EP1009405A4 - MODULATORS OF PYRROLIDINE AND PIPERIDINE OF CHEMOKINE RECEPTOR ACTIVITY - Google Patents

MODULATORS OF PYRROLIDINE AND PIPERIDINE OF CHEMOKINE RECEPTOR ACTIVITY

Info

Publication number
EP1009405A4
EP1009405A4 EP98944548A EP98944548A EP1009405A4 EP 1009405 A4 EP1009405 A4 EP 1009405A4 EP 98944548 A EP98944548 A EP 98944548A EP 98944548 A EP98944548 A EP 98944548A EP 1009405 A4 EP1009405 A4 EP 1009405A4
Authority
EP
European Patent Office
Prior art keywords
pyrrolidine
modulators
piperidine
chemokine receptor
receptor activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98944548A
Other languages
German (de)
French (fr)
Other versions
EP1009405A1 (en
Inventor
Richard J Budhu
Jeffrey J Hale
Edward Holson
Christopher Lynch
Malcolm Maccoss
Sander G Mills
Scott C Berk
Christopher A Willoughby
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9801009.3A external-priority patent/GB9801009D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP1009405A1 publication Critical patent/EP1009405A1/en
Publication of EP1009405A4 publication Critical patent/EP1009405A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
EP98944548A 1997-08-28 1998-08-27 MODULATORS OF PYRROLIDINE AND PIPERIDINE OF CHEMOKINE RECEPTOR ACTIVITY Withdrawn EP1009405A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5774397P 1997-08-28 1997-08-28
US57743P 1997-08-28
GB9801009 1998-01-16
GBGB9801009.3A GB9801009D0 (en) 1998-01-16 1998-01-16 Pyrrolidine and piperidine modulators of chemokine receptor activity
PCT/US1998/017755 WO1999009984A1 (en) 1997-08-28 1998-08-27 Pyrrolidine and piperidine modulators of chemokine receptor activity

Publications (2)

Publication Number Publication Date
EP1009405A1 EP1009405A1 (en) 2000-06-21
EP1009405A4 true EP1009405A4 (en) 2001-05-09

Family

ID=26312970

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98944548A Withdrawn EP1009405A4 (en) 1997-08-28 1998-08-27 MODULATORS OF PYRROLIDINE AND PIPERIDINE OF CHEMOKINE RECEPTOR ACTIVITY

Country Status (5)

