EP1003530A4 - Traitement oculaire a l'aide de compositions d'hormones thyroidiennes synthetiques - Google Patents

Traitement oculaire a l'aide de compositions d'hormones thyroidiennes synthetiques

Info

Publication number
EP1003530A4
EP1003530A4 EP97938483A EP97938483A EP1003530A4 EP 1003530 A4 EP1003530 A4 EP 1003530A4 EP 97938483 A EP97938483 A EP 97938483A EP 97938483 A EP97938483 A EP 97938483A EP 1003530 A4 EP1003530 A4 EP 1003530A4
Authority
EP
European Patent Office
Prior art keywords
thyroid hormone
eye treatment
synthetic thyroid
hormone compositions
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97938483A
Other languages
German (de)
English (en)
Other versions
EP1003530A1 (fr
Inventor
Daniel M Schwartz
John D Baxter
Michele D Jumper
Thomas S Scanlan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California Berkeley
University of California San Diego UCSD
Original Assignee
University of California Berkeley
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California Berkeley, University of California San Diego UCSD filed Critical University of California Berkeley
Publication of EP1003530A1 publication Critical patent/EP1003530A1/fr
Publication of EP1003530A4 publication Critical patent/EP1003530A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
EP97938483A 1996-08-20 1997-08-20 Traitement oculaire a l'aide de compositions d'hormones thyroidiennes synthetiques Withdrawn EP1003530A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2369796P 1996-08-20 1996-08-20
US23697P 1996-08-20
PCT/US1997/014691 WO1998007435A1 (fr) 1996-08-20 1997-08-20 Traitement oculaire a l'aide de compositions d'hormones thyroidiennes synthetiques

Publications (2)

Publication Number Publication Date
EP1003530A1 EP1003530A1 (fr) 2000-05-31
EP1003530A4 true EP1003530A4 (fr) 2001-10-04

Family

ID=21816699

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97938483A Withdrawn EP1003530A4 (fr) 1996-08-20 1997-08-20 Traitement oculaire a l'aide de compositions d'hormones thyroidiennes synthetiques

Country Status (6)

Country Link
US (3) US6054485A (fr)
EP (1) EP1003530A4 (fr)
JP (2) JP3345428B2 (fr)
KR (1) KR100405285B1 (fr)
CA (1) CA2260992C (fr)
WO (1) WO1998007435A1 (fr)

