EP1007540A1 - Molecules d'adn codant pour des proteines receptrices nucleaires - Google Patents

Molecules d'adn codant pour des proteines receptrices nucleaires

Info

Publication number
EP1007540A1
EP1007540A1 EP98943441A EP98943441A EP1007540A1 EP 1007540 A1 EP1007540 A1 EP 1007540A1 EP 98943441 A EP98943441 A EP 98943441A EP 98943441 A EP98943441 A EP 98943441A EP 1007540 A1 EP1007540 A1 EP 1007540A1
Authority
EP
European Patent Office
Prior art keywords
nnr2
protein
human
nnrl
expression vector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98943441A
Other languages
German (de)
English (en)
Other versions
EP1007540A4 (fr
Inventor
Fang Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1007540A1 publication Critical patent/EP1007540A1/fr
Publication of EP1007540A4 publication Critical patent/EP1007540A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors

Definitions

  • Figure 7A-C shows the nucleotide sequence (SEQ ID NO:5) which comprises the open reading frame encoding the human nuclear receptor protein, nNR2.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne l'isolement et la caractérisation de molécules d'ADNc codant pour deux protéines réceptrices nucléaires humaines, désignées par nNR1, nNR2 et/ou nNR2-1. L'invention concerne également des vecteurs recombinants, des cellules hôtes recombinantes, des techniques de criblage permettant l'identification de modulateurs de l'activité nNR1, nNR2 et/ou nNR2-1, et la production d'antibiotiques contre nNR1, nNR2 et/ou de nNR2-1, ou des épitopes de ces derniers.
EP98943441A 1997-08-27 1998-08-27 Molecules d'adn codant pour des proteines receptrices nucleaires Withdrawn EP1007540A4 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US5709097P 1997-08-27 1997-08-27
US57090P 1997-08-27
US6290297P 1997-10-21 1997-10-21
US62902P 1997-10-21
US7863398P 1998-03-19 1998-03-19
US78633P 1998-03-19
PCT/US1998/017826 WO1999010367A1 (fr) 1997-08-27 1998-08-27 Molecules d'adn codant pour des proteines receptrices nucleaires

Publications (2)

Publication Number Publication Date
EP1007540A1 true EP1007540A1 (fr) 2000-06-14
EP1007540A4 EP1007540A4 (fr) 2003-06-18

Family

ID=27369158

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98943441A Withdrawn EP1007540A4 (fr) 1997-08-27 1998-08-27 Molecules d'adn codant pour des proteines receptrices nucleaires

Country Status (4)

Country Link
EP (1) EP1007540A4 (fr)
JP (1) JP2001513984A (fr)
CA (1) CA2301554A1 (fr)
WO (1) WO1999010367A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0866127A3 (fr) * 1997-03-17 1999-12-22 Smithkline Beecham Plc HE8AN36, un homologue de récepteur d'hormone stéroide
AU2002500A (en) * 1999-01-14 2000-08-01 Kyowa Hakko Kogyo Co. Ltd. Novel protein
WO2003080831A1 (fr) * 2002-03-25 2003-10-02 Fujisawa Pharmaceutical Co., Ltd. Recepteur nucleaire err$g(g)3

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071773A (en) * 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [Online] 1 December 1995 (1995-12-01) "ys81d07.r1 Homo sapiens cDNA clone 221197 5' similar to gb:X51417_cds1 STEROID HORMONE RECEPTOR ERR2 (HUMAN)" retrieved from EBI Database accession no. H91890 XP002239023 *
DATABASE EMBL [Online] 1 December 1995 (1995-12-01) "ys81d07.s1 Homo sapiens cDNA clone 221197 3' similar to gb:X51417_cds1 STEROID HORMONE RECEPTOR ERR2 (HUMAN)" retrieved from EBI Database accession no. H91842 XP002239026 *
DATABASE EMBL [Online] 16 November 1995 (1995-11-16) "ys69h11.r1 Homo sapiens cDNA clone 220101 5' similar to gb:X51417_cds1 STEROID HORMONE RECEPTOR ERR2 (HUMAN)" retrieved from EBI Database accession no. H82542 XP002239024 *
DATABASE EMBL [Online] 16 November 1995 (1995-11-16) "ys69h11.s1 Homo sapiens cDNA clone 220101 3' similar to gb:X51417_cds1 STEROID HORMONE RECEPTOR ERR2 (HUMAN)" retrieved from EBI Database accession no. H82543 XP002239025 *
DATABASE EMBL [Online] 27 January 1996 (1996-01-27) "yw88d02.r1 Homo sapiens cDNA clone 259299 5' similar to PIR:JC2390 JC2390 nuclear receptor Rev-ErbA beta - rat [1]" retrieved from EBI Database accession no. N41813 XP002239020 *
DATABASE EMBL [Online] 29 May 1995 (1995-05-29) "yg96e07.r1 Homo sapiens cDNA clone 41139 5' similar to SP:RNR1_RAT Q07917 REGENERATING LIVER NUCLEAR RECEPTOR 1" retrieved from EBI Database accession no. R59032 XP002239022 *
DATABASE EMBL [Online] 8 April 1995 (1995-04-08) "yd21f09.r1 Homo sapiens cDNA clone 67817 5' similar to SP:ROR1_HUMAN P35397 NUCLEAR RECEPTOR" retrieved from EBI Database accession no. T79024 XP002239021 *
ENMARK E ET AL: "ORPHAN NUCLEAR RECEPTORS - THE FIRST EIGHT YEARS" MOLECULAR ENDOCRINOLOGY, BALTIMORE, MD, US, vol. 10, no. 11, 1 November 1996 (1996-11-01), pages 1293-1307, XP000645166 ISSN: 0888-8809 *
See also references of WO9910367A1 *

Also Published As

Publication number Publication date
EP1007540A4 (fr) 2003-06-18
JP2001513984A (ja) 2001-09-11
WO1999010367A1 (fr) 1999-03-04
CA2301554A1 (fr) 1999-03-04

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