP1003500A4 true EP1003500A4 (de) 2004-06-23

Family

ID=24794481

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97938163A Withdrawn EP1003500A4 (de) 1996-08-12 1997-08-07 Intramurale verabreichung von stickstoff monoxid zur hemmung der läsionsbildung nach einer gefässverletzung

Country Status (4)

Country Link
EP (1) EP1003500A4 (de)
JP (1) JP2000516612A (de)
DE (1) DE69637676D1 (de)
WO (1) WO1998006389A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6587718B2 (en) 1999-10-08 2003-07-01 Scimed Life Systems, Inc. Iontophoretic delivery to heart tissue
US6706274B2 (en) 2001-01-18 2004-03-16 Scimed Life Systems, Inc. Differential delivery of nitric oxide
US7056523B1 (en) 2002-06-21 2006-06-06 Advanced Cardiovascular Systems, Inc. Implantable medical devices incorporating chemically conjugated polymers and oligomers of L-arginine
US7011842B1 (en) 2002-06-21 2006-03-14 Advanced Cardiovascular Systems, Inc. Polycationic peptide coatings and methods of making the same
US8506617B1 (en) 2002-06-21 2013-08-13 Advanced Cardiovascular Systems, Inc. Micronized peptide coated stent
US7033602B1 (en) 2002-06-21 2006-04-25 Advanced Cardiovascular Systems, Inc. Polycationic peptide coatings and methods of coating implantable medical devices
US7217426B1 (en) 2002-06-21 2007-05-15 Advanced Cardiovascular Systems, Inc. Coatings containing polycationic peptides for cardiovascular therapy
US6994867B1 (en) 2002-06-21 2006-02-07 Advanced Cardiovascular Systems, Inc. Biocompatible carrier containing L-arginine
US7070798B1 (en) 2002-06-21 2006-07-04 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices incorporating chemically-bound polymers and oligomers of L-arginine
US7094256B1 (en) 2002-12-16 2006-08-22 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical device containing polycationic peptides
EP1888510A4 (de) 2005-05-27 2013-01-16 Univ North Carolina Stickoxidfreisetzende partikel für stickoxidtherapeutika und biomedizinische anwendungen
BR112012003804B1 (pt) 2009-08-21 2019-02-19 Novan, Inc. Curativo para ferimentos, método para formar um curativo para ferimentos, e, kit de curativo para ferimento
WO2011022652A1 (en) 2009-08-21 2011-02-24 Novan, Inc. Topical gels
US8591876B2 (en) 2010-12-15 2013-11-26 Novan, Inc. Methods of decreasing sebum production in the skin
ES2695173T3 (es) 2011-02-28 2019-01-02 Novan Inc Partículas de sílice modificadas con S-nitrosotiol que liberan óxido nítrico y procedimientos de fabricación de las mismas

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0483614A1 (de) * 1990-10-30 1992-05-06 Clintec Nutrition Company Verwendung von Aminosäuren zum Schutz von ischemischem Herzgewebe und dessen metabolischer Wiederherstellung
US5171217A (en) * 1991-02-28 1992-12-15 Indiana University Foundation Method for delivery of smooth muscle cell inhibitors
WO1995005866A1 (en) * 1993-08-27 1995-03-02 Cortrak Medical Inc. Simultaneous angioplasty and drug delivery
WO1995024898A1 (en) * 1994-03-17 1995-09-21 Comedicus, Incorporated Complexes of nitric oxide with cardiovascular amines as dual acting cardiovascular agents
WO1996000112A1 (en) * 1994-06-23 1996-01-04 Cormedics Corp. Vascular treatment method and apparatus
WO1997016983A1 (en) * 1995-11-09 1997-05-15 The Board Of Trustees Of The Leland Stanford Junior University Enhancement of vascular function by modulation of endogenous nitric oxide production or activity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5236413B1 (en) * 1990-05-07 1996-06-18 Andrew J Feiring Method and apparatus for inducing the permeation of medication into internal tissue
US5499971A (en) * 1990-06-15 1996-03-19 Cortrak Medical, Inc. Method for iontophoretically delivering drug adjacent to a heart
US5428070A (en) * 1993-06-11 1995-06-27 The Board Of Trustees Of The Leland Stanford Junior University Treatment of vascular degenerative diseases by modulation of endogenous nitric oxide production of activity

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0483614A1 (de) * 1990-10-30 1992-05-06 Clintec Nutrition Company Verwendung von Aminosäuren zum Schutz von ischemischem Herzgewebe und dessen metabolischer Wiederherstellung
US5171217A (en) * 1991-02-28 1992-12-15 Indiana University Foundation Method for delivery of smooth muscle cell inhibitors
WO1995005866A1 (en) * 1993-08-27 1995-03-02 Cortrak Medical Inc. Simultaneous angioplasty and drug delivery
WO1995024898A1 (en) * 1994-03-17 1995-09-21 Comedicus, Incorporated Complexes of nitric oxide with cardiovascular amines as dual acting cardiovascular agents
WO1996000112A1 (en) * 1994-06-23 1996-01-04 Cormedics Corp. Vascular treatment method and apparatus
WO1997016983A1 (en) * 1995-11-09 1997-05-15 The Board Of Trustees Of The Leland Stanford Junior University Enhancement of vascular function by modulation of endogenous nitric oxide production or activity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9806389A1 *

Also Published As

Publication number Publication date
JP2000516612A (ja) 2000-12-12
WO1998006389A1 (en) 1998-02-19
DE69637676D1 (de) 2008-10-23
EP1003500A1 (de) 2000-05-31

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20040507

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Ipc: 7A 61N 1/30 B

Ipc: 7A 61M 29/02 B

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Ipc: 7A 61K 31/195 A

17Q First examination report despatched

Effective date: 20061219

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Effective date: 20090408