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US6266622B1 (en) * 1995-12-13 2001-07-24 Regents Of The University Of California Nuclear receptor ligands and ligand binding domains
US6236946B1 (en) 1995-12-13 2001-05-22 Thomas S. Scanlan Nuclear receptor ligands and ligand binding domains
US20020143284A1 (en) * 2001-04-03 2002-10-03 Hosheng Tu Drug-releasing trabecular implant for glaucoma treatment
US7163918B2 (en) * 2000-08-22 2007-01-16 New River Pharmaceuticals Inc. Iodothyronine compositions
FR2816633B1 (fr) * 2000-11-10 2003-02-07 Lipha Methode de criblage d'agents susceptibles de traiter l'obesite
US7470659B2 (en) * 2001-12-07 2008-12-30 The Regents Of The University Of California Methods to increase reverse cholesterol transport in the retinal pigment epithelium (RPE) and Bruch's membrane (BM)
US20030229062A1 (en) * 2001-12-07 2003-12-11 The Regents Of The University Of California Treatments for age-related macular degeneration (AMD)
WO2003049685A2 (fr) * 2001-12-07 2003-06-19 The Regents Of The University Of California Traitement de la degenerescence maculaire liee au vieillissement
US7018646B2 (en) * 2002-05-30 2006-03-28 Van Dalen Johan T W Apparatus and method for delivering controlled quantities of one or more agents to the eye
US20050048099A1 (en) * 2003-01-09 2005-03-03 Allergan, Inc. Ocular implant made by a double extrusion process
US20040216749A1 (en) * 2003-01-23 2004-11-04 Hosheng Tu Vasomodulation during glaucoma surgery
US6969514B2 (en) * 2003-02-05 2005-11-29 Soll David B Method for treating elevated intraocular pressure, including glaucoma
CN1882327A (zh) 2003-11-19 2006-12-20 症变治疗公司 含磷的新的拟甲状腺素药
US7922702B2 (en) 2004-07-02 2011-04-12 Qlt Inc. Treatment medium delivery device and methods for delivery of such treatment mediums to the eye using such a delivery device
WO2006128056A2 (fr) * 2005-05-26 2006-11-30 Metabasis Therapeutics, Inc. Nouvelles substances thyromimetiques contenant de l'acide phosphinique
MX2007014502A (es) 2005-05-26 2008-02-07 Metabasis Therapeutics Inc Tiromimeticos para el tratamiento de enfermedades del higado graso.
WO2007002036A1 (fr) * 2005-06-24 2007-01-04 Thomas Lavin Hormones thyroidiennes dans les depots de brulures et adipeux
US20080000473A1 (en) * 2005-12-29 2008-01-03 Hugo Stephenson pH-Based Methods and Devices for Preventing Hemagglutinin Cell Membrane Fusion
SG170816A1 (en) 2006-03-31 2011-05-30 Qlt Plug Delivery Inc Drug delivery methods, structures, and compositions for nasolacrimal system
FR2924722B1 (fr) * 2007-12-10 2013-10-25 Oreal Procede de selection d'agents pour modifier la forme du cheveu et utilisation cosmetique des actifs.
US12478503B2 (en) 2009-05-18 2025-11-25 Glaukos Corporation Implants with controlled drug delivery features and methods of using same
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
WO2013011511A1 (fr) 2011-07-18 2013-01-24 Mor Research Applications Ltd. Dispositif pour l'ajustement de la tension intraoculaire
TWI698240B (zh) 2012-05-15 2020-07-11 澳大利亞商艾佛蘭屈澳洲私營有限公司 使用腺相關病毒(aav)sflt-1治療老年性黃斑部退化(amd)
WO2014178892A1 (fr) 2013-05-03 2014-11-06 Scanlan Thomas S Utilisation du sobetirome dans le traitement de l'adrénoleucodystrophie liée au chromosome x
US10258613B2 (en) 2014-02-05 2019-04-16 The Board Of Regents Of The University Of Oklahoma Compositions for treating retinal degeneration and methods of production and use thereof
EP3800191B1 (fr) 2014-03-17 2025-08-20 Adverum Biotechnologies, Inc. Compositions et procédés pour améliorer l'expression des gènes dans les cônes rétiniens
US11021519B2 (en) 2015-03-02 2021-06-01 Adverum Biotechnologies, Inc. Compositions and methods for intravitreal delivery of polynucleotides to retinal cones
CA2978727C (fr) 2015-03-04 2023-05-02 Daniel Levner Dispositif fluidique pour quantifier la permeabilite dynamique et la conductivite hydraulique de couches de tissu vivant
GB2545763A (en) 2015-12-23 2017-06-28 Adverum Biotechnologies Inc Mutant viral capsid libraries and related systems and methods
JP2020500199A (ja) 2016-11-21 2020-01-09 バイキング・セラピューティクス・インコーポレイテッド グリコーゲン蓄積症の治療方法
AU2018280118B2 (en) 2017-06-05 2021-07-15 Viking Therapeutics, Inc. Compositions for the treatment of fibrosis
ES3053674T3 (en) 2018-03-22 2026-01-23 Viking Therapeutics Inc Crystalline forms and methods of producing crystalline forms of a compound
WO2020117962A1 (fr) 2018-12-05 2020-06-11 Viking Therapeutics, Inc. Compositions pour le traitement de la fibrose et de l'inflammation
AU2019397067A1 (en) 2018-12-12 2021-07-22 Autobahn Therapeutics, Inc. Novel thyromimetics
WO2020180624A1 (fr) 2019-03-01 2020-09-10 Autobahn Therapeutics, Inc. Nouveaux thyromimétiques
US12466781B2 (en) 2019-11-29 2025-11-11 Autobahn Therapeutics, Inc. Thyromimetics
JP2023515827A (ja) * 2020-02-28 2023-04-14 ノースウェスタン ユニバーシティ 房水流出を高め、眼圧を減少させる方法
US12590072B2 (en) 2020-06-17 2026-03-31 Autobahn Therapeutics, Inc. Thyromimetics
WO2021257851A1 (fr) 2020-06-17 2021-12-23 Autobahn Therapeutics, Inc. Thyromimétiques