Country Link
EP (1) EP1009405A4 (en)
JP (1) JP2001526178A (en)
AU (1) AU9206798A (en)
CA (1) CA2298813A1 (en)
WO (1) WO1999009984A1 (en)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743594B1 (en) 1995-06-06 2004-06-01 Human Genome Sciences, Inc. Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5)
US6025154A (en) 1995-06-06 2000-02-15 Human Genome Sciences, Inc. Polynucleotides encoding human G-protein chemokine receptor HDGNR10
CA2347912A1 (en) * 1998-12-18 2000-06-22 Soo S. Ko Heterocyclic piperidines as modulators of chemokine receptor activity
EP1013276A1 (en) 1998-12-23 2000-06-28 Pfizer Inc. Aminoazacycloalkanes as CCR5 modulators
PE20001420A1 (en) 1998-12-23 2000-12-18 Pfizer CCR5 MODULATORS
US7217714B1 (en) 1998-12-23 2007-05-15 Agouron Pharmaceuticals, Inc. CCR5 modulators
AU3389300A (en) * 1999-03-02 2000-09-21 Merck & Co., Inc. Pyrrolidine modulators of chemokine receptor activity
US6489354B1 (en) * 1999-03-02 2002-12-03 Merck & Co., Inc. 3-alkyl substituted pyrrolidine modulators of chemokine receptor activity
US6303593B1 (en) * 1999-03-02 2001-10-16 Merck & Co., Inc. 3-thienyl and 3-furanyl pyrrolidine modulators of chemokine receptor activity
US6248755B1 (en) 1999-04-06 2001-06-19 Merck & Co., Inc. Pyrrolidine modulators of chemokine receptor activity
US6498161B1 (en) 1999-04-06 2002-12-24 Merck & Co., Inc. Pyrrolidine modulators of chemokine receptor activity
US6265434B1 (en) * 1999-04-06 2001-07-24 Merck & Co., Inc. Pyrrolidine modulators of chemokine receptor activity
US6399619B1 (en) 1999-04-06 2002-06-04 Merck & Co., Inc. Pyrrolidine modulators of chemokine receptor activity
GB9912701D0 (en) * 1999-06-01 1999-08-04 Smithkline Beecham Plc Novel compounds
AU5600100A (en) 1999-06-11 2001-01-02 Merck & Co., Inc. Cyclopentyl modulators of chemokine receptor activity
DE60031676T2 (en) * 1999-06-11 2007-08-30 Merck & Co., Inc. N-CYCLOPENTYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
US6472410B1 (en) 1999-06-11 2002-10-29 Merck & Co., Inc. N-cyclopentyl modulators of chemokine receptor activity
US6500844B1 (en) 1999-06-11 2002-12-31 Merck & Co., Inc. Cyclopentyl modulators of chemokine receptor activity
WO2000076513A1 (en) 1999-06-11 2000-12-21 Merck & Co., Inc. Cyclopentyl modulators of chemokine receptor activity
AU5469400A (en) 1999-06-11 2001-01-02 Merck & Co., Inc. Cyclopentyl modulators of chemokine receptor activity
US6358979B1 (en) 1999-06-11 2002-03-19 Merck & Co., Inc. N-cyclopentyl modulators of chemokine receptor activity
AU2001239885A1 (en) * 2000-02-28 2001-09-12 Merck And Co., Inc. 4-alkyl piperidinyl pyrrolidine modulators of chemokine receptor activity
MXPA02012712A (en) 2000-06-30 2003-04-25 Bristol Myers Squibb Pharma Co N-ureidoheterocycloaklyl-piperidines as modulators of chemokine receptor activity.
US6531484B2 (en) 2000-10-11 2003-03-11 Merck & Co., Inc. Pyrrolidine modulators of CCR5 chemokine receptor activity
US7175988B2 (en) 2001-02-09 2007-02-13 Human Genome Sciences, Inc. Human G-protein Chemokine Receptor (CCR5) HDGNR10
GEP20053710B (en) 2001-02-28 2005-12-26 Merck & Co Inc Acylated Piperidine Derivatives as Melanocortin-4 Receptor Agonists
EP1372653B1 (en) 2001-02-28 2006-10-04 Merck & Co., Inc. Acylated piperidine derivatives as melanocortin-4 receptor agonists
MXPA03008109A (en) 2001-03-07 2003-12-12 Pfizer Prod Inc Modulators of chemokine receptor activity.
GB0108099D0 (en) * 2001-03-30 2001-05-23 Hoffmann La Roche Aminopiperidine derivatives
BR0209129A (en) * 2001-04-18 2005-12-20 Euro Celtique Sa Compounds, pharmaceutical compositions, methods for treating pain, methods for modulating a pharmacological response and uses of compounds.