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995017178A1 (fr) * 1993-12-22 1995-06-29 The Regents Of The University Of California Inhibiteurs non steroides pour le traitement de l'elevation de la pression intraoculaire
WO1997021993A2 (fr) * 1995-12-13 1997-06-19 The Regents Of The University Of California Ligands de recepteurs nucleaires et domaines de liaison de ligands

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US2798053A (en) * 1952-09-03 1957-07-02 Goodrich Co B F Carboxylic polymers
US4038264A (en) * 1974-01-07 1977-07-26 National Patent Development Corporation Hema copolymers having high oxygen permeability
US4192827A (en) * 1974-06-27 1980-03-11 Ciba-Geigy Corporation Water-insoluble hydrophilic copolymers
US4136250A (en) * 1977-07-20 1979-01-23 Ciba-Geigy Corporation Polysiloxane hydrogels
US4548990A (en) * 1983-08-15 1985-10-22 Ciba-Geigy Corporation Crosslinked, porous polymers for controlled drug delivery
CN1011118B (zh) * 1986-06-13 1991-01-09 天津医学院附属医院 治疗白内障的眼药水的制药方法
FR2601247A1 (fr) * 1986-07-09 1988-01-15 Merk Sharp Dohme Chibret Labor Combinaison d'agents beta-bloquants et de pilocarpine.
US5360399A (en) * 1992-01-10 1994-11-01 Robert Stegmann Method and apparatus for maintaining the normal intraocular pressure
DK0831769T3 (da) * 1995-06-07 2004-02-23 Karobio Ab Hidtil ukendte anvendelser af thyroideahormoner eller thyroideahormon-lignende forbindelser
US6380255B1 (en) 1995-06-07 2002-04-30 Karo Bio Ab Treatment for dermal skin atrophy using thyroid hormone compounds or thyroid hormone-like compounds
US6221911B1 (en) 1995-06-07 2001-04-24 Karo Bio Ab Uses for thyroid hormone compounds or thyroid hormone-like compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995017178A1 (fr) * 1993-12-22 1995-06-29 The Regents Of The University Of California Inhibiteurs non steroides pour le traitement de l'elevation de la pression intraoculaire
WO1997021993A2 (fr) * 1995-12-13 1997-06-19 The Regents Of The University Of California Ligands de recepteurs nucleaires et domaines de liaison de ligands

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HALLMAN, VIVIENNE L.: "Effect of thyroid hormones on intraocular pressure", EXP. EYE RES. (1967), 6(3), 219-26, XP001002983 *
See also references of WO9807435A1 *
SMITH K.D. ET AL: "An association between hypothyroidism and primary open-angle glaucoma.", OPHTHALMOLOGY, (1993) 100/10 (1580-1584)., XP001016291 *
YONEYAMA, JOJI: "Effects of antiglaucoma agents on glycosaminoglycans in organ-cultured rabbit trabecular meshwork", OPHTHALMOLOGICA (1994), 208(5), 278-83, XP002174077 *

Also Published As

Publication number Publication date
WO1998007435A1 (fr) 1998-02-26
JP2002348249A (ja) 2002-12-04
KR100405285B1 (ko) 2003-11-12
KR20000068213A (ko) 2000-11-25
US7122579B2 (en) 2006-10-17
AU717608B2 (en) 2000-03-30
US6555582B1 (en) 2003-04-29
US20030175849A1 (en) 2003-09-18
CA2260992C (fr) 2004-03-09
JP2001500964A (ja) 2001-01-23
EP1003530A1 (fr) 2000-05-31
US6054485A (en) 2000-04-25
AU4079397A (en) 1998-03-06
CA2260992A1 (fr) 1998-02-26
JP3345428B2 (ja) 2002-11-18

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