US7115628B2 (en) 2001-07-18 2006-10-03 Merck & Co., Inc. Bridged piperidine derivatives as melanocortin receptor agonists
US7393934B2 (en) 2001-12-21 2008-07-01 Human Genome Sciences, Inc. Human G-protein chemokine receptor (CCR5) HDGNR10
MXPA04012393A (en) 2002-06-12 2005-06-17 Chemocentryx 1-aryl-4-substituted piperazines derivatives for use as ccr1 antagonists for the treatment of inflammation and immune disorders.
US7842693B2 (en) 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
US7589199B2 (en) 2002-06-12 2009-09-15 Chemocentryx, Inc. Substituted piperazines
WO2004024720A1 (en) 2002-09-11 2004-03-25 Merck & Co., Inc. Piperazine urea derivatives as melanocortin-4 receptor agonists
EP1633343A1 (en) * 2003-05-30 2006-03-15 Neuromed Technologies, Inc. 3-aminomethyl-pyrrolidines as n-type calcium channel blockers
CA2579608A1 (en) 2003-09-10 2005-03-17 Virochem Pharma Inc. Spiro compounds and methods for the modulation of chemokine receptor activity
GB0328906D0 (en) * 2003-12-12 2004-01-14 Syngenta Participations Ag Chemical compounds
US7435831B2 (en) 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
CN1950082B (en) 2004-03-03 2013-02-06 凯莫森特里克斯股份有限公司 Bicyclic and bridged nitrogen heterocycles
CA2559809A1 (en) 2004-03-12 2005-11-10 Human Genome Sciences, Inc. Antibodies against human g-protein chemokine receptor (ccr5) hdgnr10
KR20070046929A (en) * 2004-08-19 2007-05-03 버텍스 파마슈티칼스 인코포레이티드 Muscarinic receptor modulators
BRPI0519288A2 (en) * 2004-12-24 2009-01-06 Astrazeneca Ab heterocyclic compounds as ccr2b antagonists
US7880002B2 (en) 2004-12-29 2011-02-01 Millennium Pharmaceuticals, Inc. Substituted piperazinyl-pyrrolidine compounds useful as chemokine receptor antagonists
US7635698B2 (en) 2004-12-29 2009-12-22 Millennium Pharmaceuticals, Inc. Compounds useful as chemokine receptor antagonists
WO2006073361A1 (en) * 2005-01-06 2006-07-13 Astrazeneca Ab Novel pyridine compounds
GB0505969D0 (en) 2005-03-23 2005-04-27 Novartis Ag Organic compounds
GB0514203D0 (en) 2005-07-11 2005-08-17 Novartis Ag Organic compounds
GB0525957D0 (en) 2005-12-21 2006-02-01 Astrazeneca Ab Methods
JP2009521483A (en) * 2005-12-22 2009-06-04 バーテックス ファーマシューティカルズ インコーポレイテッド Muscarinic receptor modulators
NZ569135A (en) 2005-12-30 2011-08-26 Novartis Ag 3,5-Substituted piperidine compounds as renin inhibitors
US7351706B2 (en) 2006-01-05 2008-04-01 Hoffmann-La Roche Inc. Indol-3-yl-carbonyl-spiro-piperidine derivatives
EP1987034B1 (en) * 2006-02-22 2011-07-20 Vertex Pharmceuticals Incorporated Spiro condensed piperidines as modulators of muscarinic receptors
EP2027086B1 (en) 2006-05-19 2011-11-16 Wyeth LLC N-benzoyl-pyrrolidin-3-ylamines as histamine-3 antagonists
US7727978B2 (en) 2006-08-24 2010-06-01 Bristol-Myers Squibb Company Cyclic 11-beta hydroxysteroid dehydrogenase type I inhibitors
WO2009000811A1 (en) 2007-06-25 2008-12-31 Novartis Ag N5-(2-ethoxyethyl)-n3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors
US8119658B2 (en) 2007-10-01 2012-02-21 Bristol-Myers Squibb Company Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
JP5580741B2 (en) 2008-09-19 2014-08-27 武田薬品工業株式会社 Nitrogen-containing heterocyclic compounds and uses thereof
AU2021222441A1 (en) 2020-02-19 2022-09-22 Ichilov Tech Ltd. Improved antidepressant therapy
US20260014143A1 (en) * 2022-07-21 2026-01-15 The Regents Of The University Of California Prostaglandin E synthase 3 (PTGES3) Inhibiting Compounds
CN115448864B (en) * 2022-08-26 2023-12-22 上海方予健康医药科技有限公司 Preparation method of 3-fluoro-3-(1-hydroxyethyl)pyrrolidine-1-carboxylic acid tert-butyl ester

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635510A (en) * 1993-05-06 1997-06-03 Merrell Pharmaceuticals Inc. Substituted pyrrolidin-3-yl-alkyl-piperidines

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO9909984A1 *

Also Published As

Publication number Publication date
CA2298813A1 (en) 1999-03-04
WO1999009984A1 (en) 1999-03-04
AU9206798A (en) 1999-03-16
EP1009405A1 (en) 2000-06-21
JP2001526178A (en) 2001-12-18

Similar Documents

Publication Publication Date Title
EP1173170A4 (en) PYRROLIDINE MODULATORS OF CHIMIOKIN RECEPTOR ACTIVITY
EP1171122A4 (en) PYRROLIDINES MODULATORS OF THE ACTIVITY OF THE CHIMIOKIN RECEPTOR
EP0859614A4 (en) INHIBITORS OF ROTAMASE ENZYME ACTIVITY
EP1003743A4 (en) 3,3-DISUBSTITUTED PIPERIDINES FOR USE AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
EP0989822A4 (en) ACOUSTIC HEMOSTASIS METHODS AND DEVICES
DE69620930D1 (en) Plate and pen
DE69635339D1 (en) Electromagnetic-acoustic transducer and EMAR system
DE69620381D1 (en) GAME DEVICE AND SYSTEM THEREFOR
EP1018987A4 (en) NEOCARTILAGE AND ITS METHODS OF USE
DE69635607D1 (en) LIPOSOM-REINFORCED IMMUNOAGGREGATION TEST AND TEST DEVICE
DE69534362D1 (en) All-in-one multi-channel TDM-WDM converter and all-optical multi-channel time demultiplexer
EP1003514A4 (en) CYCLIC AMINES MODULATING THE ACTIVITY OF CHIMIOKIN RECEPTORS
NO973756D0 (en) Voice activity detection
EP1558250A4 (en) GAMMA-AMINOAMIDE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
IT1275903B1 (en) ESTERS AND AMIDES OF 1,4-PIPERIDINE DISPLACED
EP1622916A4 (en) HETEROCYCLIC CYCLOPENTYL TETRAHYDROISOQUINOLINE AND TETRAHYDROPYRIDOPYRIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
EP1558599A4 (en) HETEROARYLPIPERIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
DK0804078T3 (en) Composition and use thereof
EP1015430A4 (en) SPIRO PYRROLIDINE-2,3'-OXINDOLE] COMPOUNDS AND METHODS OF USE
PT806955E (en) INJECTIVE AND PERFUSION SOLUTION OF ENROFLOXACIN
BR9708677A (en) Piperidines and pyrrolidines
FI960425L (en) Use of phenylcyclohexylcarboxylic acid amides
FI953736A0 (en) I have been asked to provide and support measures
GB2325223B (en) Novel antiatherosclerosis agents for lipid-lowering and antiperoxidative activity
GB9801009D0 (en) Pyrrolidine and piperidine modulators of chemokine receptor activity

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20000328

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

AX Request for extension of the european patent

Free format text: AL PAYMENT 20000328;LT PAYMENT 20000328;LV PAYMENT 20000328;MK PAYMENT 20000328;RO PAYMENT 20000328;SI PAYMENT 20000328

A4 Supplementary search report drawn up and despatched

Effective date: 20010327

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

RIC1 Information provided on ipc code assigned before grant

Free format text: 7A 61K 31/47 A, 7A 61K 31/55 B, 7A 61K 31/435 B, 7A 61K 31/445 B, 7A 61K 31/495 B, 7C 07D 211/68 B, 7C 07D 217/02 B, 7C 07D 223/16 B, 7C 07D 401/06 B, 7C 07D 403/06 B, 7C 07D 495/10 B, 7C 07D 409/14 B, 7C 07D 401/14 B, 7C 07D 417/14 B, 7C 07D 413/14 B, 7C 07D 207/09 B, 7C 07D 405/14 B, 7A 61P 31/18 B, 7C 07D 211/26 B

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20020301